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  1. Article: PET Imaging of the Serotonin 1A Receptor in Major Depressive Disorder: Hierarchical Multivariate Analysis of [

    Matheson, Granville J / Zanderigo, Francesca / Miller, Jeffrey M / Bartlett, Elizabeth A / Mann, J John / Ogden, R Todd

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The serotonin 1A receptor has been linked to both the pathophysiology of major depressive disorder (MDD) and the antidepressant action of serotonin reuptake inhibitors. Most PET studies of the serotonin 1A receptor in MDD used the receptor antagonist ... ...

    Abstract The serotonin 1A receptor has been linked to both the pathophysiology of major depressive disorder (MDD) and the antidepressant action of serotonin reuptake inhibitors. Most PET studies of the serotonin 1A receptor in MDD used the receptor antagonist radioligand, [carbonyl-
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.12.584569
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  2. Article ; Online: Dynamic Human Brain Imaging with a Portable PET Camera: Comparison to a Standard Scanner.

    Bartlett, Elizabeth A / Lesanpezeshki, Mohammad / Anishchenko, Sergey / Shkolnik, Ilia / Ogden, R Todd / Mann, J John / Beylin, David / Miller, Jeffrey M / Zanderigo, Francesca

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  Volume 65, Issue 2, Page(s) 320–326

    Abstract: Portable, cost-effective PET cameras can radically expand the applicability of PET. We present here a within-participant comparison of fully quantified [ ...

    Abstract Portable, cost-effective PET cameras can radically expand the applicability of PET. We present here a within-participant comparison of fully quantified [
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Glucose/metabolism ; Neocortex/metabolism ; Positron-Emission Tomography/methods ; Neuroimaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.265309
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    Zs.A 114: Show issues Location:
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  3. Article ; Online: Source-to-Target Automatic Rotating Estimation (STARE) - A publicly-available, blood-free quantification approach for PET tracers with irreversible kinetics: Theoretical framework and validation for [

    Bartlett, Elizabeth A / Ogden, R Todd / Mann, J John / Zanderigo, Francesca

    NeuroImage

    2022  Volume 249, Page(s) 118901

    Abstract: Introduction: Full quantification of positron emission tomography (PET) data requires an input function. This generally means arterial blood sampling, which is invasive, labor-intensive and burdensome. There is no current, standardized method to fully ... ...

    Abstract Introduction: Full quantification of positron emission tomography (PET) data requires an input function. This generally means arterial blood sampling, which is invasive, labor-intensive and burdensome. There is no current, standardized method to fully quantify PET radiotracers with irreversible kinetics in the absence of blood data. Here, we present Source-to-Target Automatic Rotating Estimation (STARE), a novel, data-driven approach to quantify the net influx rate (K
    Methods: STARE builds upon a source-to-target tissue model, where the tracer time activity curves (TACs) in multiple "target" regions are expressed at once as a function of a "source" region, based on the two-tissue irreversible compartment model, and separates target region K
    Results: In a large dataset of human [
    Conclusion: Through simulations and application to [
    MeSH term(s) Adult ; Cerebellum/diagnostic imaging ; Cerebral Cortex/diagnostic imaging ; Fluorodeoxyglucose F18/pharmacokinetics ; Humans ; Image Processing, Computer-Assisted/methods ; Image Processing, Computer-Assisted/standards ; Models, Theoretical ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/standards ; Radiopharmaceuticals/pharmacokinetics
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2022.118901
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    Zs.MO 7: Show issues

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  4. Article ; Online: In vivo

    Bartlett, Elizabeth A / Yttredahl, Ashley A / Boldrini, Maura / Tyrer, Andrea E / Hill, Kathryn R / Ananth, Mala R / Milak, Matthew S / Oquendo, Maria A / Mann, J John / DeLorenzo, Christine / Parsey, Ramin V

    European psychiatry : the journal of the Association of European Psychiatrists

    2023  Volume 66, Issue 1, Page(s) e17

    Abstract: Background: Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT: Methods: Following up on our initial report, 28 ... ...

    Abstract Background: Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT
    Methods: Following up on our initial report, 28 unmedicated participants in a current depressive episode (bipolar
    Results: There was a group-by-region effect (
    Conclusions: With replication in larger samples, elevated hippocampal 5-HT
    MeSH term(s) Humans ; Receptor, Serotonin, 5-HT1A/metabolism ; Adverse Childhood Experiences ; Depression/diagnostic imaging ; Depression/metabolism ; Serotonin/metabolism ; Positron-Emission Tomography/methods ; Hippocampus/diagnostic imaging ; Brain/metabolism
    Chemical Substances Receptor, Serotonin, 5-HT1A (112692-38-3) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1074337-6
    ISSN 1778-3585 ; 0767-399X ; 0924-9338
    ISSN (online) 1778-3585
    ISSN 0767-399X ; 0924-9338
    DOI 10.1192/j.eurpsy.2023.4
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    Zs.MO 558: Show issues

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  5. Article ; Online: In vivo serotonin transporter and 1A receptor binding potential and ecological momentary assessment (EMA) of stress in major depression and suicidal behavior.

