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  1. Article ; Online: Letter to "Increased risk of placenta previa and preterm birth in pregnant women with endometriosis/adenomyosis: A propensity-score matching analysis of a nationwide perinatal database in Japan".

    Barra, Fabio / Izzotti, Alberto / Bogliolo, Stefano

    The journal of obstetrics and gynaecology research

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country Australia
    Document type Letter
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.15915
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    Zs.A 1810: Show issues Location:
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  2. Article ; Online: Experimental and new investigational drugs for the treatment of uterine fibroids.

    Evangelisti, Giulio / Ferrero, Simone / Perrone, Umberto / Gustavino, Claudio / Volpi, Eugenio / Izzotti, Alberto / Barra, Fabio

    Expert opinion on investigational drugs

    2024  , Page(s) 1–12

    Abstract: Introduction: Uterine fibroids, the most prevalent benign tumors among reproductive-age women, pose treatment challenges that range from surgical interventions to medical therapies for symptom control. Progestins and estroprogestins effectively manage ... ...

    Abstract Introduction: Uterine fibroids, the most prevalent benign tumors among reproductive-age women, pose treatment challenges that range from surgical interventions to medical therapies for symptom control. Progestins and estroprogestins effectively manage uterine bleeding by suppressing dysfunctional endometrium over fibroids. While GnRH agonists represent a crucial milestone in symptom treatment, their prolonged use results in menopausal-like symptoms and irreversible bone mineral density loss. Advancements in understanding fibroid pathophysiology have prompted the exploration of new compounds to overcome current therapy limitations.
    Areas covered: This manuscript offers an updated overview of investigational drugs for symptomatic uterine fibroids.
    Expert opinion: Despite ulipristal acetate's well-established efficacy as a selective progesterone receptor modulator (SPRM) in fibroid treatment, its prescription has declined due to the rare but severe risk of liver damage. Oral GnRH antagonists, like elagolix, relugolix, and linzagolix, with their novel pharmacodynamic properties, are gaining traction in fibroid management, inducing a dose-dependent reduction in circulating sex hormone levels. Ongoing research on natural compounds, such as vitamin D and epigallocatechin gallate (EGCG), presents emerging options for treating uterine fibroids. This evolving landscape reflects the ongoing efforts to improve therapeutic outcomes for individuals with symptomatic uterine fibroids.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2024.2343786
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  3. Article ; Online: Exploring the Safety Profile of Ornidazole as Drug Candidate for Endometriosis Treatment.

    Barra, Fabio / Perrone, Umberto / Iasci, Angela / Ferrero, Simone / Bogliolo, Stefano

    Gynecologic and obstetric investigation

    2023  Volume 88, Issue 3, Page(s) 185–186

    MeSH term(s) Female ; Humans ; Ornidazole/adverse effects ; Endometriosis/drug therapy
    Chemical Substances Ornidazole (62XCK0G93T)
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 800003-7
    ISSN 1423-002X ; 0378-7346
    ISSN (online) 1423-002X
    ISSN 0378-7346
    DOI 10.1159/000530461
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  4. Article ; Online: Unbalanced Pro-Inflammatory and Anti-Inflammatory Cytokines Ratio and Endometriosis: A Contributive Pathogenic Role?

    Barra, Fabio / Ferrero, Simone

    Iranian journal of immunology : IJI

    2019  Volume 16, Issue 3, Page(s) 265–267

    MeSH term(s) Clinical Trials as Topic ; Endometriosis/immunology ; Estrogens/genetics ; Estrogens/metabolism ; Female ; Gene Expression Regulation ; Humans ; Inflammation/immunology ; Interferon-gamma/metabolism ; NF-kappa B/metabolism ; Phenotype ; Signal Transduction ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Estrogens ; NF-kappa B ; Transforming Growth Factor beta1 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2019-09-25
    Publishing country Iran
    Document type Letter
    ISSN 1735-367X
    ISSN (online) 1735-367X
    DOI 10.22034/IJI.2019.80277
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  5. Article ; Online: The role of monocytic myeloid-derived suppressor cells in the pathogenesis of endometriosis.

    Barra, Fabio / Ferrero, Simone

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2019  Volume 81, Issue 3, Page(s) e13094

    MeSH term(s) Chemokines, CC ; Endometriosis ; Female ; HLA-DR Antigens ; Humans ; Monocytes ; Myeloid-Derived Suppressor Cells ; Sialic Acid Binding Ig-like Lectin 3
    Chemical Substances CCL25 protein, human ; CD33 protein, human ; Chemokines, CC ; HLA-DR Antigens ; Sialic Acid Binding Ig-like Lectin 3
    Language English
    Publishing date 2019-02-13
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13094
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    Zs.A 1653: Show issues Location:
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  6. Article ; Online: Ultrasonographic 3D Evaluation in the Diagnosis of Bladder Endometriosis: A Prospective Comparative Diagnostic Accuracy Study.

