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  1. AU="Barker, Jenny C"
  2. AU="Lorimer, D. R."
  3. AU="Peh, Kelvin S-H"
  4. AU="Hossein Safarpour"
  5. AU="Hall, Frances"
  6. AU="Weckmann, U."
  7. AU="Martínez-Sáez, O"
  8. AU="dos Santos, Alejandra Filippo Gonzalez Neves"
  9. AU="Beverly Castillo Herrera"
  10. AU="Fatin Izzati Abdul Hadi"
  11. AU="Musinguzi, Nicholas"
  12. AU=Lee Edward Y
  13. AU="Raval, Urdhva"
  14. AU="Senn, L Kirsten"
  15. AU="Matsutani, Noriyuki"
  16. AU="Bernstein, Herbert J"
  17. AU="Elisa Impresari"
  18. AU="Feldman, Noa"
  19. AU="Dhingra, Mandeep Singh"

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  1. Artikel: A Primer for Success as an Early Career Academic Plastic Surgeon.

    Lin, Lawrence O / Barker, Jenny C / Khansa, Ibrahim / Janis, Jeffrey E

    Plastic and reconstructive surgery. Global open

    2022  Band 10, Heft 1, Seite(n) e4066

    Abstract: The early career academic plastic surgeon strives to be an expert surgeon, an innovative researcher, and an impactful educator. Navigating these challenges is difficult in a healthcare landscape with diminishing public research funding, increasing demand ...

    Abstract The early career academic plastic surgeon strives to be an expert surgeon, an innovative researcher, and an impactful educator. Navigating these challenges is difficult in a healthcare landscape with diminishing public research funding, increasing demand from institutions for clinical productivity, and decreased value of surgical education. To help the junior academic plastic surgeon, this article discusses the fundamental aspects of developing an early academic plastic surgery practice, rooted in clinical care, research, and education.
    Methods: Using published literature, expert opinion, and faculty interviews, the authors prepared this primer for education and guidance of plastic surgery residents considering a career in academic plastic surgery and early career academic plastic surgeons.
    Results: This primer highlights elements important to succeeding as a junior academic plastic surgeon including defining goals and priorities, institutional and financial support, mentorship, education of students and residents, developing a practice niche, promotion and tenure, and social support and burnout.
    Conclusion: The early career academic plastic surgeon can create an environment for academic success with appropriate institutional support, mentorship, personal, and social support, to progress toward promotion while minimizing burnout and professional exhaustion.
    Sprache Englisch
    Erscheinungsdatum 2022-01-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004066
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  2. Artikel ; Online: Implanted Tissue-Engineered Vascular Graft Cell Isolation with Single-Cell RNA Sequencing Analysis.

    Mirhaidari, Gabriel J M / Barker, Jenny C / Breuer, Christopher K / Reinhardt, James W

    Tissue engineering. Part C, Methods

    2023  Band 29, Heft 2, Seite(n) 72–84

    Abstract: The advent of single-cell RNA sequencing (scRNA-Seq) has brought with it the ability to gain greater insights into the cellular composition of tissues and heterogeneity in gene expression within specific cell types. For tissue-engineered blood vessels, ... ...

    Abstract The advent of single-cell RNA sequencing (scRNA-Seq) has brought with it the ability to gain greater insights into the cellular composition of tissues and heterogeneity in gene expression within specific cell types. For tissue-engineered blood vessels, this is particularly impactful to better understand how neotissue forms and remodels into tissue resembling a native vessel. A notable challenge, however, is the ability to separate cells from synthetic biomaterials to generate high-quality single-cell suspensions to interrogate the cellular composition of our tissue-engineered vascular grafts (TEVGs) during active remodeling
    Mesh-Begriff(e) Animals ; Mice ; Blood Vessel Prosthesis ; Tissue Engineering/methods ; Suspensions ; Biocompatible Materials ; Sequence Analysis, RNA ; Tissue Scaffolds/chemistry
    Chemische Substanzen Suspensions ; Biocompatible Materials
    Sprache Englisch
    Erscheinungsdatum 2023-02-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2420585-0
    ISSN 1937-3392 ; 1937-3384
    ISSN (online) 1937-3392
    ISSN 1937-3384
    DOI 10.1089/ten.TEC.2022.0189
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Basics and Best Practices of Multimodal Pain Management for the Plastic Surgeon.