    Bartlett, Elizabeth A / Zanderigo, Francesca / Stanley, Barbara / Choo, Tse-Hwei / Galfalvy, Hanga C / Pantazatos, Spiro P / Sublette, M Elizabeth / Miller, Jeffrey M / Oquendo, Maria A / Mann, J John

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2023  Volume 70, Page(s) 1–13

    Abstract: We examined relationships between the serotonin system and stress in major depression and suicidal behavior. Twenty-five medication-free depressed participants (13 suicide attempters) underwent same-day [ ...

    Abstract We examined relationships between the serotonin system and stress in major depression and suicidal behavior. Twenty-five medication-free depressed participants (13 suicide attempters) underwent same-day [
    MeSH term(s) Humans ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/metabolism ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Suicidal Ideation ; Serotonin/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Depression ; Ecological Momentary Assessment ; Biomarkers/metabolism ; Positron-Emission Tomography/methods ; Receptor, Serotonin, 5-HT1A/metabolism
    Chemical Substances Serotonin Plasma Membrane Transport Proteins ; Serotonin (333DO1RDJY) ; Biomarkers ; Receptor, Serotonin, 5-HT1A (112692-38-3)
    Language English
    Publishing date 2023-02-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2023.01.006
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    Zs.A 3288: Show issues Location:
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    Zs.MO 630: Show issues

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  6. Article ; Online: Measuring brain glucose metabolism in order to predict response to antidepressant or placebo: A randomized clinical trial.

    Hill, Kathryn R / Gardus, John D / Bartlett, Elizabeth A / Perlman, Greg / Parsey, Ramin V / DeLorenzo, Christine

    NeuroImage. Clinical

    2021  Volume 32, Page(s) 102858

    Abstract: There is critical need for a clinically useful tool to predict antidepressant treatment outcome in major depressive disorder (MDD) to reduce suffering and mortality. This analysis sought to build upon previously reported antidepressant treatment efficacy ...

    Abstract There is critical need for a clinically useful tool to predict antidepressant treatment outcome in major depressive disorder (MDD) to reduce suffering and mortality. This analysis sought to build upon previously reported antidepressant treatment efficacy prediction from 2-[
    MeSH term(s) Antidepressive Agents/therapeutic use ; Brain/diagnostic imaging ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Double-Blind Method ; Escitalopram ; Glucose ; Humans ; Treatment Outcome
    Chemical Substances Antidepressive Agents ; Escitalopram (4O4S742ANY) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-10-19
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2021.102858
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  7. Article ; Online: Depression Severity Over 27 Months in Adolescent Girls Is Predicted by Stress-Linked Cortical Morphology.

    Bartlett, Elizabeth A / Klein, Daniel N / Li, Kaiqiao / DeLorenzo, Christine / Kotov, Roman / Perlman, Greg

    Biological psychiatry

    2019  Volume 86, Issue 10, Page(s) 769–778

    Abstract: Background: Evidence supports the notion that early-life stress and trauma impact cortical development and increase vulnerability to depression. However, it remains unclear whether common stressful life events in community-dwelling adolescents have ... ...

    Abstract Background: Evidence supports the notion that early-life stress and trauma impact cortical development and increase vulnerability to depression. However, it remains unclear whether common stressful life events in community-dwelling adolescents have similar consequences for cortical development.
    Methods: A total of 232 adolescent girls (mean age 15.29 ± 0.65 years) were assessed with the Stressful Life Events Schedule (a semistructured interview of stressors in the previous 9 months) and underwent a magnetic resonance imaging scan. FreeSurfer 5.3.0 was used to perform whole-brain surface-based morphometry. Dysphoria was assessed at the time of imaging and prospectively at three 9-month follow-up appointments using the Inventory of Depression and Anxiety Symptoms II.
    Results: At least one stressful life event was reported in 90% of the adolescent participants during the 9 months preceding imaging. Greater burden of recent life stress was associated with less left precuneus and left postcentral cortical thickness and smaller left superior frontal and right inferior parietal volume (all p < .05 after multiple comparisons correction). Left precuneus thickness in the stress-associated cluster significantly predicted dysphoria for 27 months after imaging controlling for prior dysphoria (β = -.11, p = .004). Left precuneus cortical thickness accounted for 17.0% of the association between stress and dysphoric mood for 27 months after imaging (β = .04, p = .05).
    Conclusions: Consistent with evidence from imaging studies of trauma-exposed youths and preclinical stress models, a heavy burden of recent common life stress in community-dwelling adolescent girls was associated with altered frontal/parietal cortical morphology. Stress-linked precuneus cortical thickness represents a candidate prospective biomarker of adolescent depression.
    MeSH term(s) Adolescent ; Brain Mapping ; Cerebral Cortex/pathology ; Depressive Disorder/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Organ Size ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Stress, Psychological/pathology
    Language English
    Publishing date 2019-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2019.04.027
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  8. Article ; Online: Ventral prefrontal serotonin 1A receptor binding: a neural marker of vulnerability for mood disorder and suicidal behavior?

