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Article ; Online: A Window into Understanding the Lasting Impact of the Nutritional Milieu in Adolescents: Anorexia Nervosa as a Model.

Barker, Jennifer M

The Journal of clinical endocrinology and metabolism

2021 Volume 106, Issue 4, Page(s) e1905–e1906

MeSH term(s)	Adolescent ; Anorexia Nervosa/therapy ; Humans
Language	English
Publishing date	2021-01-22
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgaa667
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Article ; Online: Parental leave during pediatric fellowship training: A national survey.

Dyess, Nicolle F / Weikel, Blair W / Barker, Jennifer M / Garrington, Timothy P / Parker, Thomas A

PloS one

2022 Volume 17, Issue 12, Page(s) e0279447

Abstract: Background: Until recently, no uniform requirements for parental leave (PL) existed in graduate medical education. We implemented a national survey, with the objective of ascertaining fellows' perceptions of PL policies and their impact. This is the ... ...

Abstract	Background: Until recently, no uniform requirements for parental leave (PL) existed in graduate medical education. We implemented a national survey, with the objective of ascertaining fellows' perceptions of PL policies and their impact. This is the first study to focus exclusively on pediatric subspecialty fellows. Methods: An online survey instrument was created targeting pediatric fellows. Results: The survey was accessed by 1003 (25%) of the estimated 4078 pediatric subspecialty fellows and 853 (21%) submitted surveys. Respondent demographic data paralleled the data reported by the American Board of Pediatrics. Half of respondents did not know whether their program had a written PL policy. Over 40% reported ≥ 5 weeks of paid PL. Most indicated that fellows use vacation, sick leave, and unpaid time for PL. Almost half of respondents (45%) indicated that their program's PL policy increases the stress of having a child. Fellows chose establishing/extending paid leave and intentionally fostering a more supportive program culture as the most crucial candidate improvements. The importance of equitable PL polices between parent fellows and co-fellows was an important theme of our qualitative data. Fellows feel there is a moral misalignment between the field of pediatrics' dedication to maternal and child health and current PL policies governing pediatric trainees. Conclusions: PL policies vary widely among pediatric fellowship programs and are often not known by fellows. Fellows are not satisfied with PL policies, which often exacerbate stress for new parents and burden their co-fellows. Targeted modification of several aspects of PL policies may improve their acceptance.
Language	English
Publishing date	2022-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0279447
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Article ; Online: Pediatric Endocrinology Milestones 2.0-guide to their implementation.

Tillotson, Cara V / Becetti, Imen / Hwu, Katherine / Page, Laura / Krishnan, Sowmya / Stafford, Dianne / Stanley, Takara / Vuguin, Patricia / Barker, Jennifer M

BMC medical education

2023 Volume 23, Issue 1, Page(s) 985

Abstract: The Milestones were initiated by the Accreditation Council for Graduate Medical Education (ACGME) to provide a framework for monitoring a trainee's progression throughout residency/fellowship. The Milestones describe stepwise skill progression through ... ...

Abstract	The Milestones were initiated by the Accreditation Council for Graduate Medical Education (ACGME) to provide a framework for monitoring a trainee's progression throughout residency/fellowship. The Milestones describe stepwise skill progression through six core domains of clinical competency: Patient Care, Medical Knowledge, Interpersonal and Communication Skills, Practice-based Learning and Improvement, Professionalism, and Systems-based Practice. Since their introduction in 2013, several barriers to implementation have emerged. Thus, the ACGME launched the Milestones 2.0 project to develop updated specialty-specific milestones. The Pediatric Endocrinology Milestones 2.0 project aimed to improve upon Milestones 1.0 by addressing common limitations, providing resources for faculty to easily incorporate milestones into their assessment of trainees, and adding sub-competencies in health disparities, patient safety, and physician well-being.This paper reviews the development of the Pediatric Endocrinology Milestones 2.0 including the major changes from Milestones 1.0, development of the Supplemental Guide, and how Milestones 2.0 can be applied at the program level. Although use of the Milestones are required only for ACGME programs, the tools provided in Milestones 2.0 are applicable to fellowship programs worldwide.
MeSH term(s)	Child ; Humans ; Internship and Residency ; Education, Medical, Graduate ; Endocrinology ; Patient Care ; Physicians
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04862-5
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Article ; Online: Compounding risk for hypoglycemia: type 1 diabetes and Addison's disease.

