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  1. Article ; Online: Focus and social contagion of environmental organization advocacy on Twitter.

    Barrios-O'Neill, Daniel

    Conservation biology : the journal of the Society for Conservation Biology

    2020  Volume 35, Issue 1, Page(s) 307–315

    Abstract: Agriculture, overexploitation, and urbanization remain the major threats to biodiversity in the Anthropocene. The attention these threats garner among leading environmental nongovernmental organizations (eNGOs) and the wider public is critical in ... ...

    Abstract Agriculture, overexploitation, and urbanization remain the major threats to biodiversity in the Anthropocene. The attention these threats garner among leading environmental nongovernmental organizations (eNGOs) and the wider public is critical in fostering the political will necessary to reverse biodiversity declines worldwide. I analyzed the advocacy of leading eNGOs on Twitter by scraping account timelines, screening content for advocacy relating to biodiversity threats and, for prevalent threats, further screening content for positive and negative emotional language with a sentiment lexicon. Twitter advocacy was dominated by the major threats of climate change and overexploitation and the minor threat of plastic pollution. The major threats of agriculture, urbanization, invasions, and pollution were rarely addressed. Content relating to overexploitation and plastic pollution was more socially contagious than other content. Increasing emotional negativity further increased social contagion, whereas increasing emotional positivity did not. Scientists, policy makers, and eNGOs should consider how narrowly focused advocacy on platforms like Twitter will contribute to effective global biodiversity conservation.
    MeSH term(s) Biodiversity ; Climate Change ; Conservation of Natural Resources ; Humans ; Organizations ; Social Media
    Language English
    Publishing date 2020-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 58735-7
    ISSN 1523-1739 ; 0888-8892
    ISSN (online) 1523-1739
    ISSN 0888-8892
    DOI 10.1111/cobi.13564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epigenetic Control of Infant B Cell Precursor Acute Lymphoblastic Leukemia.

    de Barrios, Oriol / Parra, Maribel

    International journal of molecular sciences

    2021  Volume 22, Issue 6

    Abstract: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a highly aggressive malignancy, with poorer prognosis in infants than in adults. A genetic signature has been associated with this outcome but, remarkably, leukemogenesis is commonly triggered by ...

    Abstract B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a highly aggressive malignancy, with poorer prognosis in infants than in adults. A genetic signature has been associated with this outcome but, remarkably, leukemogenesis is commonly triggered by genetic alterations of embryonic origin that involve the deregulation of chromatin remodelers. This review considers in depth how the alteration of epigenetic profiles (at DNA and histone levels) induces an aberrant phenotype in B lymphocyte progenitors by modulating the oncogenic drivers and tumor suppressors involved in key cancer hallmarks. DNA methylation patterns have been widely studied in BCP-ALL and their correlation with survival has been established. However, the effect of methylation on histone residues can be very different. For instance, methyltransferase
    MeSH term(s) DNA Methylation/genetics ; Epigenesis, Genetic ; Gene Expression Regulation, Leukemic ; Histones/metabolism ; Humans ; Infant ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Protein Processing, Post-Translational
    Chemical Substances Histones
    Language English
    Publishing date 2021-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22063127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: México y el derecho a la salud: hora de expectativas y decisiones.

    Artaza-Barrios, Osvaldo

    Salud publica de Mexico

    2019  Volume 60, Issue 6, Page(s) 736–738

    Title translation Mexico and the right to health: time for expectations and decisions.
    MeSH term(s) Decision Making ; Delivery of Health Care, Integrated/organization & administration ; Health Care Reform ; Health Policy ; Human Rights ; Humans ; Mexico ; Models, Theoretical ; National Health Programs/organization & administration ; Social Security/organization & administration ; Socioeconomic Factors ; Universal Health Insurance
    Language Spanish
    Publishing date 2019-01-30
    Publishing country Mexico
    Document type Letter
    ZDB-ID 954220-6
    ISSN 1606-7916 ; 0036-3634
    ISSN (online) 1606-7916
    ISSN 0036-3634
    DOI 10.21149/10107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Have we improved postoperative and long-term outcomes of liver surgery for colorectal cancer metastasis? Analysis of 1736 hepatectomies performed over 3 decades in a single center.

    Mils, Kristel / Lladó, Laura / López-Domínguez, Josefina / Barrios, Oriana / Leiva, David / Santos, Cristina / Serrano, Teresa / Ramos, Emilio

    Cirugia espanola

    2024  

    Abstract: Introduction: Surgery is the only potentially curative treatment for colorectal cancer liver metastases (CRLM) and its indication and results have varied in the last 30 years.: Methods: All patients operated on for CRLM in our centre from 1990 to ... ...

