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  1. Article ; Online: Hematological and clinical biochemistry profiles in Canindé goats infected by Corynebacterium pseudotuberculosis and bred in a tropical semi-arid region

    Nicoleti, Jorge Luis / Façanha, Debora Andrea / Kalil, Mauricio Alcantara / Fonseca, Elanne Paiva / Barral, Thiago Doria / Sampaio, Julia Ramos / Meyer, Roberto / Portela, Ricardo Wagner

    Trop Anim Health Prod. 2023 Feb., v. 55, no. 1 p.11-11

    2023  

    Abstract: Caseous lymphadenitis (CLA), an infectious disease caused by Corynebacterium pseudotuberculosis in goats and sheep, is highly prevalent worldwide and is characterized by economic losses in small ruminant production. Currently available techniques for ... ...

    Abstract Caseous lymphadenitis (CLA), an infectious disease caused by Corynebacterium pseudotuberculosis in goats and sheep, is highly prevalent worldwide and is characterized by economic losses in small ruminant production. Currently available techniques for clinical and laboratory diagnosis of the disease lack market availability and/or sensitivity, and therefore, infected animals can remain in the herd, serving as a source of infection for other animals. The present study aimed to verify hematological and clinical biochemistry changes in goats naturally infected by C. pseudotuberculosis. One hundred seventy-three Canindé goats were included in this study, from which blood samples and caseous lesions were collected. The animals were classified as uninfected, asymptomatic, and symptomatic according to microbiological isolation and serological assays. A high dissemination of the infection was observed in the herd, with 86.13% of positive animals, being 74.57% asymptomatic and 11.56% symptomatic. In the hemogram and clinical biochemistry analyses, the only statistical difference found was a higher level of serum urea in asymptomatic individuals than in non-infected animals. In addition, this study points to the possibility of chronic CLA being potentially reflected in hepatic and renal biochemical markers.
    Keywords Corynebacterium pseudotuberculosis ; biochemistry ; blood serum ; caseous lymphadenitis ; herds ; laboratory diagnosis ; markets ; semiarid zones ; sheep ; urea
    Language English
    Dates of publication 2023-02
    Size p. 11.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-022-03431-0
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    In stock of ZB MED Bonn / Germany

    Z 2667: Show issues

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  2. Article: Canine distemper virus in wildlife in south‐western Europe

    Oleaga, Álvaro / Vázquez, Cristina Blanco / Royo, Luis José / Barral, Thiago Doria / Bonnaire, Debby / Armenteros, José Ángel / Rabanal, Benjamín / Gortázar, Christian / Balseiro, Ana

    Transboundary and emerging diseases. 2022 July, v. 69, no. 4

    2022  

    Abstract: Multi‐host pathogens emerging and re‐emerging at the wildlife–domestic animal interface affect wildlife management and conservation. This is the case of canine distemper virus (CDV), a paramyxovirus closely related to human measles virus and rinderpest ... ...

    Abstract Multi‐host pathogens emerging and re‐emerging at the wildlife–domestic animal interface affect wildlife management and conservation. This is the case of canine distemper virus (CDV), a paramyxovirus closely related to human measles virus and rinderpest virus of cattle. With an area of 10,603 km², Asturias region in Atlantic Spain is a hotspot of carnivore diversity, which includes the largest Eurasian brown bear (Ursus arctos arctos) population and one of the largest wolf (Canis lupus) populations in south‐western Europe. In 2020–2021, we recorded mortality due to distemper in four carnivore species including three mustelids (Eurasian badger Meles meles, European marten Martes martes and European polecat Mustela putorius) and one canid (red fox, Vulpes vulpes). Clinical signs and pathology were similar across species and consistent with the emergence of a highly pathogenic viral strain, with CDV antigen mainly located in the central nervous system, lungs, spleen and lymph nodes. A molecular study in eight wild carnivore species, also including the Iberian wolf, Eurasian brown bear, American mink (Neovison vison) and stone marten (Martes foina), revealed 19.51% (16/82) of positivity. Phylogenetic analysis demonstrated that CDV belonged to the previously described European lineage. A retrospective serosurvey (2008–2020) showed a high seroprevalence of CDV antibodies (43.4%) in 684 analyzed badgers, indicating a long‐term though not stable viral circulation in this multi‐host community. The possible triggers of the 2020–2021 outbreak and the implications for carnivore management and conservation are discussed.
    Keywords Canine morbillivirus ; Canis lupus ; Martes foina ; Martes martes ; Measles morbillivirus ; Meles meles ; Mustela putorius ; Neovison vison ; Respirovirus ; Rinderpest morbillivirus ; Ursus arctos ; Vulpes vulpes ; antigens ; carnivores ; cattle ; central nervous system ; humans ; lymph ; mortality ; phylogeny ; seroprevalence ; spleen ; wildlife ; wildlife management ; wolves ; Spain
    Language English
    Dates of publication 2022-07
    Size p. e473-e485.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.14323
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  3. Article: Comparative Analysis of Tear Composition in Humans, Domestic Mammals, Reptiles, and Birds.