Barker, Jennifer M

Diabetes technology & therapeutics

2012 Volume 14, Issue 5, Page(s) 383–385

MeSH term(s)	Addison Disease/complications ; Addison Disease/diagnosis ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Female ; Humans ; Hypoglycemia/diagnosis ; Hypoglycemia/etiology ; Male ; Mass Screening ; Risk Factors
Language	English
Publishing date	2012-05
Publishing country	United States
Document type	Editorial
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2012.0043
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Article ; Online: Hypo and Hyper: Common Pediatric Endocrine and Metabolic Emergencies.

Barker, Jennifer M / Bajaj, Lalit

Advances in pediatrics

2015 Volume 62, Issue 1, Page(s) 257–282

Abstract: The presentation of endocrine and metabolic emergencies represents one of the more challenging clinical scenarios faced by pediatricians and emergency providers. In this review, the authors attempt to describe some of the more common entities that a ... ...

Abstract	The presentation of endocrine and metabolic emergencies represents one of the more challenging clinical scenarios faced by pediatricians and emergency providers. In this review, the authors attempt to describe some of the more common entities that a provider may see and provide a guide for the recognition and management of these difficult-to-assess and often very ill children.
MeSH term(s)	Child ; Disease Management ; Emergencies ; Endocrine System Diseases/diagnosis ; Endocrine System Diseases/epidemiology ; Endocrine System Diseases/therapy ; Global Health ; Humans ; Metabolic Diseases/diagnosis ; Metabolic Diseases/epidemiology ; Metabolic Diseases/therapy ; Morbidity/trends
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	210524-x
ISSN	1878-1926 ; 0065-3101
ISSN (online)	1878-1926
ISSN	0065-3101
DOI	10.1016/j.yapd.2015.04.008
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Article: Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening.

Barker, Jennifer M

The Journal of clinical endocrinology and metabolism

2006 Volume 91, Issue 4, Page(s) 1210–1217

Abstract: Context: Type 1 diabetes (T1D) is associated with autoimmune thyroid disease (AIT), celiac disease (CD), Addison's disease (AD), and other autoimmune diseases. These diseases can occur together in defined syndromes with distinct pathophysiology and ... ...

Abstract	Context: Type 1 diabetes (T1D) is associated with autoimmune thyroid disease (AIT), celiac disease (CD), Addison's disease (AD), and other autoimmune diseases. These diseases can occur together in defined syndromes with distinct pathophysiology and characteristics: autoimmune polyendocrine syndrome I, autoimmune polyendocrine syndrome II, and the immunodysregulation polyendocrinopathy enteropathy X-linked syndrome. Evidence acquisition: Review of the medical literature was performed with particular attention to the natural history, genetic factors, and syndromes associated with T1D, AIT, CD, and AD. Evidence synthesis: Genetic risk for these diseases overlaps and includes genes within the major histocompatibility complex (MHC) such as the human leukocyte antigens (HLA) DR and DQ alleles and the MHC I-related gene A (MIC-A). Other genes outside of the MHC have been associated with these autoimmune diseases, including the gene encoding the lymphoid tyrosine phosphatase (PTPN22) and the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene. Conclusion: Genetic risk for T1D overlaps with AIT, CD, and AD. Disease risk is associated with organ-specific autoantibodies, which can be used to screen subjects with T1D.
MeSH term(s)	Adrenal Gland Diseases/complications ; Adrenal Gland Diseases/genetics ; Adrenal Gland Diseases/immunology ; Animals ; Autoimmune Diseases/complications ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Celiac Disease/complications ; Celiac Disease/genetics ; Celiac Disease/immunology ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Genetic Testing ; Humans ; Risk Factors ; Thyroiditis, Autoimmune/complications ; Thyroiditis, Autoimmune/genetics ; Thyroiditis, Autoimmune/immunology
Language	English
Publishing date	2006-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2005-1679
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Article: Polyendocrine autoimmunity.

Barker, Jennifer M

Current diabetes reports

2005 Volume 5, Issue 2, Page(s) 84–90

Abstract: Autoimmune polyendocrine disorders are characterized by the presence of more than one autoimmune endocrine disease. Study of such disorders has provided unique insight into the pathogenesis of autoimmunity and the development of tolerance in the normal ... ...