    Abstract Introduction: Surgery is the only potentially curative treatment for colorectal cancer liver metastases (CRLM) and its indication and results have varied in the last 30 years.
    Methods: All patients operated on for CRLM in our centre from 1990 to 2021 were prospectively collected, establishing 3 subgroups based on the year of the first surgery: group A 1990-1999, group B 2000-2010, group C 2011-2021. Clinical characteristics and the results of survival, recurrence and prognostic factors were compared.
    Results: 1736 hepatectomies were included (Group A n = 208; Group B n = 770; Group C n = 758). Patients in group C had better survival at 5 and 10 years (A 40.5%/28.2%; B 45.9%/32.2%; C 51.6%/33.1%, p = 0.013), although there were no differences between groups in overall recurrence at 5 and 10 years (A 73%/75.7%; B 67.6%/69.2%, and C 63.9%/66%, p = 0.524), nor in liver recurrence (A 46.4%/48.2%; B 45.8%/48.2%; and C 44.4%/48.4%, p = 0.899). An improvement was observed in median survival after recurrence, being 19 months, 23 months, and 31 months (groups A, B and C respectively). Prognostic factors of long-term survival changed over the 3 study periods. The only ones that remained relevant in the last decade were the presence of >4 liver metastasis, extrahepatic disease at the time of hepatectomy, and intraoperative blood transfusion.
    Conclusions: Survival after surgery for CRLM has improved significantly, although this cannot be explained by a reduction in overall and hepatic recurrence, but rather by an improvement in post-recurrence survival. Involvement of the resection margin has lost prognostic value in the last decade.
    Language English
    Publishing date 2024-02-10
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2023.11.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biomass encounter rates limit the size scaling of feeding interactions.

    Barrios-O'Neill, Daniel / Kelly, Ruth / Emmerson, Mark C

    Ecology letters

    2019  Volume 22, Issue 11, Page(s) 1870–1878

    Abstract: The rate that consumers encounter resources in space necessarily limits the strength of feeding interactions that shape ecosystems. To explore the link between encounters and feeding, we first compiled the largest available dataset of interactions in the ...

    Abstract The rate that consumers encounter resources in space necessarily limits the strength of feeding interactions that shape ecosystems. To explore the link between encounters and feeding, we first compiled the largest available dataset of interactions in the marine benthos by extracting data from published studies and generating new data. These data indicate that the size-scaling of feeding interactions varies among consumer groups using different strategies (passive or active) to encounter different resource types (mobile or static), with filter feeders exhibiting the weakest feeding interactions. Next, we used these data to develop an agent-based model of resource biomass encounter rates, underpinned by consumer encounter strategy and resource biomass density. Our model demonstrates that passive strategies for encountering small, dispersed resources limits biomass encounter rates, necessarily limiting the strength of feeding interactions. Our model is based on generalisable assumptions, providing a framework to assess encounter-based drivers of consumption and coexistence across systems.
    MeSH term(s) Biomass ; Ecosystem ; Feeding Behavior
    Language English
    Publishing date 2019-08-21
    Publishing country England
    Document type Letter
    ZDB-ID 1441608-6
    ISSN 1461-0248 ; 1461-023X
    ISSN (online) 1461-0248
    ISSN 1461-023X
    DOI 10.1111/ele.13380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Biomass encounter rates limit the size scaling of feeding interactions

    Barrios‐O’Neill, Daniel / Kelly, Ruth / Emmerson, Mark C

    Ecology letters. 2019 Nov., v. 22, no. 11

    2019  

    Abstract: The rate that consumers encounter resources in space necessarily limits the strength of feeding interactions that shape ecosystems. To explore the link between encounters and feeding, we first compiled the largest available dataset of interactions in the ...

    Abstract The rate that consumers encounter resources in space necessarily limits the strength of feeding interactions that shape ecosystems. To explore the link between encounters and feeding, we first compiled the largest available dataset of interactions in the marine benthos by extracting data from published studies and generating new data. These data indicate that the size‐scaling of feeding interactions varies among consumer groups using different strategies (passive or active) to encounter different resource types (mobile or static), with filter feeders exhibiting the weakest feeding interactions. Next, we used these data to develop an agent‐based model of resource biomass encounter rates, underpinned by consumer encounter strategy and resource biomass density. Our model demonstrates that passive strategies for encountering small, dispersed resources limits biomass encounter rates, necessarily limiting the strength of feeding interactions. Our model is based on generalisable assumptions, providing a framework to assess encounter‐based drivers of consumption and coexistence across systems.
    Keywords benthic organisms ; biomass ; data collection ; ecosystems ; models
    Language English
    Dates of publication 2019-11
    Size p. 1870-1878.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note LETTER
    ZDB-ID 1441608-6
    ISSN 1461-0248 ; 1461-023X
    ISSN (online) 1461-0248
    ISSN 1461-023X
    DOI 10.1111/ele.13380
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: MYC's Fine Line Between B Cell Development and Malignancy.

    de Barrios, Oriol / Meler, Ainara / Parra, Maribel

    Cells

    2020  Volume 9, Issue 2

    Abstract: The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of ...

