Article ; Online: The tubulin code specializes neuronal cilia for extracellular vesicle release.
2020 Volume 81, Issue 3, Page(s) 231–252
Abstract: Cilia are microtubule-based organelles that display diversity in morphology, ultrastructure, protein composition, and function. The ciliary microtubules of C. elegans sensory neurons exemplify this diversity and provide a paradigm to understand ... ...
Abstract | Cilia are microtubule-based organelles that display diversity in morphology, ultrastructure, protein composition, and function. The ciliary microtubules of C. elegans sensory neurons exemplify this diversity and provide a paradigm to understand mechanisms driving ciliary specialization. Only a subset of ciliated neurons in C. elegans are specialized to make and release bioactive extracellular vesicles (EVs) into the environment. The cilia of extracellular vesicle releasing neurons have distinct axonemal features and specialized intraflagellar transport that are important for releasing EVs. In this review, we discuss the role of the tubulin code in the specialization of microtubules in cilia of EV releasing neurons. |
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MeSH term(s) | Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Cilia/metabolism ; Extracellular Vesicles/metabolism ; Sensory Receptor Cells/metabolism ; Tubulin/metabolism |
Chemical Substances | Caenorhabditis elegans Proteins ; Tubulin |
Language | English |
Publishing date | 2020-11-08 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2256184-5 |
ISSN | 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034 |
ISSN (online) | 1932-846X ; 1097-4695 |
ISSN | 1932-8451 ; 0022-3034 |
DOI | 10.1002/dneu.22787 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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