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Article ; Online: Alcohol and migraine: what should we tell patients?

Panconesi, Alessandro / Bartolozzi, Maria Letizia / Guidi, Leonello

2011 Volume 15, Issue 3, Page(s) 177–184

Abstract: Alcoholic drinks are a migraine trigger in about one third of patients with migraine in retrospective studies on trigger factors. Many population studies show that patients with migraine consume alcohol in a smaller percentage than the general population. ...

Abstract	Alcoholic drinks are a migraine trigger in about one third of patients with migraine in retrospective studies on trigger factors. Many population studies show that patients with migraine consume alcohol in a smaller percentage than the general population. Moreover, research has shown a decreased prevalence of headache with increasing number of alcohol units consumed. The classification criteria of alcohol-related headaches remain problematic. We discuss the role and mechanism of action of alcohol or other components of alcoholic drinks in relation to alcohol-induced headache. In accordance with data from a recent prospective study, we believe that reports overestimate the role of alcohol, as well as other foods, in the triggering of migraine. If a relationship between the intake of alcohol and the migraine attack is not clear, a small dose of alcohol is not contraindicated either for enjoyment or its protective effect on cardiovascular disease.
MeSH term(s)	Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Alcoholic Beverages/adverse effects ; Humans ; International Classification of Diseases/standards ; Migraine Disorders/epidemiology ; Migraine Disorders/etiology ; Migraine Disorders/prevention & control ; Patient Education as Topic/methods ; Patient Education as Topic/trends ; Retrospective Studies
Language	English
Publishing date	2011-02-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055062-5
ISSN	1534-3081 ; 1531-3433
ISSN (online)	1534-3081
ISSN	1531-3433
DOI	10.1007/s11916-011-0184-4
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Article ; Online: Predictive Factors for Hemorrhagic Transformation in Acute Ischemic Stroke in the REAL-World Clinical Practice.

Grifoni, Elisa / Bini, Chiara / Signorini, Ira / Cosentino, Eleonora / Micheletti, Irene / Dei, Alessandro / Pinto, Gabriele / Madonia, Elisa Maria / Sivieri, Irene / Mannini, Marianna / Baldini, Mariella / Bertini, Elisabetta / Giannoni, Sara / Bartolozzi, Maria Letizia / Guidi, Leonello / Bartalucci, Paola / Vanni, Simone / Segneri, Antonio / Pratesi, Alessandra /

Giordano, Antonio / Dainelli, Francesca / Maggi, Francesca / Romagnoli, Mario / Cioni, Elisa / Cioffi, Elisa / Pelagalli, Giulia / Mattaliano, Chiara / Schipani, Elena / Murgida, Giuseppe Salvatore / Di Martino, Stefania / Sisti, Eleonora / Cozzi, Andrea / Francolini, Valentina / Masotti, Luca

The neurologist

2023 Volume 28, Issue 3, Page(s) 150–156

Abstract: Background: Few data exists on predictive factors of hemorrhagic transformation (HT) in real-world acute ischemic stroke patients. The aims of this study were: (i) to identify predictive variables of HT (ii) to develop a score for predicting HT.: ... ...

