Article ; Online: Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
Dermatology (Basel, Switzerland)
2024
Abstract: Background: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate.: Objective: The impact of granulomatous inflammation on the prognosis of the disease remains ... ...
Abstract | Background: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate. Objective: The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there are both favorable and unfavorable outcomes documented. Methods: We performed a systematic review of 116 GMF cases previously described in the literature. Results: In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months. Conclusion: GMF is an aggressive form of mycosis fungoides. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up. |
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Language | English |
Publishing date | 2024-02-29 |
Publishing country | Switzerland |
Document type | Systematic Review |
ZDB-ID | 1099692-8 |
ISSN | 1421-9832 ; 1018-8665 |
ISSN (online) | 1421-9832 |
ISSN | 1018-8665 |
DOI | 10.1159/000537893 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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