LIVIVO - Search results -

Search results

Result 1 - 10 of total 22

Search options

Article ; Online: New concepts in EBV-associated B, T, and NK cell lymphoproliferative disorders.

Quintanilla-Martinez, Leticia / Swerdlow, Steven H / Tousseyn, Thomas / Barrionuevo, Carlos / Nakamura, Shigeo / Jaffe, Elaine S

Virchows Archiv : an international journal of pathology

2022 Volume 482, Issue 1, Page(s) 227–244

Abstract: EBV-associated lymphoproliferative disorders (LPD) include conditions of B, T, and NK cell derivation with a wide clinicopathological spectrum ranging from indolent, self-limiting, and localized conditions to highly aggressive lymphomas. Since the 2016 ... ...

Abstract	EBV-associated lymphoproliferative disorders (LPD) include conditions of B, T, and NK cell derivation with a wide clinicopathological spectrum ranging from indolent, self-limiting, and localized conditions to highly aggressive lymphomas. Since the 2016 World Health Organization (WHO) lymphoma classification, progress has been made in understanding the biology of the EBV-associated LPDs. The diagnostic criteria of EBV+ mucocutaneous ulcer and lymphomatoid granulomatosis have been refined, and a new category of EBV-positive polymorphic B cell LPD was introduced to encompass the full spectrum of EBV-driven B cell disorders. The differential diagnosis of these conditions is challenging. This report will present criteria to assist the pathologist in diagnosis. Within the group of EBV-associated T and NK cell lymphomas, a new provisional entity is recognized, namely, primary nodal EBV+ T or NK cell lymphoma. The EBV + T and NK cell LPDs in children have undergone major revisions. In contrast to the 2016 WHO classification, now four major distinct groups are recognized: hydroa vacciniforme (HV) LPD, severe mosquito bite allergy, chronic active EBV (CAEBV) disease, and systemic EBV-positive T cell lymphoma of childhood. Two forms of HV LPD are recognized: the classic and the systemic forms with different epidemiology, clinical presentation, and prognosis. The subclassification of PTLD, not all of which are EBV-positive, remains unaltered from the 2016 WHO classification. This review article summarizes the conclusions and the recommendations of the Clinical Advisory Committee (CAC), which are summarized in the International Consensus Classification of Mature Lymphoid Neoplasms.
MeSH term(s)	Child ; Humans ; Herpesvirus 4, Human ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/pathology ; Killer Cells, Natural/pathology ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/pathology ; Lymphoma, T-Cell/pathology
Language	English
Publishing date	2022-10-11
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-022-03414-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud III Zs.10: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Epidemiology of thymic epithelial tumors: 22-years experience from a single-institution.

Rioja, Patricia / Ruiz, Rossana / Galvez-Nino, Marco / Lozano, Sophia / Valdiviezo, Natalia / Olivera, Mivael / Cabero, Octavio / Guillen, Maria Eugenia / De La Guerra, Alberto / Amorin, Edgar / Barrionuevo, Carlos / Mas, Luis

Thoracic cancer

2020 Volume 12, Issue 4, Page(s) 420–425

Abstract: Background: To assess the correlation of WHO histological classification and Masaoka-Koga staging system of thymic epithelial tumors (TETs) with prognosis.: Methods: We retrospectively analyzed 83 patients with TETs in the Instituto Nacional de ... ...

