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Article ; Online: Does pre-school developmental assessment agree with later intellectual assessment? A retrospective cohort study.

Karyadiguna, Nugroho / Bernie, Charmaine / Barnes, Elizabeth H / Williams, Katrina / Lo, Bee Hong

2023 Volume 59, Issue 8, Page(s) 962–967

Abstract: Aim: This study sought to assess the association between early developmental assessment of toddlers with idiopathic global developmental delay (GDD) and their later intelligence test scores.: Methods: Toddlers with idiopathic GDD attending a ... ...

Abstract	Aim: This study sought to assess the association between early developmental assessment of toddlers with idiopathic global developmental delay (GDD) and their later intelligence test scores. Methods: Toddlers with idiopathic GDD attending a community clinic over a 6-year period were assessed initially using the Griffiths Mental Development Scales - Extended Revised version (GMDS-ER) and later completing formal intelligence testing using the Stanford-Binet Intelligence Scale - 5th Edition (SB5) at age 4-6 years. Spearman's correlation was used to assess the association of quotient scores across the tools. The composite quotient (GQ) and the subscale quotients of GMDS-ER were correlated with the full-scale IQ (FSIQ), verbal and non-verbal IQ scores from the SB5. Results: Thirty of 153 children assessed at the clinic were eligible for the study. The correlation between GMDS-ER GQ and later SB5 FSIQ was strong (r = 0.86, P < 0.001). The subscales' associations were moderate to strong (0.48-0.71). Eighty-six percent (86%) of children with delay on GMDS-ER GQ were found later to be in the impaired category based on the FSIQ of the SB5. Conclusion: There was a strong association between toddlers' early developmental quotients and later IQ scores for children with idiopathic GDD, though agreement between early GDD diagnoses and later intellectual disability is not absolute. Individualised care is needed around prognostic advice and recommendations to caregivers and families in the early years, so they may effectively plan for interventions, supports and later reassessment to optimise their child's development and learning.
MeSH term(s)	Humans ; Child, Preschool ; Child ; Retrospective Studies ; Intelligence Tests ; Intelligence
Language	English
Publishing date	2023-05-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.16428
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Article ; Online: Patterns of parental online health information-seeking behaviour.

Yudianto, Benedicta / Caldwell, Patrina Hy / Nanan, Ralph / Barnes, Elizabeth H / Scott, Karen M

Journal of paediatrics and child health

2023 Volume 59, Issue 5, Page(s) 743–752

Abstract: Aim: This study aimed to understand parents' online health information-seeking behaviour and the potential influence of this on their relationship with their child's physician.: Methods: A survey regarding parental online health information-seeking ... ...

Abstract	Aim: This study aimed to understand parents' online health information-seeking behaviour and the potential influence of this on their relationship with their child's physician. Methods: A survey regarding parental online health information-seeking behaviour was administered to parents of children aged under 18 years admitted to an Australian tertiary paediatric hospital, paediatric hospital ward and paediatric clinic, and in their social media networks. Responses were presented as frequencies and percentages. Associations between parents' trust in their child's doctor and survey responses were analysed using χ Results: In all, 300 surveys were completed. Most parents (89%) reported searching for online health information when their child was sick. Some (31%) followed online health information instead of going to the doctor. Parents who trusted their child's doctor were more likely to follow the doctor instead of online health information when it contained conflicting advice. Most parents (91%) wanted health-care professionals' help in searching for online health information. Conclusion: Almost all parents search for online health information, but most do not act on it. Parents' trust in their child's doctor influences how parents use online health information. Thus, clinicians could recommend trustworthy websites with information that complements their advice to ensure parents access reliable online health information.
MeSH term(s)	Humans ; Child ; Adolescent ; Information Seeking Behavior ; Australia ; Parents ; Physicians ; Surveys and Questionnaires
Language	English
Publishing date	2023-04-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.16387
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Article ; Online: Learning outcomes from a systematic review workshop series for junior doctors.

S Patabendige, Nounu / Scott, Karen M / Barnes, Elizabeth H / Caldwell, Patrina H Y

Internal medicine journal

2023 Volume 54, Issue 2, Page(s) 258–264

Abstract: Background: Systematic reviews provide the highest level of evidence about a topic. Ten-week workshops in conducting systematic reviews were held with hospital doctors in 2019 and 2020.: Aim: This study analysed participants' feedback about the ... ...