    Barker, Jenny C / Joshi, Girish P / Janis, Jeffrey E

    Plastic and reconstructive surgery. Global open

    2020  Band 8, Heft 5, Seite(n) e2833

    Abstract: Pain management is a central focus for the plastic surgeon's perioperative planning, and it no longer represents a postoperative afterthought. Protocols that rely on opioid-only pain therapy are outdated and discouraged, as they do not achieve optimal ... ...

    Abstract Pain management is a central focus for the plastic surgeon's perioperative planning, and it no longer represents a postoperative afterthought. Protocols that rely on opioid-only pain therapy are outdated and discouraged, as they do not achieve optimal pain relief, increase postoperative morbidity, and contribute to the growing opioid epidemic. A multimodal approach to pain management using non-opioid analgesic techniques is an integral component of enhanced recovery after surgery protocols. Careful perioperative planning for optimal pain management must be achieved in multidisciplinary collaboration with the perioperative care team including anesthesiology. This allows pain management interventions to occur at 3 critical opportunities-preoperative, intraoperative, and postoperative settings.
    Sprache Englisch
    Erscheinungsdatum 2020-05-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000002833
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  4. Artikel ; Online: Opioid Overprescribing and Procedure-Specific Opioid Consumption Patterns for Plastic and Reconstructive Surgery Patients.

    Chu, Jacqueline J / Janis, Jeffrey E / Skoracki, Roman / Barker, Jenny C

    Plastic and reconstructive surgery

    2021  Band 147, Heft 4, Seite(n) 669e–679e

    Abstract: Background: Opioid prescribing practices contribute to opioid misuse, dependency, and diversion. There are currently no comprehensive and quantitative evidence-based guidelines that give procedure-specific recommendations regarding opioid prescribing in ...

    Abstract Background: Opioid prescribing practices contribute to opioid misuse, dependency, and diversion. There are currently no comprehensive and quantitative evidence-based guidelines that give procedure-specific recommendations regarding opioid prescribing in plastic surgery.
    Methods: A retrospective review of 479 plastic surgery patients encompassing 23 different plastic surgery procedure categories was performed. Opioid prescribing patterns and patient-reported opioid use at 1 and 3 months postoperatively are reported.
    Results: Opioid overprescribing was common, averaging an excess of 13 pills per patient across all procedure categories (prescribed versus consumed, 25.4 ± 23.1 versus 12.1 ± 19.7; p = 3.0 × 10-19), with a total excess of 5895 pills (30,967 oral morphine equivalents) for the study's sample. Fifty-two percent of all opioid pills prescribed went unused. Opioid consumption ranged between four and 37 pills across procedure categories. A greater proportion of patients who reported a history of preoperative opioid use were still using opioids at the time of their 1-month and 3-month follow-up appointments (62 percent versus 9 percent at 1 month, and 31 percent versus 1 percent at 3 months). Most patients (83 percent) did not store opioids in a locked location, and 64 percent did not dispose of opioids at 1 month.
    Conclusions: Opioids are commonly overprescribed by plastic surgery providers. This study determined procedure-specific opioid consumption patterns, which can help providers reduce opioid waste. In addition, patients do not properly store or dispose of opioids, demonstrating the need for better patient education.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analgesics, Opioid/therapeutic use ; Female ; Humans ; Inappropriate Prescribing/statistics & numerical data ; Male ; Middle Aged ; Practice Patterns, Physicians'/statistics & numerical data ; Plastic Surgery Procedures ; Retrospective Studies ; Surgery, Plastic ; Young Adult
    Chemische Substanzen Analgesics, Opioid
    Sprache Englisch
    Erscheinungsdatum 2021-03-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000007782
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  5. Artikel ; Online: Tamoxifen reduces silicone implant capsule formation in a mouse model.

