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  1. AU="Barnestein, R"
  2. AU="Grafton, R. Quentin"
  3. AU="Lee, Cin-Ty Aeolus"
  4. AU="Tahmasbi, Fateme"
  5. AU="Marmolejo-Ramos, Fernando"
  6. AU="Michel, Christoph M"
  7. AU="Drury, Ashleigh"
  8. AU="Besson, François"
  9. AU="Lee, Seong-Min"
  10. AU=Fath Mohsen Karami AU=Fath Mohsen Karami
  11. AU="Isabel, P."
  12. AU="Melniker, Larry"
  13. AU="Wagner, Marlies"
  14. AU="Karina A. Dow"
  15. AU="Prieto, A. Fernández"
  16. AU=Arnaout Omar AU=Arnaout Omar
  17. AU="Holden, Joseph M."
  18. AU="Balcells, Ll"
  19. AU="Ho, Raymond W"
  20. AU="Richardson, Marcy"
  21. AU="Stephanie Fischinger"
  22. AU="Wilkinson, Michelle J"

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  1. Artikel ; Online: L’échographie diaphragmatique pour le pneumologue : méthodologie et intérêt clinique.

    Schenesse, D / Mouillot, P / Rabec, C / Barnestein, R / Tankere, P / Giboulot, M / Bonniaud, P / Georges, M

    Revue des maladies respiratoires

    2023  Band 41, Heft 1, Seite(n) 1–17

    Abstract: Introduction: Ultrasonography is an emerging tool that helps to assess diaphragmatic function. It is now widely used in ICUs to predict weaning from mechanical ventilation. Ultrasonography is readily available, harmless (no radiation), and repeatable ... ...

    Titelübersetzung Diaphragmatic ultrasonography for the pulmonologist: Technique and clinical use.
    Abstract Introduction: Ultrasonography is an emerging tool that helps to assess diaphragmatic function. It is now widely used in ICUs to predict weaning from mechanical ventilation. Ultrasonography is readily available, harmless (no radiation), and repeatable with good interoperator reproducibility. Over the past few years, ultrasonography has seen increasing use in patients with chronic pulmonary pathologies.
    State of the art: The aim of this review is (1) to describe the ultrasound techniques used to assess diaphragmatic excursion and thickening, (2) to indicate the expected, normal values in healthy patients, and (3) to summarize the main findings and clinical applications in treatment of chronic respiratory disorders.
    Conclusions: Chronic pulmonary diseases are associated with diaphragmatic dysfunction that can be assessed with ultrasound. Diaphragmatic dysfunction is primary in neuromuscular disorders and secondary to respiratory disease in other chronic pulmonary conditions (COPD, ILD). Ultrasound is correlated with the severity of the underlying disease (functional and clinical parameters).
    Perspectives: The prognostic interest of diaphragm ultrasonography remains to be established, after which its utilization should become routine.
    Mesh-Begriff(e) Humans ; Diaphragm/diagnostic imaging ; Pulmonologists ; Reproducibility of Results ; Lung ; Ultrasonography/methods
    Sprache Französisch
    Erscheinungsdatum 2023-11-18
    Erscheinungsland France
    Dokumenttyp English Abstract ; Journal Article ; Review
    ZDB-ID 605743-3
    ISSN 1776-2588 ; 0301-0279 ; 0761-8425
    ISSN (online) 1776-2588
    ISSN 0301-0279 ; 0761-8425
    DOI 10.1016/j.rmr.2023.10.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness.

    Barnestein, Robby / Galland, Loïck / Kalfeist, Laura / Ghiringhelli, François / Ladoire, Sylvain / Limagne, Emeric

    Oncoimmunology

    2022  Band 11, Heft 1, Seite(n) 2120676

    Abstract: With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of care in cancer management has evolved rapidly. However, immunotherapy is not currently beneficial for all patients. In addition to intrinsic tumor factors, other ... ...