    Raposo, Ana Cláudia / Portela, Ricardo Dias / Aldrovani, Marcela / Barral, Thiago Doria / Cury, Dayse / Oriá, Arianne Pontes

    Frontiers in veterinary science

    2020  Volume 7, Page(s) 283

    Abstract: Tears are an important component of the ocular surface protection mechanism and are in close contact with the corneal epithelium and the environment. Their composition is well-known in humans; however, there are few investigations on the composition and ... ...

    Abstract Tears are an important component of the ocular surface protection mechanism and are in close contact with the corneal epithelium and the environment. Their composition is well-known in humans; however, there are few investigations on the composition and function of tears in reptiles, birds and others mammals, which would elucidate the mechanisms governing the maintenance of ocular homeostasis. In this work, electrophoretic profiles and an evaluation of total protein, albumin, urea, glucose, and cholesterol concentrations in tears of semi-aquatic, terrestrial, and marine reptiles (
    Language English
    Publishing date 2020-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.00283
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  4. Article ; Online: A serum NMR metabolomic analysis of the Corynebacterium pseudotuberculosis infection in goats.

    Nicoleti, Jorge Luis / Braga, Erik Sobrinho / Stanisic, Danijela / Jadranin, Milka / Façanha, Débora Andréa Evangelista / Barral, Thiago Doria / Hanna, Samira Abdallah / Azevedo, Vasco / Meyer, Roberto / Tasic, Ljubica / Portela, Ricardo Wagner

    Applied microbiology and biotechnology

    2023  Volume 107, Issue 14, Page(s) 4593–4603

    Abstract: Caseous lymphadenitis (CLA), an infectious disease caused by Corynebacterium pseudotuberculosis in small ruminants, is highly prevalent worldwide. Economic losses have already been associated with the disease, and little is known about the host-pathogen ... ...

    Abstract Caseous lymphadenitis (CLA), an infectious disease caused by Corynebacterium pseudotuberculosis in small ruminants, is highly prevalent worldwide. Economic losses have already been associated with the disease, and little is known about the host-pathogen relationship associated with the disease. The present study aimed to perform a metabolomic study of the C. pseudotuberculosis infection in goats. Serum samples were collected from a herd of 173 goats. The animals were classified as controls (not infected), asymptomatic (seropositives but without detectable CLA clinical signs), and symptomatic (seropositive animals presenting CLA lesions), according to microbiological isolation and immunodiagnosis. The serum samples were analyzed using nuclear magnetic resonance (
    MeSH term(s) Animals ; Corynebacterium pseudotuberculosis/metabolism ; Goats/microbiology ; Lymphadenitis/diagnosis ; Lymphadenitis/veterinary ; Lymphadenitis/microbiology ; Corynebacterium Infections/diagnosis ; Corynebacterium Infections/veterinary ; Corynebacterium Infections/microbiology ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2023-05-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-023-12595-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Canine distemper virus in wildlife in south-western Europe.

    Oleaga, Álvaro / Vázquez, Cristina Blanco / Royo, Luis José / Barral, Thiago Doria / Bonnaire, Debby / Armenteros, José Ángel / Rabanal, Benjamín / Gortázar, Christian / Balseiro, Ana

    Transboundary and emerging diseases

    2021  Volume 69, Issue 4, Page(s) e473–e485

    Abstract: Multi-host pathogens emerging and re-emerging at the wildlife-domestic animal interface affect wildlife management and conservation. This is the case of canine distemper virus (CDV), a paramyxovirus closely related to human measles virus and rinderpest ... ...

    Abstract Multi-host pathogens emerging and re-emerging at the wildlife-domestic animal interface affect wildlife management and conservation. This is the case of canine distemper virus (CDV), a paramyxovirus closely related to human measles virus and rinderpest virus of cattle. With an area of 10,603 km
    MeSH term(s) Animals ; Animals, Wild ; Carnivora ; Cattle ; Cattle Diseases ; Distemper/epidemiology ; Distemper Virus, Canine ; Dog Diseases ; Dogs ; Europe/epidemiology ; Ferrets ; Foxes ; Humans ; Mink ; Mustelidae ; Phylogeny ; Retrospective Studies ; Seroepidemiologic Studies ; Viruses ; Wolves
    Language English
    Publishing date 2021-09-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.14323
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  6. Article ; Online: Chemokine production induced by Corynebacterium pseudotuberculosis in a murine model.

