Article ; Online: The in situ near-total pancreatectomy (LIVOCADO procedure) for end-staged chronic pancreatitis.
Langenbeck's archives of surgery
2021 Volume 406, Issue 8, Page(s) 2657–2668
Abstract: Purpose: Total pancreatectomy for severe pain in end-stage chronic pancreatitis may be the only option, but with vascular involvement, this is usually too high risk and/or technically not feasible. The purpose of the study was to present the clinical ... ...
| Abstract | Purpose: Total pancreatectomy for severe pain in end-stage chronic pancreatitis may be the only option, but with vascular involvement, this is usually too high risk and/or technically not feasible. The purpose of the study was to present the clinical outcomes of a novel procedure in severe chronic pancreatitis complicated by uncontrollable pain and vascular involvement. Methods: We describe an in situ near-total pancreatectomy that avoids peripancreatic vascular dissection (Livocado procedure) and report on surgical and clinical outcomes. Results: The Livocado procedure was carried out on 18 (3.9%) of 465 patients undergoing surgery for chronic pancreatitis. There were 13 men and 5 women with a median (IQR) age of 48.5 (42.4-57) years and weight of 60.7 (58.0-75.0) kg. All had severe pain and vascular involvement; 17 had pancreatic parenchymal calcification; the median (IQR) oral morphine equivalent dose requirement was 86 (33-195) mg/day. The median (IQR) maximal pain scores were 9 (9-10); the average pain score was 6 (IQR 4-7). There was no peri-operative or 90-day mortality. At a median (IQR) follow-up of 32.5 (21-45.75) months, both maximal and average pain scores were significantly improved post-operatively, and at 12 months, two-thirds of patients were completely pain free. Six (33%) patients had employment pre-operatively versus 13 (72%) post-operatively (p = 0.01). Conclusions: The Livocado procedure was safe and carried out successfully in patients with chronic pancreatitis with vascular involvement where other procedures would be contraindicated. Perioperative outcomes, post-operative pain scores, and employment rehabilitation were comparable with other procedures carried out in patients without vascular involvement. |
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| MeSH term(s) | Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pain, Postoperative ; Pancreatectomy ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/surgery ; Treatment Outcome |
| Language | English |
| Publishing date | 2021-06-25 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 1423681-3 |
| ISSN | 1435-2451 ; 1435-2443 |
| ISSN (online) | 1435-2451 |
| ISSN | 1435-2443 |
| DOI | 10.1007/s00423-021-02107-x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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