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  1. Article ; Online: Editorial: The Value of Genetically Informative Designs to Understand Pathways of Intergenerational Transmission and Direction of Causality.

    Bartels, Meike

    Journal of the American Academy of Child and Adolescent Psychiatry

    2021  Volume 60, Issue 7, Page(s) 808–810

    Abstract: One of the greatest challenges in the social, behavioral, and medical sciences is to determine the causality underlying associations between risk factors and behavioral or disease outcomes. An area in which insight into causality, and especially ... ...

    Abstract One of the greatest challenges in the social, behavioral, and medical sciences is to determine the causality underlying associations between risk factors and behavioral or disease outcomes. An area in which insight into causality, and especially direction of causation of possible risk factors and outcomes, could have enormous (clinical) impact is the field of childhood and adolescent psychiatry. Abundant evidence shows that psychopathology runs in families, but the pathways underlying shared family risk are unclear. Large twin family studies provide robust estimates for the heritability of childhood and adolescent behavioral and emotional problems, but direct non-genetic effects from parent to offspring or vice versa cannot be excluded. Question remains as to whether there is a direct causal effect of parental mental health status on the mental health and well-being of their offspring above and beyond the transmission of genetic susceptibility. Genetically informed methods provide opportunities to tackle this causality challenge.
    MeSH term(s) Adolescent ; Causality ; Child of Impaired Parents ; Humans ; Mental Disorders/genetics ; Parents ; Psychopathology
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2021.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Association of Childhood Maltreatment and Mental Health Problems: Partly Causal and Partly Due to Other Factors.

    Bartels, Meike / Middeldorp, Christel M

    The American journal of psychiatry

    2023  Volume 180, Issue 2, Page(s) 105–107

    MeSH term(s) Humans ; Child ; Mental Health ; Child Abuse
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.20220969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Using Polygenic Scores for Circadian Rhythms to Predict Wellbeing, Depressive Symptoms, Chronotype, and Health.

    Landvreugd, Anne / Pool, René / Nivard, Michel G / Bartels, Meike

    Journal of biological rhythms

    2024  , Page(s) 7487304241230577

    Abstract: The association between circadian rhythms and diseases has been well established, while the association with mental health is less explored. Given the heritable nature of circadian rhythms, this study aimed to investigate the relationship between genes ... ...

    Abstract The association between circadian rhythms and diseases has been well established, while the association with mental health is less explored. Given the heritable nature of circadian rhythms, this study aimed to investigate the relationship between genes underlying circadian rhythms and mental health outcomes, as well as a possible gene-environment correlation for circadian rhythms. Polygenic scores (PGSs) represent the genetic predisposition to develop a certain trait or disease. In a sample from the Netherlands Twin Register (
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/07487304241230577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The stability and change of wellbeing across the lifespan: a longitudinal twin-sibling study.

    de Vries, Lianne P / Pelt, Dirk H M / Bartels, Meike

    Psychological medicine

    2024  , Page(s) 1–13

    Abstract: Background: Wellbeing is relatively stable over the life span. However, individuals differ in this stability and change. One explanation for these differences could be the influence of different genetic or environmental factors on wellbeing over time.!## ...

    Abstract Background: Wellbeing is relatively stable over the life span. However, individuals differ in this stability and change. One explanation for these differences could be the influence of different genetic or environmental factors on wellbeing over time.
    Methods: To investigate causes of stability and change of wellbeing across the lifespan, we used cohort-sequential data on wellbeing from twins and their siblings of the Netherlands Twin Register (NTR) (total
    Results: Wellbeing peaked in childhood, decreased during adolescence, and stabilized during adulthood. In childhood and adolescence, around 40% of the individual differences was explained by genetic effects. The heritability decreased toward old adulthood (35-24%) and the contribution of unique environmental effects increased to 76%. Environmental innovation was found at every age, whereas genetic innovation was only observed during adolescence (10-18 years). In childhood and adulthood, the absence of genetic innovation indicates a stable underlying set of genes influencing wellbeing during these life phases.
    Conclusion: These findings provide insights into the stability and change of wellbeing and the genetic and environmental influences across the lifespan. Genetic effects were mostly stable, except in adolescence, whereas the environmental innovation at every age suggests that changing environmental factors are a source of changes in individual differences in wellbeing over time.
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291724000692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetic confounding in the association of early motor development with childhood and adolescent exercise behavior.

    Zi, Yahua / Bartels, Meike / Dolan, Conor / de Geus, Eco J C

    The international journal of behavioral nutrition and physical activity

    2024  Volume 21, Issue 1, Page(s) 33

    Abstract: Introduction: Early motor development has been found to be a predictor of exercise behavior in children and adolescents, but whether this reflects a causal effect or confounding by genetic or shared environmental factors remains to be established.: ... ...

