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  1. Article: A Yellow Flower With Jaundice Power: Liver Injury Attributed to Greater Celandine.

    Power, Sydney / Barritt, A Sidney

    ACG case reports journal

    2024  Volume 11, Issue 5, Page(s) e01347

    Abstract: Greater celandine ( ...

    Abstract Greater celandine (
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000001347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: We Are What We Eat: Food as Medicine in Health and Disease.

    Barritt, A Sidney

    Clinical therapeutics

    2022  Volume 44, Issue 5, Page(s) 642–643

    MeSH term(s) Food ; Humans
    Language English
    Publishing date 2022-05-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2022.04.008
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  3. Article ; Online: Nonalcoholic Fatty Liver Disease: Epidemiology, Assessments, and Interventions Entering 2021.

    Barritt, A Sidney

    Clinical therapeutics

    2021  Volume 43, Issue 3, Page(s) 436–437

    MeSH term(s) Disease Progression ; Humans ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Risk Factors
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2021.01.022
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  4. Article ; Online: Dynamic α-Fetoprotein Response-Are We Ready to Change the Dynamics of Hepatocellular Carcinoma Liver Transplant Practice?

    Desai, Chirag S / Barritt, A Sidney

    JAMA surgery

    2021  Volume 156, Issue 6, Page(s) 567–568

    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Humans ; Liver Neoplasms/surgery ; Liver Transplantation ; alpha-Fetoproteins
    Chemical Substances alpha-Fetoproteins
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2021.0955
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  5. Article ; Online: Bariatric Surgery and Cancer Risk in Nonalcoholic Fatty Liver Disease-Effective Intervention for a Select Few.

    Barritt, A Sidney / Moon, Andrew M

    Gastroenterology

    2021  Volume 161, Issue 6, Page(s) 2063–2064

    MeSH term(s) Bariatric Surgery ; Humans ; Neoplasms ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Obesity, Morbid ; Risk
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.06.003
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  6. Article ; Online: Review article: role of glucagon-like peptide-1 receptor agonists in non-alcoholic steatohepatitis, obesity and diabetes-what hepatologists need to know.

    Barritt, A Sidney / Marshman, Emma / Noureddin, Mazen

    Alimentary pharmacology & therapeutics

    2022  Volume 55, Issue 8, Page(s) 944–959

    Abstract: Background: Non-alcoholic steatohepatitis (NASH) is characterised by hepatic lipid accumulation, cell injury, inflammation and fibrosis. Insulin resistance, a hallmark of type 2 diabetes (T2D) and obesity, is a key pathogenic driver of NASH. Other than ... ...

    Abstract Background: Non-alcoholic steatohepatitis (NASH) is characterised by hepatic lipid accumulation, cell injury, inflammation and fibrosis. Insulin resistance, a hallmark of type 2 diabetes (T2D) and obesity, is a key pathogenic driver of NASH. Other than difficult-to-maintain lifestyle changes, there are no approved treatments for NASH. Due to their effects on multiple pathophysiological processes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been tested in disorders related to insulin resistance and metabolic defects.
    Aims: To summarise studies of GLP-1RAs relevant to the treatment of NASH.
    Methods: PubMed searches were performed and results were compiled.
    Results: Large trials with GLP-1RAs in T2D demonstrate highly effective glucose lowering, with body weight loss, and in some cases, reduced cardiovascular events and improved liver transaminases. The GLP-1RAs, liraglutide and semaglutide, were associated with clinically relevant, sustained body weight reduction in individuals with overweight or obesity and without T2D. In a phase II trial in NASH, liraglutide reduced metabolic dysfunction, insulin resistance and lipotoxicity in key organs associated with NASH pathogenesis. Furthermore, liraglutide and semaglutide led to histological resolution of NASH in ~40% to 60% of patients, although a statistically significant effect on fibrosis has not been confirmed. Regarding safety, GLP-1RAs are associated with gastrointestinal and gallbladder-related adverse events, with the latter perhaps related to weight loss. Meta-analyses do not indicate increased risk of acute pancreatitis, pancreatic cancer or other malignancies with GLP-1RAs.
    Conclusions: These studies support the use of GLP-1RAs for the improvement of underlying metabolic dysfunction observed in NASH and suggest further long-term phase III trials are warranted.
    MeSH term(s) Acute Disease ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Gastroenterologists ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hypoglycemic Agents/adverse effects ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/drug therapy ; Obesity/complications ; Obesity/drug therapy ; Pancreatitis/complications
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16794
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  7. Article ; Online: Elevated Liver Enzymes in Patients with COVID-19: Look, but Not Too Hard.