    Blum, Kevin M / Mirhaidari, Gabriel J M / Zbinden, Jacob C / Breuer, Christopher K / Barker, Jenny C

    FASEB bioAdvances

    2022  Band 4, Heft 10, Seite(n) 638–647

    Abstract: Capsular contracture as a result of the foreign body response (FBR) is a common issue after implant-based breast reconstruction, affecting up to 20% of patients. New evidence suggests that tamoxifen may mitigate the FBR. C57BL/6 female mice were treated ... ...

    Abstract Capsular contracture as a result of the foreign body response (FBR) is a common issue after implant-based breast reconstruction, affecting up to 20% of patients. New evidence suggests that tamoxifen may mitigate the FBR. C57BL/6 female mice were treated with daily tamoxifen or control injections and implanted with bilateral silicone implants in the submammary glandular plane. Implants were removed
    Sprache Englisch
    Erscheinungsdatum 2022-08-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2573-9832
    ISSN (online) 2573-9832
    DOI 10.1096/fba.2022-00036
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  6. Artikel: Reducing Opioid Overprescribing through Procedure-specific Prescribing Guidelines.

    Zhang, Kevin K / Blum, Kevin M / Chu, Jacqueline J / Sharma, Shuchi / Skoracki, Roman J / Moore, Amy M / Janis, Jeffrey E / Barker, Jenny C

    Plastic and reconstructive surgery. Global open

    2023  Band 11, Heft 1, Seite(n) e4776

    Abstract: Despite advances in opioid-sparing pain management, postdischarge opioid overprescribing in plastic surgery remains an issue. Procedure-specific prescribing protocols have been implemented successfully in other surgical specialties but not broadly in ... ...

    Abstract Despite advances in opioid-sparing pain management, postdischarge opioid overprescribing in plastic surgery remains an issue. Procedure-specific prescribing protocols have been implemented successfully in other surgical specialties but not broadly in plastic surgery. This study examined the efficacy of procedure-specific prescribing guidelines for reducing postdischarge opioid overprescribing.
    Methods: A total of 561 plastic surgery patients were evaluated retrospectively after a prescribing guideline, which recommended postdischarge prescription amounts based on the type of operation, was introduced in July 2020. Prescription and postdischarge opioid consumption amounts before (n = 428) and after (n = 133) guideline implementation were compared. Patient satisfaction and prescription frequency of nonopioid analgesia were also compared.
    Results: The average number of opioid pills per prescription decreased by 25% from 19.3 (27.4 OME) to 15.0 (22.7 OME;
    Conclusions: A procedure-specific prescribing model is a straight-forward intervention to promote safer opioid-prescribing practices in plastic surgery. Its usage in clinical practice may lead to more appropriate opioid prescribing.
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004776
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  7. Artikel ; Online: The lysosomal trafficking regulator "LYST": an 80-year traffic jam.

    Turner, Mackenzie E / Che, Jingru / Mirhaidari, Gabriel J M / Kennedy, Catherine C / Blum, Kevin M / Rajesh, Sahana / Zbinden, Jacob C / Breuer, Christopher K / Best, Cameron A / Barker, Jenny C

    Frontiers in immunology

    2024  Band 15, Seite(n) 1404846

    Abstract: Lysosomes and lysosome related organelles (LROs) are dynamic organelles at the intersection of various pathways involved in maintaining cellular hemostasis and regulating cellular functions. Vesicle trafficking of lysosomes and LROs are critical to ... ...

