LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 600

Search options

  1. Article: Learning environments: the Scotland experience.

    Barron, Derek

    British journal of nursing (Mark Allen Publishing)

    2022  Volume 31, Issue 13, Page(s) 678

    MeSH term(s) Humans ; Learning ; Scotland
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2022.31.13.678
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3449: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: The supersaturation perspective on the amyloid hypothesis.

    Portugal Barron, Diana / Guo, Zhefeng

    Chemical science

    2023  Volume 15, Issue 1, Page(s) 46–54

    Abstract: Development of therapeutic interventions for Alzheimer's over the past three decades has been guided by the amyloid hypothesis, which puts Aβ deposition as the initiating event of a pathogenic cascade leading to dementia. In the current form, the amyloid ...

    Abstract Development of therapeutic interventions for Alzheimer's over the past three decades has been guided by the amyloid hypothesis, which puts Aβ deposition as the initiating event of a pathogenic cascade leading to dementia. In the current form, the amyloid hypothesis lacks a comprehensive framework that considers the complex nature of Aβ aggregation. The explanation of how Aβ deposition leads to downstream pathology, and how reducing Aβ plaque load
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc03981a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Parents' Journeys of Mastery and Knowledge Construction After Their Infant's First Stage of Surgery for Complex Congenital Heart Disease.

    Gaskin, Kerry L / Barron, David / Wray, Jo

    Comprehensive child and adolescent nursing

    2024  Volume 47, Issue 1, Page(s) 68–81

    Abstract: Background: A growing body of conceptual evidence over the last decade has increased our understanding of parents' experiences of having an infant with complex congenital heart disease. These concepts include parents' feelings of uncertainty, fear, ... ...

    Abstract Background: A growing body of conceptual evidence over the last decade has increased our understanding of parents' experiences of having an infant with complex congenital heart disease. These concepts include parents' feelings of uncertainty, fear, excitement, and mastery. However, little is known about parents' experiences, confidence, and knowledge acquisition during transition from hospital to home with their infant after the first stage of complex cardiac surgery. A theoretical framework to assess, plan and implement child and family centered care would assist children's cardiac nurses responsible for parental education, discharge planning and coordination.
    Aim: To explore parents' experiences of the transition from hospital to home with their infant, following the first stage of cardiac surgery.
    Design: A prospective mixed methods longitudinal design. Semi-structured interviews were undertaken, including administration of the Maternal Confidence Questionnaire at four timepoints: before discharge following stage one cardiac surgery (T0), 2 weeks' post discharge (T1), 8 weeks' post discharge (T2) and after stage two surgery (T3). Qualitative data were thematically analyzed. Descriptive statistics were used to characterize the sample and non-parametric repeated measures analysis of variance was used to analyze changes over time in maternal confidence scores.
    Results: Sixteen parents of 12 infants participated. Four "patterns of transition experience" emerged, the fourth "Mastery", is discussed in this paper. Mastery can be contextualized in terms of the parents' journeys of knowledge construction, gaining confidence and reflection. Learning was dynamic and transformational, but successful learning and acquisition of knowledge was also dependent upon the parents' ability to absorb, integrate and adjust at any given time. Confidence at T0 was significantly lower than at T1 (
    Conclusion: Parents of infants with complex congenital heart disease obtain knowledge, confidence, and mastery dependent upon their transition experience and their personal journey through pre-liminal, liminal, and post-liminal phases of discharge from hospital to home. A conceptual framework "Parenting through Transitions - hospital to home" emerged that could assist in structuring assessment of parents' knowledge and support needs within a coordinated discharge process. Identifying individualized support would promote adaptation and adjustment during transition from the pre to post liminal phase, following their infant's first stage of complex cardiac surgery.
    MeSH term(s) Infant ; Child ; Humans ; Aftercare ; Prospective Studies ; Patient Discharge ; Qualitative Research ; Parents/education ; Heart Defects, Congenital/surgery
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2854778-0
    ISSN 2469-4207 ; 2469-4193
    ISSN (online) 2469-4207
    ISSN 2469-4193
    DOI 10.1080/24694193.2023.2293993
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2590: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A protein aggregation platform that distinguishes oligomers from amyloid fibrils.

    Zhang, Amy / Portugal Barron, Diana / Chen, Erica W / Guo, Zhefeng

    The Analyst

    2023  Volume 148, Issue 10, Page(s) 2283–2294

    Abstract: Deposition of aggregated proteins is a pathological feature in many neurodegenerative disorders such as Alzheimer's and Parkinson's. In addition to insoluble amyloid fibrils, protein aggregation leads to the formation of soluble oligomers, which are more ...