    Barral, Thiago Doria / Rebouças, Miriam Flores / Loureiro, Dan / Raynal, José Tadeu / Sousa, Thiago Jesus / Moura-Costa, Lilia Ferreira / Azevedo, Vasco / Meyer, Roberto / Portela, Ricardo Wagner

    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

    2022  Volume 53, Issue 2, Page(s) 1019–1027

    Abstract: Corynebacterium pseudotuberculosis is the etiological agent of caseous lymphadenitis. The main clinical sign of this disease is the development of granulomas, especially in small ruminants; however, the pathways that are involved in the formation and ... ...

    Abstract Corynebacterium pseudotuberculosis is the etiological agent of caseous lymphadenitis. The main clinical sign of this disease is the development of granulomas, especially in small ruminants; however, the pathways that are involved in the formation and maintenance of these granulomas are unknown. Cytokines and chemokines are responsible for the migration of immune cells to specific sites and tissues; therefore, it is possible that chemokines participate in abscess formation. This study aimed to evaluate the induction of chemokine production by two C. pseudotuberculosis strains in a murine model. A highly pathogenic (VD57) and an attenuated (T1) strain of C. pseudotuberculosis, as well as somatic and secreted antigens derived from these strains, was used to stimulate murine splenocytes. Then, the concentrations of the chemokines CCL-2, CCL-3, CCL-4, and CCL-5 and the cytokines IL-1 and TNF were measured in the culture supernatants. The VD57 strain had a higher ability to stimulate the production of chemokines when compared to T1 strain, especially in the early stages of stimulation, which can have an impact on granuloma formation. The T1 lysate antigen was able to stimulate most of the chemokines studied herein when compared to the other antigenic fractions of both strains. These results indicate that C. pseudotuberculosis is a chemokine production inducer, and the bacterial strains differ in their induction pattern, a situation that can be related to the specific behavior of each strain.
    MeSH term(s) Animals ; Corynebacterium Infections/microbiology ; Corynebacterium Infections/veterinary ; Corynebacterium pseudotuberculosis ; Cytokines/metabolism ; Disease Models, Animal ; Lymphadenitis/microbiology ; Mice
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-02-09
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2017175-4
    ISSN 1678-4405 ; 1517-8382
    ISSN (online) 1678-4405
    ISSN 1517-8382
    DOI 10.1007/s42770-022-00694-5
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  7. Article ; Online: P22 protein complex in the serodiagnosis of animal tuberculosis: Antigenic stability and cross-reactivity with Corynebacterium pseudotuberculosis infection.

    Barral, Thiago Doria / Infantes-Lorenzo, José A / Moreno, Inmaculada / de Garnica García, M Gracia / de Val, Bernat Pérez / Gortázar, Christian / Meyer, Roberto / Portela, Ricardo D / Domínguez, Lucas / Domínguez, Mercedes / Balseiro, Ana

    Comparative immunology, microbiology and infectious diseases

    2022  Volume 90-91, Page(s) 101891

    Abstract: The P22 ELISA was recently developed for the serodiagnosis of animal tuberculosis. Herein, the stability of the P22 antigen in different presentations and storage conditions, and the cross-reactivity with Corynebacterium pseudotuberculosis infection in ... ...

    Abstract The P22 ELISA was recently developed for the serodiagnosis of animal tuberculosis. Herein, the stability of the P22 antigen in different presentations and storage conditions, and the cross-reactivity with Corynebacterium pseudotuberculosis infection in small ruminants were evaluated. For the stability assay, serum samples from cows, sheep, goats, alpacas, badgers, and wild boar were used in the P22 ELISA. The cross-reactivity analysis used sera from sheep and goats with caseous lymphadenitis (CLA). Differences in the immune recognition of P22 were found when the antigen was stored at 40 °C, but without altering the negative or positive status of each sample. P22 ELISA presented 5.71 % cross-reactivity when CLA-positive sheep were evaluated, but no cross-reaction was observed among CLA-positive goat serum samples. This study showed that the P22 protein complex is stable under different formulations and temperatures, and that the assay presents a low cross-reactivity with CLA.
    MeSH term(s) Female ; Sheep ; Cattle ; Animals ; Corynebacterium pseudotuberculosis ; Goat Diseases/microbiology ; Sheep Diseases/microbiology ; Corynebacterium Infections/diagnosis ; Corynebacterium Infections/veterinary ; Corynebacterium Infections/microbiology ; Goats/microbiology ; Serologic Tests/veterinary ; Tuberculosis/veterinary ; Cattle Diseases
    Language English
    Publishing date 2022-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2022.101891
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1443: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Immunoprophylactic properties of the Corynebacterium pseudotuberculosis-derived MBP:PLD:CP40 fusion protein.

