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  1. Book: Hepatitis C virus

    Bartenschlager, Ralf

    from molecular virology to antiviral therapy

    (Current topics in microbiology and immunology ; 369 ; Biomedicine)

    2013  

    Title variant Hepatitis C virus
    Author's details Ralf Bartenschlager ed
    Series title Current topics in microbiology and immunology ; 369
    Biomedicine
    Collection
    Keywords Hepatitis-C-Virus
    Subject NANB-Hepatitisvirus ; Hepatitisvirus C
    Language English
    Size VIII, 346 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017603309
    ISBN 978-3-642-27339-1 ; 3-642-27339-4 ; 978342273407 ; 9783422734074 ; 3422734074
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -369- verfügbar in Königswinter Königswinter

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  2. Book ; Thesis: Characterization of cell-intrinsic antiviral response pathways in the context of DNA damage-induced cell death

    Zander, David Y. / Bartenschlager, Ralf

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von David Yves Zander ; Doktorvater: Prof. Dr. rer. nat. Ralf Bartenschlager
    Language English
    Size XIX, 143 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    HBZ-ID HT021730950
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 290 order for loan Magazin

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  3. Book ; Thesis: The role of tumor cell-expressed Angiopoietin 2 in malignant melanoma

    Abdul Pari, Ashik Ahmed / Bartenschlager, Ralf

    2021  

    Institution Universität Heidelberg
    Author's details presented by M.Sc. (Life Sciences and Technology) Ashik Ahmed Abdul Pari ; referees: Prof. Dr. Ralf Bartenschlager, Prof. Dr. Hellmut G. Augustin
    Language English
    Size viii, 121 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruperto Carola University of Heidelberg, Germany, 2021
    Note Text Englisch, Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT021128166
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 E 1313 order for loan Magazin

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  4. Article: [No title information]

    Bartenschlager, Ralf

    Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)

    2022  Volume 28, Issue 1, Page(s) 47–49

    Abstract: The severe acute respiratory syndrome Coronavirus type 2 (SARS-CoV-2) has caused a pandemic with major impact on human society, the economy, and our daily life. SARS-CoV-2 is a plus-strand RNA virus causing death of infected cells and an inflammation- ... ...

    Title translation Kurzübersicht des SARS-Coronavirus-2-Vermehrungszyklus.
    Abstract The severe acute respiratory syndrome Coronavirus type 2 (SARS-CoV-2) has caused a pandemic with major impact on human society, the economy, and our daily life. SARS-CoV-2 is a plus-strand RNA virus causing death of infected cells and an inflammation-dominated immune response. Replication of the virus occurs in the cytoplasm in distinct membranous compartments designated replication organelles, providing a shielded environment for synthesis of viral RNAs. Here, I will briefly summarize key aspects of the SARS-CoV-2 replication cycle.
    Language German
    Publishing date 2022-02-13
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2203536-9
    ISSN 1868-6249 ; 0947-0867
    ISSN (online) 1868-6249
    ISSN 0947-0867
    DOI 10.1007/s12268-022-1706-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Book ; Thesis: Determinants of efficient Hepatitis C Virus RNA replication in cell culture

    Schenk, Christian / Bartenschlager, Ralf

    2020  

    Institution Universität Heidelberg
    Author's details presented by M.Sc. Christian H. Schenk ; referees: Prof. Dr. Ralf Bartenschlager, Prof. apl. Dr. Volker Lohmann
    Language English
    Size IV, 140 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruperto Carola University Heidelberg, Germany, 2020
    Note Text Englisch, Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT020648844
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2020 E 1604 order for loan Magazin

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  6. Article ; Online: Cutting edges in the HBV genome: How RNA splicing is involved in modulating virus ultrastructure to promote infection.

    Seitz, Stefan / Bartenschlager, Ralf

    Journal of hepatology

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.02.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Thesis: Production and characterization of novel BMMF2 rep-specific antibodies and application in cancer histology

    Beck, Simon / Bartenschlager, Ralf / Zur Hausen, Harald

    2022  

    Institution Universität Heidelberg
    Author's details presented by M.Sc. Simon Beck ; referees: Prof. Dr. Ralf Bartenschlager, Prof. Dr. Harald zur Hausen
    Language English
    Size 148 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprechts-Karls-University Heidelberg, 2022
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT030067946
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1159 order for loan Magazin

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  8. Article: Im Gespräch: Ralf Bartenschlager (Heidelberg) über die Auswirkungen der Corona-Pandemie auf die Virologie als Fachdisziplin

    Bartenschlager, Ralf

    Laborjournal

    2021  Volume 28, Issue 3, Page(s) 30

    Language German
    Document type Article
    ZDB-ID 1237282-1
    ISSN 1612-8354
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4842: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A snapshot of protein trafficking in SARS-CoV-2 infection.