    Abstract Deposition of aggregated proteins is a pathological feature in many neurodegenerative disorders such as Alzheimer's and Parkinson's. In addition to insoluble amyloid fibrils, protein aggregation leads to the formation of soluble oligomers, which are more toxic and pathogenic than fibrils. However, it is challenging to screen for inhibitors targeting oligomers due to the overlapping processes of oligomerization and fibrillization. Here we report a protein aggregation platform that uses intact and split TEM-1 β-lactamase proteins as reporters of protein aggregation. The intact β-lactamase fused with an amyloid protein can report the overall protein aggregation, which leads to loss of lactamase activity. On the other hand, reconstitution of active β-lactamase from the split lactamase construct requires the formation of amyloid oligomers, making the split lactamase system sensitive to oligomerization. Using Aβ, a protein that forms amyloid plaques in Alzheimer's disease, we show that the growth curves of bacterial cells expressing either intact or split lactamase-Aβ fusion proteins can report changes in the Aβ aggregation. The cell lysate lactamase activity assays show that the oligomer fraction accounts for 20% of total activity for the split lactamase-Aβ construct, but only 3% of total activity for the intact lactamase-Aβ construct, confirming the sensitivity of the split lactamase to oligomerization. The combination of the intact and split lactamase constructs allows the distinction of aggregation modulators targeting oligomerization from those targeting overall aggregation. These low-cost bacterial cell-based and biochemical assays are suitable for high-throughput screening of aggregation inhibitors targeting oligomers of various amyloid proteins.
    MeSH term(s) Humans ; Amyloid beta-Peptides/metabolism ; Amyloid ; Protein Aggregates ; Alzheimer Disease/pathology
    Chemical Substances Amyloid beta-Peptides ; Amyloid ; Protein Aggregates
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an00487b
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Associations between Schizotypal Facets and Symptoms of Disordered Eating in Women.

    Swami, Viren / Barron, David / Furnham, Adrian

    International journal of environmental research and public health

    2022  Volume 19, Issue 18

    Abstract: Research has suggested that schizotypy-a personality organisation representing latent vulnerability for schizophrenia-spectrum disorders-may be elevated in women with symptoms of disordered eating. However, studies have not fully considered associations ... ...

    Abstract Research has suggested that schizotypy-a personality organisation representing latent vulnerability for schizophrenia-spectrum disorders-may be elevated in women with symptoms of disordered eating. However, studies have not fully considered associations between symptoms of disordered eating and multidimensional schizotypy. To overcome this limitation, we asked an online sample of 235 women from the United States to complete measures of symptoms of disordered eating (drive for thinness, body dissatisfaction, and bulimic symptoms) and multidimensional schizotypy. Correlational analyses indicated significant associations between drive for thinness and bulimic symptoms, respectively, and most schizotypal facets. Body dissatisfaction was significantly associated with only two schizotypal facets. Overall, the strength of correlations was weak-to-moderate. Regression results indicated that only the schizotypal feature of excessive social anxiety was significantly associated with all risk for disordered eating factors. These results are consistent with aetiological models of disordered eating that highlight socio-affective difficulties as risk factors for symptoms of disordered eating.
    MeSH term(s) Body Image ; Bulimia ; Drive ; Feeding and Eating Disorders/complications ; Feeding and Eating Disorders/epidemiology ; Female ; Humans ; Thinness/psychology
    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191811157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Appearance Orientation and Dating Anxiety in Emerging Adults: Considering the Roles of Appearance-Based Rejection Sensitivity, Social Physique Anxiety, and Self-Compassion.

    Swami, Viren / Barron, David / Furnham, Adrian

    Archives of sexual behavior

    2022  Volume 51, Issue 8, Page(s) 3981–3992

    Abstract: Emerging research has suggested that appearance-related factors, such as greater appearance orientation, are associated with dating anxiety in emerging adults, but much more could be done to understand mechanistic pathways and potential buffers. Here, we ...

    Abstract Emerging research has suggested that appearance-related factors, such as greater appearance orientation, are associated with dating anxiety in emerging adults, but much more could be done to understand mechanistic pathways and potential buffers. Here, we tested a moderated mediation model in which appearance-based rejection sensitivity and social physique anxiety were explored as mediators, and self-compassion was explored as a moderator, of the relationship between appearance orientation and dating anxiety. A total of 501 heterosexual emerging adults (248 women, 253 men) from the UK completed instruments measuring the aforementioned constructs. Relationships among all variables were largely similar across women and men, with only the association between social physique anxiety and appearance-based rejection sensitivity being significantly stronger in women. Mediation analysis in the total sample indicated that both social physique anxiety and appearance-based rejection anxiety were significant mediators. Additionally, we confirmed a serial mediation involving appearance orientation → appearance-based rejection sensitivity → social physique anxiety → dating anxiety. Conversely, self-compassion did not moderate the effects of either social physique anxiety or appearance-based rejection sensitivity on dating anxiety, although greater self-compassion was moderately associated lower dating anxiety. We suggest ways in which existing interventions aimed at reducing dating anxiety could be combined with body image interventions to reduce dating anxiety in heterosocial contexts.
    MeSH term(s) Adult ; Male ; Female ; Humans ; Self Concept ; Self-Compassion ; Body Image ; Anxiety ; Fear
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-022-02367-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Metabolites in Milk after Enrofloxacin Treatment and Their Persistence to Temperature.

