Article ; Online: Utility of Oral Anticoagulants as Prophylaxis of Recurrent Portal Thrombosis after Liver Transplantation.
2018 Volume 51, Issue 1, Page(s) 83–86
Abstract: Introduction: Portal vein thrombosis (PVT) is a relatively common finding in patients undergoing liver transplantation. Although the recommendation to prevent its recurrence is anticoagulation for a duration of 3 to 6 months, this is controversial.: ... ...
| Abstract | Introduction: Portal vein thrombosis (PVT) is a relatively common finding in patients undergoing liver transplantation. Although the recommendation to prevent its recurrence is anticoagulation for a duration of 3 to 6 months, this is controversial. Aim: The aim of our study was to determine the efficacy of oral anticoagulants (OAC) as prophylaxis for recurrent PVT after liver transplantation. Materials and methods: Our study included 215 liver transplant patients who underwent surgery in our center from January 2012 to August 2017. We selected all patients diagnosed with PVT either pre-transplantation (using Doppler echography or Angio-CT) or during transplant surgery. All patients with PVT were initially anticoagulated with low-molecular-weight heparin in the postoperative period; at discharge they received OAC for a duration of six months. Control Doppler ultrasound was performed at 3, 6, and 12 months post-transplantation. Results: PVT was identified in 37 out of 215 patients (17.2%). PVT was diagnosed with a pre-transplant vascular study in 17 out of 37 cases (45.9%). All patients were anticoagulated with OAC (warfarin) for at least 6 months. There were no cases of recurrent thrombosis and no complications associated with anticoagulant treatment throughout the follow-up period. Conclusions: The prevalence of portal thrombosis in liver transplant patients in our study was fairly high, at 17.2%. PVT was identified in nearly 50% of patients using high-quality vascular studies prior to transplant surgery. Anticoagulation with OAC for 6 months was effective in preventing a recurrence of thrombosis and there were no associated complications. |
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| MeSH term(s) | Adult ; Anticoagulants/therapeutic use ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Portal Vein/pathology ; Prevalence ; Recurrence ; Retrospective Studies ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control ; Warfarin/therapeutic use |
| Chemical Substances | Anticoagulants ; Heparin, Low-Molecular-Weight ; Warfarin (5Q7ZVV76EI) |
| Language | English |
| Publishing date | 2018-07-10 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 82046-5 |
| ISSN | 1873-2623 ; 0041-1345 |
| ISSN (online) | 1873-2623 |
| ISSN | 0041-1345 |
| DOI | 10.1016/j.transproceed.2018.07.014 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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