Abstract	Background: To assess the correlation of WHO histological classification and Masaoka-Koga staging system of thymic epithelial tumors (TETs) with prognosis. Methods: We retrospectively analyzed 83 patients with TETs in the Instituto Nacional de Enfermedades Neoplasicas between 1996 to 2018. We analyzed the clinical stages, histological types and treatment modalities and attempted to determine the impact on overall survival. The data was retrieved from clinical files and reviewed by a pathologist who reclassificated according to the 2004 WHO classification system. The staging was performed with the Masaoka-Koga staging system. Survival curves were constructed with Kaplan-Meir method. Results: There was a total of 83 patients with a median age of 55 years old included in the study. The histological type corresponded to thymoma (T) in 63.8% (n = 53) and to thymic carcinoma (TC) in 36.1%. T were type A, AB, B1, B2 and B3 in 14.4%, 18%, 12%, 3.6%, 7.4% of cases, respectively. The proportion of advanced disease (Masaoka stage III-IV) was high (65%). With a median follow-up of 88.4 months, median overall survival (OS) was 81.6 months for T and 12.3 months for TC (P = 0.01). Univariate analysis showed that sex, histological type, clinical stage and surgery (P = 0.01) were significant independent prognostic factors. On multivariate analysis, histology type and Masaoka-Koga staging had an effect on survival. Conclusions: The results indicates a clear association between the WHO histological classification and Masaoka-Koga staging system with survival. We found a higher proportion of TETs with advanced disease at diagnosis. Further research are required and collaboration is important to foster knowledge focused on classification and treatment. Key points: SIGNIFICANT FINDINGS OF THE STUDY: The WHO histological classification, the Masaoka-Koga system and surgery treatment were associated with overall survival. What this study adds: To determine prognosis factors in TETs.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Neoplasms, Glandular and Epithelial/epidemiology ; Prognosis ; Retrospective Studies ; Thymus Neoplasms/epidemiology ; Time Factors
Language	English
Publishing date	2020-12-23
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.13760
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6921: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Notch Signaling Promotes Mature T-Cell Lymphomagenesis.

Cancer research

2022 Volume 82, Issue 20, Page(s) 3763–3773

Abstract: Peripheral T-cell lymphomas (PTCL) are agressive lymphomas that develop from mature T cells. The most common PTCLs are genetically, molecularly, and clinically diverse and are generally associated with dismal outcomes. While Notch signaling plays a ... ...

Abstract	Peripheral T-cell lymphomas (PTCL) are agressive lymphomas that develop from mature T cells. The most common PTCLs are genetically, molecularly, and clinically diverse and are generally associated with dismal outcomes. While Notch signaling plays a critically important role in both the development of immature T cells and their malignant transformation, its role in PTCL is poorly understood, despite the increasingly appreciated function of Notch in regulating the proliferation and differentiation of mature T cells. Here, we demonstrate that Notch receptors and their Delta-like family ligands (DLL1/DLL4) play a pathogenic role in PTCL. Notch1 activation was observed in common PTCL subtypes, including PTCL-not otherwise specified (NOS). In a large cohort of PTCL-NOS biopsies, Notch1 activation was significantly associated with surrogate markers of proliferation. Complementary genetically engineered mouse models and spontaneous PTCL models were used to functionally examine the role of Notch signaling, and Notch1/Notch2 blockade and pan-Notch blockade using dominant-negative MAML significantly impaired the proliferation of malignant T cells and PTCL progression in these models. Treatment with DLL1/DLL4 blocking antibodies established that Notch signaling is ligand-dependent. Together, these findings reveal a role for ligand-dependent Notch signaling in driving peripheral T-cell lymphomagenesis. Significance: This work demonstrates that ligand-dependent Notch activation promotes the growth and proliferation of mature T-cell lymphomas, providing new therapeutic strategies for this group of aggressive lymphomas.
MeSH term(s)	Animals ; Antibodies, Blocking ; Ligands ; Mice ; Receptor, Notch1 ; Receptors, Notch/genetics ; Signal Transduction ; T-Lymphocytes
Chemical Substances	Antibodies, Blocking ; Ligands ; Receptor, Notch1 ; Receptors, Notch
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-22-1215
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.135/5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED.

Chabay, Paola / Lens, Daniela / Hassan, Rocio / Rodríguez Pinilla, Socorro María / Valvert Gamboa, Fabiola / Rivera, Iris / Huamán Garaicoa, Fuad / Ranuncolo, Stella Maris / Barrionuevo, Carlos / Morales Sánchez, Abigail / Scholl, Vanesa / De Matteo, Elena / Preciado, Ma Victoria / Fuentes-Pananá, Ezequiel M

Cancers

2020 Volume 12, Issue 8

Abstract: The Epstein-Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, ...

Abstract	The Epstein-Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.
Language	English
Publishing date	2020-08-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12082166
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Proximal-type epithelioid sarcoma: report of two cases in the perineum: differential diagnosis and review of soft tissue tumors with epithelioid and/or rhabdoid features.

Zevallos-Giampietri, Eduardo-Alfredo / Barrionuevo, Carlos

Applied immunohistochemistry & molecular morphology : AIMM

2005 Volume 13, Issue 3, Page(s) 221–230

Abstract: The authors report two cases of perineal proximal-type epithelioid sarcoma in middle-aged men, age 51 and 43 years old. Both tumors were located in the right side. In the first patient a 7.5-cm, well-encapsulated tumor was completely excised. The second ... ...

