LIVIVO - Search results -

Search results

Result 1 - 10 of total 261

Search options

Book ; Conference proceedings: Proceedings of the 10th International Symposium on Long Term Clinical Trials

Barton, Bruce

Oxford, UK, September 2005

(Clinical trials ; 3,6)

2006

Title variant	Proceedings of the 10th International Symposium on Long-Term Clinical Trials
Event/congress	International Symposium on Long Term Clinical Trials (10, 2005, Oxford)
Author's details	guest ed.: Bruce Barton
Series title	Clinical trials ; 3,6
Collection
Language	English
Size	S. 495 - 553 : graph. Darst.
Publisher	Arnold
Publishing place	London
Publishing country	Great Britain
Document type	Book ; Conference proceedings
HBZ-ID	HT014953188
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 5831 -3-	not available for loan	Zeitschriften-Lesesaal

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Rapid brain MRI protocols result in comparable differential diagnoses versus a full brain protocol in most canine and feline cases

Johnson, Kelsey A. / Sutherland‐Smith, James / Oura, Trisha J. / Sato, Amy F. / Barton, Bruce

Veterinary Radiology & Ultrasound. 2023 Jan., v. 64, no. 1 p.86-94

2023

Abstract: Evaluation of brain disease in veterinary patients uses a wide variety of MRI sequences. A shortened protocol that maintains consistency of interpretation would reduce radiologist reporting time, patient anesthetic time, and client cost. The aims of this ...

Abstract	Evaluation of brain disease in veterinary patients uses a wide variety of MRI sequences. A shortened protocol that maintains consistency of interpretation would reduce radiologist reporting time, patient anesthetic time, and client cost. The aims of this retrospective, methods comparison, observer agreement study were to evaluate whether abbreviated MRI protocols alter differential diagnoses and recommendations compared to our institution's standard protocol; evaluate interobserver agreement on standard brain MRIs; and assess whether differential diagnoses change after postcontrast images. Normal and pathologic canine and feline brain MRIs were retrieved from hospital archives. Three protocols were created from each: a 5‐sequence noncontrast enhanced Fast Brain Protocol 1 (FBP1); a 6‐sequence contrast‐enhanced Fast Brain Protocol 2 (FBP2); and an 11‐sequence standard brain protocol (SBP). Three blinded veterinary radiologists interpreted FBP images for 98 cases (1 reader/case) and SBP images for 20 cases (3 readers/case). A fourth observer compared these interpretations to the original MRI reports (OMR). Overall agreement between FBPs and OMR was good (k = 0.75) and comparable to interobserver agreement for multiple reviews of SBP cases. Postcontrast images substantially altered conclusions in 17/97 cases (17.5%), as well as improved interobserver agreement compared to noncontrast studies. The conclusions reached with shortened brain protocols were comparable to those of a full brain study. The findings supported the use of a 6‐sequence brain MRI protocol (sagittal T2‐weighted [T2w] TSE; transverse T2w turbo spin echo fluid‐attenuated inversion recovery, T2*‐weighted gradient recalled echo, T1‐weighted spin echo, and diffusion weighted imaging/apparent diffusion coefficient; and postcontrast transverse T1‐weighted spin echo) for dogs and cats with suspected intracranial disease.
Keywords	anesthetics ; brain ; cats ; diffusivity ; dogs ; hospitals ; patients ; radiology ; ultrasonics
Language	English
Dates of publication	2023-01
Size	p. 86-94.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.13134
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Adjustment for Renal Function Improves the Prognostic Performance of Urinary Thromboxane Metabolites.

Barton, Bruce A / Kronsberg, Shari S / Hariri, Essa / Vasan, Ramachandran S / Rade, Grace A / Xanthakis, Vanessa / Kickler, Thomas S / Rade, Jeffrey J

Clinical chemistry

2024 Volume 70, Issue 4, Page(s) 660–668

Abstract: Background: Systemic thromboxane A2 generation, assessed by quantifying the concentration of stable thromboxane B2 metabolites (TXB2-M) in the urine adjusted for urinary creatinine, is strongly associated with mortality risk. We sought to define optimal ...