    Moon, Andrew M / Barritt, A Sidney

    Digestive diseases and sciences

    2020  Volume 66, Issue 6, Page(s) 1767–1769

    MeSH term(s) COVID-19 ; Consultants ; Gastroenterology ; Humans ; Liver ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06585-9
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  8. Article ; Online: Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not.

    Kumar, Aman / Abbas, Daniyal / Barritt, A Sidney / Lachiewicz, Anne / Fix, Oren K / Desai, Chirag S

    Journal of liver transplantation

    2023  Volume 10, Page(s) 100146

    Abstract: The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor- ... ...

    Abstract The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown. We present our experience with two cases in which a liver was transplanted successfully from a brain-dead donor with incidental SARS-CoV-2 infection. Both donors were asymptomatic SARS-CoV-2-positive with negative bronchoalveolar lavage polymerase chain reaction (BAL PCR) and mechanism of death unrelated to COVID-19. Both the recipients did well after transplant and went home with a well-functioning liver. One patient did get readmitted and was found to be SARS-CoV-2-positive; however, it was probably related to hospital exposure rather than donor-derived. SARS-CoV-2-positive donors in select cases may be used for organ donation and liver transplant is safe for recipients.
    Language English
    Publishing date 2023-02-24
    Publishing country France
    Document type Case Reports
    ISSN 2666-9676
    ISSN (online) 2666-9676
    DOI 10.1016/j.liver.2023.100146
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  9. Article ; Online: When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network.

    Barritt, A Sidney / Barnhart, Huiman / Gu, Jiezhun / Dellinger, Andrew / Rudnick, Sean / Bonkovsky, Herbert L

    The American journal of gastroenterology

    2023  Volume 118, Issue 12, Page(s) 2301–2304

    Abstract: Introduction: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.: ... ...

    Abstract Introduction: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.
    Methods: Cases were adjudicated by expert opinion and scored from 1 (definite DILI) to 5 (unlikely DILI). Confirmed cases (1-3) were compared with unlikely cases (5).
    Results: One hundred thirty-four of the 1,916 cases (7%) were unlikely DILI. Alternative diagnoses were autoimmune hepatitis (20%), hepatitis C (20%), bile duct pathology (13%), and hepatitis E (8%).
    Discussion: Thorough evaluation, including follow-up, is essential to minimize incorrect diagnosis of idiosyncratic DILI.
    MeSH term(s) Humans ; Prospective Studies ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/epidemiology ; Chemical and Drug Induced Liver Injury/etiology ; Liver/pathology ; Hepatitis C/pathology ; Causality
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002370
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  10. Article ; Online: High concordance between nonalcoholic fatty liver disease and metabolic dysfunction associated steatotic liver disease in the TARGET-NASH real world cohort.

    Barritt, A Sidney / Yu, Feng / Mospan, Andrea R / Newsome, Philip / Roden, Michael / Morris, Heather L / Loomba, Rohit / Neuschwander-Tetri, Brent A

    The American journal of gastroenterology

    2024  

    Abstract: Introduction: This study investigates the applicability of the new MASLD nomenclature to the real-world TARGET-NASH US adult cohort.: Methods: The new MASLD/MASH nomenclature was applied to patients enrolled with pragmatic diagnoses of NAFL, NASH and ...

    Abstract Introduction: This study investigates the applicability of the new MASLD nomenclature to the real-world TARGET-NASH US adult cohort.
    Methods: The new MASLD/MASH nomenclature was applied to patients enrolled with pragmatic diagnoses of NAFL, NASH and NASH cirrhosis and concordance was determined between the definitions.
    Results: 99% of TARGET-NASH participants met the new MASLD diagnostic criteria. 1484/1541 (96.3%, kappa 0.974) NAFL patients (MASL), 2195/2201 (99.7%, kappa 0.998) NASH patients (MASH), and 1999/2003 (99.8%, kappa 0.999) NASH cirrhosis patients met the new criteria.
    Conclusion: The new MASLD nomenclature is highly concordant with the prior TARGET-NASH pragmatic definitions.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002796
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