Abstract	The authors report two cases of perineal proximal-type epithelioid sarcoma in middle-aged men, age 51 and 43 years old. Both tumors were located in the right side. In the first patient a 7.5-cm, well-encapsulated tumor was completely excised. The second patient was a referral case with incomplete excision, but the computed tomography scan and magnetic resonance imaging showed a 14-cm nonencapsulated tumor involving the soft tissues of the inner thigh and perineum, as well as metastasis in right inguinal and retroperitoneal lymph nodes. Both neoplasms had a predominant solid pattern alternating with occasional discohesive areas. Both were composed of large oval to polygonal cells with vesicular nuclei, conspicuous nucleoli, and amphophilic to eosinophilic cytoplasm. Rhabdoid phenotype was identified in the second case only. The first neoplasm displayed 15% necrosis, 7 mitoses per 10 high-power field, focal vascular invasion, and no extracapsular invasion. The other exhibited 60% necrosis, 12 mitoses per 10 high-power fields, extensive vascular invasion, no distinct capsule, and invasion of the surrounding fatty tissue. Both were positive for vimentin, cytokeratin, epithelial membrane antigen, and CD34. Muscle-specific actin was negative in the first case and focally positive in the second. CD56 was positive in the second case and negative in the first case. Desmin, CD45, CD30, factor VIII, CD31, S100, HMB45, calretinin, and synaptophysin were negative in both. Since proximal-type epithelioid sarcoma can be confused with a number of other soft tissue tumors with epithelioid and/or rhabdoid features, the authors emphasize the immunohistochemical differential diagnosis.
MeSH term(s)	Adult ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Immunophenotyping ; Lymph Nodes/pathology ; Male ; Middle Aged ; Necrosis/pathology ; Neoplasm Invasiveness/pathology ; Neoplasm Metastasis ; Perineum/pathology ; Rhabdoid Tumor/diagnosis ; Rhabdoid Tumor/pathology ; Sarcoma/diagnosis ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology
Language	English
Publishing date	2005-08-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	1541-2016
ISSN	1541-2016
DOI	10.1097/01.pai.0000145131.80060.6c
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Common blue nevus of the uterine cervix: case report and review.

Zevallos-Giampietri, Eduardo-Alfredo / Barrionuevo, Carlos

Applied immunohistochemistry & molecular morphology : AIMM

2004 Volume 12, Issue 1, Page(s) 79–82

Abstract: A case of common blue nevus of the uterine cervix in a 32-year-old woman is reported. This lesion was incidentally discovered in a hysterectomy performed for leiomyomas; in addition, a right ovarian benign serous cyst was found. The common blue nevus was ...

Abstract	A case of common blue nevus of the uterine cervix in a 32-year-old woman is reported. This lesion was incidentally discovered in a hysterectomy performed for leiomyomas; in addition, a right ovarian benign serous cyst was found. The common blue nevus was restricted to the stroma of the endocervix and was characterized by clusters of dendritic melanocytes with benign histologic features. These cells were positive for melanin, S100, and HMB45. Electron microscopy disclosed melanosomes and premelanosomes. The differential diagnosis with other pigmented lesions, particularly with malignant melanoma, is emphasized.
MeSH term(s)	Female ; Humans ; Nevus, Blue/diagnosis ; Nevus, Blue/pathology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology
Language	English
Publishing date	2004-05-06
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ISSN	1541-2016
ISSN	1541-2016
DOI	10.1097/00129039-200403000-00015
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Importancia de la evaluación externa del desempeño en citología cervicouterina: programa piloto.

Miraval, María / Merejildo, Mercy / Núñez, María / Barrionuevo, Carlos / Sarria-Bardales, Gustavo / Nuñez, Carmen / Vargas, Javier

Revista peruana de medicina experimental y salud publica

2013 Volume 30, Issue 1, Page(s) 142–143

Title translation	Importance of external quality assessment in cervical cytology: a pilot program.
MeSH term(s)	Female ; Humans ; Pilot Projects ; Quality Assurance, Health Care ; Vaginal Smears/standards
Language	Spanish
Publishing date	2013-04-24
Publishing country	Peru
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2120092-0
ISSN	1726-4642 ; 1726-4634
ISSN (online)	1726-4642
ISSN	1726-4634
DOI	10.1590/s1726-46342013000100027
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Porocarcinoma ecrino: estudio clínico-patológico de 19 casos en el Instituto Nacional de Enfermedades Neoplásicas, Lima - Perú

