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  1. Article ; Online: Complications of fibrotic interstitial lung disease for the general radiologist.

    Watson, S / Dixon, G / Savill, A / Gibbons, M A / Barratt, S L / Rodrigues, J C L

    Clinical radiology

    2024  Volume 79, Issue 5, Page(s) 323–329

    Abstract: Interstitial lung diseases (ILDs) are a heterogeneous group of conditions characterised by non-infective inflammation and scarring of the lung parenchyma. They are not infrequently encountered by the general radiologist in both acute and outpatient ... ...

    Abstract Interstitial lung diseases (ILDs) are a heterogeneous group of conditions characterised by non-infective inflammation and scarring of the lung parenchyma. They are not infrequently encountered by the general radiologist in both acute and outpatient reporting settings who may even be the first to make the diagnosis. In the acute setting, patients with ILD can present with respiratory deterioration due to a number of causes and in addition to the common causes of dyspnoea, an acute exacerbation of ILD needs to be considered. An exacerbation can be initiated by common triggers such as infection, pulmonary embolism (PE), and heart failure, and it can also be initiated by an insult to the lung or occur due to an unknown cause. Particular care needs to be taken when interpreting computed tomography (CT) examinations in these patients as the findings of an acute exacerbation are non-specific and patient and technical factors can cause spurious appearances including dependent changes, breathing artefact and contrast medium opacification. In the non-acute setting, patients with ILD are at increased risk of lung cancer and pulmonary hypertension (PH), with lung cancer being a particularly important consideration as treatments carry the risk of triggering an acute exacerbation or deterioration in lung function. Overall, this review aims to provide an overview for the general radiologist of additional factors to consider when interpreting scans in patients with ILD and how the presence of ILD impacts the differential diagnoses and complications that can occur in these patients in both acute and non-acute settings.
    MeSH term(s) Humans ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/complications ; Lung/diagnostic imaging ; Prognosis ; Lung Neoplasms ; Dyspnea ; Disease Progression
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2024.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A role for cardiopulmonary exercise testing in detecting physiological changes underlying health status in Idiopathic pulmonary fibrosis: a feasibility study.

    Davis, R / Dixon, C / Millar, A B / Maskell, N A / Barratt, S L

    BMC pulmonary medicine

    2021  Volume 21, Issue 1, Page(s) 147

    Abstract: Introduction: There is limited data available on the use of CPET as a predictive tool for disease outcomes in the setting of IPF. We investigated the feasibility of undertaking CPET and the relationship between CPET and quality of life measurements in a ...

    Abstract Introduction: There is limited data available on the use of CPET as a predictive tool for disease outcomes in the setting of IPF. We investigated the feasibility of undertaking CPET and the relationship between CPET and quality of life measurements in a well-defined population of mild and moderate IPF patients.
    Methods: A prospective, single-centre observational study.
    Results: Thirty-two IPF patients (mild n = 23, moderate n = 9) participated in the study, n = 13 mild patients attended for repeat CPET testing at 12 months. At baseline, total K-BILD scores and total IPF-PROM scores significantly correlated with 6MWT distance, but not with baseline FVC % predicted, TLco % predicted, baseline or minimum SpO
    MeSH term(s) Aged ; Aged, 80 and over ; Anaerobic Threshold ; Feasibility Studies ; Female ; Health Status ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/physiopathology ; Idiopathic Pulmonary Fibrosis/psychology ; Idiopathic Pulmonary Fibrosis/therapy ; Male ; Minimal Clinically Important Difference ; Prospective Studies ; Quality of Life/psychology ; Respiratory Function Tests ; Surveys and Questionnaires ; Walk Test/methods ; Walk Test/psychology
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-021-01520-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Utility of illness severity scores to predict mortality in patients hospitalized with respiratory deterioration of idiopathic pulmonary fibrosis.

    Hyams, C / Hettle, D / Bibby, A / Adamali, H A / Barratt, S L

    QJM : monthly journal of the Association of Physicians

    2020  Volume 114, Issue 8, Page(s) 559–567

    Abstract: Introduction: In the context of idiopathic pulmonary fibrosis (IPF), respiratory-related admissions to hospital are associated with a high morbidity and short-term mortality with significant burden on secondary care services. It has yet to be determined ...

    Abstract Introduction: In the context of idiopathic pulmonary fibrosis (IPF), respiratory-related admissions to hospital are associated with a high morbidity and short-term mortality with significant burden on secondary care services. It has yet to be determined how to accurately identify patients at risk of acute respiratory deterioration (ARD) or the prognosticating factors.
    Aim: We sought to define the characteristics of hospitalized ARD-IPF patients in a real-world cohort and investigate factors associated with worse outcomes. Specifically, we wished to determine the association between baseline CURB-65 and NEWS-2 and mortality in IPF, given illness severity scores have not previously been validated in this cohort.
    Methods: Single-centre retrospective observational cohort study.
    Results: Of 172 first hospitalizations for ARD, 27 admissions (15.7%) were due to an acute exacerbation of IPF (AE-IPF), 28 (16.3%) secondary to cardiac failure/fluid overload and 17 due to pneumonia (9.9%). Other admissions related to lower respiratory tract infection, extra-parenchymal causes and those without a specific trigger. Baseline patient characteristics were comparable for all underlying aetiologies of ARD-IPF. Treatment pathways did not differ significantly between AE-IPF and other causes of ARD-IPF. Short-term mortality was high, with ∼22% patients dying within 30 days. Illness severity scores (NEWS-2 and CURB-65) were independent predictors of mortality in multivariable logistic regression modelling.
    Conclusions: Our findings suggest significant mortality related to hospitalization with ARD-IPF of any underlying cause. Our data support the use of CURB-65 and NEWS-2 scores as illness severity scores that can provide a simple tool to help future prognostication in IPF. Research should be aimed at refining the management of these episodes, to try to reduce mortality, where possible, or to facilitate palliative care for those with adverse prognostic characteristics.
    MeSH term(s) Disease Progression ; Hospitalization ; Humans ; Idiopathic Pulmonary Fibrosis ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcaa214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pleuroparenchymal sarcoidosis - A recognised but rare manifestation of disease.

    Walker, S / Adamali, H / Bhatt, N / Maskell, N / Barratt, S L

    Respiratory medicine case reports

    2018  Volume 23, Page(s) 110–114

    Abstract: Pleural involvement is rare in sarcoidosis. The presence of a large symptomatic effusion in a patient with sarcoidosis should therefore prompt further investigation for an alternate aetiology. Here we present a case of confirmed pleuro-parenchymal ... ...

    Abstract Pleural involvement is rare in sarcoidosis. The presence of a large symptomatic effusion in a patient with sarcoidosis should therefore prompt further investigation for an alternate aetiology. Here we present a case of confirmed pleuro-parenchymal sarcoidosis. We discuss the important differential diagnoses and review the current literature.
    Language English
    Publishing date 2018-02-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2018.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Musical instruments, fungal spores and hypersensitivity pneumonitis.

    Davidson, J / McErlane, J / Aljboor, K / Barratt, S L / Jeyabalan, A / Medford, A R L / Borman, A M / Adamali, H

    QJM : monthly journal of the Association of Physicians

    2019  Volume 112, Issue 4, Page(s) 287–289

    MeSH term(s) Alveolitis, Extrinsic Allergic/microbiology ; Decontamination ; Humans ; Hypocreales/isolation & purification ; Male ; Middle Aged ; Music ; Mycoses/diagnosis ; Occupational Diseases/microbiology ; Spores, Fungal/isolation & purification
    Language English
    Publishing date 2019-03-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcz020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: An evaluation of blood creatinine measurement by creatinase on the NOVA M7 blood gas analyzer.

    Rowe, D J / Omar, H / Barratt, S L / Biggs, P

    Clinica chimica acta; international journal of clinical chemistry

    2001  Volume 307, Issue 1-2, Page(s) 23–25

    Abstract: This study compared a creatininase method for the analysis at the bedside of creatinine (CR) in whole blood on a NOVA Biomedical M7 analyser, with rate-Jaffe and creatininase-based laboratory methods. Correlation and precision data were obtained and the ... ...

    Abstract This study compared a creatininase method for the analysis at the bedside of creatinine (CR) in whole blood on a NOVA Biomedical M7 analyser, with rate-Jaffe and creatininase-based laboratory methods. Correlation and precision data were obtained and the effect of increased bilirubin concentration was assessed.
    MeSH term(s) Clinical Chemistry Tests/instrumentation ; Clinical Chemistry Tests/methods ; Creatinine/blood ; Humans ; Reproducibility of Results ; Ureohydrolases/metabolism
    Chemical Substances Creatinine (AYI8EX34EU) ; Ureohydrolases (EC 3.5.3.-) ; creatinase (EC 3.5.3.3)
    Language English
    Publishing date 2001-05
    Publishing country Netherlands
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/s0009-8981(01)00458-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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