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  1. Article ; Online: What does acne genetics teach us about disease pathogenesis?

    Common, J E A / Barker, J N / van Steensel, M A M

    The British journal of dermatology

    2019  Volume 181, Issue 4, Page(s) 665–676

    Abstract: Background: Acne vulgaris is a highly prevalent inflammatory skin disorder with a complex pathogenesis, characterized by comedones, papules, pustules and nodules. Familial preponderance clearly indicates a genetic basis for acne vulgaris, but until ... ...

    Abstract Background: Acne vulgaris is a highly prevalent inflammatory skin disorder with a complex pathogenesis, characterized by comedones, papules, pustules and nodules. Familial preponderance clearly indicates a genetic basis for acne vulgaris, but until recently solid genetic associations were lacking.
    Results: The advent of high-resolution genotyping array technologies has allowed for large-scale studies with both family-based and cross-sectional designs. These studies have revealed genetic loci encompassing genes that could be active in biological pathways and processes underlying acne vulgaris. However, specific functional consequences of those variants remain elusive. In parallel, investigations into rare disorders and syndromes that incorporate features of acne or acne-like lesions have recently accelerated our understanding of disease pathogenesis. The genes revealed by these rare disorders highlight mechanisms cardinal for pilosebaceous biology and therefore anchor our insights from genetic association studies for acne vulgaris.
    Conclusions: The next phase of research will require more in-depth mechanistic investigations of loci and genes implicated in acne phenotypes to define the key molecular players driving the disorder. Concurrently, new treatments for acne vulgaris could be developed by dissecting the candidate molecular pathways to identify druggable targets.
    MeSH term(s) Acne Vulgaris/drug therapy ; Acne Vulgaris/genetics ; Acne Vulgaris/immunology ; Acne Vulgaris/pathology ; Dermatologic Agents/pharmacology ; Dermatologic Agents/therapeutic use ; Genetic Association Studies ; Genetic Loci ; Genetic Predisposition to Disease ; Humans ; Medical History Taking ; Molecular Targeted Therapy/methods ; Precision Medicine/methods ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Signal Transduction/immunology ; Skin/immunology ; Skin/pathology
    Chemical Substances Dermatologic Agents
    Language English
    Publishing date 2019-03-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.17721
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  2. Article ; Online: Methotrexate or fumarates: which is the best oral treatment for psoriasis?

    Barker, J N W N

    The British journal of dermatology

    2011  Volume 164, Issue 4, Page(s) 695

    MeSH term(s) Biological Therapy ; Dermatologic Agents/therapeutic use ; Fumarates/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Methotrexate/therapeutic use ; Psoriasis/drug therapy
    Chemical Substances Dermatologic Agents ; Fumarates ; Immunosuppressive Agents ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2011-04
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/j.1365-2133.2011.10282.x
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  3. Article ; Online: Switching from a fumaric acid ester mixture to dimethylfumarate monotherapy in psoriasis.

    Warren, R B / Barker, J N W / Van de Kerkhof, P / Reich, K / Mrowietz, U

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2019  Volume 33, Issue 10, Page(s) e352–e353

    MeSH term(s) Dermatologic Agents/therapeutic use ; Dimethyl Fumarate/therapeutic use ; Esters ; Fumarates/chemistry ; Fumarates/therapeutic use ; Humans ; Psoriasis/drug therapy
    Chemical Substances Dermatologic Agents ; Esters ; Fumarates ; fumaric acid (88XHZ13131) ; Dimethyl Fumarate (FO2303MNI2)
    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.15644
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  4. Article ; Online: Tumour necrosis factor antagonist-induced lupus: a Critically Appraised Topic.

    Momen, S E / Kirkham, B / Barker, J N / Smith, C H

    The British journal of dermatology

    2017  Volume 177, Issue 6, Page(s) 1519–1526

    MeSH term(s) Adolescent ; Adult ; Aged ; Drug Eruptions/etiology ; Drug Substitution ; Female ; Humans ; Lupus Erythematosus, Cutaneous/chemically induced ; Lupus Erythematosus, Cutaneous/prevention & control ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Young Adult
    Chemical Substances Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2017-12-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.15866
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  5. Article: Fetal plasma potassium.

