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Article ; Online: Evaluación de la expresión de PD-L1 e infiltración linfocitaria intratumoral en carcinoma de mama invasivo triple negativo.

Barrios Barreto, Rina / Silvera Redondo, Carlos / Garavito, María Del Pilar / Ardila Pereira, Laura

2024 Volume 84, Issue 2, Page(s) 227–235

Abstract: Introduction: Triple negative breast cancer endophenotype (TNBC) is one of the least frequent and without therapeutic target; therefore we propose to study the correlation of PD-L1 immune checkpoint with the establishment of tumor microenvironment ... ...

Title translation	Evaluation of PD-L1 expression and intratumoral lymphocytic infiltration in triple-negative invasive breast carcinoma.
Abstract	Introduction: Triple negative breast cancer endophenotype (TNBC) is one of the least frequent and without therapeutic target; therefore we propose to study the correlation of PD-L1 immune checkpoint with the establishment of tumor microenvironment assessed by intratumoral stromal lymphocyte infiltration (TILS) and its importance in clinical practice. Methods: A retrospective case-control study was performed, with 31 cases of triple-negative infiltrating breast carcinoma and 57 unmatched controls of Luminal A, Luminal B and HER-2 endophenotype seen in one year. The following variables were evaluated: histologic type and grade, PD-L1 expression with clone 22C3, TILS, lymphovascular invasion, tumor size, lymph node involvement and metastasis. Statistical analysis was performed with the chi-square test and Spearman correlation coefficient test. Results: a statistically significant negative correlation was found between TILS and PD-L1 (rho - 0.106, p 0.025), indicating that the higher the expression of PD-L1, the lower the intratumoral lymphocytic infiltration. In the TILS B (10-40% TILS) and C (40-90% TILS) groups where there was a marked intratumoral inflammatory infiltrate, a greater number of patients were negative for PD-L1 (CPS <10) with 16 and 10 cases, respectively. For TNBC cases a negative association coefficient was identified (rho -0.378) with statistical significance (p 0.01). Discussion: The association between TNBC, TILS and PDL1 expression was established, which is important for the establishment of target therapies and the development of precision medicine.
MeSH term(s)	Aged ; Female ; Humans ; Middle Aged ; B7-H1 Antigen/analysis ; B7-H1 Antigen/metabolism ; Case-Control Studies ; Lymphocytes, Tumor-Infiltrating/immunology ; Retrospective Studies ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/immunology ; Tumor Microenvironment/immunology
Chemical Substances	B7-H1 Antigen ; CD274 protein, human
Language	Spanish
Publishing date	2024-05-07
Publishing country	Argentina
Document type	English Abstract ; Journal Article
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article ; Online: Secondary involvement of breasts by follicular lymphoma.

Barrios Barreto, Rina / Mendoza Suarez, Liney / Del Valle, Astrid / Silvera Redondo, Carlos / De La Hoz Herazo, Haydee P

Medicina

2023 Volume 83, Issue 1, Page(s) 149–152

Abstract: Metastatic lesions involving the breast are exceptional; hematolymphoid neoplasias rank second as per their frequency in case series reported in the literature with a prevalence of 0.04% to 1.6% when considering all malignant breast tumors and reaching ... ...

Title translation	Compromiso secundario de glándulas mamarias por linfoma folicular.
Abstract	Metastatic lesions involving the breast are exceptional; hematolymphoid neoplasias rank second as per their frequency in case series reported in the literature with a prevalence of 0.04% to 1.6% when considering all malignant breast tumors and reaching an annual incidence of 0.07%, mainly accounted for by secondary lymphomas. Eighty percent of them are diffuse, large B cells lymphomas (DLBCL), followed by follicular lymphoma and marginal zone lymphoma. This case is about a 60 year-old woman with a diagnosis of follicular lymphoma, who presented with a right perirenal mass and ipsilateral retroperitoneal and inguinal lymph nodes, whose clinical status progressed during the treatment with unusual secondary involvement of both breasts by hematolymphoid neoplasia. The biological behavior of the condition was evaluated to understand the pathophysiological mechanisms; this was done analyzing clinical, histologic and prognostic factors that led to a definitive staging, which was key to select the individualized therapy following the clinical practice guidelines based on scientific evidence, with a positive impact on the patient's medical progress.
MeSH term(s)	Female ; Humans ; Middle Aged ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/drug therapy ; Lymphoma, Follicular/pathology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, B-Cell, Marginal Zone/diagnosis ; Lymph Nodes/pathology ; Incidence
Language	English
Publishing date	2023-02-11
Publishing country	Argentina
Document type	Case Reports
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Renal epidermoid cyst: A case report.