    Barra, Fabio / Alessandri, Franco / Scala, Carolina / Ferrero, Simone

    Gynecologic and obstetric investigation

    2021  Volume 86, Issue 3, Page(s) 299–306

    Abstract: Objective: The use of three-dimensional (3D) transvaginal ultrasonography (TVS) has been investigated for the diagnosis of deep endometriosis (DE). This study aimed to evaluate if 3D reconstructions improve the performance of TVS) in assessing the ... ...

    Abstract Objective: The use of three-dimensional (3D) transvaginal ultrasonography (TVS) has been investigated for the diagnosis of deep endometriosis (DE). This study aimed to evaluate if 3D reconstructions improve the performance of TVS) in assessing the presence and characteristics of bladder endometriosis (BE).
    Design: This was a single-center comparative diagnostic accuracy study. Participants/Materials, Setting, Methods: Patients referred to our institution (Piazza della Vittoria 14 Srl, Genova, Italy) with clinical suspicion of DE were included. In case of surgery, women underwent systematic preoperative ultrasonographic imaging; an experienced sonographer performed a conventional TVS; another experienced sonographer, blinded to results of the previous exam, performed TVS, with the addition of 3D modality. The presence and characteristics of BE nodules were described in accord with International DE Analysis group consensus. Ultrasound data were compared with surgical and histological results.
    Results: Overall, BE was intraoperatively found in 34 out of 194 women who underwent surgery for DE (17.5%; 95% confidence interval: 12.8-23.5%). TVS without and with 3D reconstructions were able to detect endometriotic BE in 82.2% (n = 28/34) and 85.3% (n = 29/34) of the cases (p = 0.125). Both the exams similarly estimated the largest diameter of BE (p = 0.652) and the distance between the endometriotic nodule and the closest ureteral meatus (p = 0.341). However, TVS with 3D reconstructions was more precise in estimating the volume of BE (p = 0.031). In one case (2.9%), TVS without and with 3D reconstructions detected the infiltration of the intramural ureter, which was confirmed at surgery and required laparoscopic ureterovesical reimplantation.
    Limitations: The extensive experience of the gynecologists performing the ultrasonographic scans, the lack of prestudy power analysis, and the population selected, which may have been influenced by the position of the institution as a referral center specialized in the treatment of severe endometriosis, are limitations of the current study.
    Conclusion: Our results demonstrated the high accuracy of ultrasound for diagnosing BE. The addition of 3D reconstructions does not improve the performance of TVS in diagnosing the presence and characteristics of BE. However, the volume of BE may be more precisely assessed by 3D ultrasound.
    MeSH term(s) Endometriosis/diagnostic imaging ; Endometriosis/surgery ; Female ; Humans ; Prospective Studies ; Sensitivity and Specificity ; Ultrasonography ; Urinary Bladder
    Language English
    Publishing date 2021-06-22
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 800003-7
    ISSN 1423-002X ; 0378-7346
    ISSN (online) 1423-002X
    ISSN 0378-7346
    DOI 10.1159/000516634
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  7. Article ; Online: Proteomic Research of Molecular Defects in Globozoospermia.

    Ferrero, Simone / Barra, Fabio

    Proteomics. Clinical applications

    2019  Volume 13, Issue 6, Page(s) e1900111

    Abstract: Globozoospermia is a form of teratozoospermia characterized by round-headed spermatozoa and lack of acrosome. These spermatozoa cannot penetrate the zona pellucida of the oocyte, resulting in unsuccessful fertilization and infertility. When ... ...

