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  1. Article ; Online: Severe complication of early cessation of therapy with ticagrelor after drug-eluting stent implantation

    Natasha Ahmed / Bartlomiej Perek

    Polish Journal of Thoracic and Cardiovascular Surgery, Vol 18, Iss 2, Pp 119-

    2021  Volume 120

    Keywords Surgery ; RD1-811 ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A large asymptomatic postinfarction left ventricular pseudoaneurysm – an incidental finding during a recurrent coronary event

    Anna Witkowska / Tomasz Urbanowicz / Anna Olasińska-Wiśniewska / Sławomir Katarzyński / Bartłomiej Perek / Marek Jemielity

    Polish Journal of Thoracic and Cardiovascular Surgery, Vol 20, Iss 1, Pp 47-

    2023  Volume 49

    Keywords Surgery ; RD1-811 ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Thrombotic Thrombocytopenia after COVID-19 Vaccination

    Piotr Rzymski / Bartłomiej Perek / Robert Flisiak

    Vaccines, Vol 9, Iss 559, p

    In Search of the Underlying Mechanism

    2021  Volume 559

    Abstract: The rollout of COVID-19 vaccines brings hope for successful pandemic mitigation and getting the transmission of SARS-CoV-2 under control. The vaccines authorized in Europe displayed a good safety profile in the clinical trials. However, during their post- ...

    Abstract The rollout of COVID-19 vaccines brings hope for successful pandemic mitigation and getting the transmission of SARS-CoV-2 under control. The vaccines authorized in Europe displayed a good safety profile in the clinical trials. However, during their post-authorization use, unusual thrombotic events associated with thrombocytopenia have rarely been reported for vector vaccines. This led to the temporary suspension of the AZD1222 vaccine (Oxford/AstraZeneca) in various European countries and the Ad26.COV2 vaccine (Janssen/Johnson&Johnson) in the United States, with regulatory bodies launching investigations into potential causal associations. The thromboembolic reactions were also rarely reported after mRNA vaccines. The exact cause of these adverse effects remains to be elucidated. The present paper outlines the hypotheses on the mechanisms behind the very rare thrombotic thrombocytopenia reported after the COVID-19 vaccination, along with currently existing evidence and future research prospects. The following are discussed: (i) the role of antibodies against platelet factor 4 (PF4), (ii) the direct interaction between adenoviral vector and platelets, (iii) the cross-reactivity of antibodies against SARS-CoV-2 spike protein with PF4, (iv) cross-reactivity of anti-adenovirus antibodies and PF4, (v) interaction between spike protein and platelets, (vi) the platelet expression of spike protein and subsequent immune response, and (vii) the platelet expression of other adenoviral proteins and subsequent reactions. It is also plausible that thrombotic thrombocytopenia after the COVID-19 vaccine is multifactorial. The elucidation of the causes of these adverse events is pivotal in taking precautionary measures and managing vaccine hesitancy. It needs to be stressed, however, that the reported cases are currently sporadic and that the benefits of COVID-19 vaccines vastly outweigh their potential risks.
    Keywords vector vaccines ; mRNA vaccines ; thrombosis ; thrombocytopenia ; adverse effects ; COVID-19 ; Medicine ; R
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Short- and long-term outcomes of thoracoscopic pneumonectomy – single center experience

    Cezary Piwkowski / Piotr Gabryel / Magdalena Roszak / Bartłomiej Perek / Mariusz Kasprzyk

    Videosurgery and Other Miniinvasive Techniques, Vol 16, Iss 2, Pp 369-

    2021  Volume 376

    Keywords thoracoscopy/video-assisted thoracic surgery ; lung cancer ; minimally invasive surgery ; pneumonectomy ; Medicine ; R
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Negative pressure wound therapy for surgical site infection after sternotomy and its role in preparing the wound for reconstruction

    Eyal Schwartzmann / Micah Sy / Mehul Sharma / Bartosz Mańkowski / Marek Jemielity / Bartłomiej Perek

    Polish Journal of Thoracic and Cardiovascular Surgery, Vol 18, Iss 3, Pp 190-

    2021  Volume 191

    Abstract: Surgical site infection (SSI) involving the mediastinum after cardiac surgical procedures carried out through median sternotomy is associated with significant mortality and morbidity [1]. Up to now a few methods have been describe to treat such severe ... ...

    Abstract Surgical site infection (SSI) involving the mediastinum after cardiac surgical procedures carried out through median sternotomy is associated with significant mortality and morbidity [1]. Up to now a few methods have been describe to treat such severe adverse events in the early postoperative period [2]. One of them is negative pressure wound therapy (NPWT) [3]. Since its introduction by Argenta and Morykwas, NPWT has been an efficacious method, in terms of improved early and long-term outcomes, of managing SSI after cardiac surgical procedures [4]. This method was also proved to be of paramount importance in assisting wound healing in subjects at the highest risk for developing SSI, such as obese, insulin-treated diabetic and chronic obstructive pulmonary disease (COPD) patients [3]. In some individuals it may enable the infected wound to be closed definitely by playing the role of the intermediate stage before either placing mattress adapting skin sutures or transferring different local free cutaneous flaps with/without muscle tissue.
    Keywords Surgery ; RD1-811 ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Management of High-Risk Atherosclerotic Patients by Statins May Be Supported by Logistic Model of Intima-Media Thickening

    Dorota Formanowicz / Jacek B. Krawczyk / Bartłomiej Perek / Dawid Lipski / Andrzej Tykarski

    Journal of Clinical Medicine, Vol 10, Iss 2876, p

    2021  Volume 2876

    Abstract: While the use of statins in treating patients with atherosclerosis is an undisputed success, the questions regarding an optimal starting time for treatment and its strength remain open. We proposed in our earlier paper published in Int. J. Mol. Sci. ( ... ...

    Abstract While the use of statins in treating patients with atherosclerosis is an undisputed success, the questions regarding an optimal starting time for treatment and its strength remain open. We proposed in our earlier paper published in Int. J. Mol. Sci. (2019, 20) that the growth of intima-media thickness of the carotid artery follows an S-shape (i.e., logistic) curve. In our subsequent paper in PLoS ONE (2020, 15), we incorporated this feature into a logistic control-theoretic model of atherosclerosis progression and showed that some combinations of patient age and intima-media thickness are better suited than others to start treatment. In this study, we perform a new and comprehensive calibration of our logistic model using a recent clinical database. This allows us to propose a procedure for inferring an optimal age to start statin treatment for a particular group of patients. We argue that a decrease in the slope of the IMT logistic growth curve, induced by statin treatment, is most efficient where the curve is at its steepest, whereby the efficiency means lowering the future IMT levels. Using the procedure on an aggregate group of severely sick men, 38 years of age is observed to correlate with the steepest point of the logistic curve, and, thus, it is the preferred time to start statin treatment. We believe that detecting the logistic curve’s steepest fragment and commencing statin administration on that fragment are courses of action that agree with clinician intuition and may support decision-making processes.
    Keywords atherosclerosis ; statins ; control-theoretic model ; logistic growth ; Medicine ; R
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery

    Tomasz Urbanowicz / Michał Michalak / Anna Olasińska-Wiśniewska / Michał Rodzki / Anna Witkowska / Aleksandra Gąsecka / Piotr Buczkowski / Bartłomiej Perek / Marek Jemielity

    Cells, Vol 11, Iss 1124, p

    2022  Volume 1124

    Abstract: Background: Several perioperative inflammatory markers are postulated to be significant factors for long-term survival after off-pump coronary artery bypass surgery (OPCAB). Hematological parameters, whether single or combined as indices, provide higher ... ...

    Abstract Background: Several perioperative inflammatory markers are postulated to be significant factors for long-term survival after off-pump coronary artery bypass surgery (OPCAB). Hematological parameters, whether single or combined as indices, provide higher predictive values. Methods: The study group comprised 538 consecutive patients (125 (23%) females and 413 (77%) males) with a mean age of 65 ± 9 years, who underwent OPCAB with a mean follow-up time of 4.7 ± 1.7 years. This single-center retrospective analysis included perioperative inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), aggregate index of systemic inflammation (AISI), and systemic inflammatory index (SII). Results: Multivariable analysis identified levels of neutrophils above 4.3 × 10 9 /L (HR 13.44, 95% CI 1.05–3.68, p = 0.037), values of SIRI above 5.4 (HR 0.29, 95% CI 0.09–0.92, p = 0.036) and values of NLR above 3.5 (HR 2.21, 95% CI 1.48–3.32, p < 0.001) as being significant predictors of long-term mortality. The multifactorial models revealed the possibility of strong prediction by combining preoperative factors (COPD, stroke, PAD, and preoperative PLR) and postoperative neutrophil counts ( p = 0.0136) or NLR ( p = 0.0136) or SIRI ( p = 0.0136). Conclusions: Among the postoperative inflammatory indices, the levels of neutrophils, NLR, and SIRI are the most prominent markers for long-term survival after off-pump coronary artery bypass surgery, when combined with preoperative characteristics.
    Keywords OPCAB ; NLR ; SIRI ; AISI ; SII ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study