Barrios Barreto, Rina / Mendoza Suarez, Liney / Del Valle Pestana, Astrid / Silvera Redondo, Carlos

Urology case reports

2021 Volume 38, Page(s) 101649

Abstract: A 56-year-old male patient with no significant clinical history manifested lumbar pain, macroscopic hematuria and dysuria. Radiology images found a renal mass in the upper right pole at the pyelocaliceal level. A partial nephrectomy was performed to ... ...

Abstract	A 56-year-old male patient with no significant clinical history manifested lumbar pain, macroscopic hematuria and dysuria. Radiology images found a renal mass in the upper right pole at the pyelocaliceal level. A partial nephrectomy was performed to resect the tumor, and histology revealed the diagnosis of a renal epidermoid cyst, which is an infrequent lesion with a benign biological behavior. Its etiology is still controversial, but its clinical course is satisfactory after complete resection of the lesion.
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2021.101649
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Article ; Online: Dermatofibrosarcoma protuberans with unusual presentation in vulva.

Barrios Barreto, Rina / Mendoza Suarez, Liney / Del Valle, Astrid / Silvera Redondo, Carlos / De La Hoz Pabola, Andrés

Medicina

2022 Volume 82, Issue 3, Page(s) 441–444

Abstract: Gynecological sarcomas are rare and their location in the vulva and vagina has an incidence of 5% of all malignant neoplasms in the female genital tract. We present the case of a 54-year-old patient with a diagnosis of dermatofibrosarcoma protuberans in ... ...

Title translation	Dermatofibrosarcoma protuberans con presentación inusual en vulva.
Abstract	Gynecological sarcomas are rare and their location in the vulva and vagina has an incidence of 5% of all malignant neoplasms in the female genital tract. We present the case of a 54-year-old patient with a diagnosis of dermatofibrosarcoma protuberans in the vulva, an infrequent pathology with less than 60 cases reported worldwide in this anatomical location. Clinically, it is locally aggressive, due to the proliferation of spindle cells with pleomorphism and frequent mitotic figures infiltrating the reticular dermis and subcutaneous cellular tissue, giving rise to variable size tumors with high local recurrence rates. The first-line treatment is surgical excision of the tumor with Mohs micrographic surgery among other surgical techniques for complete circumferential peripheral and deep margin assessment. However, identification of carcinogenesis mechanisms where the chromosomal translocation t (17; 22) (q22; q13) is recognized, forming the COL1A1-PDGFB fusion gene, which participates in stimulating tumor cell proliferation, allowing treatment with tyrosine kinase inhibitors such as imatinib for neoadjuvant therapy of surgically unresectable tumors and local recurrences.
MeSH term(s)	Dermatofibrosarcoma/diagnosis ; Dermatofibrosarcoma/genetics ; Dermatofibrosarcoma/surgery ; Female ; Humans ; Imatinib Mesylate/therapeutic use ; Middle Aged ; Skin Neoplasms/diagnosis ; Translocation, Genetic ; Vulva/pathology
Chemical Substances	Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2022-05-27
Publishing country	Argentina
Document type	Case Reports
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ACUTE ABDOMEN SECONDARY TO NEOPLASM IN A HIV/SIDA PATIENT (IN SPANISH)

Herrera-Lomónaco Sandra / Barrios-Barreto Rina / Angulo-Díaz Indira / Oliveros-Jiménez Diana

Revista Ciencias Biomédicas, Vol 5, Iss 2, Pp 351-

2014 Volume 356

Abstract: Introduction: patients with HIV/SIDA might present as complications, symptoms of acute abdomen that could be of infectious, neoplasic or idiopathic etiology. The frequency of epithelial, mesenchymal and hemato-lymphoid neoplasm, tend to be increased in ... ...