Abstract	Background: Systematic reviews provide the highest level of evidence about a topic. Ten-week workshops in conducting systematic reviews were held with hospital doctors in 2019 and 2020. Aim: This study analysed participants' feedback about the systematic review workshops to improve how we teach clinicians about conducting systematic reviews. Methods: Attendees completed a post-workshop survey (with multiple-choice and free-text items) to assess knowledge and skills gained. We compared the responses of senior and junior doctors. We used descriptive statistics for the quantitative data and compared groups using Χ Results: Of 81 attendees, 52% completed the survey. Of those, 69% had no prior experience with systematic reviews, 93% reported increased knowledge and ability to conduct research and 69% reported increased ability to conduct systematic reviews. More senior than junior clinicians reported gaining knowledge about writing and publishing (37% vs 11%, P = 0.047) and making greater use of skills gained to conduct research (56% vs 23%, P = 0.029). Five themes were identified: learning through course structure; learning through course organisation; teaching style; flexible learning; and suggestions for progression and improvement. Respondents suggested running the workshops during protected teaching time, more time for some sessions, conducting the workshop series more often and making clinicians aware of the workshop series at hospital orientation. Conclusion: The skills learnt from the systematic review workshop series impacted not only participants' research knowledge and skills, and plans to conduct future research, but also facilitated looking up medical literature in daily clinical work, supporting evidence-based clinical practice.
MeSH term(s)	Humans ; Learning ; Physicians ; Medical Staff, Hospital ; Surveys and Questionnaires
Language	English
Publishing date	2023-07-19
Publishing country	Australia
Document type	Systematic Review ; Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16168
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Urinary incontinence during laughter in children: Is it giggle incontinence?

San, Soe T / Barnes, Elizabeth H / Caldwell, Patrina H Y

Journal of paediatrics and child health

2021 Volume 57, Issue 12, Page(s) 1971–1975

Abstract: Aim: Giggle incontinence is a distinct entity of childhood daytime urinary incontinence (DUI), where children wet themselves only when they laugh. The prevalence of true giggle incontinence is unknown, with confusion about the diagnosis of urinary ... ...

Abstract	Aim: Giggle incontinence is a distinct entity of childhood daytime urinary incontinence (DUI), where children wet themselves only when they laugh. The prevalence of true giggle incontinence is unknown, with confusion about the diagnosis of urinary incontinence occurring during laughter and true giggle incontinence. The aim of the study is to improve our understanding of urinary incontinence during laughter by comparing those children with children who have DUI at other times, but not with laughter. Methods: We conducted a retrospective medical record review of children with DUI who presented to a tertiary continence service from 2017 to 2018, collecting data on age, gender, associated comorbidities, lower urinary tract symptoms, investigations, provisional diagnosis at first visit and initial treatment responses. Differences between those with DUI occurring during laughter and those with DUI at other times, but not with laughter were compared using standard statistical methods. Results: Of the 277 new patients seen during the study period, 140 (51%) had DUI, and of these, 72 (51%) had DUI occurring during laughter. Children with incontinence occurring during laughter were more likely to have incontinence associated with other activities. One child had giggle incontinence according to the International Children's Continence Society's definition. Four other children were referred specifically for urinary incontinence associated with laughter, with the term giggle incontinence sometimes used by the referring doctor. Conclusion: Children with DUI commonly experience incontinence during laughter, but true giggle incontinence is rare. Correct diagnosis is essential as it directs treatment.
MeSH term(s)	Child ; Diurnal Enuresis ; Family ; Humans ; Laughter ; Retrospective Studies ; Urinary Incontinence/diagnosis ; Urinary Incontinence/epidemiology
Language	English
Publishing date	2021-06-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.15631
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Article ; Online: An exploration of factors associated with food protein-induced enterocolitis syndrome: Birth, infant feeding and food triggers.

Lee, Eric / Barnes, Elizabeth H / Mehr, Sam / Campbell, Dianne E

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2021 Volume 32, Issue 4, Page(s) 742–749

Abstract: Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergic disorder with a well-characterized phenotype, but limited understanding of factors associated with food cross-reactivity, severity and tolerance.: ... ...