Abstract	Background: Systemic thromboxane A2 generation, assessed by quantifying the concentration of stable thromboxane B2 metabolites (TXB2-M) in the urine adjusted for urinary creatinine, is strongly associated with mortality risk. We sought to define optimal TXB2-M cutpoints for aspirin users and nonusers and determine if adjusting TXB2-M for estimated glomerular filtration rate (eGFR) in addition to urinary creatinine improved mortality risk assessment. Methods: Urinary TXB2-M were measured by competitive ELISA in 1363 aspirin users and 1681 nonusers participating in the Framingham Heart Study. Cutpoints were determined for TXB2-M and TXB2-M/eGFR using log-rank statistics and used to assess mortality risk by Cox proportional hazard modeling and restricted mean survival time. Multivariable models were compared using the Akaike Information Criterion (AIC). A cohort of 105 aspirin users with heart failure was used for external validation. Results: Optimized cutpoints of TXB2-M were 1291 and 5609 pg/mg creatinine and of TXB2-M/eGFR were 16.6 and 62.1 filtered prostanoid units (defined as pg·min/creatinine·mL·1.73 m2), for aspirin users and nonusers, respectively. TXB2-M/eGFR cutpoints provided more robust all-cause mortality risk discrimination than TXB2-M cutpoints, with a larger unadjusted hazard ratio (2.88 vs 2.16, AIC P < 0.0001) and greater differences in restricted mean survival time between exposure groups (1.46 vs 1.10 years), findings that were confirmed in the external validation cohort of aspirin users. TXB2-M/eGFR cutpoints also provided better cardiovascular/stroke mortality risk discrimination than TXB2-M cutpoints (unadjusted hazard ratio 3.31 vs 2.13, AIC P < 0.0001). Conclusion: Adjustment for eGFR strengthens the association of urinary TXB2-M with long-term mortality risk irrespective of aspirin use.
MeSH term(s)	Humans ; Thromboxanes ; Prognosis ; Creatinine/urine ; Aspirin/therapeutic use ; Thromboxane B2/metabolism ; Kidney/metabolism
Chemical Substances	Thromboxanes ; Creatinine (AYI8EX34EU) ; Aspirin (R16CO5Y76E) ; Thromboxane B2 (54397-85-2)
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvae015
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prospective study of thyroid function in the first year of life in infants with Down syndrome.

Feldman, Penny M / Rodriguez, Nicolas / Morrison, Emily / Barton, Bruce / Lee, Mary M

European journal of pediatrics

2023 Volume 182, Issue 6, Page(s) 2903–2911

Abstract: Current American Academy of Pediatrics (AAP) Guidelines recommend monitoring thyroid function in infants with Down syndrome (DS) at birth, 6 and 12 months, and annually thereafter. This study aimed to determine whether these guidelines are optimal for ... ...