Abstract	Introduction: patients with HIV/SIDA might present as complications, symptoms of acute abdomen that could be of infectious, neoplasic or idiopathic etiology. The frequency of epithelial, mesenchymal and hemato-lymphoid neoplasm, tend to be increased in the HIV/SIDA patients. Case report: a 23-year-old male with diagnosis of HIV since three years ago and without regular antiretroviral treatment due to voluntary suspension. He presented symptoms of two days of evolution consistent in diarrhea, pain in right iliac region, vomiting and clinical signs of peritoneal irritation. Then, with diagnosis of acute abdomen secondary to acute appendicitis, he was carried to laparotomy. During the surgery procedure, intestinal perforation in the ileocecal region was found. Debridement, enterorrhaphy and appendicectomy were done, with adequate postoperative improvement. The histopathological diagnosis was Diffuse Large-B-cell Non-hodgkin Lymphoma of the ileocecal region. He was discharged for the oncological and integral management of the HIV/SIDA. Conclusion: the Diffuse Large-B-cell Non-Hodgkin Lymphoma is the type of lymphoma most frequently reported in association with the HIV/SIDA. The presented case is unusual, where the intestinal perforation caused acute abdomen imitating appendicular event. The lack of use of antiretroviral treatment probably contributed to the development and evolution of the Diffuse Large-B-cell Non-Hodgkin Lymphoma. Rev. cienc.biomed.2014;5(2):351-356. KEYWORDS Acute abdomen, Neoplasm, Non-Hodgkin lymphoma, HIV.
Keywords	Acute abdomen ; Neoplasm ; Non-Hodgkin lymphoma ; HIV ; Medicine (General) ; R5-920
Subject code	610
Language	Spanish
Publishing date	2014-06-01T00:00:00Z
Publisher	Universidad de Cartagena
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PARRY-ROMBERG SYNDROME

Redondo-Bermúdez César / Redondo-De Oro Katherine / Mendoza-Suárez Liney / Barrios-Barreto Rina / Buj-Vargas Julián

Revista Ciencias Biomédicas, Vol 6, Iss 1, Pp 142-

2015 Volume 149

Abstract: Introduction: the progressive hemifacial atrophy or Parry-Romberg syndrome is a rare disease, of slow clinical evolution that generates atrophy of the soft tissues. It compromises frequently only one side of the face, where the left side is the most ... ...

Abstract	Introduction: the progressive hemifacial atrophy or Parry-Romberg syndrome is a rare disease, of slow clinical evolution that generates atrophy of the soft tissues. It compromises frequently only one side of the face, where the left side is the most affected. The disease usually establishes in early ages and with the time it could compromise one or more branches of the trigeminal nerve. In this occasion, a case in which the diagnosis was notoriously late, despite repeated consultation due to facial asymmetry and other manifestations, is presented. Case record: a 73-year-old-female patient from a Colombian rural area, who attended several times to consultation due to facial asymmetry without obtaining a definitive diagnosis is presented. She had clinical history of orbito-zygomatic and right shoulder trauma two decades ago. Also, clinical history of two ophthalmological surgeries: Cataract and glaucoma. It was observed a notorious depression in the right cheek with marked signs of atrophy, accompanied of periodic migraine disorders and local symptoms. And a skin biopsy of the cutaneous adnexal, where the atrophy was observed, was taken. There were not demonstrated other neurological lesions. Conclusions: the Parry-Romberg syndrome is a chronic disease that could have ophthalmological or neurological implications. It involves migraine symptoms, paresthesias and facial asymmetry that merits early diagnosis and adequate treatment, so much of the progressive as stationary phase. Rev.cienc.biomed. 2015;6(1):142- 149 KEYWORDS Facial asymmetry; Facial hemiatrophy; Vasculitis.
Keywords	Facial asymmetry ; Facial hemiatrophy ; Vasculitis ; Medicine (General) ; R5-920
Subject code	616
Language	Spanish
Publishing date	2015-01-01T00:00:00Z
Publisher	Universidad de Cartagena
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: O’BRIEN’S ACTINIC GRANULOMA (IN SPANISH)

Redondo-Bermúdez César / Camacho-Chaljub Francisco / Barrios-Barreto Rina / Mendoza Suárez Liney / Borré-Naranjo Diana

Revista Ciencias Biomédicas, Vol 5, Iss 2, Pp 336-

2014 Volume 340

Abstract: Giant-Cell Granuloma, was described initially in 1975. It is an infrequent dermatosis that is characterized by annular plaques with erythematous margins that are distributed in sun-exposed areas of the body. Case report: 52-year-old female patient with ... ...

Abstract	Giant-Cell Granuloma, was described initially in 1975. It is an infrequent dermatosis that is characterized by annular plaques with erythematous margins that are distributed in sun-exposed areas of the body. Case report: 52-year-old female patient with symptomatology of 24 months of evolution, characterized by scattered and symmetric dermatosis, with commitment of superior members, superior chest and thigh, in form of annular plaques. It was not documented sun exposition higher to the habitual. Betamethasone dipropionate 0.05% was use topically accompanied of sunscreen with adequate improvement of the disease. Conclusion: the OAG is a rare skin lesion, of unknown pathogenesis, that is developed in sun-exposed areas. It has as the most widely accepted theory for its appearance, the development of immune response by cells to antigenic determinants, present in the elastic fibers with actinic alteration. The findings of the patient were concordant with the previously reported. Rev.cienc.biomed. 2014;5(2):336-340. KEYWORDS Granuloma, Dermatoses, O’Brien’s granuloma
Keywords	Granuloma ; Dermatoses ; O’Brien’s granuloma ; Medicine (General) ; R5-920
Language	Spanish
Publishing date	2014-06-01T00:00:00Z
Publisher	Universidad de Cartagena
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CHROMOPHOBE RENAL CELL CARCINOMA IN A YOUNG PATIENT WITH PARTIAL NEPHRECTOMY AS TREATMENT

