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  1. Article: The confound of hemodynamic response function variability in human resting-state functional MRI studies.

    Rangaprakash, D / Barry, Robert L / Deshpande, Gopikrishna

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 934138

    Abstract: Functional magnetic resonance imaging (fMRI) is an indirect measure of neural activity with the hemodynamic response function (HRF) coupling it with unmeasured neural activity. The HRF, modulated by several non-neural factors, is variable across brain ... ...

    Abstract Functional magnetic resonance imaging (fMRI) is an indirect measure of neural activity with the hemodynamic response function (HRF) coupling it with unmeasured neural activity. The HRF, modulated by several non-neural factors, is variable across brain regions, individuals and populations. Yet, a majority of human resting-state fMRI connectivity studies continue to assume a non-variable HRF. In this article, with supportive prior evidence, we argue that HRF variability cannot be ignored as it substantially confounds within-subject connectivity estimates and between-subjects connectivity group differences. We also discuss its clinical relevance with connectivity impairments confounded by HRF aberrations in several disorders. We present limited data on HRF differences between women and men, which resulted in a 15.4% median error in functional connectivity estimates in a group-level comparison. We also discuss the implications of HRF variability for fMRI studies in the spinal cord. There is a need for more dialogue within the community on the HRF confound, and we hope that our article is a catalyst in the process.
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.934138
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  2. Article: Comparison of hemodynamic response functions obtained from resting-state functional MRI and invasive electrophysiological recordings in rats.

    Rangaprakash, D / David, Olivier / Barry, Robert L / Deshpande, Gopikrishna

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Resting-state functional MRI (rs-fMRI) is a popular technology that has enriched our understanding of brain and spinal cord functioning, including how different regions communicate (connectivity). But fMRI is an indirect measure of neural activity ... ...

    Abstract Resting-state functional MRI (rs-fMRI) is a popular technology that has enriched our understanding of brain and spinal cord functioning, including how different regions communicate (connectivity). But fMRI is an indirect measure of neural activity capturing blood hemodynamics. The hemodynamic response function (HRF) interfaces between the unmeasured neural activity and measured fMRI time series. The HRF is variable across brain regions and individuals, and is modulated by non-neural factors. Ignoring this HRF variability causes errors in FC estimates. Hence, it is crucial to reliably estimate the HRF from rs-fMRI data. Robust techniques have emerged to estimate the HRF from fMRI time series. Although such techniques have been validated non-invasively using simulated and empirical fMRI data, thorough invasive validation using simultaneous electrophysiological recordings, the gold standard, has been elusive. This report addresses this gap in the literature by comparing HRFs derived from invasive intracranial electroencephalogram recordings with HRFs estimated from simultaneously acquired fMRI data in six epileptic rats. We found that the HRF shape parameters (HRF amplitude, latency and width) were not significantly different (
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.27.530359
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  3. Article ; Online: Measurement of T

    Barry, Robert L / Smith, Seth A

    Magnetic resonance in medicine

    2019  Volume 82, Issue 2, Page(s) 743–748

    Abstract: Purpose: To measure the transverse relaxation time T: Methods: Thirty healthy volunteers were recruited. Axial images were acquired using an averaged multi-echo gradient-echo (mFFE) T: Results: No global difference in T: Conclusions: ... ...

    Abstract Purpose: To measure the transverse relaxation time T
    Methods: Thirty healthy volunteers were recruited. Axial images were acquired using an averaged multi-echo gradient-echo (mFFE) T
    Results: No global difference in T
    Conclusions: Significant differences in T
    MeSH term(s) Adult ; Female ; Gray Matter/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neck/diagnostic imaging ; Spinal Cord/diagnostic imaging ; White Matter/diagnostic imaging ; Young Adult
    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.27755
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1959: Show issues Location:
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  4. Book: Set no limits

    Barry, Robert L.

    a rebuttal to Daniel Callahan's proposal to limit health care for the elderly

    1991  

    Author's details ed. by Robert L. Barry
    Keywords Health Services for the Aged ; Health Care Rationing ; Right to Die ; Ethics, Medical ; Alter ; Medizinische Versorgung ; Gesundheitsökonomie ; Ärztliche Behandlung ; Lebensalter ; Entscheidungskriterium ; Verweigerung ; Ethik
    Subject Ethische Theorie ; Moral ; Philosophische Ethik ; Sittenlehre ; Moralphilosophie ; Behandlung ; Arzt ; Ärztliche Tätigkeit ; Ärztliches Handeln ; Arztbesuch ; Alter Mensch ; Betagter ; Senioren ; Senior ; Entscheidung ; Chronologisches Alter ; Kalendarisches Alter ; Gesundheitsökonomik ; Gesundheitswesen ; Medizinökonomie ; Medizinökonomik ; Medizinische Ökonomie ; Medizinische Ökonomik ; Health Economics ; Gesundheitsversorgung ; Gesundheitliche Versorgung ; Patientenversorgung
    Size XIX, 134 S. : graph. Darst.
    Publisher Univ. of Illinois Press
    Publishing place Urbana u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004279508
    ISBN 0-252-01860-5 ; 978-0-252-01860-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 A 4344 order for loan Magazin

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  5. Article ; Online: Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures.

    Guan, Michelle / Dong, Tien S / Subramanyam, Vishvak / Guo, Yiming / Bhatt, Ravi R / Vaughan, Allison / Barry, Robert L / Gupta, Arpana

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10332

    Abstract: Obesity contributes to physical comorbidities and mental health consequences. We explored whether physical activity could influence more than metabolic regulation and result in psychological benefits through the brain-gut microbiome (BGM) system in a ... ...

    Abstract Obesity contributes to physical comorbidities and mental health consequences. We explored whether physical activity could influence more than metabolic regulation and result in psychological benefits through the brain-gut microbiome (BGM) system in a population with high BMI. Fecal samples were obtained for 16 s rRNA profiling and fecal metabolomics, along with psychological and physical activity questionnaires. Whole brain resting-state functional MRI was acquired, and brain connectivity metrics were calculated. Higher physical activity was significantly associated with increased connectivity in inhibitory appetite control brain regions, while lower physical activity was associated with increased emotional regulation network connections. Higher physical activity was also associated with microbiome and metabolite signatures protective towards mental health and metabolic derangements. The greater resilience and coping, and lower levels of food addiction seen with higher physical activity, may be explained by BGM system differences. These novel findings provide an emphasis on the psychological and resilience benefits of physical activity, beyond metabolic regulation and these influences seem to be related to BGM interactions.
    MeSH term(s) Humans ; Gastrointestinal Microbiome/genetics ; Brain/physiology ; Microbiota ; Obesity ; Exercise
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37009-z
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  6. Article ; Online: Screening for post-traumatic stress disorder following childbirth using the Peritraumatic Distress Inventory.

    Jagodnik, Kathleen M / Ein-Dor, Tsachi / Chan, Sabrina J / Titelman Ashkenazy, Adi / Bartal, Alon / Barry, Robert L / Dekel, Sharon

    Journal of affective disorders

    2023  Volume 348, Page(s) 17–25

    Abstract: Background: Post-traumatic stress disorder (PTSD) following traumatic childbirth may undermine maternal and infant health, but screening for maternal childbirth-related PTSD (CB-PTSD) remains lacking. Acute emotional distress in response to a traumatic ... ...

    Abstract Background: Post-traumatic stress disorder (PTSD) following traumatic childbirth may undermine maternal and infant health, but screening for maternal childbirth-related PTSD (CB-PTSD) remains lacking. Acute emotional distress in response to a traumatic experience strongly associates with PTSD. The Peritraumatic Distress Inventory (PDI) assesses acute distress in non-postpartum individuals, but its use to classify women likely to endorse CB-PTSD is unknown.
    Methods: 3039 women provided information about their mental health and childbirth experience. They completed the PDI regarding their recent childbirth event, and a PTSD symptom screen to determine CB-PTSD. We employed Exploratory Graph Analysis and bootstrapping to reveal the PDI's factorial structure and optimal cutoff value for CB-PTSD classification.
    Results: Factor analysis revealed two strongly correlated stable factors based on a modified version of the PDI: (1) negative emotions and (2) bodily arousal and threat appraisal. A score of 15+ on the modified PDI produced high sensitivity and specificity: 88 % with a positive CB-PTSD screen in the first postpartum months and 93 % with a negative screen.
    Limitations: In this cross-sectional study, the PDI was administered at different timepoints postpartum. Future work should examine the PDI's predictive utility for screening women as closely as possible to the time of childbirth, and establish clinical cutoffs in populations after complicated deliveries.
    Conclusions: Brief self-report screening concerning a woman's emotional reactions to childbirth using our modified PDI tool can detect those likely to endorse CB-PTSD in the early postpartum. This may serve as the initial step of managing symptoms to ultimately prevent chronic manifestations.
    MeSH term(s) Pregnancy ; Humans ; Female ; Stress Disorders, Post-Traumatic/psychology ; Cross-Sectional Studies ; Parturition/psychology ; Postpartum Period/psychology ; Delivery, Obstetric
    Language English
    Publishing date 2023-12-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2023.12.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1485: Show issues Location:
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  7. Book: Breaking the thread of life

    Barry, Robert L.

    on rational suicide

    1994  

    Author's details Robert L. Barry
    Keywords Suicide ; Ethics, Medical ; Religion and Medicine ; Catholicism ; Suizid ; Katholische Theologie
    Subject Selbstmord ; Freitod ; Selbsttötung
    Language English
    Size XXII, 353 S.
    Publisher Transaction Publ
    Publishing place New Brunswick
    Publishing country United States
    Document type Book
    HBZ-ID HT007160294
    ISBN 1-56000-142-9 ; 978-1-56000-142-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 2388 order for loan Magazin

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  8. Article ; Online: Structural and resting state functional connectivity beyond the cortex.