Abstract	Background: Few data exists on predictive factors of hemorrhagic transformation (HT) in real-world acute ischemic stroke patients. The aims of this study were: (i) to identify predictive variables of HT (ii) to develop a score for predicting HT. Methods: We retrospectively analyzed the clinical, radiographic, and laboratory data of patients with acute ischemic stroke consecutively admitted to our Stroke Unit along two years. Patients with HT were compared with those without HT. A multivariate logistic regression analysis was performed to identify independent predictors of HT on CT scan at 24 hours to develop a practical score. Results: The study population consisted of 564 patients with mean age 77.5±11.8 years. Fifty-two patients (9.2%) showed HT on brain CT at 24 hours (4.9% symptomatic). NIHSS score ≥8 at Stroke Unit admission (3 points), cardioembolic etiology (2 points), acute revascularization by systemic thrombolysis and/or mechanical thrombectomy (1 point), history of previous TIA/stroke (1 point), and major vessel occlusion (1 point) were found independent risk factors of HT and were included in the score (Hemorrhagic Transformation Empoli score (HTE)). The predictive power of HTE score was good with an AUC of 0.785 (95% CI: 0.749-0.818). Compared with 5 HT predictive scores proposed in the literature (THRIVE, SPAN-100, MSS, GRASPS, SITS-SIC), the HTE score significantly better predicted HT. Conclusions: NIHSS score ≥8 at Stroke Unit admission, cardioembolism, urgent revascularization, previous TIA/stroke, and major vessel occlusion were independent predictors of HT. The HTE score has a good predictive power for HT. Prospective studies are warranted.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Ischemic Stroke/complications ; Ischemic Stroke/diagnostic imaging ; Retrospective Studies ; Ischemic Attack, Transient ; Stroke/complications ; Stroke/diagnostic imaging ; Risk Factors
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1361380-7
ISSN	2331-2637 ; 1074-7931
ISSN (online)	2331-2637
ISSN	1074-7931
DOI	10.1097/NRL.0000000000000462
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Article ; Online: SUNCT syndrome or first division trigeminal neuralgia associated with cerebellar hypoplasia.

Panconesi, Alessandro / Bartolozzi, Maria Letizia / Guidi, Leonello

The journal of headache and pain

2009 Volume 10, Issue 6, Page(s) 461–464

Abstract: Short-lasting unilateral neuralgiform headache (SUNCT) and first division trigeminal neuralgia (TN) are rare and very similar periorbital unilateral pain syndromes. Few cases of SUNCT are associated with posterior skull lesions. We describe a 54-year-old ...

Abstract	Short-lasting unilateral neuralgiform headache (SUNCT) and first division trigeminal neuralgia (TN) are rare and very similar periorbital unilateral pain syndromes. Few cases of SUNCT are associated with posterior skull lesions. We describe a 54-year-old man with symptoms compatible with both the previous painful syndromes, associated with a small posterior skull and a cerebellar hypoplasia. The short height and the reported bone fractures could be compatible with a mild form of osteogenesis imperfecta, previously described in one case associated with SUNCT. However, a hypoplastic posterior cranial fossa characterizes also Chiari I malformation. The difficult differential diagnosis between SUNCT and TN and their relation with posterior skull malformations is debated.
MeSH term(s)	Amines/therapeutic use ; Arnold-Chiari Malformation/complications ; Arnold-Chiari Malformation/pathology ; Arnold-Chiari Malformation/physiopathology ; Carbamazepine/therapeutic use ; Cerebellum/abnormalities ; Cranial Fossa, Posterior/abnormalities ; Cyclohexanecarboxylic Acids/therapeutic use ; Drug Therapy, Combination ; Fractures, Bone/complications ; Fractures, Bone/congenital ; Gabapentin ; Growth Disorders/complications ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nervous System Malformations/complications ; Nervous System Malformations/pathology ; Nervous System Malformations/physiopathology ; Ophthalmic Nerve/physiopathology ; Osteogenesis Imperfecta/complications ; SUNCT Syndrome/etiology ; SUNCT Syndrome/pathology ; SUNCT Syndrome/physiopathology ; Treatment Outcome ; Trigeminal Neuralgia/etiology ; Trigeminal Neuralgia/pathology ; Trigeminal Neuralgia/physiopathology ; gamma-Aminobutyric Acid/therapeutic use
Chemical Substances	Amines ; Cyclohexanecarboxylic Acids ; Carbamazepine (33CM23913M) ; gamma-Aminobutyric Acid (56-12-2) ; Gabapentin (6CW7F3G59X)
Language	English
Publishing date	2009-09-16
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2036768-5
ISSN	1129-2377 ; 1129-2369
ISSN (online)	1129-2377
ISSN	1129-2369
DOI	10.1007/s10194-009-0152-0
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Article ; Online: Migraine pain: reflections against vasodilatation.

