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  1. Article ; Online: Bone Marrow Clonogenic Myeloid Progenitors from

    Guardia, Rafael Diaz de la / González-Silva, Laura / López-Millán, Belén / Rodríguez-Sevilla, Juan José / Baroni, Matteo L / Bueno, Clara / Anguita, Eduardo / Vives, Susana / Palomo, Laura / Lapillonne, Helene / Varela, Ignacio / Menendez, Pablo

    Genes

    2020  Volume 11, Issue 1

    Abstract: The cell-of-origin ... ...

    Abstract The cell-of-origin of
    MeSH term(s) Adult ; Aged ; Bone Marrow/metabolism ; Bone Marrow Cells/cytology ; Female ; Genotype ; Humans ; Karyotyping ; Leukemia, Myeloid, Acute/genetics ; Male ; Mesenchymal Stem Cells/metabolism ; Middle Aged ; Mutation ; Myeloid Progenitor Cells/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phenotype ; fms-Like Tyrosine Kinase 3/genetics ; fms-Like Tyrosine Kinase 3/metabolism
    Chemical Substances Nuclear Proteins ; nucleophosmin (117896-08-9) ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Language English
    Publishing date 2020-01-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11010073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML

    Diaz de la Guardia, Rafael / González-Silva, Laura / López-Millán, Belén / Rodríguez-Sevilla, Juan José / Baroni, Matteo L / Bueno, Clara / Anguita, Eduardo / Vives, Susana / Palomo, Laura / Lapillonne, Helene / Varela, Ignacio / Menendez, Pablo

    Genes. 2020 Jan. 09, v. 11, no. 1

    2020  

    Abstract: The cell-of-origin of NPM1- and FLT3-mutated acute myeloid leukemia (AML) is still a matter of debate. Here, we combined in vitro clonogenic assays with targeted sequencing to gain further insights into the cell-of-origin of NPM1 and FLT3-ITD-mutated AML ...

    Abstract The cell-of-origin of NPM1- and FLT3-mutated acute myeloid leukemia (AML) is still a matter of debate. Here, we combined in vitro clonogenic assays with targeted sequencing to gain further insights into the cell-of-origin of NPM1 and FLT3-ITD-mutated AML in diagnostic bone marrow (BM) from nine NPM1+/FLT3-ITD (+/-) AMLs. We reasoned that individually plucked colony forming units (CFUs) are clonal and reflect the progeny of a single stem/progenitor cell. NPM1 and FLT3-ITD mutations seen in the diagnostic blasts were found in only 2/95 and 1/57 individually plucked CFUs, suggesting that BM clonogenic myeloid progenitors in NPM1-mutated and NPM1/FLT3-ITD-mutated AML patients do not harbor such molecular lesions. This supports previous studies on NPM1 mutations as secondary mutations in AML, likely acquired in an expanded pool of committed myeloid progenitors, perhaps CD34-, in line with the CD34⁻/ˡᵒʷ phenotype of NPM1-mutated AMLs. This study has important implications on the cell-of-origin of NPM1+ AML, and reinforces that therapeutic targeting of either NPM1 or FLT3-ITD mutations might only have a transient clinical benefit in debulking the leukemia, but is unlikely to be curative since will not target the AML-initiating/preleukemic cells. The absence of NPM1 and FLT3-ITD mutations in normal clonogenic myeloid progenitors is in line with their absence in clonal hematopoiesis of indeterminate potential.
    Keywords bone marrow ; hematopoiesis ; mutation ; myeloid leukemia ; patients ; phenotype ; progeny ; stem cells ; therapeutics
    Language English
    Dates of publication 2020-0109
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11010073
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity.

    Bueno, Clara / Velasco-Hernandez, Talia / Gutiérrez-Agüera, Francisco / Zanetti, Samanta Romina / Baroni, Matteo L / Sánchez-Martínez, Diego / Molina, Oscar / Closa, Adria / Agraz-Doblás, Antonio / Marín, Pedro / Eyras, Eduardo / Varela, Ignacio / Menéndez, Pablo

    Leukemia

    2019  Volume 33, Issue 8, Page(s) 2090–2125

    MeSH term(s) AC133 Antigen/immunology ; Antigens, CD19/immunology ; Granulocyte Precursor Cells/immunology ; Humans ; Immunotherapy ; Leukemia, Biphenotypic, Acute/immunology ; Leukemia, Biphenotypic, Acute/therapy ; Receptors, Chimeric Antigen/immunology
    Chemical Substances AC133 Antigen ; Antigens, CD19 ; CD19 molecule, human ; PROM1 protein, human ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2019-02-18
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-019-0418-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia.

    Sánchez-Martínez, Diego / Baroni, Matteo L / Gutierrez-Agüera, Francisco / Roca-Ho, Heleia / Blanch-Lombarte, Oscar / González-García, Sara / Torrebadell, Montserrat / Junca, Jordi / Ramírez-Orellana, Manuel / Velasco-Hernández, Talía / Bueno, Clara / Fuster, José Luís / Prado, Julia G / Calvo, Julien / Uzan, Benjamin / Cools, Jan / Camos, Mireia / Pflumio, Françoise / Toribio, María Luisa /
    Menéndez, Pablo

    Blood

    2019  Volume 133, Issue 21, Page(s) 2291–2304

    Abstract: Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the ... ...

    Abstract Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the shared expression of target antigens between CARTs and T-ALL blasts leads to CART fratricide. CD1a is exclusively expressed in cortical T-ALL (coT-ALL), a major subset of T-ALL, and retained at relapse. This article reports that the expression of CD1a is mainly restricted to developing cortical thymocytes, and neither CD34
    MeSH term(s) Animals ; Antigens, CD1/immunology ; Drug Resistance, Neoplasm/immunology ; Humans ; Immunotherapy, Adoptive ; Jurkat Cells ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Receptors, Chimeric Antigen/immunology ; Xenograft Model Antitumor Assays
    Chemical Substances Antigens, CD1 ; CD1a antigen ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2019-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-10-882944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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