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  1. Article ; Online: Time in Range Does Not Associate With Carotid Artery Wall Thickness and Endothelial Function in Type 1 Diabetes.

    Cutruzzolà, Antonio / Parise, Martina / Scavelli, Faustina B / Barone, Milena / Gnasso, Agostino / Irace, Concetta

    Journal of diabetes science and technology

    2021  Volume 16, Issue 4, Page(s) 904–911

    Abstract: Background: Patients with Type 1 diabetes (T1D) have an increased risk of developing atherosclerosis and complications as myocardial infarction and peripheral artery disease. The thickening of the carotid wall and the brachial artery dysfunction are ... ...

    Abstract Background: Patients with Type 1 diabetes (T1D) have an increased risk of developing atherosclerosis and complications as myocardial infarction and peripheral artery disease. The thickening of the carotid wall and the brachial artery dysfunction are early and preclinical manifestations of atherosclerosis. The standard marker of care for assessment of glycemic control, glycated hemoglobin, does not associate with early atherosclerosis. We have hypothesized that the emerging metric of glycemic control, as the time spent in the target range (TIR), might be associated with carotid thickening and endothelial dysfunction. According to the hypothesis, we have designed the present research with the aim to evaluate the association between TIR collected in the short and long term and the measures of arterial morphology and function in patients with T1D.
    Methods: In our study, 70 patients and 35 healthy controls underwent ultrasound vascular study to measure carotid artery intima-media thickness (IMT) and brachial artery endothelial function by the flow-mediated dilation (FMD) technique. TIR was collected by a continuous glucose monitoring system for 2 weeks, 3 months, and 6 months before the vascular study.
    Results: Patients with T1D showed a significantly higher carotid IMT (mean±SE, 644±19 vs. 568±29 µ;
    Conclusions: Young patients with T1D have early vascular abnormalities. The percent of TIR does not correlate with preclinical atherosclerosis. This finding underlines the complexity of the interplay between diabetes and atherosclerosis.
    MeSH term(s) Atherosclerosis/etiology ; Blood Glucose ; Blood Glucose Self-Monitoring/adverse effects ; Carotid Arteries/diagnostic imaging ; Carotid Intima-Media Thickness ; Diabetes Mellitus, Type 1/complications ; Endothelium, Vascular/diagnostic imaging ; Humans ; Ultrasonography/adverse effects ; Vasodilation
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Journal Article
    ISSN 1932-2968
    ISSN (online) 1932-2968
    DOI 10.1177/1932296821993178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hepatic Steatosis Index Is Associated with Type 1 Diabetes Complications.

    Tripolino, Cesare / Irace, Concetta / Cutruzzolà, Antonio / Parise, Martina / Barone, Milena / Scicchitano, Caterina / Cortese, Claudio / Gnasso, Agostino

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2019  Volume 12, Page(s) 2405–2410

    Abstract: Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of complications in type 1 diabetes (T1DM) patients. To date, several biochemical indexes of NAFLD have been developed. Among these, hepatic steatosis index ( ... ...

    Abstract Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of complications in type 1 diabetes (T1DM) patients. To date, several biochemical indexes of NAFLD have been developed. Among these, hepatic steatosis index (HSI) strongly relates with the results of magnetic resonance.
    Aim: The aim of the present study was to evaluate the possible association between HSI and complications in T1DM.
    Methods: Medical records of patients with T1DM were evaluated. Macro- and micro-vascular complications were evaluated by a combination of instrumental (ECG, carotid artery echo-Doppler, fundus examination, vibration threshold at biothesiometry) and laboratory examination. HSI was calculated based on gender, body mass index and transaminases level.
    Results: Of the 124 patients evaluated, 71 were free of complications and 53 had at least one complication. The prevalence of diabetes complications was: 27% for retinopathy, 15% for carotid atherosclerosis, 16% for neuropathy. HSI was directly correlated with age, disease duration, triglycerides, total daily insulin and inversely with HDL and eGFR. In logistic regression analysis, HSI was independently associated with diabetic complications.
    Conclusion: These findings show that HSI is independently associated with the presence of complications in subjects with T1DM. This can be of clinical utility, allowing a better diagnostic classification of the patient and possibly guiding the therapeutic choice.
    Language English
    Publishing date 2019-11-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S221969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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