Abstract	Current American Academy of Pediatrics (AAP) Guidelines recommend monitoring thyroid function in infants with Down syndrome (DS) at birth, 6 and 12 months, and annually thereafter. This study aimed to determine whether these guidelines are optimal for early diagnosis and treatment of (subclinical) hypothyroidism. Enrolled infants with DS less than age 7 months, born at ≥ 30 weeks gestation to monitor thyroid function test (TFT). A filter paper (FP) blood sample was analyzed for TSH and total T4 at ages 2 and 4 weeks and monthly thereafter until 12 months. Subjects with abnormal FP sample and confirmatory serum TFT for hypothyroidism promptly started treatment. Subjects with thyroid dysfunction identified had thyroid antibodies measured at diagnosis and 12 months. Descriptive statistics determined average time to diagnosis of abnormal TFT. Sixteen (30%) of 54 subjects were diagnosed with a thyroid disorder, the majority with subclinical hypothyroidism (SH) and 1 with hyperthyroidism. Diagnosis occurred in 6 (11%), 9 (17%), and 12 (22.2%) infants in the first 30, 60, and 90 days of life (DOL), respectively. Eight infants had an abnormal NBS and half were diagnosed with a thyroid disorder by DOL 8 and the remainder prior to 4 months. Among subjects with a normal NBS, four were diagnosed at a mean of 104 days and three at a mean of 101 days prior to the 6-month and 12-month routine screens, respectively. Conclusion: Based on current AAP guidelines, thyroid disorder diagnosis would have been delayed in nearly 20% of the subjects. An additional TFT screen at 1 and 3 months can lead to earlier diagnosis and treatment. What is Known: • Current American Academy of Pediatrics (AAP) Guidelines recommend thyroid function tests (TFT) in infants with Down syndrome (DS) at birth and 6 and 12 months. • Peer- reviewed retrospective studies report an increased incidence of hypothyroidism in infants with DS undetected by the newborn screen (NBS) and prior to 6 months. What is New: • This prospective study monitored TFT in infants with DS at age 2 weeks and monthly throughout the first year of life. • The findings in this study support additional TFT screens at 1 and 3 months in infants with DS.
MeSH term(s)	Infant, Newborn ; Infant ; Humans ; Child ; Down Syndrome/complications ; Down Syndrome/diagnosis ; Prospective Studies ; Retrospective Studies ; Hypothyroidism/complications ; Hypothyroidism/diagnosis ; Thyroid Diseases/complications ; Thyroid Diseases/diagnosis ; Thyroid Function Tests ; Thyrotropin ; Thyroxine ; Congenital Hypothyroidism/diagnosis
Chemical Substances	Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2023-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-023-04954-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Um IV Zs.75: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A liposomal bupivacaine infiltrative block reduces rescue analgesia administration compared to a bupivacaine splash block after canine ovariohysterectomy in a teaching laboratory.

Wheeler, Emily P / Abelson, Amanda L / Paul, April L / Barton, Bruce A / McCobb, Emily C

Journal of the American Veterinary Medical Association

2023 Volume 261, Issue 11, Page(s) 1673–1682

Abstract: Objective: This study aimed to determine whether an infiltrative block with liposomal bupivacaine was associated with less rescue analgesia administration and lower pain scores than a bupivacaine splash block after ovariohysterectomy in dogs.: Animals! ...

Abstract	Objective: This study aimed to determine whether an infiltrative block with liposomal bupivacaine was associated with less rescue analgesia administration and lower pain scores than a bupivacaine splash block after ovariohysterectomy in dogs. Animals: Eligible dogs included those that were spayed as part of a veterinary teaching laboratory. Dogs were up to 7 years old and otherwise healthy. A total of 136 dogs were analyzed. Methods: All dogs underwent ovariohysterectomy performed by veterinary students. Dogs received hydromorphone and acepromazine premedication, propofol induction, isoflurane maintenance, and an NSAID. Dogs were randomly allocated to receive either a splash block with standard bupivacaine or an infiltrative block with liposomal bupivacaine for incisional analgesia. Postoperatively, all dogs were assessed by a blinded evaluator using the Colorado State University-Canine Acute Pain Scale (CSU-CAPS) and Glasgow Composite Measures Pain Scale-Short Form (GCPS-SF). Dogs received rescue analgesia with buprenorphine if they scored ≥ 2 on the CSU-CAPS scale. Results: Dogs that received liposomal bupivacaine had a significantly lower incidence of (P = .04) and longer time to (P = .03) administration of rescue analgesia. There was an overall time-averaged significant difference between groups for CSU-CAPS (P = .049) and GCPS-SF scores (P = .015), with dogs in the bupivacaine group being more likely to have an elevated pain score at some point for both scales. Clinical relevance: The use of liposomal bupivacaine in an infiltrative block may decrease the need for rescue analgesia in dogs undergoing ovariohysterectomy compared to a bupivacaine splash block.
MeSH term(s)	Animals ; Dogs ; Female ; Analgesia/veterinary ; Anesthetics, Local/therapeutic use ; Bupivacaine/therapeutic use ; Dog Diseases/drug therapy ; Dog Diseases/prevention & control ; Hysterectomy/veterinary ; Ovariectomy/veterinary ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Pain, Postoperative/veterinary ; Random Allocation
Chemical Substances	Anesthetics, Local ; Bupivacaine (Y8335394RO)
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.23.01.0057
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 423: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Rapid brain MRI protocols result in comparable differential diagnoses versus a full brain protocol in most canine and feline cases.

