Article: Ferroptosis: A Specific Vulnerability of RAS-Driven Cancers?
2022 Volume 12, Page(s) 923915
Abstract: Ferroptosis has emerged as a new type of programmed cell death that can be harnessed for cancer therapy. The concept of ferroptosis was for the first time proposed in in the early 2000s, as an iron-dependent mode of regulated cell death caused by ... ...
| Abstract | Ferroptosis has emerged as a new type of programmed cell death that can be harnessed for cancer therapy. The concept of ferroptosis was for the first time proposed in in the early 2000s, as an iron-dependent mode of regulated cell death caused by unrestricted lipid peroxidation (LPO) and subsequent plasma membrane rupture. Since the discovery and characterization of ferroptosis, a wealth of research has improved our understanding of the main pathways regulating this process, leading to both the repurposing and the development of small molecules. However, ferroptosis is still little understood and several aspects remain to be investigated. For instance, it is unclear whether specific oncogenes, cells of origin or tumor niches impose specific susceptibility/resistance to ferroptosis or if there are some ferroptosis-related genes that may be used as |
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| Language | English |
| Publishing date | 2022-07-15 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2649216-7 |
| ISSN | 2234-943X |
| ISSN | 2234-943X |
| DOI | 10.3389/fonc.2022.923915 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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