Panconesi, Alessandro / Bartolozzi, Maria Letizia / Guidi, Leonello

The journal of headache and pain

2009 Volume 10, Issue 5, Page(s) 317–325

Abstract: The original Wolff's vascular theory of migraine was supported by the discovery of a class of drugs, the triptans, developed as a selective cephalic vasoconstrictor agents. Even in the neurovascular hypothesis of Moskowitz, that is the neurogenic ... ...

Abstract	The original Wolff's vascular theory of migraine was supported by the discovery of a class of drugs, the triptans, developed as a selective cephalic vasoconstrictor agents. Even in the neurovascular hypothesis of Moskowitz, that is the neurogenic inflammation of meningeal vessels provoked by peptides released from trigeminal sensory neurons, the vasodilatation provoked by calcitonin gene-related peptide (CGRP) is considered today much more important than oedema. The role of cephalic vasodilatation as a cause of migraine pain was recently sustained by studies showing the therapeutic effect of CGRP receptor antagonists. We discuss the evidence against vasodilatation as migraine pain generator and some findings which we suggest in support of a central (brain) origin of pain.
MeSH term(s)	Brain/blood supply ; Brain/physiopathology ; Calcitonin Gene-Related Peptide/metabolism ; Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/physiopathology ; Neurogenic Inflammation/complications ; Neurogenic Inflammation/physiopathology ; Pain/drug therapy ; Pain/physiopathology ; Serotonin/metabolism ; Vasoconstrictor Agents/therapeutic use ; Vasodilation/physiology
Chemical Substances	Vasoconstrictor Agents ; Serotonin (333DO1RDJY) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2009-06-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036768-5
ISSN	1129-2377 ; 1129-2369
ISSN (online)	1129-2377
ISSN	1129-2369
DOI	10.1007/s10194-009-0130-6
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Article ; Online: Alcoholic drinks as triggers in primary headaches.

Panconesi, Alessandro / Franchini, Michela / Bartolozzi, Maria Letizia / Mugnai, Stefania / Guidi, Leonello

Pain medicine (Malden, Mass.)

2013 Volume 14, Issue 8, Page(s) 1254–1259

Abstract: Objective: This project aims to investigate the role of alcoholic drinks (ADs) as triggers for primary headaches.: Methods: Patients followed in the Headache Centre and presenting with migraine without aura, migraine with aura (MA), chronic migraine ( ...

Abstract	Objective: This project aims to investigate the role of alcoholic drinks (ADs) as triggers for primary headaches. Methods: Patients followed in the Headache Centre and presenting with migraine without aura, migraine with aura (MA), chronic migraine (CM), and tension-type headache (TH) were asked if their headache was precipitated by AD and also about their alcohol habits. Individual characteristics and drink habits were evaluated within two binary logistic models. Results: About one half (49.7%) of patients were abstainers, 17.6% were habitual consumers, and 32.5% were occasional consumers. Out of 448 patients, only 22 (4.9%), all with migraine, reported AD as a trigger factor. None of 44 patients with MA and none of 47 patients with TH reported AD as a trigger factor. Among those patients with migraine who consume AD, only 8% reported that AD can precipitate their headache. Multivariate analyses showed that AD use, both occasional and habitual, is unrelated to TH. Moreover, analysis performed among migraine patients, points out that occasional and habitual drinkers have a lower risk of presenting with CM than abstainers, although statistical significance occurred only among occasional drinkers. Only 3% of migraine patients who abstain from AD reported that they do not consume alcohol because it triggers their headache. Conclusion: Our study shows that AD acts as headache triggers in a small percentage of migraine patients. Differing from some prior studies, our data suggest that AD do not trigger MA and TH attacks. Moreover, the percentage of abstainers in our sample is higher compared with that reported in general population surveys.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Alcohol Drinking/adverse effects ; Central Nervous System Depressants/pharmacology ; Confidence Intervals ; Ethanol/pharmacology ; Female ; Headache/etiology ; Humans ; Male ; Middle Aged ; Migraine Disorders/etiology ; Migraine with Aura/complications ; Prevalence ; Sex Factors ; Temperance ; Tension-Type Headache/etiology ; Young Adult
Chemical Substances	Central Nervous System Depressants ; Ethanol (3K9958V90M)
Language	English
Publishing date	2013-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1111/pme.12127
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Article ; Online: Long-term assessment of no evidence of disease activity in relapsing-remitting MS.