    BARKER, J N

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

    2003  Volume 108, Page(s) 803–805

    MeSH term(s) Fetal Blood ; Fetus/blood ; Potassium/blood
    Chemical Substances Potassium (RWP5GA015D)
    Language English
    Publishing date 2003-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.3181/00379727-108-27073
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  6. Article ; Online: Characteristics and skin cancer risk of psoriasis patients with a history of skin cancer in BADBIR.

    Mason, K J / Burden, A D / Barker, J N W N / Lunt, M / Ali, H / Kleyn, C E / McElhone, K / Soliman, M M / Green, A C / Griffiths, C E M / Reynolds, N J / Ormerod, A D

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2021  Volume 35, Issue 8, Page(s) e498–e501

    MeSH term(s) Humans ; Psoriasis/complications ; Psoriasis/epidemiology ; Skin Neoplasms/epidemiology ; Ustekinumab
    Chemical Substances Ustekinumab (FU77B4U5Z0)
    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.17230
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  7. Article ; Online: Risks of basal cell and squamous cell carcinoma in psoriasis patients after treatment with biologic vs non-biologic systemic therapies.

    Mason, K J / Burden, A D / Barker, J N W N / Lunt, M / Ali, H / Kleyn, C E / McElhone, K / Soliman, M M / Green, A C / Griffiths, C E M / Reynolds, N J / Ormerod, A D

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2021  Volume 35, Issue 8, Page(s) e496–e498

    MeSH term(s) Biological Products ; Carcinoma, Squamous Cell/drug therapy ; Dermatologic Agents/therapeutic use ; Humans ; Psoriasis/drug therapy
    Chemical Substances Biological Products ; Dermatologic Agents
    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.17282
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  8. Article: Genetic aspects of psoriasis.

    Barker, J N

    Clinical and experimental dermatology

    2001  Volume 26, Issue 4, Page(s) 321–325

    Abstract: Epidemiological studies indicate that genes play an important role in the pathogenesis of psoriasis. Multiple genes are likely to be involved, interacting not only with each other but also with the environment to cause disease expression. Molecular ... ...

    Abstract Epidemiological studies indicate that genes play an important role in the pathogenesis of psoriasis. Multiple genes are likely to be involved, interacting not only with each other but also with the environment to cause disease expression. Molecular genetic studies indicate that there are multiple susceptibility loci present throughout the human genome. It is clear that a gene or genes of major impact on psoriasis is present on chromosome 6 within the major histocompatibility complex (MHC). Linkage disequilibrium studies indicate this gene to reside within a 300 kb interval centred around the centromeric end of class I MHC. Known candidate genes in this region are HLA-C, corneodesmosin and HCR, although novel genes, as yet unknown, may also exist. There is accumulating evidence that HLA-C is not itself the causative gene but rather a marker for it. Identification of the genes involved in psoriasis susceptibility will represent a step forward in our understanding of the disease and our future ability to help patients with psoriasis.
    MeSH term(s) Adult ; Aged ; Autoimmune Diseases/genetics ; Chromosome Mapping ; Chromosomes, Human, Pair 6 ; Diseases in Twins ; Female ; Genes, MHC Class I ; Genetic Predisposition to Disease ; Glycoproteins/genetics ; Humans ; Intracellular Signaling Peptides and Proteins ; Linkage Disequilibrium ; Male ; Middle Aged ; Pedigree ; Proteins/genetics ; Psoriasis/genetics
    Chemical Substances CCHCR1 protein, human ; CDSN protein, human ; Glycoproteins ; Intracellular Signaling Peptides and Proteins ; Proteins
    Language English
    Publishing date 2001-06-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1046/j.1365-2230.2001.00830.x
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  9. Article ; Online: Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis? A Critically Appraised Topic.

    Mahil, S K / McSweeney, S M / Kloczko, E / McGowan, B / Barker, J N / Smith, C H

    The British journal of dermatology

    2019  Volume 181, Issue 5, Page(s) 946–953

    Abstract: Clinical question: Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis (PsA) in obese individuals?: Background: Obesity presents a rising public health challenge and is more prevalent among individuals with ... ...