Johnson, Kelsey A / Sutherland-Smith, James / Oura, Trisha J / Sato, Amy F / Barton, Bruce

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

2022 Volume 64, Issue 1, Page(s) 86–94

Abstract	Evaluation of brain disease in veterinary patients uses a wide variety of MRI sequences. A shortened protocol that maintains consistency of interpretation would reduce radiologist reporting time, patient anesthetic time, and client cost. The aims of this retrospective, methods comparison, observer agreement study were to evaluate whether abbreviated MRI protocols alter differential diagnoses and recommendations compared to our institution's standard protocol; evaluate interobserver agreement on standard brain MRIs; and assess whether differential diagnoses change after postcontrast images. Normal and pathologic canine and feline brain MRIs were retrieved from hospital archives. Three protocols were created from each: a 5-sequence noncontrast enhanced Fast Brain Protocol 1 (FBP1); a 6-sequence contrast-enhanced Fast Brain Protocol 2 (FBP2); and an 11-sequence standard brain protocol (SBP). Three blinded veterinary radiologists interpreted FBP images for 98 cases (1 reader/case) and SBP images for 20 cases (3 readers/case). A fourth observer compared these interpretations to the original MRI reports (OMR). Overall agreement between FBPs and OMR was good (k = 0.75) and comparable to interobserver agreement for multiple reviews of SBP cases. Postcontrast images substantially altered conclusions in 17/97 cases (17.5%), as well as improved interobserver agreement compared to noncontrast studies. The conclusions reached with shortened brain protocols were comparable to those of a full brain study. The findings supported the use of a 6-sequence brain MRI protocol (sagittal T2-weighted [T2w] TSE; transverse T2w turbo spin echo fluid-attenuated inversion recovery, T2*-weighted gradient recalled echo, T1-weighted spin echo, and diffusion weighted imaging/apparent diffusion coefficient; and postcontrast transverse T1-weighted spin echo) for dogs and cats with suspected intracranial disease.
MeSH term(s)	Animals ; Cats ; Dogs ; Brain/diagnostic imaging ; Brain/pathology ; Cat Diseases/diagnostic imaging ; Cat Diseases/pathology ; Diagnosis, Differential ; Dog Diseases/diagnostic imaging ; Dog Diseases/pathology ; Magnetic Resonance Imaging/standards ; Magnetic Resonance Imaging/veterinary ; Retrospective Studies
Language	English
Publishing date	2022-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.13134
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Intravenous and intraosseous regional limb perfusion of ceftiofur sodium in an avian model.

Knafo, Sophie Emmanuelle / Graham, Jennifer E / Barton, Bruce A

American journal of veterinary research

2019 Volume 80, Issue 6, Page(s) 539–546

Abstract: Objective: To assess whether IV regional limb perfusion (IVRLP) and intraosseous regional limb perfusion (IORLP) of ceftiofur sodium resulted in clinically relevant drug concentrations in the synovial fluid of the tibiotarsal-tarsometatarsal joint of ... ...