Lambis-Ricardo Jorge / Herrera-Lomónaco Sandra / De León-Manotas Gabriel / Ballestas-Almario Carlos / Montenegro-Castañeda Stephany / González-Peralta Aura / Barrios-Barreto Rina

Revista Ciencias Biomédicas, Vol 6, Iss 1, Pp 160-

2015 Volume 164

Abstract: Introduction: the renal cell carcinomas represent 90% of all malignant renal tumors, being the chromophobe renal cell carcinoma (CRCC) a histological variant. Its clinical presentation is unspecific and generally it is a well-circumscribed tumor, with ... ...

Abstract	Introduction: the renal cell carcinomas represent 90% of all malignant renal tumors, being the chromophobe renal cell carcinoma (CRCC) a histological variant. Its clinical presentation is unspecific and generally it is a well-circumscribed tumor, with major prevalence in the sixth decade of life and with good prognostic. Case report: 23-year-old female patient with symptomatology of intermittent hemorrhage and irritating symptoms. The imagenological studies reported nodular mass in the left inferior side of 33 x 36 mmm of diameter. The image-guided percutaneous biopsy showed CRCC. And a partial nephrectomy with preservation of the healthy side was carried out. The patient had satisfactory evolution. Conclusion: the CRCC is an uncommon histological subtype of renal carcinoma. Its early detection is important and its symptomatology occurs in a wide age group, thus it must be suspected in young patients with renal mass. Due to it is a delimited tumor, in some cases, it could be treated with partial nephrectomy to preserve the renal function. Rev.cienc.biomed. 2015;6(1):160-164 KEYWORDS Kidney neoplasms; Hematuria; Nephrectomy.
Keywords	Kidney neoplasms ; Hematuria ; Nephrectomy ; Medicine (General) ; R5-920
Subject code	616
Language	Spanish
Publishing date	2015-01-01T00:00:00Z
Publisher	Universidad de Cartagena
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SYSTEMIC AMYLOIDOSIS

Martínez-Muñoz Elsa / Baena-Del Valle Javier / Barrios-Barreto Rina / Herrera-Lomonaco Sandra / Redondo-Bermúdez César / Miranda-Marzola María del Carmen

Revista Ciencias Biomédicas, Vol 5, Iss 1, Pp 123-

FINDING ON AUTOPSY. REPORT OF TWO CASES (IN SPANISH)

2014 Volume 129

Abstract: Introduction: amyloidosis is the extracellular accumulation of amyloid material, which causes damage in the functioning of organs and tissues. It is characterized by the presence of protein folding, which acquire the capacity of self-assembly creating ... ...

Abstract	Introduction: amyloidosis is the extracellular accumulation of amyloid material, which causes damage in the functioning of organs and tissues. It is characterized by the presence of protein folding, which acquire the capacity of self-assembly creating unusual configurations. Case reports: the case reports of two female patients are presented. Both with 47 years of age, who died without clinical diagnosis. Due to not evident cause of the deaths, clinical autopsies were carried out. Massive presence of amyloid in different organs was found, which was confirmed with the Congo red staining method and the assessment in the polarized light microscopy. Multiple organ dysfunction syndromes secondary to the presence of systemic amyloidosis was diagnosed and in both patients was considered as the cause of death. Conclusion: the clinical symptoms of the amyloidosis are variable and nonspecific, depending of the extracellular deposits and its location in the body. It is a challenge to do a diagnosis. It is recommended to consider the diagnostic possibility of the amyloidosis in patients with suggestive symptoms of damage in the function of the organ and it is required the histological confirmation. Rev. cienc.biomed. 2014;5(1):123-129 KEYWORDS Amyloid, Amyloid beta-protein precursor, Amyloidosis, Autopsy.
Keywords	Amyloid ; Amyloid beta-protein precursor ; Amyloidosis ; Autopsy ; Medicine (General) ; R5-920
Subject code	610
Language	Spanish
Publishing date	2014-01-01T00:00:00Z
Publisher	Universidad de Cartagena
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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