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  1. Article ; Online: Recycling of

    Kretowicz, Margarita N / Barrett, Kendall E / Barnhart, Todd E / Engle, Jonathan W

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2023  Volume 200, Page(s) 110924

    Abstract: ... ...

    Abstract 52g
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2023.110924
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Radiolabeling Diaminosarcophagine with Cyclotron-Produced Cobalt-55 and [

    Lin, Wilson / Fonseca Cabrera, German Oscar / Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Mixdorf, Jason C / Li, Zibo / Wu, Zhanhong / Engle, Jonathan W

    Bioconjugate chemistry

    2024  Volume 35, Issue 3, Page(s) 412–418

    Abstract: Cobalt-sarcophagine complexes exhibit high kinetic inertness under various stringent conditions, but there is limited literature on radiolabeling and in vivo positron emission tomography (PET) imaging using no carrier ... ...

    Abstract Cobalt-sarcophagine complexes exhibit high kinetic inertness under various stringent conditions, but there is limited literature on radiolabeling and in vivo positron emission tomography (PET) imaging using no carrier added
    MeSH term(s) Humans ; Animals ; Mice ; Tissue Distribution ; Cyclotrons ; Heterografts ; Copper Radioisotopes/pharmacokinetics ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/pharmacokinetics ; Neoplasms ; Cell Line, Tumor ; Cobalt Radioisotopes
    Chemical Substances Cobalt-55 ; Copper Radioisotopes ; Radiopharmaceuticals ; Cobalt Radioisotopes
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.4c00043
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
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  3. Article ; Online: Copper-Mediated Radiobromination of (Hetero)Aryl Boronic Pinacol Esters.

    Mixdorf, Jason C / Hoffman, Sabrina L V / Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Engle, Jonathan W / Ellison, Paul A

    The Journal of organic chemistry

    2023  Volume 88, Issue 4, Page(s) 2089–2094

    Abstract: A copper-mediated radiobromination of (hetero)aryl boronic pinacol esters is described. Cyclotron-produced [ ...

    Abstract A copper-mediated radiobromination of (hetero)aryl boronic pinacol esters is described. Cyclotron-produced [
    MeSH term(s) Copper ; Esters ; Boron ; Glycols
    Chemical Substances Copper (789U1901C5) ; pinacol ; Esters ; Boron (N9E3X5056Q) ; Glycols
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c02420
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  4. Article ; Online: Separation of cyclotron-produced cobalt-55/58m from iron targets using cation exchange chromatography with non-aqueous solvents and extraction chromatography.

    Lin, Wilson / Aluicio-Sarduy, Eduardo / Barrett, Kendall E / Barnhart, Todd E / Mixdorf, Jason C / DeLuca, Molly C / Engle, Jonathan W

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2023  Volume 200, Page(s) 110980

    Abstract: Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron- ... ...

    Abstract Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron-produced
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2023.110980
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Amplification of Cerenkov luminescence using semiconducting polymers for cancer theranostics.

    Rosenkrans, Zachary T / Hsu, Jessica C / Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Engle, Jonathan W / Cai, Weibo

    Advanced functional materials

    2023  Volume 33, Issue 33

    Abstract: The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy ... ...

    Abstract The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy referred to as Cerenkov radiation induced therapy (CRIT). Semiconducting polymer nanoparticles (SPNs) have ideal optical properties, such as large absorption cross-sections and broad absorbance, which can be utilized to harness the relatively weak CL produced by radionuclides. SPNs can be doped with photosensitizers and have nearly 100% energy transfer efficiency by multiple energy transfer mechanisms. Herein, we investigated an optimized photosensitizer doped SPN as a nanosystem to harness and amplify CL for cancer theranostics. We found that semiconducting polymers significantly amplified CL energy transfer efficiency. Bimodal PET and optical imaging studies showed high tumor uptake and retention of the optimized SPNs when administered intravenously or intratumorally. Lastly, we found that photosensitizer doped SPNs have excellent potential as a cancer theranostics nanosystem in an in vivo tumor therapy study. Our study shows that SPNs are ideally suited to harness and amplify CL for cancer theranostics, which may provide a significant advancement for CRIT that are unabated by tissue penetration limits.
    Language English
    Publishing date 2023-05-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039420-2
    ISSN 1616-3028 ; 1616-301X
    ISSN (online) 1616-3028
    ISSN 1616-301X
    DOI 10.1002/adfm.202302777
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  6. Article ; Online: Spleen-Targeted Glabridin-Loaded Nanoparticles Regulate Polarization of Monocyte/Macrophage (M

    Li, Shiyong / Wang, Ye / Wu, Miaojin / Younis, Muhsin H / Olson, Aeli P / Barnhart, Todd E / Engle, Jonathan W / Zhu, Xingen / Cai, Weibo

    Advanced materials (Deerfield Beach, Fla.)