Casavilca, Sandro / Lama, Anny / Guerrero, Melvy / Essary, Lydia R / Mantilla, Raúl / Cano, Luis / Barrionuevo, Carlos

Revista peruana de medicina experimental y salud publica

2013 Volume 30, Issue 3, Page(s) 437–440

Abstract: In order to describe the clinical-pathological characteristics of the cases of Eccrine Porocarcinoma (EP) found in the Instituto Nacional de Enfermedades Neoplásicas (INEN), a cross-sectional study was carried out, including all EP cases recorded between ...

Title translation	Eccrine Porocarcinoma: clinical-pathological study of 19 cases in the Instituto Nacional de Enfermedades Neoplásicas, Lima - Peru.
Abstract	In order to describe the clinical-pathological characteristics of the cases of Eccrine Porocarcinoma (EP) found in the Instituto Nacional de Enfermedades Neoplásicas (INEN), a cross-sectional study was carried out, including all EP cases recorded between 1998 and 2009. A revision of the clinical-pathological records indentified and a new reading of the pathology slides of the cases found were performed. 19 EP cases were found, the median age of which was 64 years (range: 37-98). EP was primarily found on male patients (57.9%) and was most commonly located on the foot (21.1%), followed by the head, thorax and thigh (15.8%, respectively). In one case, EP was located on the gluteal region, and showed an unusually invasive behavior and rectal involvement. We conclude that EP is a rather uncommon entity in Peru. Its most common location is on the foot and it affects mostly male patients for the most part.
MeSH term(s)	Academies and Institutes ; Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Eccrine Porocarcinoma/pathology ; Female ; Humans ; Male ; Middle Aged ; Peru ; Sweat Gland Neoplasms/pathology
Language	Spanish
Publishing date	2013-07
Publishing country	Peru
Document type	English Abstract ; Journal Article
ZDB-ID	2120092-0
ISSN	1726-4642 ; 1726-4634
ISSN (online)	1726-4642
ISSN	1726-4634
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases.

Haverkos, Bradley M / Pan, Zenggang / Gru, Alejandro A / Freud, Aharon G / Rabinovitch, Rachel / Xu-Welliver, Meng / Otto, Brad / Barrionuevo, Carlos / Baiocchi, Robert A / Rochford, Rosemary / Porcu, Pierluigi

Current hematologic malignancy reports

2016 Volume 11, Issue 6, Page(s) 514–527

Abstract: Purpose of review: Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT) is an aggressive extranodal non-Hodgkin lymphoma most commonly occurring in East Asia and Latin America but with increasing incidence in the United States. Data on epidemiology, ... ...

Abstract	Purpose of review: Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT) is an aggressive extranodal non-Hodgkin lymphoma most commonly occurring in East Asia and Latin America but with increasing incidence in the United States. Data on epidemiology, disease presentation, and outcome for European and North American ("Western") cases are very limited. We review published landmark clinical studies on ENKTL-NT in the West and report in detail recent data, including our institutional experience. Recent findings: We highlight key observations in its epidemiology, natural history, and trends in clinical management. In the USA, ENKTL-NT is more common among Asian Pacific Islanders (API) and Hispanics compared to non-Hispanic whites. Published studies indicate less heterogeneity in clinical presentation in Western ENKTL-NT compared to Asian patients. While there is variation in age at diagnosis, presence of antecedent lymphoproliferative disorders, and outcomes among racial/ethnic groups, the universal association of ENKTL-NT with EBV and the poor response of this neoplasm to anthracycline-based therapy is consistent across all geographic areas. Data on epidemiology, disease presentation, and clinical outcomes in mature T cell and NK cell (T/NK cell) neoplasms, including ENKTL-NT, in Europe and North America are very limited. As the classification and diagnostic characterization of the currently recognized T/NK cell lymphoma disease entities continue to evolve, gaps and inconsistencies in data reporting across different studies are being recognized. Despite these limitations, several studies from the USA suggest that the incidence of ENKTL-NT is higher in Asian Pacific Islanders (API) and non-white Hispanics and that outcomes may be worse in non-whites. However, the universal association of ENKTL-NT with Epstein-Barr virus (EBV) across all ethnic groups suggests a common pathogenesis. Given the overlap between the entities included in the category of T/NK cell neoplasms, there is a need to further define biological and clinical differences that may affect diagnosis, treatment, and outcome.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Asparaginase/therapeutic use ; Biomarkers/blood ; DNA, Viral/analysis ; Europe/epidemiology ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/isolation & purification ; Herpesvirus 4, Human/physiology ; Humans ; Lymphoma, Extranodal NK-T-Cell/drug therapy ; Lymphoma, Extranodal NK-T-Cell/epidemiology ; Lymphoma, Extranodal NK-T-Cell/pathology ; Lymphoma, Extranodal NK-T-Cell/virology ; North America/epidemiology
Chemical Substances	Antineoplastic Agents ; Biomarkers ; DNA, Viral ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2229765-0
ISSN	1558-822X ; 1558-8211
ISSN (online)	1558-822X
ISSN	1558-8211
DOI	10.1007/s11899-016-0355-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6332: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Mutational profile and EBV strains of extranodal NK/T-cell lymphoma, nasal type in Latin America.