    Abstract Globozoospermia is a form of teratozoospermia characterized by round-headed spermatozoa and lack of acrosome. These spermatozoa cannot penetrate the zona pellucida of the oocyte, resulting in unsuccessful fertilization and infertility. When intracytoplasmic sperm injection is performed, the fertilization rate tends to be low. Until now, the causes of this disorder remain to be elucidated; however, mutations of some genes segregating on an autosomal recessive mode have been associated with this infertile condition. DPY19L2 (dpy-19-like 2 [Caenorhabditis elegans]) codes for a transmembrane protein expressed predominantly in spermatids, with specific localization limited to the internal nuclear membrane. Genetic defects in the DPY19L2 gene have been demonstrated the most frequent genetic cause of globozoospermia; however, intracellular molecular pathways related to its encoded protein are largely unknown. In this issue of Proteomics Clinical Applications, Guo and co-workers investigate the proteome of gloobozoospermic spermatozoa. The authors identified 491 proteins that are differentially expressed in globozoospermia (370 are upregulated and 121 are downregulated in DPY19L2-deficient globozoospermic sperm). Notably, the molecular defects identified by the authors are closely related to biological processes involved in acrosome formation, chromatin composition, sperm-egg binding, and fertilization.
    MeSH term(s) Acrosome ; Humans ; Infertility, Male ; Male ; Membrane Proteins ; Proteomics ; Spermatozoa ; Teratozoospermia
    Chemical Substances DPY19L2 protein, human ; Membrane Proteins
    Language English
    Publishing date 2019-10-22
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 2261788-7
    ISSN 1862-8354 ; 1862-8346
    ISSN (online) 1862-8354
    ISSN 1862-8346
    DOI 10.1002/prca.201900111
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  8. Article ; Online: Adhesion proteins: Suitable therapeutic targets or biomarkers of therapy response for endometriosis?

    Barra, Fabio / Ferrero, Simone

    Acta obstetricia et gynecologica Scandinavica

    2019  Volume 98, Issue 6, Page(s) 810–811

    MeSH term(s) Biomarkers ; Down-Regulation ; Endometriosis ; Female ; Gonadotropin-Releasing Hormone ; Humans ; Tensins
    Chemical Substances Biomarkers ; Tensins ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2019-02-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.13533
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  9. Article ; Online: Impact of surgery for endometriosis on the outcomes of in vitro fertilization.

    Ferrero, Simone / Gazzo, Irene / Crosa, Marco / Rosato, Francesco Paolo / Barra, Fabio / Leone Roberti Maggiore, Umberto

    Best practice & research. Clinical obstetrics & gynaecology

    2024  , Page(s) 102496

    Abstract: This narrative review aims to summarize available evidence on the IVF-associated outcomes after surgery for endometriosis. Only one retrospective study investigated if surgical treatment of superficial/peritoneal endometriosis may modify the outcomes of ... ...

    Abstract This narrative review aims to summarize available evidence on the IVF-associated outcomes after surgery for endometriosis. Only one retrospective study investigated if surgical treatment of superficial/peritoneal endometriosis may modify the outcomes of IVF; therefore, more data are needed to confirm the benefit of surgery for this type of disease for improving ART outcomes, and to be able to support it in routine practice. Solid evidence from several meta-analyses demonstrates that surgical treatment of endometriomas does not enhance the outcomes of IVF. In contrast, surgical treatment of ovarian endometriosis may lead to a reduction in ovarian reserve, especially in cases involving bilateral endometriomas or repeated surgical procedures. Some non-randomized studies have examined if surgical treatment on deep endometriosis may influence IVF outcomes. A systematic review with meta-analysis revealed that patients who underwent surgery before IVF exhibited significantly higher pregnancy rates per patient, pregnancy rates per cycle, and live birth rates per patient compared to those without prior surgery. However, the available data are insufficient to recommend surgical excision of deep endometriosis as the first-line treatment for asymptomatic patients to enhance IVF outcomes.
    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2024.102496
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  10. Article ; Online: Rituximab for endometriosis: Unlikely translatability from oncology due to safety concerns?

    Barra, Fabio / Perrone, Umberto / Ferrero, Simone / Gustavino, Claudio / Bogliolo, Stefano / Izzotti, Alberto

    Journal of reproductive immunology

    2023  Volume 158, Page(s) 103967

    Abstract: This letter discusses the article "The Effects of Rituximab on Experimental Endometriosis Model in Rats" by Dogan et al., which evaluated the potential therapeutic efficacy of rituximab in an experimental animal model of endometriosis. While the study ... ...

    Abstract This letter discusses the article "The Effects of Rituximab on Experimental Endometriosis Model in Rats" by Dogan et al., which evaluated the potential therapeutic efficacy of rituximab in an experimental animal model of endometriosis. While the study showed promising results in decreasing the volume of endometriotic implants and differences in B-cell count and fibrosis score, rituximab is typically used as a therapy for B lymphocyte malignancies and has potential short-term and long-term side effects. Additionally, animal models for endometriosis have limitations, and novel models are still being developed. Therefore, further preclinical research is necessary to evaluate the safety and efficacy of rituximab as a potential treatment for endometriosis in humans.
    MeSH term(s) Humans ; Female ; Rats ; Animals ; Endometriosis/drug therapy ; Endometriosis/pathology ; Rituximab/therapeutic use ; Rituximab/pharmacology ; Disease Models, Animal ; Endometrium/pathology
    Chemical Substances Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-05-21
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2023.103967
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