    Harrison, Olivia K / Guell, Xavier / Klein-Flügge, Miriam C / Barry, Robert L

    NeuroImage

    2021  Volume 240, Page(s) 118379

    Abstract: Mapping the structural and functional connectivity of the central nervous system has become a key area within neuroimaging research. While detailed network structures across the entire brain have been probed using animal models, non-invasive neuroimaging ...

    Abstract Mapping the structural and functional connectivity of the central nervous system has become a key area within neuroimaging research. While detailed network structures across the entire brain have been probed using animal models, non-invasive neuroimaging in humans has thus far been dominated by cortical investigations. Beyond the cortex, subcortical nuclei have traditionally been less accessible due to their smaller size and greater distance from radio frequency coils. However, major neuroimaging developments now provide improved signal and the resolution required to study these structures. Here, we present an overview of the connectivity between the amygdala, brainstem, cerebellum, spinal cord and the rest of the brain. While limitations to their imaging and analyses remain, we also provide some recommendations and considerations for mapping brain connectivity beyond the cortex.
    MeSH term(s) Amygdala/diagnostic imaging ; Animals ; Brain Stem/diagnostic imaging ; Cerebellum/diagnostic imaging ; Connectome ; Default Mode Network ; Diffusion Tensor Imaging/methods ; Humans ; Magnetic Resonance Imaging/methods ; Signal-To-Noise Ratio ; Spinal Cord/diagnostic imaging
    Language English
    Publishing date 2021-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2021.118379
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    Zs.A 3664: Show issues Location:
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    Zs.MO 7: Show issues

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  9. Book: Medical ethics

    Barry, Robert L.

    essays on abortion and euthanasia

    (American university studies : Series 7 ; 45)

    1989  

    Author's details Robert L. Barry
    Series title American university studies : Series 7 ; 45
    American university studies
    American university studies ; Series 7
    Collection American university studies
    American university studies ; Series 7
    Keywords Ethics, Medical / essays ; Abortion, Spontaneous / essays ; Euthanasia / essays ; Schwangerschaftsabbruch ; Medizinische Ethik ; Sterbehilfe
    Subject Ärztliche Ethik ; Klinische Ethik ; Ärztliches Ethos ; Arzt ; Medizin ; Heilberuf ; Medizinethik ; Aktive Sterbehilfe ; Passive Sterbehilfe ; Indirekte Sterbehilfe ; Euthanasie ; Suizidassistenz ; Suizidhilfe ; Suizidbeihilfe ; Beihilfe zur Selbsttötung ; Assistierter Suizid ; Abortus artificialis ; Interruptio graviditatis ; Abruptio graviditatis ; Schwangerschaft ; Schwangerschaftsunterbrechung ; Abtreibung
    Size XI, 308 S.
    Publisher Lang
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003509838
    ISBN 0-8204-0925-1 ; 978-0-8204-0925-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 701 order for loan Magazin

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  10. Article ; Online: Enhanced phase regression with Savitzky-Golay filtering for high-resolution BOLD fMRI.

    Barry, Robert L / Gore, John C

    Human brain mapping

    2014  Volume 35, Issue 8, Page(s) 3832–3840

    Abstract: Phase regression exploits the temporal evolution of phase in individual voxels to suppress blood oxygenation level dependent (BOLD) signal fluctuations caused by larger vessels and draining veins while preserving signal changes from microvascular effects. ...

    Abstract Phase regression exploits the temporal evolution of phase in individual voxels to suppress blood oxygenation level dependent (BOLD) signal fluctuations caused by larger vessels and draining veins while preserving signal changes from microvascular effects. However, this process does not perform well when phase time series have low signal-to-noise ratios because of high levels of physiological noise. We demonstrate that Savitzky-Golay filters may be used to recover the underlying change in phase and completely restore the efficacy of phase regression. We do not make a priori assumptions regarding phase evolution and perform a data-driven exploration of parameter space to select the Savitzky-Golay filter parameters that minimize temporal variance in each voxel after phase regression. This approach is shown to work well on data acquired with single-shot and multi-shot pulse sequences, and should therefore be useful for both human and animal gradient-echo fMRI at high spatial resolutions at high fields. The ability to improve the spatial specificity of BOLD activation may be especially advantageous for clinical applications of fMRI that rely upon the accuracy of individual subject's activation maps to assist with presurgical planning and clinical decision-making. Enhanced phase regression with Savitzky-Golay filtering may also find other uses in analyses of resting state functional connectivity.
    MeSH term(s) Algorithms ; Brain/physiology ; Cerebrovascular Circulation/physiology ; Humans ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging/methods ; Oxygen/blood ; Photic Stimulation ; Signal Processing, Computer-Assisted ; Visual Perception/physiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2014-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.22440
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