Abstract	Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergic disorder with a well-characterized phenotype, but limited understanding of factors associated with food cross-reactivity, severity and tolerance. Methods: A retrospective cohort study spanning 20 years on children with acute FPIES from a single paediatric tertiary centre in New South Wales, Australia, focusing on identifying food trigger co-associations and factors associated with reaction severity, multiple trigger FPIES and/or tolerance was performed. Results: A total of 168 individuals with 329 recorded FPIES episodes between 1997 and 2017 were included. 49% were male. The median age at first reaction was 5 months, and median age at diagnosis was 9 months. 73% experienced at least one severe FPIES reaction. Rice (45%), cow's milk (30%) and soya (13%) were the most common triggers. Rice or cow's milk FPIES was strongly associated with increased odds of having multiple trigger FPIES. The odds of having multiple food FPIES and severe reactions were slightly decreased with vaginal delivery. No factors were associated with increased risk of severe reactions. Infants with rice and grains FPIES outgrew their reactions at an earlier age, compared to those with fish FPIES. Conclusions: Rice remains the most common trigger in Australia with co-associations between rice/oats and cow's milk/soya observed. This suggests that taxonomically related foods may share similar protein structure and trigger similar mechanisms of antigen recognition. Vaginal delivery may have a mild protective effect on the development of multiple FPIES and severe reactions. No other features from birth or infant-feeding history influenced outcomes in FPIES.
MeSH term(s)	Animals ; Cattle ; Dietary Proteins/adverse effects ; Enterocolitis/epidemiology ; Enterocolitis/etiology ; Female ; Food Hypersensitivity/epidemiology ; Humans ; Infant ; Male ; Milk ; Retrospective Studies ; Syndrome
Chemical Substances	Dietary Proteins
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.13448
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Zs.A 3096: Show issues

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Article ; Online: The relationship between hand hygiene and rates of acute respiratory infections among Umrah pilgrims: A pilot randomised controlled trial.

Albutti, Aqel / Mahdi, Hashim A / Alwashmi, Ameen S / Alfelali, Mohammad / Barasheed, Osamah / Barnes, Elizabeth H / Shaban, Ramon Z / Booy, Robert / Rashid, Harunor

Journal of infection and public health

2023 Volume 17 Suppl 1, Page(s) 34–41

Abstract: Background: There is a lack of randomised controlled trials (RCTs) investigating the role of hand hygiene in preventing and containing acute respiratory infections (ARIs) in mass gatherings. In this pilot RCT, we assessed the feasibility of establishing ...

Abstract	Background: There is a lack of randomised controlled trials (RCTs) investigating the role of hand hygiene in preventing and containing acute respiratory infections (ARIs) in mass gatherings. In this pilot RCT, we assessed the feasibility of establishing a large-scale trial to explore the relationship between practising hand hygiene and rates of ARI in Umrah pilgrimage amidst the COVID-19 pandemic. Methods: A parallel RCT was conducted in hotels in Makkah, Saudi Arabia, between April and July 2021. Domestic adult pilgrims who consented to participate were randomised 1:1 to the intervention group who received alcohol-based hand rub (ABHR) and instructions, or to the control group who did not receive ABHR or instructions but were free to use their own supplies. Pilgrims in both groups were then followed up for seven days for ARI symptoms. The primary outcome was the difference in the proportions of syndromic ARIs among pilgrims between the randomised groups. Results: A total of 507 (control: intervention = 267: 240) participants aged between 18 and 75 (median 34) years were randomised; 61 participants were lost to follow-up or withdrew leaving 446 participants (control: intervention = 237:209) for the primary outcome analysis; of whom 10 (2.2 %) had developed at least one respiratory symptom, three (0.7 %) had 'possible ILI' and two (0.4 %) had 'possible COVID-19'. The analysis of the primary outcome found no evidence of difference in the proportions of ARIs between the randomised groups (odds ratio 1.1 [0.3-4.0] for intervention relative to control). Conclusion: This pilot trial suggests that conducting a future definitive RCT to assess the role of hand hygiene in the prevention of ARIs is feasible in Umrah setting amidst such a pandemic; however, outcomes from this trial are inconclusive, and such a study would need to be very large given the low rates of outcomes observed here. Trial registration: This trial was registered in the Australian New Zealand Clinical Trials Registry (ANZCTR) (ACTRN12622001287729), the full protocol can be accessed there.
MeSH term(s)	Adult ; Humans ; Adolescent ; Young Adult ; Middle Aged ; Aged ; Pilot Projects ; Hand Hygiene ; Australia ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; COVID-19/prevention & control ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2023.04.003
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Article ; Online: Clinical features associated with epilepsy occurrence, resolution, and drug resistance in children with cerebral palsy: A population-based study.