    Abstract Lysosomes and lysosome related organelles (LROs) are dynamic organelles at the intersection of various pathways involved in maintaining cellular hemostasis and regulating cellular functions. Vesicle trafficking of lysosomes and LROs are critical to maintain their functions. The lysosomal trafficking regulator (LYST) is an elusive protein important for the regulation of membrane dynamics and intracellular trafficking of lysosomes and LROs. Mutations to the LYST gene result in Chédiak-Higashi syndrome, an autosomal recessive immunodeficiency characterized by defective granule exocytosis, cytotoxicity, etc. Despite eight decades passing since its initial discovery, a comprehensive understanding of LYST's function in cellular biology remains unresolved. Accumulating evidence suggests that dysregulation of LYST function also manifests in other disease states. Here, we review the available literature to consolidate available scientific endeavors in relation to LYST and discuss its relevance for immunomodulatory therapies, regenerative medicine and cancer applications.
    Mesh-Begriff(e) Humans ; Lysosomes/metabolism ; Vesicular Transport Proteins/metabolism ; Vesicular Transport Proteins/genetics ; Animals ; Chediak-Higashi Syndrome/genetics ; Protein Transport ; Mutation
    Chemische Substanzen LYST protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1404846
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  8. Artikel ; Online: Medical Student Mentorship in Plastic Surgery: The Mentor's Perspective.

    Janis, Jeffrey E / Barker, Jenny C

    Plastic and reconstructive surgery

    2016  Band 138, Heft 5, Seite(n) 925e–935e

    Abstract: Background: The reproducible benefits of mentoring to mentees have been studied extensively. However, insights from the mentor perspective are less well described. This study evaluates mentorship of plastic surgery medical students from the attending ... ...

    Abstract Background: The reproducible benefits of mentoring to mentees have been studied extensively. However, insights from the mentor perspective are less well described. This study evaluates mentorship of plastic surgery medical students from the attending surgeon's perspective. A comparison is made with a previous publication evaluating mentorship from the medical student's perspective.
    Methods: An electronic survey was sent to 1025 active members of the American Council of Academic Plastic Surgeons (ACAPS) and the American Association of Plastic Surgeons (AAPS), with a combined response rate of 23 percent. For individual organizations, the response rate was 40 percent for ACAPS and 24 percent for AAPS.
    Results: Eighty-three percent of attending surgeons reported participation in medical student mentoring. Mentor demographics and preferences were defined. The majority of mentors are men, older than 50 years, with a clinically focused, academic practice. Although scheduled, one-on-one meetings were the most preferred form of interaction, mentors generally favored group activities. Mentors also preferred to meet less frequently and in less personalized formats than mentees. Mentors perceived enhanced job satisfaction and a sense of "giving back" as most important. The most common barriers included mentor time constraints and lack of exposure to medical students. The presence of plastic surgery involvement in the medical school curriculum correlated directly with the formation of mentoring relationships.
    Conclusions: By comparing the perspectives on mentoring between attending surgeons and medical students, discrepancies and similarities were identified. These findings can be used to increase efficacy and strengthen mentoring efforts for medical students in plastic surgery.
    Mesh-Begriff(e) Adult ; Attitude of Health Personnel ; Education, Medical, Undergraduate ; Faculty, Medical/psychology ; Female ; Humans ; Male ; Mentors/psychology ; Middle Aged ; Surgery, Plastic/education ; Surveys and Questionnaires ; United States
    Sprache Englisch
    Erscheinungsdatum 2016-09-22
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000002670
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A Personalized Opioid Prescription Model for Predicting Postoperative Discharge Opioid Needs.

    Zhang, Kevin K / Blum, Kevin M / Chu, Jacqueline J / Zewdu, Abeba / Janse, Sarah / Skoracki, Roman / Janis, Jeffrey E / Barker, Jenny C

    Plastic and reconstructive surgery

    2022  Band 151, Heft 2, Seite(n) 450–460

    Abstract: Background: Opioid overprescribing after surgery is common. There is currently no universal predictive tool available to accurately anticipate postdischarge opioid need in a patient-specific manner. This study examined the efficacy of a patient-specific ...