De Stefano, Nicola / Stromillo, Maria Laura / Giorgio, Antonio / Battaglini, Marco / Bartolozzi, Maria Letizia / Amato, Maria Pia / Sormani, Maria Pia

Neurology

2015 Volume 85, Issue 19, Page(s) 1722–1723

MeSH term(s)	Adult ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Multiple Sclerosis, Relapsing-Remitting/diagnosis ; Multiple Sclerosis, Relapsing-Remitting/epidemiology ; Time Factors
Language	English
Publishing date	2015-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000002105
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Article ; Online: GAD antibodies associated neurological disorders: incidence and phenotype distribution among neurological inflammatory diseases.

Matà, Sabrina / Muscas, Gian Carlo / Cincotta, Massimo / Bartolozzi, Maria Letizia / Ambrosini, Stefano / Sorbi, Sandro

Journal of neuroimmunology

2010 Volume 227, Issue 1-2, Page(s) 175–177

Abstract: We investigated the prevalence and the clinical association of high titer of antibodies against glutamic acid decarboxylase (hGADAb) among unselected patients with inflammatory/autoimmune disorders of the nervous system. By indirect immunofluorescence ... ...

Abstract	We investigated the prevalence and the clinical association of high titer of antibodies against glutamic acid decarboxylase (hGADAb) among unselected patients with inflammatory/autoimmune disorders of the nervous system. By indirect immunofluorescence examination of samples from 1435 patients, we identified 7 cases (0.48%) with hGADAb. Although stiff-person plus syndrome was the commonest clinical accompaniment, most of the patients presented with a combination of different symptoms, including psychiatric disturbances and intestinal motility disorders. Diagnosis delay and chronic evolution were common findings. In two cases persistently high values of hGADAb over the years were observed. The rarity and the phenotype heterogeneity of hGADAb clinical association should not discourage clinicians from antibody screening, at least in selected cases, as an early immunotherapy can change the otherwise chronic progression of this complex disorder spectrum.
MeSH term(s)	Adult ; Aged ; Autoantibodies/blood ; Autoimmune Diseases of the Nervous System/epidemiology ; Autoimmune Diseases of the Nervous System/immunology ; Autoimmune Diseases of the Nervous System/pathology ; Female ; Follow-Up Studies ; Glutamate Decarboxylase/immunology ; Humans ; Immunophenotyping ; Incidence ; Inflammation/epidemiology ; Inflammation/immunology ; Inflammation/pathology ; Male ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Stiff-Person Syndrome/epidemiology ; Stiff-Person Syndrome/immunology ; Stiff-Person Syndrome/pathology ; Young Adult
Chemical Substances	Autoantibodies ; Glutamate Decarboxylase (EC 4.1.1.15)
Language	English
Publishing date	2010-10-08
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2010.07.011
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Article ; Online: Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis.

De Stefano, Nicola / Stromillo, Maria Laura / Giorgio, Antonio / Bartolozzi, Maria Letizia / Battaglini, Marco / Baldini, Mariella / Portaccio, Emilio / Amato, Maria Pia / Sormani, Maria Pia

Journal of neurology, neurosurgery, and psychiatry

2016 Volume 87, Issue 1, Page(s) 93–99

Abstract: Objective: To assess whether it is feasible to establish specific cut-off values able to discriminate 'physiological' or 'pathological' brain volume rates in patients with multiple sclerosis (MS).: Methods: The study was based on the analysis of ... ...