    Pantazatos, Spiro P / Melhem, Nadine M / Brent, David A / Zanderigo, Francesca / Bartlett, Elizabeth A / Lesanpezeshki, Mohammad / Burke, Ainsley / Miller, Jeffrey M / Mann, J John

    Molecular psychiatry

    2022  Volume 27, Issue 10, Page(s) 4136–4143

    Abstract: Mood disorders and suicidal behavior have moderate heritability and are associated with altered corticolimbic serotonin 1A receptor (5- ... ...

    Abstract Mood disorders and suicidal behavior have moderate heritability and are associated with altered corticolimbic serotonin 1A receptor (5-HT
    MeSH term(s) Humans ; Suicidal Ideation ; Receptor, Serotonin, 5-HT1A/genetics ; Genetic Predisposition to Disease ; Serotonin ; Mood Disorders/genetics
    Chemical Substances Receptor, Serotonin, 5-HT1A (112692-38-3) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01671-y
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  9. Article ; Online: Serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy.

    Bartlett, Elizabeth A / Zanderigo, Francesca / Shieh, Denise / Miller, Jeffrey / Hurley, Patrick / Rubin-Falcone, Harry / Oquendo, Maria A / Sublette, M Elizabeth / Ogden, R Todd / Mann, J John

    Molecular psychiatry

    2022  Volume 27, Issue 8, Page(s) 3417–3424

    Abstract: Serotonin transporter (5-HTT) binding deficits are reported in major depressive disorder (MDD). However, most studies have not considered serotonin system anatomy when parcellating brain regions of interest (ROIs). We now investigate 5-HTT binding in MDD ...

    Abstract Serotonin transporter (5-HTT) binding deficits are reported in major depressive disorder (MDD). However, most studies have not considered serotonin system anatomy when parcellating brain regions of interest (ROIs). We now investigate 5-HTT binding in MDD in two novel ways: (1) use of a 5-HTT tract-based analysis examining binding along serotonergic axons; and (2) using the Copenhagen University Hospital Neurobiology Research Unit (NRU) 5-HT Atlas, based on brain-wide binding patterns of multiple serotonin receptor types. [
    MeSH term(s) Humans ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Depressive Disorder, Major/drug therapy ; Serotonin/metabolism ; Bayes Theorem ; Positron-Emission Tomography ; Brain/diagnostic imaging ; Brain/metabolism ; Antidepressive Agents/therapeutic use
    Chemical Substances Serotonin Plasma Membrane Transport Proteins ; Serotonin (333DO1RDJY) ; Antidepressive Agents
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01578-8
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  10. Article ; Online: Examining the underpinnings of loudness dependence of auditory evoked potentials with positron emission tomography.

    Pillai, Rajapillai L I / Bartlett, Elizabeth A / Ananth, Mala R / Zhu, Chencan / Yang, Jie / Hajcak, Greg / Parsey, Ramin V / DeLorenzo, Christine

    NeuroImage

    2020  Volume 213, Page(s) 116733

    Abstract: Loudness dependence of auditory evoked potentials (LDAEP) has long been considered to reflect central basal serotonin transmission. However, the relationship between LDAEP and individual serotonin receptors and transporters has not been fully explored in ...

    Abstract Loudness dependence of auditory evoked potentials (LDAEP) has long been considered to reflect central basal serotonin transmission. However, the relationship between LDAEP and individual serotonin receptors and transporters has not been fully explored in humans and may involve other neurotransmitter systems. To examine LDAEP's relationship with the serotonin system, we performed PET using serotonin-1A (5-HT
    MeSH term(s) Adolescent ; Adult ; Aged ; Bipolar Disorder ; Brain/physiology ; Electroencephalography ; Evoked Potentials, Auditory/physiology ; Female ; Humans ; Loudness Perception/physiology ; Male ; Middle Aged ; Positron-Emission Tomography ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Young Adult
    Chemical Substances SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2020-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2020.116733
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