    2022  Volume 34, Issue 39, Page(s) e2204976

    Abstract: During cerebral ischemia-reperfusion (I-R) injury, the infiltration of monocyte/macrophages ( ... ...

    Abstract During cerebral ischemia-reperfusion (I-R) injury, the infiltration of monocyte/macrophages (M
    MeSH term(s) Animals ; Isoflavones ; Macrophages ; Mice ; Monocytes ; Nanoparticles ; Phenols ; Reperfusion Injury/drug therapy ; Spleen
    Chemical Substances Isoflavones ; Phenols ; glabridin (HOC5567T41)
    Language English
    Publishing date 2022-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202204976
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  7. Article ; Online: "Off-Label Use" of the Siderophore Enterobactin Enables Targeted Imaging of Cancer with Radioactive Ti

    Koller, Angus J / Glaser, Owen / DeLuca, Molly C / Motz, Rachel N / Amason, Edith K / Carbo-Bague, Imma / Mixdorf, Jason C / Guzei, Ilia A / Aluicio-Sarduy, Eduardo / Śmiłowicz, Dariusz / Barnhart, Todd E / Ramogida, Caterina F / Nolan, Elizabeth M / Engle, Jonathan W / Boros, Eszter

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 18, Page(s) e202319578

    Abstract: The development of inert, biocompatible chelation methods is required to harness the emerging positron emitting ... ...

    Abstract The development of inert, biocompatible chelation methods is required to harness the emerging positron emitting radionuclide
    MeSH term(s) Humans ; Male ; Animals ; Mice ; Siderophores/chemistry ; Enterobactin/metabolism ; Titanium/chemistry ; Off-Label Use ; Prostatic Neoplasms/metabolism ; Radioisotopes
    Chemical Substances Siderophores ; Enterobactin (28384-96-5) ; Titanium (D1JT611TNE) ; Radioisotopes
    Language English
    Publishing date 2024-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202319578
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  8. Article ; Online: Cyclotron-Produced

    Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Weichert, Jamey / Hernandez, Reinier / Engle, Jonathan W

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 62, Issue 7, Page(s) 1012–1015

    Abstract: The aim of this work was to ... ...

    Abstract The aim of this work was to explore
    MeSH term(s) Cell Line, Tumor ; Cyclotrons ; Humans ; Positron Emission Tomography Computed Tomography ; Tissue Distribution
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.255794
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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  9. Article ; Online: A Review of Accelerator-Produced Ga-68 with Solid Targets.

    Becker, Kaelyn V / Chernysheva, Margarita / Barnhart, Todd E / Gagnon, Katherine / Engle, Jonathan W

    Current radiopharmaceuticals

    2020  Volume 14, Issue 4, Page(s) 315–324

    Abstract: Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium- ... ...

    Abstract Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium-68/gallium-68 generators. An alternative method of production currently being explored uses accelerators to form gallium-68 directly. This review of gallium-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.
    MeSH term(s) Cyclotrons ; Gallium Radioisotopes/chemistry ; Lutetium/chemistry ; Positron-Emission Tomography ; Precision Medicine ; Radiochemistry/methods ; Radioisotopes/chemistry ; Radiopharmaceuticals/chemical synthesis
    Chemical Substances Gallium Radioisotopes ; Radioisotopes ; Radiopharmaceuticals ; Lutetium (5H0DOZ21UJ) ; Gallium-68 (98B30EPP5S) ; Lutetium-177 (BRH40Y9V1Q)
    Language English
    Publishing date 2020-12-24
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 1874-4729
    ISSN (online) 1874-4729
    DOI 10.2174/1874471013666201224113651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Cyclotron production of

    Becker, Kaelyn V / Aluicio-Sarduy, Eduardo / Bradshaw, Tyler / Hurley, Samuel A / Olson, Aeli P / Barrett, Kendall E / Batterton, Jeanine / Ellison, Paul A / Barnhart, Todd E / Pirasteh, Ali / Engle, Jonathan W

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1167783

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1167783
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