Feroze, Nimra / Karim, Tasneem / Ostojic, Katarina / Mcintyre, Sarah / Barnes, Elizabeth H / Lee, Byoung Chan / Dale, Russell C / Gill, Deepak / Kothur, Kavitha

Developmental medicine and child neurology

2023 Volume 66, Issue 6, Page(s) 793–803

Abstract: Aim: To investigate clinicoradiological features associated with epilepsy, its resolution, and drug resistance in children with cerebral palsy (CP).: Method: Data were gathered from the New South Wales/Australian Capital Territory CP Register, ... ...

Abstract	Aim: To investigate clinicoradiological features associated with epilepsy, its resolution, and drug resistance in children with cerebral palsy (CP). Method: Data were gathered from the New South Wales/Australian Capital Territory CP Register, encompassing children with CP born between 2003 and 2015 (n = 1916). Clinical features and the severity of impairments were compared among three groups: children with current epilepsy (n = 604), those with resolved epilepsy by age 5 years (n = 109), and those without epilepsy (n = 1203). Additionally, a subset of the registry cohort attending Children's Hospital Westmead (n = 256) was analysed to compare epilepsy and treatment characteristics between drug-responsive (n = 83) and drug-resistant groups (n = 147) using logistic regression and hierarchical cluster analysis. Results: Manual Ability Classification System levels IV and V, intellectual impairment, and vision impairment were found to be associated with epilepsy in children with CP on multivariable analysis (p < 0.01). Moderate to severe intellectual impairment and bilateral spastic CP were independent positive and negative predictors of epilepsy persistence at the age of 5 years respectively (p < 0.05). Microcephaly and multiple seizure types were predictors of drug-resistant epilepsy (area under the receiver operating characteristic curve of 0.83; 95% confidence interval 0.77-0.9). Children with a known genetic cause (14%) and CP epilepsy surgery group (4.3%) formed specific clinical subgroups in CP epilepsy. Interpretation: Our study highlights important clinical associations of epilepsy, its resolution, and treatment response in children with CP, providing valuable knowledge to aid in counselling families and identifying distinct prognostic groups for effective medical surveillance and optimal treatment. What this paper adds: Severe motor and non-motor impairments in cerebral palsy (CP) increase epilepsy risk. Epilepsy more likely resolves in bilateral spastic and milder CP impairments. Epilepsy in CP often manifests at an early age with multiple seizure types and high drug resistance. Children with a known genetic cause and CP epilepsy surgery group represent distinct clinical subgroups.
MeSH term(s)	Humans ; Cerebral Palsy/complications ; Male ; Female ; Child, Preschool ; Epilepsy/drug therapy ; Child ; Drug Resistant Epilepsy/drug therapy ; Drug Resistant Epilepsy/genetics ; Intellectual Disability ; Anticonvulsants/therapeutic use ; Registries ; New South Wales/epidemiology ; Infant ; Severity of Illness Index ; Drug Resistance ; Vision Disorders/etiology
Chemical Substances	Anticonvulsants
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.15807
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Article ; Online: A natural history study of autosomal dominant GUCY2D-associated cone-rod dystrophy.

Scopelliti, Amanda J / Jamieson, Robyn V / Barnes, Elizabeth H / Nash, Benjamin / Rajagopalan, Sulekha / Cornish, Elisa L / Grigg, John R

Documenta ophthalmologica. Advances in ophthalmology

2023 Volume 147, Issue 3, Page(s) 189–201

Abstract: Purpose: To describe the natural history of autosomal dominant (AD) GUCY2D-associated cone-rod dystrophies (CRDs), and evaluate associated structural and functional biomarkers.: Methods: Retrospective analysis was conducted on 16 patients with AD ... ...