    Abstract The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of expression are maintained, and its protein levels are not completely silenced until the B cell becomes fully differentiated into a plasma cell or a memory B cell. MYC has been described as a proto-oncogene that is closely involved in many cancers, including leukemia and lymphoma. Aberrant expression of MYC protein in these hematological malignancies results in an uncontrolled rate of proliferation and, thereby, a blockade of the differentiation process. MYC is not activated by mutations in the coding sequence, and, as reviewed here, its overexpression in leukemia and lymphoma is mainly caused by gene amplification, chromosomal translocations, and aberrant regulation of its transcription. This review provides a thorough overview of the role of MYC in the developmental steps of B cells, and of how it performs its essential function in an oncogenic context, highlighting the importance of appropriate MYC regulation circuitry.
    MeSH term(s) Animals ; B-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Cell Transformation, Neoplastic/genetics ; Child ; Gene Amplification ; Gene Expression Regulation, Neoplastic ; Humans ; Leukemia/metabolism ; Leukemia/pathology ; Lymphoma/metabolism ; Lymphoma/pathology ; Mice ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Translocation, Genetic ; Young Adult
    Chemical Substances MAS1 protein, human ; MYC protein, human ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-myc
    Language English
    Publishing date 2020-02-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9020523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Turnbull-Cutait pull-through technique for delayed coloanal anastomosis after ultralow rectal resection: A step-by-step video vignette.

    Pera, Meritxell / Barrios, Oriana / Pellino, Gianluca / Golda, Thomas / Biondo, Sebastiano / Espín-Basany, Eloy

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 24, Issue 7, Page(s) 889–890

    MeSH term(s) Anal Canal/surgery ; Anastomosis, Surgical/methods ; Colon/surgery ; Digestive System Surgical Procedures/methods ; Humans ; Proctectomy ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Double-barrelled wet colostomy for urinary reconstruction after pelvic exenteration: a step-by-step video vignette demonstration.

    Barrios, Oriana / Pera, Meritxell / Golda, Thomas / Pellino, Gianluca / Espín-Basany, Eloy / Biondo, Sebastiano

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 24, Issue 7, Page(s) 883–884

    MeSH term(s) Colostomy ; Humans ; Pelvic Exenteration ; Urinary Diversion ; Urinary Tract
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diagnosis and treatment of hepatic cysts. Usefulness of intracystic tumor markers (CEA and CA 19.9.).

    Polette, Daniela / Mils, Kristel / López-Domínguez, Fina / Barrios, Oriana / Leiva, David / Puig, Isabel / Ramos, Emilio / Lladó, Laura

    Cirugia espanola

    2023  Volume 102, Issue 1, Page(s) 19–24

    Abstract: Introduction: To decide treatment of hepatic cysts diagnosis between simple hepatic cyst (SHC) and cystic mucinous neoplasm (CMN). Radiological features are not patognomonic. Some studies have suggested the utility of intracystic tumor markers.: ... ...

    Abstract Introduction: To decide treatment of hepatic cysts diagnosis between simple hepatic cyst (SHC) and cystic mucinous neoplasm (CMN). Radiological features are not patognomonic. Some studies have suggested the utility of intracystic tumor markers.
    Methods: Retrospective analysis of our prospective database including patients treated due to symptomatic SHC from 2003 to 2021. The aim of the study was to evaluate the results of treatment of symptomatic SHC and the usefulness of the determination of intracystic "carcinoembryonic antigen" (CEA) and "carbohydrate antigen" CA 19.9.
    Results: 50 patients diagnosed and treated for symptomatic SHC were included. In 15 patients the first treatment was percutaneous drainage. In 35 patients the first treatment was laparoscopic fenestration. Four patients were diagnosed of premalignant or malignant liver cystic lesions (MCN, IPMN, lymphoma B); three of them required surgery after initial fenestration and pathological diagnosis. Median CEA and CA 19-9 were 196 μg/L and 227.321 U/mL respectively. Patients with malignant or premalignant pathology did not have higher levels of intracystic tumor markers. Positive predictive value was 0% for both markers, and negative predictive value was 89% and 91% respectively.
    Conclusion: Values of intracystic tumor markers CEA and CA 19-9 do not allow distinguishing simple cysts from cystic liver neoplasms. The most effective treatment for symptomatic simple liver cysts is surgical fenestration. The pathological analysis of the wall of the cysts enables the correct diagnosis, allowing to indicate a surgical reintervention in cases of hepatic cyst neoplasia.
    MeSH term(s) Humans ; Carcinoembryonic Antigen/analysis ; Biomarkers, Tumor ; Retrospective Studies ; Cysts/diagnosis ; Cysts/surgery ; CA-19-9 Antigen/analysis ; Liver Neoplasms/diagnosis ; Liver Neoplasms/surgery ; Liver Diseases
    Chemical Substances Carcinoembryonic Antigen ; Biomarkers, Tumor ; CA-19-9 Antigen
    Language English
    Publishing date 2023-11-20
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2023.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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