    Barral, Thiago Doria / Kalil, Mauricio Alcantara / Mariutti, Ricardo Barros / Arni, Raghuvir Krishnaswamy / Gismene, Carolina / Sousa, Fernanda Severo / Collares, Tiago / Seixas, Fabiana Kommling / Borsuk, Sibele / Estrela-Lima, Alessandra / Azevedo, Vasco / Meyer, Roberto / Portela, Ricardo Wagner

    Applied microbiology and biotechnology

    2022  Volume 106, Issue 24, Page(s) 8035–8051

    Abstract: Caseous lymphadenitis (CLA) is a disease that affects small ruminants, and the best way to prevent its spread on a herd is through immunoprophylaxis. Thus, we aimed to evaluate the MBP:PLD:CP40 fusion protein as a new CLA immunogen. The fusion protein ... ...

    Abstract Caseous lymphadenitis (CLA) is a disease that affects small ruminants, and the best way to prevent its spread on a herd is through immunoprophylaxis. Thus, we aimed to evaluate the MBP:PLD:CP40 fusion protein as a new CLA immunogen. The fusion protein was constructed by combining Corynebacterium pseudotuberculosis PLD and CP40 proteins with maltose-binding protein (MBP) as an intrinsic adjuvant. The antigenicity, allergenic potential, prediction of B epitopes, binding to MHC receptors, and docking on the Toll-Like 2 receptor were evaluated in silico. MBP:PLD:CP40 was expressed and purified. 40 BALB/c were divided into four groups (G1 - control, G2 - Saponin, G3 - MBP:PLD:CP40, and G4 - rPLD + rCP40). Total IgG, IgG1, and IgG2a were quantified, and the expressions of cytokines after splenocyte in vitro stimulation were assessed. Mice were challenged 42 days after the first immunization. The in silico analysis showed that MBP:PLD:CP40 has immunogenic potential, does not have allergic properties, and can dock on the TRL2 receptor. MBP:PLD:CP40 stimulated the production of IgG1 antibodies in a fivefold proportion to IgG2a, and TNF and IL-17 were significantly expressed in response to the antigenic stimuli. When rPLD and rCP40 were used together for immunization, they could induce IFN-γ and IL-12, but with no detectable antibody production. The G3 and G4 groups presented a survival of 57.14% and 42.86%, respectively, while the G1 and G2 mice were all dead 15 days after the challenge. MBP:PLD:CP40 partially protected the mice against C. pseudotuberculosis infection and can be considered a potential new CLA immunogen. KEY POINTS: • The fusion protein induced more IgG1 than IgG2a antibodies; • The fusion protein also induced the expression of the TNF and IL-17 cytokines; • Mice inoculated with MBP:PLD:CP40 presented a 57.14% survival.
    MeSH term(s) Animals ; Mice ; Corynebacterium pseudotuberculosis/genetics ; Maltose-Binding Proteins ; Interleukin-17
    Chemical Substances Maltose-Binding Proteins ; Interleukin-17
    Language English
    Publishing date 2022-11-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-022-12279-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Immunoprophylactic properties of the Corynebacterium pseudotuberculosis-derived MBP:PLD:CP40 fusion protein

    Barral, Thiago Doria / Kalil, Mauricio Alcantara / Mariutti, Ricardo Barros / Arni, Raghuvir Krishnaswamy / Gismene, Carolina / Sousa, Fernanda Severo / Collares, Tiago / Seixas, Fabiana Kommling / Borsuk, Sibele / Estrela-Lima, Alessandra / Azevedo, Vasco / Meyer, Roberto / Portela, Ricardo Wagner

    Appl Microbiol Biotechnol. 2022 Dec., v. 106, no. 24 p.8035-8051

    2022  

    Abstract: Caseous lymphadenitis (CLA) is a disease that affects small ruminants, and the best way to prevent its spread on a herd is through immunoprophylaxis. Thus, we aimed to evaluate the MBP:PLD:CP40 fusion protein as a new CLA immunogen. The fusion protein ... ...

    Abstract Caseous lymphadenitis (CLA) is a disease that affects small ruminants, and the best way to prevent its spread on a herd is through immunoprophylaxis. Thus, we aimed to evaluate the MBP:PLD:CP40 fusion protein as a new CLA immunogen. The fusion protein was constructed by combining Corynebacterium pseudotuberculosis PLD and CP40 proteins with maltose-binding protein (MBP) as an intrinsic adjuvant. The antigenicity, allergenic potential, prediction of B epitopes, binding to MHC receptors, and docking on the Toll-Like 2 receptor were evaluated in silico. MBP:PLD:CP40 was expressed and purified. 40 BALB/c were divided into four groups (G1 – control, G2 – Saponin, G3 – MBP:PLD:CP40, and G4 – rPLD + rCP40). Total IgG, IgG1, and IgG2a were quantified, and the expressions of cytokines after splenocyte in vitro stimulation were assessed. Mice were challenged 42 days after the first immunization. The in silico analysis showed that MBP:PLD:CP40 has immunogenic potential, does not have allergic properties, and can dock on the TRL2 receptor. MBP:PLD:CP40 stimulated the production of IgG1 antibodies in a fivefold proportion to IgG2a, and TNF and IL-17 were significantly expressed in response to the antigenic stimuli. When rPLD and rCP40 were used together for immunization, they could induce IFN-γ and IL-12, but with no detectable antibody production. The G3 and G4 groups presented a survival of 57.14% and 42.86%, respectively, while the G1 and G2 mice were all dead 15 days after the challenge. MBP:PLD:CP40 partially protected the mice against C. pseudotuberculosis infection and can be considered a potential new CLA immunogen. KEY POINTS: • The fusion protein induced more IgG1 than IgG2a antibodies; • The fusion protein also induced the expression of the TNF and IL-17 cytokines; • Mice inoculated with MBP:PLD:CP40 presented a 57.14% survival.
    Keywords Corynebacterium pseudotuberculosis ; adjuvants ; allergenicity ; antibody formation ; caseous lymphadenitis ; computer simulation ; epitopes ; herds ; immunization ; immunoglobulin G ; interleukin-12 ; interleukin-17 ; prediction ; saponins ; splenocytes
    Language English
    Dates of publication 2022-12
    Size p. 8035-8051.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-022-12279-1
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    In stock of ZB MED Bonn / Germany

    Z 79/727: Show issues

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  10. Article: Correlation between the natural infection by Corynebacterium pseudotuberculosis in goats and serum progesterone levels and corpus luteum development

    Costa, Jackeline Oliveira / Barral, Thiago Doria / Portela, Ricardo Dias / da Costa, Laura Nicole Filipin / Bittencourt, Catarina Nunes / Machado, Alessandro Lima / Marques, Franciane Santos / Cavalcante, Ana Karina da Silva

    Domestic animal endocrinology. 2022 Jan., v. 78

    2022  

    Abstract: Caseous Lymphadenitis (CLA) is an infectious disease that affects small ruminants, and the bacterium Corynebacterium pseudotuberculosis is its etiologic agent. This disease presents a high morbidity and a great economic impact on goat farming, leading to ...

    Abstract Caseous Lymphadenitis (CLA) is an infectious disease that affects small ruminants, and the bacterium Corynebacterium pseudotuberculosis is its etiologic agent. This disease presents a high morbidity and a great economic impact on goat farming, leading to reduced milk and meat production and reproductive losses. The available data about the influence of C. pseudotuberculosis on the reproductive system were obtained after experimental inoculations. In this way, this study aimed to evaluate the influence of the natural infection by C. pseudotuberculosis on the luteal function and serum progesterone (P₄) levels in goats. Sixteen female goats were diagnosed for the presence of C. pseudotuberculosis specific antibodies and divided into 2 groups: CLA positive and negative animals. They were submitted to estrous synchronization, followed by controlled mating. Corpus luteum and serum levels of P₄ were evaluated on the 7th and 20th days after mating (D7 and D20). The ultrasonographic results were not statistically different between the 2 groups, as well as serum P₄ levels on D7. However, a significant increase in serum P₄ levels on the CLA positive group was identified on D20, along with a significant correlation between C. pseudotuberculosis specific antibody production, and P₄ serum levels. The result of this study indicates that the infection by C. pseudotuberculosis may influence the reproductive status of female goats through an enhanced production of progesterone.
    Keywords Corynebacterium pseudotuberculosis ; antibody formation ; bacteria ; blood serum ; caseous lymphadenitis ; corpus luteum ; economic impact ; etiological agents ; meat production ; milk ; morbidity ; progesterone ; ultrasonography
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 594468-5
    ISSN 1879-0054 ; 0739-7240
    ISSN (online) 1879-0054
    ISSN 0739-7240
    DOI 10.1016/j.domaniend.2021.106677
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4204: Show issues Location:
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