    Abstract Clinical question: Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis (PsA) in obese individuals?
    Background: Obesity presents a rising public health challenge and is more prevalent among individuals with psoriasis or PsA than in the general population. Longitudinal population-based studies suggest a causal role for obesity in psoriasis and PsA onset and that obesity drives greater disease severity.
    Methods: We systematically reviewed evidence within the MEDLINE, Embase and CENTRAL databases and clinical trials registries examining lifestyle, pharmacological and surgical weight loss interventions in the treatment and prevention of psoriasis and PsA in obese individuals. Meta-analysis was conducted using random-effects models, followed by sensitivity analyses.
    Results: Of 176 full-text articles reviewed, 14 met the inclusion criteria. Meta-analysis of six randomized control trials (RCTs) confirmed that weight loss following lifestyle interventions (diet or physical activity) improves psoriasis compared with control [mean change in Psoriasis Area and Severity Index -2·59, 95% confidence interval (CI) -4·09 to -1·09; P < 0·001]. One RCT demonstrated a greater likelihood of achieving minimal PsA activity following diet-induced weight loss (odds ratio 4·20, 95% CI 1·82-9·66; P < 0·001). Three studies of pharmacological treatments reported conflicting results, and no RCTs of bariatric surgery were identified. Two cohort studies suggested that bariatric surgery, particularly gastric bypass, reduces the risk of developing psoriasis (hazard ratio 0·52, 95% CI 0·33-0·81; P < 0·01).
    Conclusions: These limited data indicate that weight loss can improve pre-existing psoriasis and PsA, and prevent the onset of psoriasis in obese individuals. Together with the National Institute for Health and Care Excellence obesity guidance, this informed a local obesity screening and management pathway, providing multidisciplinary weight loss interventions alongside conventional skin-focused care for patients with psoriasis.
    MeSH term(s) Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/epidemiology ; Arthritis, Psoriatic/etiology ; Arthritis, Psoriatic/therapy ; Bariatric Surgery ; Diet, Reducing ; Humans ; Incidence ; Life Style ; Obesity/complications ; Obesity/therapy ; Psoriasis/diagnosis ; Psoriasis/epidemiology ; Psoriasis/etiology ; Psoriasis/therapy ; Randomized Controlled Trials as Topic ; Severity of Illness Index ; Treatment Outcome ; Weight Loss
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.17741
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  10. Article ; Online: Diagnosing liver fibrosis: a narrative review of current literature for dermatologists.

    Potts, J R / Maybury, C M / Salam, A / Barker, J N / Agarwal, K / Smith, C H

    The British journal of dermatology

    2017  Volume 177, Issue 3, Page(s) 637–644

    Abstract: Chronic liver disease is a growing problem worldwide due to obesity, alcohol-related liver disease and viral hepatitis. Liver fibrosis is generally asymptomatic and patients may not present until they have advanced cirrhosis, when the scope for ... ...

    Abstract Chronic liver disease is a growing problem worldwide due to obesity, alcohol-related liver disease and viral hepatitis. Liver fibrosis is generally asymptomatic and patients may not present until they have advanced cirrhosis, when the scope for reversibility is limited. Identification of asymptomatic individuals at an early stage is fundamental to reversing the rising toll of liver-related morbidity and mortality. Awareness of liver disease and the techniques for diagnosis is important for dermatologists, not only due to the burden of disease in the general population but also because some dermatology cohorts may have an elevated risk. For example, there is an increased prevalence of metabolic syndrome and excess alcohol use in those with psoriasis and hidradenitis suppurativa. In isolation, standard liver function tests lack sensitivity to detect advanced fibrosis and cirrhosis and are of limited value. Traditionally diagnosis has relied on liver biopsy, which remains the gold standard but is both costly and invasive. There have been several recent advances in the development of noninvasive alternatives. These include scoring systems combining clinical and conventional laboratory parameters for use as screening tools, direct serum biomarkers of fibrogenesis and tissue elastography using both ultrasound (Fibroscan) and magnetic resonance. This review summarizes current and future noninvasive diagnostic techniques for evaluation of liver fibrosis.
    MeSH term(s) Biomarkers/metabolism ; Biopsy/methods ; Chronic Disease ; Early Diagnosis ; Elasticity Imaging Techniques/methods ; Forecasting ; Humans ; Liver Cirrhosis/diagnosis ; Liver Function Tests ; Magnetic Resonance Imaging/methods ; Practice Guidelines as Topic ; Reference Standards ; Risk Assessment/methods ; Ultrasonography/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.15246
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