Abstract	Objective: To assess whether IV regional limb perfusion (IVRLP) and intraosseous regional limb perfusion (IORLP) of ceftiofur sodium resulted in clinically relevant drug concentrations in the synovial fluid of the tibiotarsal-tarsometatarsal joint of chickens (ie, an avian model) and to determine whether one of those techniques was superior to the other. Animals: 12 healthy adult hens. Procedures: Birds were randomly assigned to receive ceftiofur sodium (2 mg/kg) by the IVRLP (n = 4), IORLP (4), or IM (control; 4) route once daily for 6 consecutive days. Blood and tibiotarsal-tarsometatarsal synovial fluid samples were collected 15 minutes after ceftiofur administration on predetermined days for quantification of ceftiofur concentration. Plasma and synovial fluid ceftiofur concentrations were compared among the 3 groups. Results: All 4 birds in the IVRLP group developed mild to moderate bruising around the injection site, but this bruising did not prohibit completion of the prescribed treatment regimen. No adverse effects were observed in any of the other birds. The mean plasma and synovial fluid ceftiofur concentrations exceeded the therapeutic threshold for most common bacterial pathogens (> 1.0 μg/mL) at all sample acquisition times for all 3 groups. The mean synovial fluid ceftiofur concentration for the IVRLP group was significantly greater than that for the IORLP and control groups at all sample acquisition times. Conclusions and clinical relevance: Results suggested that IVRLP may be a safe and effective technique for antimicrobial administration to birds with joint infections, contaminated wounds, pododermatitis, and other musculoskeletal infections of the distal aspect of a limb.
MeSH term(s)	Administration, Intravenous/veterinary ; Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Cephalosporins/administration & dosage ; Cephalosporins/pharmacokinetics ; Chickens/metabolism ; Female ; Forelimb ; Perfusion/veterinary ; Random Allocation ; Synovial Fluid/metabolism
Chemical Substances	Anti-Bacterial Agents ; Cephalosporins ; ceftiofur (83JL932I1C)
Language	English
Publishing date	2019-06-13
Publishing country	United States
Document type	Clinical Trial, Veterinary ; Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.80.6.539
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 422: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive heart failure secondary to myxomatous mitral valve disease

Yang, Vicky K. / Meola, Dawn M. / Davis, Airiel / Barton, Bruce / Hoffman, Andrew M.

American journal of veterinary research. 2021 June, v. 82, no. 6

2021

Abstract: OBJECTIVE To evaluate whether mesenchymal stem cells (MSCs) can be safely administered IV to dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) to improve cardiac function and prolong survival time. ANIMALS 10 ... ...

Abstract	OBJECTIVE To evaluate whether mesenchymal stem cells (MSCs) can be safely administered IV to dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) to improve cardiac function and prolong survival time. ANIMALS 10 client-owned dogs with CHF secondary to MMVD. PROCEDURES Dogs with an initial episode of CHF secondary to MMVD were enrolled in a double-blind, placebo-controlled clinical trial. Five dogs in the MSC group received allogeneic Wharton jelly-derived MSCs (2 × 106 cells/kg, IV), and 5 dogs in the placebo group received a 1% solution of autologous serum (IV) for 3 injections 3 weeks apart. Cell-release criteria included trilineage differentiation, expression of CD44 and CD90 and not CD34 and major histocompatability complex class II, normal karyotype, and absence of contamination by pathogenic microorganisms. Patients were followed for 6 months or until death or euthanasia. Echocardiographic data, ECG findings, serum cardiac biomarker concentrations, CBC, and serum biochemical analysis results were obtained prior to and 4 hours after the first injection and every 3 months after the final injection. RESULTS Lymphocyte and eosinophil counts decreased significantly 4 hours after injection, and monocytes decreased significantly only in dogs that received an MSC injection. No significant differences were seen in the echocardiographic variables, ECG results, serum cardiac biomarker concentrations, survival time, and time to first diuretic drug dosage escalation between the 2 groups. CONCLUSIONS AND CLINICAL RELEVANCE This study showed that MSCs can be easily collected from canine Wharton jelly as an allogeneic source of MSCs and can be safely delivered IV to dogs with CHF secondary to MMVD.
Keywords	biomarkers ; blood serum ; cardiac output ; clinical trials ; death ; dogs ; drugs ; echocardiography ; euthanasia ; heart failure ; intravenous injection ; karyotyping ; mesenchymal stromal cells ; monocytes ; placebos ; veterinary medicine
Language	English
Dates of publication	2021-06
Size	p. 487-493.
Publishing place	American Veterinary Medical Association
Document type	Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.82.6.487
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3312: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Evaluation of the clinical presentation and histologic lesions of hepatic copper accumulation in sugar gliders (Petaurus breviceps)

Yuschenkoff, Daniela / Graham, Jennifer / Barton, Bruce A. / Garner, Michael M.