    Tomasz Urbanowicz / Anna Olasińska-Wiśniewska / Michał Michalak / Michał Rodzki / Anna Witkowska / Ewa Straburzyńska-Migaj / Bartłomiej Perek / Marek Jemielity

    Diagnostics, Vol 12, Iss 37, p

    2022  Volume 37

    Abstract: 1) Background: The combination of candidate selection, immunosuppressive therapy adjustment, and scrutinous monitoring is a cornerstone for optimizing long-term survival after a heart transplant. Neutrophil-to-lymphocyte ratio (NLR) is a simple marker ... ...

    Abstract (1) Background: The combination of candidate selection, immunosuppressive therapy adjustment, and scrutinous monitoring is a cornerstone for optimizing long-term survival after a heart transplant. Neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory reactions activation and may play a clinical role as a predictive marker in oncological and cardiovascular diseases. The aim of the study was to find simple hematologic indices available from whole blood count to help in immunosuppressive therapy monitoring. (2) Methods: Thirty patients (23 men and 7 women) with a mean age of 43 +/− 13 years who had undergone orthotopic heart transplantation were enrolled into the study. The blood samples for whole blood count and Tacrolimus level were collected during outpatient visits in heart transplant recipients every two months for 18 months after first year post transplantation. (3) Results: There was a significant correlation between Tacrolimus overdose (>15 ng/mL) and NLR (Spearman’s rho 0.99, p < 0.001) and mean platelet volume (Spearman’s rho 0.989, p < 0.001). The ROC analysis for NLR above 3.62 showed predictive properties for Tacrolimus overdose (over 15 ng/mL) (AUC =0.633, p = 0.008) with a sensitivity of 50% and specificity of 83.73%. (4) Conclusions: Our results suggest that NLR above 3.62 may be regarded as a simple indicator of tacrolimus overdose.
    Keywords heart transplantation ; tacrolimus ; NLR ; MPV ; drug overdose ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Mean platelet volume as a simple marker of repeated coronary artery intervention after off-pump technique (OPCAB) procedures – initial report

    Tomasz K. Urbanowicz / Michał Michalak / Weronika Mikołajewska / Michał Rodzki / Bartłomiej Perek / Anna Olasińska-Wiśniewska / Michał Bociański / Marek Jemielity

    Polish Journal of Thoracic and Cardiovascular Surgery, Vol 18, Iss 4, Pp 231-

    2022  Volume 235

    Keywords off-pump coronary artery bypass ; mean platelet volume ; major adverse cardiac events ; white blood cells ; Surgery ; RD1-811 ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A Control-Theoretic Model of Atherosclerosis

    Dorota Formanowicz / Jacek B. Krawczyk / Bartłomiej Perek / Piotr Formanowicz

    International Journal of Molecular Sciences, Vol 20, Iss 3, p

    2019  Volume 785

    Abstract: We propose a control-theoretic aggregate model of the progression of atherosclerosis plaque, a chronic inflammatory disease of the arterial wall, to study the basic features of this disease. In the model, we exploit the role of inflammation in the ... ...

    Abstract We propose a control-theoretic aggregate model of the progression of atherosclerosis plaque, a chronic inflammatory disease of the arterial wall, to study the basic features of this disease. In the model, we exploit the role of inflammation in the disease progression, and use statins—drugs commonly recommended in atherosclerosis—to control this progression. We use a logistic function to allow for constrained growth of plaque. In the model, both the patient’s age and overall health impact the plaque growth and its sensitivity to statins. The model parameters are estimated using original data, or calibrated using published research as well as our own clinical and laboratory studies. We contend that our model helps to gauge the statins’ impact on a patient’s plaque thickness, hence the disease’s progression and cardiovascular risk, without requiring artery scans.
    Keywords atherosclerosis ; statins ; control-theoretic model ; logistic growth ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 519
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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