Abstract	Purpose: To describe the natural history of autosomal dominant (AD) GUCY2D-associated cone-rod dystrophies (CRDs), and evaluate associated structural and functional biomarkers. Methods: Retrospective analysis was conducted on 16 patients with AD GUCY2D-CRDs across two sites. Assessments included central macular thickness (CMT) and length of disruption to the ellipsoid zone (EZ) via optical coherence tomography (OCT), electroretinography (ERG) parameters, best corrected visual acuity (BCVA), and fundus autofluorescence (FAF). Results: At first visit, with a mean age of 30 years (range 5-70 years), 12 patients had a BCVA below Australian driving standard (LogMAR ≥ 0.3 bilaterally), and 1 patient was legally blind (LogMAR ≥ 1). Longitudinal analysis demonstrated a deterioration of LogMAR by - 0.019 per year (p < 0.001). This accompanied a reduction in CMT of - 1.4 µm per year (p < 0.0001), lengthened EZ disruption by 42 µm per year (p = < 0.0001) and increased area of FAF by 0.05 mm Conclusion: We have described the natural long-term decline in vision and cone function associated with mutations in GUCY2D and identified a set of functional and structural biomarkers that may be useful as outcome parameters for future therapeutic clinical trials.
MeSH term(s)	Humans ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Cone-Rod Dystrophies/diagnosis ; Cone-Rod Dystrophies/genetics ; Retrospective Studies ; Electroretinography ; Visual Acuity ; Australia ; Retinitis Pigmentosa ; Biomarkers ; Tomography, Optical Coherence/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-09-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212594-8
ISSN	1573-2622 ; 0012-4486
ISSN (online)	1573-2622
ISSN	0012-4486
DOI	10.1007/s10633-023-09954-7
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Article ; Online: Adjuvant chemotherapy for locally advanced cervical cancer - Authors' reply.

Mileshkin, Linda R / Narayan, Kailash / Gaffney, David K / Barnes, Elizabeth H / Lee, Yeh Chen / Monk, Bradley J / Stockler, Martin R

The Lancet. Oncology

2023 Volume 24, Issue 7, Page(s) e290

MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Neoadjuvant Therapy ; Neoplasm Staging ; Cisplatin/therapeutic use
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(23)00294-2
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Paediatric pneumonia: deriving a model to identify severe disease.

Haggie, Stuart / Barnes, Elizabeth H / Selvadurai, Hiran / Gunasekera, Hasantha / Fitzgerald, Dominic A

Archives of disease in childhood

2021 Volume 107, Issue 5, Page(s) 491–496

Abstract: Background: Community-acquired pneumonia (CAP) is a leading cause of childhood hospitalisation. Limited data exist on factors predicting severe disease with no paediatric-specific predictive tools.: Methods: Retrospective cohort (2011-2016) of ... ...

Abstract	Background: Community-acquired pneumonia (CAP) is a leading cause of childhood hospitalisation. Limited data exist on factors predicting severe disease with no paediatric-specific predictive tools. Methods: Retrospective cohort (2011-2016) of hospitalised CAP cases. We analysed clinical variables collected at hospital presentation against outcomes. Stratified outcomes were mild (hospitalised), moderate (invasive drainage procedure, intensive care) or severe (mechanical ventilation, vasopressors, death). Results: We report 3330 CAP cases, median age 2.0 years (IQR 1-5 years), with 2950 (88.5%) mild, 305 (9.2%) moderate and 75 (2.3%) severe outcomes. Moderate-severe outcomes were associated with hypoxia (SaO Conclusions: A clinical risk prediction tool is needed for child CAP. We have identified risk factors and derived a simple clinical tool using clinical variables at hospital presentation to determine a child's risk of invasive or intensive care treatment with an ROC AUC comparable with adult pneumonia tools.
MeSH term(s)	Adult ; Child ; Child, Preschool ; Community-Acquired Infections/diagnosis ; Humans ; Pneumonia/diagnosis ; Pneumonia/epidemiology ; Pneumonia/etiology ; Prognosis ; Prospective Studies ; ROC Curve ; Retrospective Studies ; Severity of Illness Index
Language	English
Publishing date	2021-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2021-322665
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