    Prasad, Vibhu / Bartenschlager, Ralf

    Biology of the cell

    2022  Volume 115, Issue 2, Page(s) e2200073

    Abstract: SARS-CoV-2 is a human pathogenic virus responsible for the COVID-19 (coronavirus disease 2019) pandemic. The infection cycle of SARS-CoV-2 involves several related steps, including virus entry, gene expression, RNA replication, assembly of infectious ... ...

    Abstract SARS-CoV-2 is a human pathogenic virus responsible for the COVID-19 (coronavirus disease 2019) pandemic. The infection cycle of SARS-CoV-2 involves several related steps, including virus entry, gene expression, RNA replication, assembly of infectious virions and their egress. For all of these steps, the virus relies on and exploits host cell factors, cellular organelles, and processes such as endocytosis, nuclear transport, protein secretion, metabolite transport at membrane contact sites (MSC) and exocytotic pathways. To do this, SARS-CoV-2 has evolved multifunctional viral proteins that hijack cellular factors and modulate their function by unique strategies. In this Review, we highlight cellular trafficking factors, processes, and organelles of relevance to the SARS-CoV-2 infection cycle and how viral proteins make use of and perturb cellular transport during the viral infection cycle.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Viral Proteins/metabolism ; Virus Internalization ; Protein Transport
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 245745-3
    ISSN 1768-322X ; 0399-0311 ; 0248-4900
    ISSN (online) 1768-322X
    ISSN 0399-0311 ; 0248-4900
    DOI 10.1111/boc.202200073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 758: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Glycan-directed SARS-CoV-2 inhibition by leek extract and lectins with insights into the mode-of-action of Concanavalin A.

    Klevanski, Maja / Kim, Heeyoung / Heilemann, Mike / Kuner, Thomas / Bartenschlager, Ralf

    Antiviral research

    2024  Volume 225, Page(s) 105856

    Abstract: Four years after its outbreak, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global challenge for human health. At its surface, SARS-CoV-2 features numerous extensively glycosylated spike proteins. This glycan coat supports ... ...

    Abstract Four years after its outbreak, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global challenge for human health. At its surface, SARS-CoV-2 features numerous extensively glycosylated spike proteins. This glycan coat supports virion docking and entry into host cells and at the same time renders the virus less susceptible to neutralizing antibodies. Given the high genetic plasticity of SARS-CoV-2 and the rapid emergence of immune escape variants, targeting the glycan shield by carbohydrate-binding agents emerges as a promising strategy. However, the potential of carbohydrate-targeting reagents as viral inhibitors remains underexplored. Here, we tested seven plant-derived carbohydrate-binding proteins, called lectins, and one crude plant extract for their antiviral activity against SARS-CoV-2 in two types of human lung cells: A549 cells ectopically expressing the ACE2 receptor and Calu-3 cells. We identified three lectins and an Allium porrum (leek) extract inhibiting SARS-CoV-2 infection in both cell systems with selectivity indices (SI) ranging between >2 and >299. Amongst these, the lectin Concanavalin A (Con A) exerted the most potent and broad activity against a panel of SARS-CoV-2 variants. We used multiplex super-resolution microscopy to address lectin interactions with SARS-CoV-2 and its host cells. Notably, we discovered that Con A not only binds to SARS-CoV-2 virions and their host cells, but also causes SARS-CoV-2 aggregation. Thus, Con A exerts a dual mode-of-action comprising both, antiviral and virucidal, mechanisms. These results establish Con A and other plant lectins as candidates for COVID-19 prevention and basis for further drug development.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Onions/metabolism ; Concanavalin A/metabolism ; Lectins/metabolism ; Polysaccharides ; Antiviral Agents/pharmacology ; Plant Extracts ; Spike Glycoprotein, Coronavirus
    Chemical Substances Concanavalin A (11028-71-0) ; Lectins ; Polysaccharides ; Antiviral Agents ; Plant Extracts ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2024.105856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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