    Abstract Introduction: Early motor development has been found to be a predictor of exercise behavior in children and adolescents, but whether this reflects a causal effect or confounding by genetic or shared environmental factors remains to be established.
    Methods: For 20,911 complete twin pairs from the Netherlands Twin Register a motor development score was obtained from maternal reports on the timing of five motor milestones. During a 12-year follow-up, subsamples of the mothers reported on the twins' ability to perform seven gross motor skills ability (N = 17,189 pairs), and weekly minutes of total metabolic equivalents of task (MET) spent on sports and exercise activities at age 7 (N = 3632 pairs), age 10 (N = 3735 pairs), age 12 (N = 7043 pairs), and age 14 (N = 3990 pairs). Multivariate phenotypic and genetic regression analyses were used to establish the predictive strength of the two motor development traits for future exercise behavior, the contribution of genetic and shared environmental factors to the variance in all traits, and the contribution of familial confounding to the phenotypic prediction.
    Results: Significant heritability (h
    Conclusion: No support was found for a direct causal effect in the association between rapid early motor development on future exercise behavior. In boys, early motor development appears to be an expression of the same genetic factors that underlie the heritability of childhood and early adolescent exercise behavior.
    MeSH term(s) Adolescent ; Child ; Female ; Humans ; Male ; Adolescent Behavior ; Environment ; Exercise ; Mothers ; Twins/genetics
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article ; Twin Study
    ZDB-ID 2134691-4
    ISSN 1479-5868 ; 1479-5868
    ISSN (online) 1479-5868
    ISSN 1479-5868
    DOI 10.1186/s12966-024-01583-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bias in Gene-by-Environment Interaction Effects with Sum Scores; An Application to Well-being Phenotypes.

    Pelt, Dirk H M / Schwabe, Inga / Bartels, Meike

    Behavior genetics

    2023  Volume 53, Issue 4, Page(s) 359–373

    Abstract: In the current study, we investigated the influence of using skewed sum scores on estimated gene-by-environment interaction effects (GxE) for life satisfaction and happiness with perceived social support. To this end, we analyzed item-level data from a ... ...

    Abstract In the current study, we investigated the influence of using skewed sum scores on estimated gene-by-environment interaction effects (GxE) for life satisfaction and happiness with perceived social support. To this end, we analyzed item-level data from a large adult twin sample (Ns between 3610 and 11,305) of the Netherlands Twin Register. Item response theory (IRT) models were incorporated in unmeasured (univariate) GxE models, and measured GxE models (with social support as moderator). We found that skewness introduced spurious GxE effects, with the largest effect for the most skewed variable (social support). Finally, in the IRT model for life satisfaction, but not for happiness, heritability estimates decreased with higher social support, while this was not observed when analyzing sum scores. Together, our results indicate that IRT can be used to address psychometric issues related to the use of sum scores, especially in the context of GxE, for complex traits like well-being.
    MeSH term(s) Gene-Environment Interaction ; Phenotype ; Multifactorial Inheritance ; Netherlands
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280238-7
    ISSN 1573-3297 ; 0005-7851 ; 0001-8244
    ISSN (online) 1573-3297
    ISSN 0005-7851 ; 0001-8244
    DOI 10.1007/s10519-023-10137-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A systematic review of the neural correlates of well-being reveals no consistent associations.

    de Vries, Lianne P / van de Weijer, Margot P / Bartels, Meike

    Neuroscience and biobehavioral reviews

    2023  Volume 145, Page(s) 105036

    Abstract: Findings from behavioral and genetic studies indicate a potential role for the involvement of brain structures and brain functioning in well-being. We performed a systematic review on the association between brain structures or brain functioning and well- ...

    Abstract Findings from behavioral and genetic studies indicate a potential role for the involvement of brain structures and brain functioning in well-being. We performed a systematic review on the association between brain structures or brain functioning and well-being, including 56 studies. The 11 electroencephalography (EEG) studies suggest a larger alpha asymmetry (more left than right brain activation) to be related to higher well-being. The 18 Magnetic Resonance Imaging (MRI) studies, 26 resting-state functional MRI studies and two functional near-infrared spectroscopy (fNIRS) studies identified a wide range of brain regions involved in well-being, but replication across studies was scarce, both in direction and strength of the associations. The inconsistency could result from small sample sizes of most studies and a possible wide-spread network of brain regions with small effects involved in well-being. Future directions include well-powered brain-wide association studies and innovative methods to more reliably measure brain activity in daily life.
    MeSH term(s) Humans ; Brain Mapping/methods ; Electroencephalography/methods ; Spectroscopy, Near-Infrared/methods ; Brain/diagnostic imaging ; Brain/physiology ; Cerebral Cortex ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Genetics of wellbeing and its components satisfaction with life, happiness, and quality of life: a review and meta-analysis of heritability studies.