Abstract	Objective: To assess whether it is feasible to establish specific cut-off values able to discriminate 'physiological' or 'pathological' brain volume rates in patients with multiple sclerosis (MS). Methods: The study was based on the analysis of longitudinal MRI data sets of patients with MS (n=206, 87% relapsing-remitting, 7% secondary progressive and 6% primary progressive) and healthy controls (HC; n=35). Brain atrophy rates were computed over a mean follow-up of 7.5 years (range 1-12) for patients with MS and 6.3 years (range 1-12.5) for HC with the SIENA software and expressed as annualised per cent brain volume change (PBVC/y). A weighted (on the follow-up length) receiver operating characteristic analysis and the area under the curve (AUC) were used for statistics. Results: The weighted PBVC/y was -0.51±0.27% in patients with MS and -0.27±0.15% in HC (p<0.0001). There was a significant age-related difference in PBVC/y between HC older and younger than 35 years of age (p=0.02), but not in patients with MS (p=0.8). The cut-off of PBVC/y, as measured by SIENA that could maximise the accuracy in discriminating patients with MS from HC, was -0.37%, with 67% sensitivity and 80% specificity. According to the observed distribution, values of PBVC/y as measured by SIENA that could define a pathological range were above -0.52% with 95% specificity, above -0.46% with 90% specificity and above -0.40% with 80% specificity. Conclusions: Our evidence-based criteria provide values able to discriminate the presence or absence of 'pathological' brain volume loss in MS with high specificity. Such results could be of great value in a clinical setting, particularly in assessing treatment efficacy in MS.
MeSH term(s)	Adult ; Age Factors ; Area Under Curve ; Atrophy ; Brain/pathology ; Disease Progression ; Evidence-Based Medicine ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/pathology ; Multiple Sclerosis/therapy ; ROC Curve ; Reference Standards ; Reproducibility of Results ; Young Adult
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2014-309903
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Article ; Online: Age-related burden and characteristics of embolic stroke of undetermined source in the real world clinical practice.

Grifoni, Elisa / Giglio, Davide / Guazzini, Giulia / Cosentino, Eleonora / Latini, Ester / Dei, Alessandro / Del Rosso, Attilio / Guarnaccia, Vincenzo / Baldini, Mariella / Bartolozzi, Maria Letizia / Martinucci, Pietro / Sani, Francesca / Giordano, Antonio / Dainelli, Francesca / Maggi, Francesca / Giulietti, Chiara / Romagnoli, Mario / Cinotti, Stefano / Schipani, Elena /

Murgida, Giuseppe Salvatore / Di Martino, Stefania / Cozzi, Andrea / Carli Ballola, Adele / Dacomo, Debora / Valori, Debora / Masotti, Luca

Journal of thrombosis and thrombolysis

2019 Volume 49, Issue 1, Page(s) 75–85

Abstract: Few data are available on age-related burden and characteristics of embolic stroke of undetermined source (ESUS) in the real world clinical practice. The aim of our study was to provide information about it. We retrospectively analyzed data of patients ... ...

Abstract	Few data are available on age-related burden and characteristics of embolic stroke of undetermined source (ESUS) in the real world clinical practice. The aim of our study was to provide information about it. We retrospectively analyzed data of patients consecutively admitted to our Stroke Unit along 1 year (2017, November 1st-2018, October 31st). The etiology of ischemic stroke was defined at hospital discharge; ESUS was considered as a subset of cryptogenic stroke, and defined according to the 2014 international criteria. In the analyzed period, 306 patients, 52.3% females, mean age ± SD 77.9 ± 11.9 years, were discharged with diagnosis of ischemic stroke. Ischemic strokes of cardioembolic and lacunar origin were the most frequent subtypes: 30.1% and 29.4%, respectively. Cardioembolic strokes were particularly frequent in patients ≥ 75 years, and almost always associated with atrial fibrillation. Overall, in 80 patients (26.1%) the etiology of stroke was undetermined; in 25 (8.2%) it remained undefined because of death or severe comorbidity, making further diagnostic work-up not worthy. Cryptogenic stroke occurred in 55 patients (18%), and ESUS criteria were satisfied in 39 of them (12.7%). According to age, cryptogenic stroke was diagnosed in 21.1% (21.1% ESUS) of patients < 65 years, 24.2% (19.4% ESUS) of patients aged 65-74 years, 15.5% (9.2% ESUS) of patients ≥ 75 years. After diagnostic work-up, patent foramen ovale was most commonly associated with ESUS (17.9%), especially in patients < 65 years (62.5%); covert paroxysmal atrial fibrillation was detected in 10.5% of ESUS patients ≥ 75 years. In the real world clinical practice, the frequency of ischemic strokes of undetermined etiology, and of those satisfying ESUS criteria, is not negligible, especially in younger patients. A thorough diagnostic work-up, with an age-specific approach, is therefore necessary and of the utmost importance for the identification of stroke etiology, in order to optimize secondary stroke prevention strategies.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Brain Ischemia/diagnosis ; Brain Ischemia/epidemiology ; Brain Ischemia/etiology ; Female ; Follow-Up Studies ; Foramen Ovale ; Humans ; Intracranial Embolism/diagnosis ; Intracranial Embolism/epidemiology ; Intracranial Embolism/etiology ; Male ; Middle Aged ; Retrospective Studies ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology
Language	English
Publishing date	2019-09-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-019-01951-5
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Article ; Online: Relevance of hypointense brain MRI lesions for long-term worsening of clinical disability in relapsing multiple sclerosis.

Giorgio, Antonio / Stromillo, Maria Laura / Bartolozzi, Maria Letizia / Rossi, Francesca / Battaglini, Marco / De Leucio, Alessandro / Guidi, Leonello / Maritato, Patrizia / Portaccio, Emilio / Sormani, Maria Pia / Amato, Maria Pia / De Stefano, Nicola

Multiple sclerosis (Houndmills, Basingstoke, England)

2014 Volume 20, Issue 2, Page(s) 214–219

Abstract: Background: The accrual of brain focal pathology is considered a good substrate of disability in relapsing-remitting multiple sclerosis (RRMS). However, knowledge on long-term lesion evolution and its relationship with disability progression is poor.: ...

Abstract	Background: The accrual of brain focal pathology is considered a good substrate of disability in relapsing-remitting multiple sclerosis (RRMS). However, knowledge on long-term lesion evolution and its relationship with disability progression is poor. Objective: The objective of this paper is to evaluate in RRMS the long-term clinical relevance of brain lesion evolution. Methods: In 58 RRMS patients we acquired, using the same scanner and protocol, brain magnetic resonance imaging (MRI) at baseline and 10±0.5 years later. MRI data were correlated with disability changes as measured by the Expanded Disability Status Scale (EDSS). Results: The annualized 10-year lesion volume (LV) growth was +0.25±0.5 cm(3) (+6.7±8.7%) for T2-weighted (T2-W) lesions and +0.20±0.31 cm(3) (+11.5±12.3%) for T1-weighted (T1-W) lesions. The univariate analysis showed moderate correlations between baseline MRI measures and EDSS at 10 years (p < 0.001). Also, 10-year EDSS worsening correlated with LV growth and the number of new/enlarging lesions measured over the same period (p < 0.005). In the stepwise multiple regression analysis, EDSS worsening over 10 years was best correlated with the combination of baseline T1-W lesion count and increasing T1-W LV (R = 0.61, p < 0.001). Conclusion: In RRMS patients, long-term brain lesion accrual is associated with worsening in clinical disability. This is particularly true for hypointense, destructive lesions.
MeSH term(s)	Adult ; Brain/pathology ; Disability Evaluation ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Multiple Sclerosis, Relapsing-Remitting/complications ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Time Factors
Language	English
Publishing date	2014-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/1352458513494490
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