    Abstract Background: Opioid overprescribing after surgery is common. There is currently no universal predictive tool available to accurately anticipate postdischarge opioid need in a patient-specific manner. This study examined the efficacy of a patient-specific opioid prescribing framework for estimating postdischarge opioid consumption.
    Methods: A total of 149 patients were evaluated for a single-center retrospective cohort study of plastic and reconstructive surgery patients. Patients with length of stay of 2 to 8 days and quantifiable inpatient opioid consumption (n = 116) were included. Each patient's daily postoperative inpatient opioid consumption was used to generate a personalized logarithmic regression model to estimate postdischarge opioid need. The validity of the personalized opioid prescription (POP) model was tested through comparison with actual postdischarge opioid consumption reported by patients 4 weeks after surgery. The accuracy of the POP model was compared with two other opioid prescribing models.
    Results: The POP model had the strongest association (R2 = 0.899; P < 0.0001) between model output and postdischarge opioid consumption when compared to a procedure-based (R2 = 0.226; P = 0.025) or a 24-hour (R2 = 0.152; P = 0.007) model. Accuracy of the POP model was unaffected by age, gender identity, procedure type, or length of stay. Odds of persistent use at 4 weeks increased, with a postdischarge estimated opioid need at a rate of 1.16 per 37.5 oral morphine equivalents (P = 0.010; 95% CI, 1.04 to 1.30).
    Conclusions: The POP model accurately estimates postdischarge opioid consumption and risk of developing persistent use in plastic surgery patients. Use of the POP model in clinical practice may lead to more appropriate and personalized opioid prescribing.
    Mesh-Begriff(e) Humans ; Male ; Female ; Analgesics, Opioid/adverse effects ; Patient Discharge ; Pain, Postoperative/drug therapy ; Pain, Postoperative/chemically induced ; Retrospective Studies ; Aftercare ; Practice Patterns, Physicians' ; Gender Identity ; Drug Prescriptions
    Chemische Substanzen Analgesics, Opioid
    Sprache Englisch
    Erscheinungsdatum 2022-11-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000009865
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  10. Artikel: Targeted Peripheral Nerve-directed Onabotulinumtoxin A Injection for Effective Long-term Therapy for Migraine Headache.

    Janis, Jeffrey E / Barker, Jenny C / Palettas, Marilly

    Plastic and reconstructive surgery. Global open

    2017  Band 5, Heft 3, Seite(n) e1270

    Abstract: Background: Onabotulinumtoxin A (BOTOX) is an FDA-approved treatment for chronic migraine headaches (MHs) that involves on-label, high-dose administration across 31 anatomic sites. Anatomically specific peripheral nerve trigger sites have been ... ...

    Abstract Background: Onabotulinumtoxin A (BOTOX) is an FDA-approved treatment for chronic migraine headaches (MHs) that involves on-label, high-dose administration across 31 anatomic sites. Anatomically specific peripheral nerve trigger sites have been identified that contribute to MH pathogenesis and are amenable to both BOTOX injection and surgical decompression. These sites do not always correlate with the on-label FDA-approved injection pattern, but represent a more targeted approach. The efficacy of peripheral nerve-directed BOTOX injection as an independent long-term therapeutic option has not been investigated.
    Methods: The technique for peripheral nerve-directed therapeutic long-term BOTOX injection is described. A retrospective review was subsequently completed for 223 patients with MH. Sixty-six patients elected to proceed with diagnostic BOTOX injections. Of these, 24 continued long-term therapeutic BOTOX injections, whereas 42 matriculated to surgery. Outcomes were tracked.
    Results: Initial outcomes included significant improvement in migraine headache index (MHI) (53.5 ± 83.0,
    Conclusions: Though inferior to surgical decompression, preliminary data demonstrate that targeted peripheral nerve-directed BOTOX injection is an effective primary therapy for MH representing a possible alternative to nondirected BOTOX injection with decreased dosage requirements and potentially decreased cost.
    Sprache Englisch
    Erscheinungsdatum 2017-03-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000001270
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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