    Bartels, Meike

    Behavior genetics

    2015  Volume 45, Issue 2, Page(s) 137–156

    Abstract: Wellbeing is a major topic of research across several disciplines, reflecting the increasing recognition of its strong value across major domains in life. Previous twin-family studies have revealed that individual differences in wellbeing are accounted ... ...

    Abstract Wellbeing is a major topic of research across several disciplines, reflecting the increasing recognition of its strong value across major domains in life. Previous twin-family studies have revealed that individual differences in wellbeing are accounted for by both genetic as well as environmental factors. A systematic literature search identified 30 twin-family studies on wellbeing or a related measure such as satisfaction with life or happiness. Review of these studies showed considerable variation in heritability estimates (ranging from 0 to 64 %), which makes it difficult to draw firm conclusions regarding the genetic influences on wellbeing. For overall wellbeing twelve heritability estimates, from 10 independent studies, were meta-analyzed by computing a sample size weighted average heritability. Ten heritability estimates, derived from 9 independent samples, were used for the meta-analysis of satisfaction with life. The weighted average heritability of wellbeing, based on a sample size of 55,974 individuals, was 36 % (34-38), while the weighted average heritability for satisfaction with life was 32 % (29-35) (n = 47,750). With this result a more robust estimate of the relative influence of genetic effects on wellbeing is provided.
    MeSH term(s) Family ; Female ; Genetic Predisposition to Disease ; Genotype ; Happiness ; Humans ; Male ; Molecular Biology ; Personal Satisfaction ; Quality of Life ; Registries ; Sample Size ; Sex Factors ; Surveys and Questionnaires ; Twin Studies as Topic ; Twins
    Language English
    Publishing date 2015-02-26
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 280238-7
    ISSN 1573-3297 ; 0005-7851 ; 0001-8244
    ISSN (online) 1573-3297
    ISSN 0005-7851 ; 0001-8244
    DOI 10.1007/s10519-015-9713-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The human physiology of well-being: A systematic review on the association between neurotransmitters, hormones, inflammatory markers, the microbiome and well-being.

    de Vries, Lianne P / van de Weijer, Margot P / Bartels, Meike

    Neuroscience and biobehavioral reviews

    2022  Volume 139, Page(s) 104733

    Abstract: To understand the pathways through which well-being contributes to health, we performed a systematic review according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines on the association between well-being and ... ...

    Abstract To understand the pathways through which well-being contributes to health, we performed a systematic review according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines on the association between well-being and physiological markers in four categories, neurotransmitters, hormones, inflammatory markers, and microbiome. We identified 91 studies. Neurotransmitter studies (k
    MeSH term(s) Biomarkers ; Humans ; Hydrocortisone/metabolism ; Microbiota ; Neurotransmitter Agents ; Serotonin
    Chemical Substances Biomarkers ; Neurotransmitter Agents ; Serotonin (333DO1RDJY) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2022-06-11
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2022.104733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: No gene by stressful life events interaction on individual differences in adults' self-control.

    Willems, Yayouk Eva / Raffington, Laurel / Ligthart, Lannie / Pool, Rene / Hottenga, Jouke Jan / Finkenauer, Catrin / Bartels, Meike

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1388264

    Abstract: Background: Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding, and ... ...

    Abstract Background: Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding, and intervention for low self-control is, therefore, a public health goal. A prominent developmental theory proposes that individuals with high genetic propensity for low self-control that are also exposed to stressful environments may be most at-risk of low levels of self-control. Here we examine if polygenic measures associated with behaviors marked by low self-control interact with stressful life events in predicting self-control.
    Methods: Leveraging molecular data from a large population-based Dutch sample (N = 7,090, Mage = 41.2) to test for effects of genetics (i.e., polygenic scores for ADHD and aggression), stressful life events (e.g., traffic accident, violent assault, financial problems), and a gene-by-stress interaction on self-control (measured with the ASEBA Self-Control Scale).
    Results: Both genetics (β =.03 -.04, p <.001) and stressful life events (β = .11 -.14, p <.001) were associated with individual differences in self-control. We find no evidence of a gene-by-stressful life events interaction on individual differences in adults' self-control.
    Conclusion: Our findings are consistent with the notion that genetic influences and stressful life events exert largely independent effects on adult self-control. However, the small effect sizes of polygenic scores increases the likelihood of null results. Genetically-informed longitudinal research in large samples can further inform the etiology of individual differences in self-control from early childhood into later adulthood and its downstream implications for public health.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1388264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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