Abstract	Autoimmune polyendocrine disorders are characterized by the presence of more than one autoimmune endocrine disease. Study of such disorders has provided unique insight into the pathogenesis of autoimmunity and the development of tolerance in the normal individual. Autoimmune polyendocrine syndromes I and II have distinctive inheritance patterns, genetic causes, component diseases, and implications for follow-up. Care for individuals with these diseases requires monitoring for additional autoimmune disorders and aggressive treatment of identified diseases to prevent morbidity and mortality in affected individuals.
MeSH term(s)	Autoimmune Diseases/prevention & control ; Endocrine System Diseases/prevention & control ; Humans ; Immune Tolerance
Language	English
Publishing date	2005-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	2065167-3
ISSN	1534-4827
ISSN	1534-4827
DOI	10.1007/s11892-005-0033-0
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Article ; Online: Male song quality modulates c-Fos expression in the auditory forebrain of the female canary.

Monbureau, Marie / Barker, Jennifer M / Leboucher, Gérard / Balthazart, Jacques

Physiology & behavior

2015 Volume 147, Page(s) 7–15

Abstract: In canaries, specific phrases of male song (sexy songs, SS) that are difficult to produce are especially attractive for females. Females exposed to SS produce more copulation displays and deposit more testosterone into their eggs than females exposed to ... ...

Abstract	In canaries, specific phrases of male song (sexy songs, SS) that are difficult to produce are especially attractive for females. Females exposed to SS produce more copulation displays and deposit more testosterone into their eggs than females exposed to non-sexy songs (NS). Increased expression of the immediate early genes c-Fos or zenk (a.k.a. egr-1) has been observed in the auditory forebrain of female songbirds hearing attractive songs. C-Fos immunoreactive (Fos-ir) cell numbers were quantified here in the brain of female canaries that had been collected 30min after they had been exposed for 60min to the playback of SS or NS or control white noise. Fos-ir cell numbers increased in the caudomedial mesopallium (CMM) and caudomedial nidopallium (NCM) of SS birds as compared to controls. Song playback (pooled SS and NS) also tended to increase average Fos-ir cell numbers in the mediobasal hypothalamus (MBH) but this effect did not reach full statistical significance. At the individual level, Fos expression in CMM was correlated with its expression in NCM and in MBH but also with the frequency of calls that females produced in response to the playbacks. These data thus indicate that male songs of different qualities induce a differential metabolic activation of NCM and CMM. The correlation between activation of auditory regions and of the MBH might reflect the link between auditory stimulation and changes in behavior and reproductive physiology.
MeSH term(s)	Acoustic Stimulation ; Animals ; Auditory Perception/physiology ; Canaries/physiology ; Cell Count ; Female ; Male ; Prosencephalon/cytology ; Prosencephalon/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Psychoacoustics ; Statistics, Nonparametric ; Vocalization, Animal/physiology
Chemical Substances	Proto-Oncogene Proteins c-fos
Language	English
Publishing date	2015-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2015.04.005
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Article ; Online: Hepatic abnormalities in youth with Turner syndrome.

Singh, Isani / Noel, Gillian / Barker, Jennifer M / Chatfield, Kathryn C / Furniss, Anna / Khanna, Amber D / Nokoff, Natalie J / Patel, Sonali / Pyle, Laura / Nahata, Leena / Cole, Francis S / Ikomi, Chijioke / Bamba, Vaneeta / Fechner, Patricia Y / Davis, Shanlee M

Liver international : official journal of the International Association for the Study of the Liver

2022 Volume 42, Issue 10, Page(s) 2237–2246

Abstract: Background & aims: Liver disease in children with Turner Syndrome (TS) is poorly understood relative to associated growth, cardiac and reproductive complications. This study sought to better characterize hepatic abnormalities in a large national cohort ... ...

Abstract	Background & aims: Liver disease in children with Turner Syndrome (TS) is poorly understood relative to associated growth, cardiac and reproductive complications. This study sought to better characterize hepatic abnormalities in a large national cohort of youth with TS. Methods: Using electronic health record data from PEDSnet institutions, 2145 females with TS were matched to 8580 females without TS on eight demographic variables. Outcomes included liver enzymes (AST and ALT) stratified as normal, 1-2 times above the upper limit of normal (ULN), 2-3 times ULN and >3 times ULN, as well as specific liver disease diagnoses. Results: Fifty-eight percent of youth with TS had elevated liver enzymes. Patients with TS had higher odds of enzymes 1-2 times ULN (OR: 1.7, 95% CI: 1.4-1.9), 2-3 times ULN (OR: 2.7, 95% CI: 1.7-3.3) and >3 times ULN (OR: 1.7, 95% CI: 1.3-2.2). They also had higher odds of any liver diagnosis (OR: 2.4, 95% CI: 1.7-3.3), fatty liver disease (OR: 1.9, 95% CI: 1.1-3.2), hepatitis (OR: 3.7, 95% CI: 1.9-7.1), cirrhosis/fibrosis (OR: 5.8, 95% CI: 1.3-25.0) and liver tumour/malignancy (OR: 4.8, 95% CI: 1.4-17.0). In a multinomial model, age, BMI and presence of cardiovascular disease or diabetes significantly increased the odds of elevated liver enzymes in girls with TS. Conclusions: Youth with TS have higher odds for elevated liver enzymes and clinically significant liver disease compared with matched controls. These results emphasize the need for clinical screening and additional research into the aetiology and treatment of liver disease in TS. Lay summary: Turner Syndrome, a chromosomal condition in which females are missing the second sex chromosome, is often associated with short stature, infertility and cardiac complications. Liver abnormalities are less well described in the literature. In this study, nearly 60% of youth with TS have elevated liver enzymes. Furthermore, patients with TS had a diagnosis of liver disease more often than patients without TS. Our results support the importance of early and consistent liver function screening and of additional research to define mechanisms that disrupt liver function in paediatric TS females.
MeSH term(s)	Adolescent ; Child ; Cohort Studies ; Female ; Humans ; Liver Cirrhosis/complications ; Liver Diseases/complications ; Turner Syndrome/complications ; Turner Syndrome/diagnosis ; Turner Syndrome/genetics
Language	English
Publishing date	2022-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15358
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Article ; Online: Anatomically discrete sex differences and enhancement by testosterone of cell proliferation in the telencephalic ventricle zone of the adult canary brain.

Barker, Jennifer M / Ball, Gregory F / Balthazart, Jacques

Journal of chemical neuroanatomy

2013 Volume 55, Page(s) 1–8

Abstract: Previous work in songbirds has suggested that testosterone increases neuronal recruitment and survival in HVC but does not affect neuronal proliferation in the ventricular zone and that males and females have similar rates of proliferation except at ... ...

Abstract	Previous work in songbirds has suggested that testosterone increases neuronal recruitment and survival in HVC but does not affect neuronal proliferation in the ventricular zone and that males and females have similar rates of proliferation except at discrete locations. Many of these conclusions are however based on limited data or were inferred indirectly. Here we specifically tested the effects of testosterone on cellular proliferation in the ventricular zone of both male and female adult canaries. We implanted adult birds of both sexes with testosterone or empty implants for 1 week and injected them with BrdU. One day later, we collected their brains and quantified BrdU-positive cells in the ventricular zone (VZ) at different rostro-caudal levels of the brain, ranging from the level where the song nucleus Area X occurs through the caudal extent of HVC. Proliferation in the dorsal part of the VZ was low and unaffected by sex or testosterone treatment. In the ventral part of the VZ, females had more proliferating cells than males, but only at rostral levels, near Area X. Also in the ventral part of the VZ, testosterone increased proliferation in birds of both sexes, but only in the mid- to caudal-VZ, caudal to the level of Area X, around the septum and HVC. We thus demonstrate here that there is both an effect of testosterone and possibly a more subtle effect of sex on cellular proliferation in the adult songbird brain, and that these effects are specific to different levels of the brain.
MeSH term(s)	Animals ; Brain/cytology ; Brain/drug effects ; Canaries ; Cell Proliferation/drug effects ; Cerebral Ventricles/cytology ; Cerebral Ventricles/drug effects ; Female ; Male ; Neurons/drug effects ; Sex Characteristics ; Testosterone/pharmacology
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2013-11-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639443-7
ISSN	1873-6300 ; 0891-0618
ISSN (online)	1873-6300
ISSN	0891-0618
DOI	10.1016/j.jchemneu.2013.10.005
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