    Abstract With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of care in cancer management has evolved rapidly. However, immunotherapy is not currently beneficial for all patients. In addition to intrinsic tumor factors, other etiologies of resistance to ICIs arise from the complex interplay between cancer and its microenvironment. Recognition of the essential role of the tumor microenvironment (TME) in cancer progression has led to a shift from a tumor-cell-centered view of cancer development, to the concept of a complex tumor ecosystem that supports tumor growth and metastatic dissemination. The expansion of immunosuppressive cells represents a cardinal strategy deployed by tumor cells to escape detection and elimination by the immune system. Regulatory T lymphocytes (Treg), myeloid-derived suppressor cells (MDSCs), and type-2 tumor-associated macrophages (TAM2) are major components of these inhibitory cellular networks, with the ability to suppress innate and adaptive anticancer immunity. They therefore represent major impediments to anticancer therapies, particularly immune-based interventions. Recent work has provided evidence that, beyond their direct cytotoxic effects on cancer cells, several conventional chemotherapeutic (CT) drugs and agents used in targeted therapies (TT) can promote the elimination or inactivation of suppressive immune cells, resulting in enhanced antitumor immunity. In this review, we will analyze findings pertaining to this concept, discuss the possible molecular bases underlying the selective targeting of these immunosuppressive cells by antineoplastic agents (CT and/or TT), and consider current challenges and future prospects related to the integration of these molecules into more efficient anticancer strategies, in the era of immunotherapy.
    Mesh-Begriff(e) Ecosystem ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy/methods ; Neoplasms/drug therapy ; Neoplasms/pathology ; Tumor Microenvironment
    Chemische Substanzen Immune Checkpoint Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-09-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2022.2120676
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Outcomes of Therapeutic Bronchoscopy in Malignant Airway Obstruction Causing Acute Respiratory Failure.

    Roy, Pascalin / Fournier, Clément / Barnestein, Robby / Wallyn, Frédéric / Bourinet, Valérian / Briault, Amandine / Camuset, Juliette / Cellerin, Laurent / Crutu, Adrian / Dewolf, Maxime / Egenod, Thomas / Favrolt, Nicolas / Héluain, Valentin / Lorut, Christine / Mangiapan, Gilles / Schlossmasscher, Pascal / Toublanc, Benedicte / Usturoi, Daniela / Legodec, Julien /
    Vergnon, Jean-Michel / Pajiep Chapda, Marie-Christelle / Dutau, Hervé / Guibert, Nicolas

    Annals of the American Thoracic Society

    2024  Band 21, Heft 5, Seite(n) 833–837

    Mesh-Begriff(e) Humans ; Bronchoscopy/methods ; Airway Obstruction/etiology ; Airway Obstruction/diagnosis ; Airway Obstruction/therapy ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Male ; Female ; Middle Aged ; Aged ; Lung Neoplasms/complications ; Acute Disease ; Treatment Outcome ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202311-943RL
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.

    Limagne, Emeric / Nuttin, Lisa / Thibaudin, Marion / Jacquin, Elise / Aucagne, Romain / Bon, Marjorie / Revy, Solène / Barnestein, Robby / Ballot, Elise / Truntzer, Caroline / Derangère, Valentin / Fumet, Jean-David / Latour, Charlène / Rébé, Cédric / Bellaye, Pierre-Simon / Kaderbhaï, Coureche-Guillaume / Spill, Aodrenn / Collin, Bertrand / Callanan, Mary B /
    Lagrange, Aurélie / Favier, Laure / Coudert, Bruno / Arnould, Laurent / Ladoire, Sylvain / Routy, Bertrand / Joubert, Philippe / Ghiringhelli, François

    Cancer cell

    2022  Band 40, Heft 2, Seite(n) 136–152.e12

    Abstract: Chemotherapy with anti PD-1/PD-L1 antibodies has become the standard of care for patients with metastatic non-small cell lung cancer (mNSCLC). Using lung tumor models, where pemetrexed and cisplatin (PEM/CDDP) chemotherapy remains unable to synergize ... ...

    Abstract Chemotherapy with anti PD-1/PD-L1 antibodies has become the standard of care for patients with metastatic non-small cell lung cancer (mNSCLC). Using lung tumor models, where pemetrexed and cisplatin (PEM/CDDP) chemotherapy remains unable to synergize with immune checkpoint inhibitors (ICIs), we linked the failure of this treatment with its inability to induce CXCL10 expression and CD8
    Mesh-Begriff(e) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Autophagy/drug effects ; Autophagy/genetics ; B7-H1 Antigen/antagonists & inhibitors ; Biomarkers, Tumor ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Cell Line, Tumor ; Chemokine CXCL10/genetics ; Chemokine CXCL10/metabolism ; Disease Models, Animal ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Drug Synergism ; Gene Expression Regulation, Neoplastic ; Humans ; Immune Checkpoint Proteins/genetics ; Immune Checkpoint Proteins/metabolism ; Mice ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Mitophagy/genetics ; Mitophagy/immunology ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Binding ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays
    Chemische Substanzen Antineoplastic Agents ; B7-H1 Antigen ; Biomarkers, Tumor ; CD274 protein, human ; CXCL10 protein, human ; Chemokine CXCL10 ; Immune Checkpoint Proteins ; Protein Kinase Inhibitors ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
    Sprache Englisch
    Erscheinungsdatum 2022-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2021.12.009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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