Montes-Mojarro, Ivonne A / Chen, Bo-Jung / Ramirez-Ibarguen, Ana F / Quezada-Fiallos, Carmen M / Pérez-Báez, Wendy B / Dueñas, Daniela / Casavilca-Zambrano, Sandro / Ortiz-Mayor, Marcela / Rojas-Bilbao, Erica / García-Rivello, Hernan / Metrebian, Maria F / Narbaitz, Marina / Barrionuevo, Carlos / Lome-Maldonado, Carmen / Bonzheim, Irina / Fend, Falko / Steinhilber, Julia / Quintanilla-Martinez, Leticia

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2019 Volume 33, Issue 5, Page(s) 781–791

Abstract: Extranodal NK/T-cell lymphoma (ENKTL) is an Epstein-Barr virus (EBV) associated lymphoma, prevalent in Asia and Latin America. Studies in Asian cohorts have identified some recurrent gene mutations in ENKTL; however, the mutational landscape of ENKTL in ... ...

Abstract	Extranodal NK/T-cell lymphoma (ENKTL) is an Epstein-Barr virus (EBV) associated lymphoma, prevalent in Asia and Latin America. Studies in Asian cohorts have identified some recurrent gene mutations in ENKTL; however, the mutational landscape of ENKTL in Latin America is unknown. In this study, we investigated the mutational profile and EBV strains of 71 ENKTL cases from Latin America (42 from Mexico, 17 from Peru, and 12 from Argentina) and compared it with Asian cohorts. The mutational analysis was performed by next generation sequencing (NGS) using an Ion AmpliSeq™ custom panel covering for the most frequently mutated genes identified in ENKTL. STAT3 was the most frequent mutated gene (16 cases: 23%), followed by MSN (10 cases; 14%), BCOR (9 cases; 13%), DDX3X (6 cases; 8%), TP53 (6 cases; 8%), MGA (3 cases; 4%), JAK3 (2 cases; 3%), and STAT5B (1 case; 1%). Mutations in STAT3, BCOR, and DDX3X were nearly mutually exclusive, suggesting different molecular pathways involved in the pathogenesis of ENKTL; whereas mutations in MGA, MSN, and TP53 were concomitant with other mutations. Most cases (75%) carried Type A EBV without the 30-bp LMP1 gene deletion. The overall survival was significantly associated with serum LDH level, Eastern Cooperative Oncology Group (ECOG) performance status, International Prognostic Index (IPI) score, and therapy (p < 0.05), but not associated with any mutation, EBV strain or deletion in EBV LMP1 gene. In conclusion, mutational analysis of ENKTL from Latin America reveals frequent gene mutations leading to activation of the JAK-STAT pathway (25%), mostly STAT3. Compared to Asian cohorts, BCOR, DDX3X and TP53 mutations were also identified but with different frequencies. None of these mutations were associated with prognosis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; DNA Mutational Analysis ; Epstein-Barr Virus Infections/virology ; Female ; Herpesvirus 4, Human ; Humans ; Latin America ; Lymphoma, Extranodal NK-T-Cell/genetics ; Lymphoma, Extranodal NK-T-Cell/pathology ; Lymphoma, Extranodal NK-T-Cell/virology ; Male ; Middle Aged ; Mutation ; Young Adult
Language	English
Publishing date	2019-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/s41379-019-0415-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2450: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito