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  1. Article ; Online: Autoimmune Thyroid Disease in Primary Sjögren's Syndrome: Real-life Screening Practice and Clinical Outcomes.

    Girón-Pïllado, Mario / Cruz-Bautista, Ivette / Saavedra-González, Vanessa / Atisha-Fregoso, Yemil / Barraza, Gustavo / Aguilar-Salinas, Carlos A / Hernández-Molina, Gabriela

    Current rheumatology reviews

    2022  Volume 18, Issue 3, Page(s) 272–277

    Abstract: Background: Notwithstanding the frequent coexistence of autoimmune thyroid disease (ATD) and primary Sjögren's Syndrome (SS), it is still unknown how often this association is studied along with its clinical impact.: Objective: This study aimed to ... ...

    Abstract Background: Notwithstanding the frequent coexistence of autoimmune thyroid disease (ATD) and primary Sjögren's Syndrome (SS), it is still unknown how often this association is studied along with its clinical impact.
    Objective: This study aimed to describe real-world screening practices for ATD in patients with SS and evaluate clinical outcomes of patients with both diagnoses using validated activity and chronicity indexes.
    Methods: It is a retrospective study of 223 patients with SS attending a tertiary referral center. Patients were under rheumatology surveillance and might have attended other clinics, including internal medicine and/or endocrinology. We registered glandular and extraglandular features, serology and scored the activity (ESSDAI) and the accrual damage (SSDDI) indexes. We also identified any thyroid function tests (TFT) performed, anti-thyroid antibodies, images, and histological thyroid examinations. A single endocrinologist reviewed all data.
    Results: One hundred forty-nine patients had at least one set of TFT. Younger age was associated with a lack of screening (OR 0.98, 95 % CI 0.95-0.99, p=0.01). Sixty-nine patients had thyroid disease, with the most common diagnosis being ATD (n=24). Patients with ATD had a lower prevalence of Ro/SSA and anti-La/SSB antibodies but similar cumulative SS activity and damage scores.
    Conclusion: At least one-third of our patients were not screened for thyroid disease, with these patients being the youngest. Thyroid disorders were found in about 40 % of patients with SS, with ATD being the most common. Having SS/ATD did not confer more disease activity or damage accrual. These results highlight the importance of making treating physicians aware of screening for thyroid disease in this population.
    MeSH term(s) Antibodies, Antinuclear ; Humans ; Prevalence ; Retrospective Studies ; Sjogren's Syndrome ; Thyroid Diseases
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2022-01-27
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6360
    ISSN (online) 1875-6360
    DOI 10.2174/1573397118666220127105546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hepatic steatosis as an independent risk factor for severe disease in patients with COVID-19: A computed tomography study.

    Palomar-Lever, Andres / Barraza, Gustavo / Galicia-Alba, Julieta / Echeverri-Bolaños, Melissa / Escarria-Panesso, Robert / Padua-Barrios, Jorge / Halabe-Cherem, Jose / Hernandez-Molina, Gabriela / Chargoy-Loustaunau, Talia Nila / Kimura-Hayama, Eric

    JGH open : an open access journal of gastroenterology and hepatology

    2020  Volume 4, Issue 6, Page(s) 1102–1107

    Abstract: Background and aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia.: Methods: ...

    Abstract Background and aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia.
    Methods: We included 213 patients with a positive real time polymerase chain reaction (RT-PCR) test and chest computed tomography (CT) from an out-hospital facility and a hospital. We obtained information on demographics; weight; height; smoking history; diabetes; hypertension; and cardiovascular, lung, and renal disease. Two radiologists scored the CO-RADs system (COVID-19 Reporting and Data System) (1 = normal, 2 = inconsistent, 3-4 = indeterminate, and 5 = typical findings) and the chest CT severity index (≥20 of 40 was considered severe disease). They evaluated the liver-to-spleen ratio (CT
    Results: Of the patients, 61% were men, with a mean age of 51.2 years, 48.3% were CO-RADs 1 and 51.7% CO-RADs 2-5. Severe tomographic disease was present in 103 patients (48.4%), all CO-RADs 5. This group was older; mostly men; and with a higher prevalence of obesity, hypertension, diabetes, and HS (69.9
    Conclusion: HS was independently associated with severe COVID pneumonia. The physiopathological explanation of this finding remains to be elucidated. CT
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country Australia
    Document type Journal Article
    ISSN 2397-9070
    ISSN (online) 2397-9070
    DOI 10.1002/jgh3.12395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hepatic steatosis as an independent risk factor for severe disease in patients with COVID-19: A computed tomography study

    Palomar-Lever, Andres / Barraza, Gustavo / Galicia-Alba, Julieta / Echeverri-Bolaños, Melissa / Escarria-Panesso, Robert / Padua-Barrios, Jorge / Halabe-Cherem, Jose / Hernandez-Molina, Gabriela / Chargoy-Loustaunau, Talia Nila / Kimura-Hayama, Eric

    Abstract: Background and Aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia. Methods: We ... ...

    Abstract Background and Aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia. Methods: We included 213 patients with a positive real time polymerase chain reaction (RT-PCR) test and chest computed tomography (CT) from an out-hospital facility and a hospital. We obtained information on demographics; weight; height; smoking history; diabetes; hypertension; and cardiovascular, lung, and renal disease. Two radiologists scored the CO-RADs system (COVID-19 Reporting and Data System) (1 = normal, 2 = inconsistent, 3-4 = indeterminate, and 5 = typical findings) and the chest CT severity index (≥20 of 40 was considered severe disease). They evaluated the liver-to-spleen ratio (CTL/S) and defined tomographic steatosis as a CTL/S index ≤0.9. We used descriptive statistics, χ2 and t student tests, logistic regression, and reported odds ratio (OR) with 95% confidence interval (CI). Results: Of the patients, 61% were men, with a mean age of 51.2 years, 48.3% were CO-RADs 1 and 51.7% CO-RADs 2-5. Severe tomographic disease was present in 103 patients (48.4%), all CO-RADs 5. This group was older; mostly men; and with a higher prevalence of obesity, hypertension, diabetes, and HS (69.9 vs 29%). On multivariate analysis, age (OR 1.058, 95% CI 1.03-1.086, P < 0.0001), male gender (OR 1.9, 95% CI 1.03-3.8, P = 0.04), and HS (OR 4.9, 95% CI 2.4-9.7, P < 0.0001) remained associated. Conclusion: HS was independently associated with severe COVID pneumonia. The physiopathological explanation of this finding remains to be elucidated. CTL/S should be routinely measured in thoracic CT scans in patients with COVID-19 pneumonia.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #693238
    Database COVID19

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  4. Article ; Online: Hepatic steatosis as an independent risk factor for severe disease in patients with COVID ‐19

    Palomar‐Lever, Andres / Barraza, Gustavo / Galicia‐Alba, Julieta / Echeverri‐Bolaños, Melissa / Escarria‐Panesso, Robert / Padua‐Barrios, Jorge / Halabe‐Cherem, Jose / Hernandez‐Molina, Gabriela / Chargoy‐Loustaunau, Talia Nila / Kimura‐Hayama, Eric

    JGH Open ; ISSN 2397-9070 2397-9070

    A computed tomography study

    2020  

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jgh3.12395
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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