    Junza, Alexandra / Saurina, Javier / Minguillón, Cristina / Barrón, Dolores

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 27, Page(s) 8441–8450

    Abstract: In this work, metabolomic profile changes in milk from cows affected by mastitis and treated with enrofloxacin (ENR) have been studied using LC-HRMS techniques. Principal component analysis was applied to the obtained results, and the interest was ... ...

    Abstract In this work, metabolomic profile changes in milk from cows affected by mastitis and treated with enrofloxacin (ENR) have been studied using LC-HRMS techniques. Principal component analysis was applied to the obtained results, and the interest was focused on changes affecting compounds without a structural relationship to ENR. Most of the compounds, whose concentrations were modified as a result of the pharmacological treatment and/or the pathological status, were related to amino acids and peptides. Compounds that may become possible biomarkers for either disease or treatment have been detected. Additionally, the alterations caused by thermal processes, such as those applied to milk before consumption, on the identified metabolites have also been considered.
    MeSH term(s) Animals ; Cattle ; Enrofloxacin/analysis ; Enrofloxacin/metabolism ; Enrofloxacin/therapeutic use ; Female ; Fluoroquinolones/analysis ; Mastitis, Bovine/metabolism ; Milk/chemistry ; Temperature
    Chemical Substances Fluoroquinolones ; Enrofloxacin (3DX3XEK1BN)
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c02230
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Commentary: Lateral tunnel or extracardiac conduit for a Fontan operation: Is that your final answer?

    Barron, David / Guariento, Alvise

    The Journal of thoracic and cardiovascular surgery

    2020  Volume 162, Issue 6, Page(s) 1835–1836

    MeSH term(s) Fontan Procedure/adverse effects ; Heart Defects, Congenital/surgery ; Humans ; Pulmonary Artery/surgery
    Language English
    Publishing date 2020-12-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2020.12.108
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.104: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Attaining efficiency with imperfect public monitoring and one-sided Markov adverse selection

    Barron, Daniel

    Theoretical economics : TE : journal of the Econometric Society : open access to research in economic theory Vol. 12, No. 3 , p. 957-978

    2017  Volume 12, Issue 3, Page(s) 957–978

    Author's details Daniel Barron
    Keywords Repeated Bayesian games ; efficiency
    Language English
    Publisher Econometric Society
    Publishing place New York, NY
    Document type Article
    ZDB-ID 2398911-7 ; 2220447-7
    ISSN 1555-7561 ; 1933-6837
    ISSN (online) 1555-7561
    ISSN 1933-6837
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Attaining efficiency with imperfect public monitoring and one-sided Markov adverse selection

    Barron, Daniel

    Theoretical economics : TE : an open access journal in economic theory Vol. 12, No. 3 , p. 957-978

    2017  Volume 12, Issue 3, Page(s) 957–978

    Abstract: I prove an efficiency result for repeated games with imperfect public monitoring in which one player's utility is privately known and evolves according to a Markov process. Under certain assumptions, patient players can attain approximately efficient ... ...

    Author's details Daniel Barron
    Abstract I prove an efficiency result for repeated games with imperfect public monitoring in which one player's utility is privately known and evolves according to a Markov process. Under certain assumptions, patient players can attain approximately efficient payoffs in equilibrium. The public signal must satisfy a “pairwise full rank” condition that is somewhat stronger than the monitoring condition required in the Folk Theorem proved by Fudenberg, Levine, and Maskin (1994). Under stronger assumptions, the efficiency result partially extends to settings in which one player has private information that determines every player's payoff. The proof is partially constructive and uses an intuitive technique to mitigate the impact of private information on continuation payoffs.
    Keywords Repeated Bayesian games ; efficiency
    Language English
    Size Online-Ressource
    Publisher Wiley
    Publishing place Toronto
    Document type Article ; Online
    ZDB-ID 2220447-7
    ISSN 1555-7561 ; 1933-6837
    ISSN (online) 1555-7561
    ISSN 1933-6837
    DOI 10.3982/TE1934
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top