Journal of exotic pet medicine. 2021 Oct., v. 39

2021

Abstract: Hepatic toxicosis caused by copper accumulation has been reported in most domestic species, as well as multiple small exotic mammals, including ferrets, fruit bats, and sugar gliders. The purpose of this study was to determine the signalments, clinical ... ...

Abstract	Hepatic toxicosis caused by copper accumulation has been reported in most domestic species, as well as multiple small exotic mammals, including ferrets, fruit bats, and sugar gliders. The purpose of this study was to determine the signalments, clinical presentations, and histologic findings associated with hepatic copper accumulation in sugar gliders based on post-mortem histologic findings and retrospective analysis of reported antemortem clinical signs. Sugar gliders with histologic evidence of various hepatopathies were identified within the Northwest ZooPath archive. Sections of formalin-fixed, paraffin-embedded hepatic samples were stained for copper, and copper deposition was graded semiquantitatively. The prevalence of copper accumulation in the evaluated hepatopathies was 28%. Copper deposition was seen in all individuals with icterus and non-ataxia neurologic signs. Grossly, individuals with hepatic masses and nodules were 5.50 times more likely to have hepatic copper accumulation. Sugar gliders with biliary hyperplasia were 16.20 times more likely to have copper accumulation while all individuals with cholestasis had hepatic copper accumulation. The results of this study indicate that hepatic copper accumulation is frequently identified in post-mortem evaluation of sugar gliders with hepatopathy. Copper accumulation is frequently noted in individuals with icterus, neurologic abnormalities, hepatic masses, biliary hyperplasia, and cholestasis. This study details the prevalence of hepatic copper accumulation in sugar gliders and illustrates associations between copper hepatotoxicosis and other hepatic diseases.
Keywords	Petaurus breviceps ; cholestasis ; copper ; fruits ; histology ; hyperplasia ; medicine ; poisoning ; retrospective studies ; sugars
Language	English
Dates of publication	2021-10
Size	p. 51-56.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2228614-7
ISSN	1557-5063
ISSN	1557-5063
DOI	10.1053/j.jepm.2021.06.007
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Stress in fishes: a diversity of responses with particular reference to changes in circulating corticosteroids.

Barton, Bruce A

Integrative and comparative biology

2011 Volume 42, Issue 3, Page(s) 517–525

Abstract: Physical, chemical and perceived stressors can all evoke non-specific responses in fish, which are considered adaptive to enable the fish to cope with the disturbance and maintain its homeostatic state. If the stressor is overly severe or long-lasting to ...

Abstract	Physical, chemical and perceived stressors can all evoke non-specific responses in fish, which are considered adaptive to enable the fish to cope with the disturbance and maintain its homeostatic state. If the stressor is overly severe or long-lasting to the point that the fish is not capable of regaining homeostasis, then the responses themselves may become maladaptive and threaten the fish's health and well-being. Physiological responses to stress are grouped as primary, which include endocrine changes such as in measurable levels of circulating catecholamines and corticosteroids, and secondary, which include changes in features related to metabolism, hydromineral balance, and cardiovascular, respiratory and immune functions. In some instances, the endocrine responses are directly responsible for these secondary responses resulting in changes in concentration of blood constituents, including metabolites and major ions, and, at the cellular level, the expression of heat-shock or stress proteins. Tertiary or whole-animal changes in performance, such as in growth, disease resistance and behavior, can result from the primary and secondary responses and possibly affect survivorship.Fishes display a wide variation in their physiological responses to stress, which is clearly evident in the plasma corticosteroid changes, chiefly cortisol in actinopterygian fishes, that occur following a stressful event. The characteristic elevation in circulating cortisol during the first hour after an acute disturbance can vary by more than two orders of magnitude among species and genetic history appears to account for much of this interspecific variation. An appreciation of the factors that affect the magnitude, duration and recovery of cortisol and other physiological changes caused by stress in fishes is important for proper interpretation of experimental data and design of effective biological monitoring programs.
Language	English
Publishing date	2011-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	201481-6
ISSN	1540-7063 ; 0003-1569
ISSN	1540-7063 ; 0003-1569
DOI	10.1093/icb/42.3.517
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 672: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito