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  1. Article: What do mathematics lessons look like? Analyses of primary students' drawings.

    Rott, Benjamin / Barton, Laura / Hatisaru, Vesife

    Frontiers in psychology

    2023  Volume 14, Page(s) 1019299

    Abstract: The use of student drawings to assess their experiences and beliefs about teaching and learning of mathematics has become almost a regular research method - especially when working with young students who may not express themselves well, for example, in ... ...

    Abstract The use of student drawings to assess their experiences and beliefs about teaching and learning of mathematics has become almost a regular research method - especially when working with young students who may not express themselves well, for example, in self-report questionnaires. These methods, nevertheless, need to be improved regarding their objectivity and validity. By building on the existing research, in this study, we focus on objectivity and validity issues in drawing-based methods. We use a drawing-based instrument:
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1019299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Locally advanced mismatch repair-deficient gastroesophageal junction cancer: Diagnosis, treatment modifications, and monitoring.

    Mehta, Rutika / Sinnamon, Andrew / Dam, Aamir / Walko, Christine / Palm, Russell / Barton, Laura / Lauwers, Gregory / Pimiento, Jose M

    CA: a cancer journal for clinicians

    2023  Volume 74, Issue 2, Page(s) 123–131

    MeSH term(s) Humans ; DNA Mismatch Repair/genetics ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/therapy ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/therapy ; Esophagogastric Junction
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603553-x
    ISSN 1542-4863 ; 0007-9235
    ISSN (online) 1542-4863
    ISSN 0007-9235
    DOI 10.3322/caac.21813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Interpretation of ambiguous TP53 test results: Mosaicism, clonal hematopoiesis, and variants of uncertain significance.

    Berry, Darcy K / Gillis, Nancy / Padron, Eric / Moore, Colin / Barton, Laura V / Gewandter, Kathleen R / Haskins, Carolyn G / Knepper, Todd C

    Journal of genetic counseling

    2023  

    Abstract: The increased use of next-generation sequencing has led to the detection of pathogenic TP53 variants in the germline setting in patients without a personal or family history consistent with Li-Fraumeni syndrome (LFS). These variants can represent low- ... ...

    Abstract The increased use of next-generation sequencing has led to the detection of pathogenic TP53 variants in the germline setting in patients without a personal or family history consistent with Li-Fraumeni syndrome (LFS). These variants can represent low-penetrance LFS, mosaic LFS, or clonal hematopoiesis of indeterminate potential. Additionally, TP53 variants of uncertain significance can be detected in patients with a history suspicious for LFS. The interpretation of the significance of these variants can be challenging but is crucial for an accurate diagnosis and appropriate medical management. This retrospective case review provides illustrative examples of the interpretation of challenging TP53 results through multidisciplinary expertise and use of a flowchart. The authors describe eight patients with TP53 variants associated with ambiguous diagnoses and, for each case, describe how the results were interpreted and the medical care that was implemented. This report presents illustrative cases to help guide clinicians to reach definitive diagnoses for patients when confronted with TP53 variants that are inconsistent with the clinical picture and to add to the body of literature regarding interpretation and medical management of TP53 variants discovered on germline testing.
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1117799-8
    ISSN 1573-3599 ; 1059-7700
    ISSN (online) 1573-3599
    ISSN 1059-7700
    DOI 10.1002/jgc4.1789
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: Genetic testing for breast cancer varies across UK.

    Barton, Laura

    The Lancet. Oncology

    2001  Volume 7, Issue 2, Page(s) 113

    MeSH term(s) Breast Neoplasms/genetics ; Delivery of Health Care ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Testing ; Humans ; Time Factors ; United Kingdom
    Language English
    Publishing date 2001-11-15
    Publishing country England
    Document type News
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/s1470-2045(06)70568-x
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    Zs.A 5696: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  5. Article ; Online: Survey-based personas for a target-group-specific consideration of elderly end users of information and communication systems in the German health-care sector.

    Schäfer, Katharina / Rasche, Peter / Bröhl, Christina / Theis, Sabine / Barton, Laura / Brandl, Christopher / Wille, Matthias / Nitsch, Verena / Mertens, Alexander

    International journal of medical informatics

    2019  Volume 132, Page(s) 103924

    Abstract: Background: In many countries, including Germany, older people are increasing in numbers, while fewer caregivers are available. A way to address the problem is to develop new medical assistance and monitoring systems that are operated by the elderly on ... ...

    Abstract Background: In many countries, including Germany, older people are increasing in numbers, while fewer caregivers are available. A way to address the problem is to develop new medical assistance and monitoring systems that are operated by the elderly on their own, e.g. in-home aftercare systems.
    Objective: The development of a set of eight data-based personas in terms of a best practice approach is presented.
    Method: "Personas" are an integral method of the user-centered design approach. They address the problem of incomplete knowledge of individual user behaviour by introducing archetypal user groups. Thus, personas can be used at an early stage of development to raise the awareness of developers to the needs, skills, and abilities of the elderly. Personas are also a cost-effective method and quickly and easily accessible. In order to guarantee representativeness the development of personas needs to occur based on a robust data set of a certain user group.
    Results: This article presents the data-driven development of eight personas. The applied data set results from a nationwide questionnaire study on the elderly's use of information and communication technology, out of elderly people in Germany. The results will be presented in terms of best practice.
    Conclusion: To conclude, survey-based personas of older end users can play an important role in the research and development of innovative devices.
    Application: The personas presented in this paper can be used in research and development to raise awareness of the needs and demands of end users.
    MeSH term(s) Aged ; Databases, Factual ; Female ; Germany ; Health Care Sector/organization & administration ; Health Communication ; Humans ; Information Dissemination/methods ; Male ; Patient-Centered Care/standards ; Research Design ; Surveys and Questionnaires ; User-Computer Interface
    Language English
    Publishing date 2019-08-11
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1466296-6
    ISSN 1872-8243 ; 1386-5056
    ISSN (online) 1872-8243
    ISSN 1386-5056
    DOI 10.1016/j.ijmedinf.2019.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: "I think that a brief conversation from their provider can go a very long way": Patient and provider perspectives on barriers and facilitators of genetic testing after ovarian cancer.

    Mallen, Adrianne R / Conley, Claire C / Fuzzell, Lindsay / Ketcher, Dana / Augusto, Bianca M / McIntyre, McKenzie / Barton, Laura V / Townsend, Mary K / Fridley, Brooke L / Tworoger, Shelley S / Wenham, Robert M / Vadaparampil, Susan T

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2020  Volume 29, Issue 5, Page(s) 2663–2677

    Abstract: Objective: Identify predisposing, enabling, and reinforcing factors impacting genetic counseling/testing among ovarian cancer patients guided by Green and Kreuter's PRECEDE-PROCEED model.: Methods: Gynecologic oncology providers (N = 4), genetic ... ...

    Abstract Objective: Identify predisposing, enabling, and reinforcing factors impacting genetic counseling/testing among ovarian cancer patients guided by Green and Kreuter's PRECEDE-PROCEED model.
    Methods: Gynecologic oncology providers (N = 4), genetic counselors (N = 4), and ovarian cancer patients (N = 9) completed semi-structured qualitative interviews exploring participants' knowledge of and experiences with genetic counseling/testing. Interviews were audio recorded, transcribed verbatim, and analyzed using inductive content analysis by two independent raters.
    Results: Thematic analysis identified predisposing, enabling, and reinforcing factors impacting referral for and uptake of genetic counseling/testing. Predisposing factors included participant's knowledge, beliefs, and attitudes related to genetic counseling/testing. Both patients and providers also cited that insurance coverage and out-of-pocket cost are major concerns for ovarian cancer patients considering genetic testing. Finally, both patients and providers emphasized that genetic counseling/testing would provide additional information to an ovarian cancer patient. While providers emphasized that genetic testing results were useful for informing a patient's personal treatment plan, patients emphasized that this knowledge would be beneficial for their family members.
    Conclusion: Barriers to genetic testing for ovarian cancer patients exist at multiple levels, including the patient (e.g., knowledge, attitudes), the provider (e.g., workload, availability of services), the institution (e.g., difficulty with referrals/scheduling), and the healthcare system (e.g., insurance/cost). Interventions aiming to increase genetic testing among ovarian cancer patients will likely need to target multiple levels of influence. Future quantitative studies are needed to replicate these results. This line of work will inform specific multilevel intervention strategies that are adaptable to different practice settings, ultimately improving guideline concordant care.
    MeSH term(s) Female ; Genetic Counseling/methods ; Genetic Testing/methods ; Humans ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Physician-Patient Relations
    Language English
    Publishing date 2020-09-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-020-05779-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3697: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Individuals with Smith-Magenis syndrome display profound neurodevelopmental behavioral deficiencies and exhibit food-related behaviors equivalent to Prader-Willi syndrome.

    Alaimo, Joseph T / Barton, Laura V / Mullegama, Sureni V / Wills, Rachel D / Foster, Rebecca H / Elsea, Sarah H

    Research in developmental disabilities

    2015  Volume 47, Page(s) 27–38

    Abstract: Smith-Magenis syndrome (SMS) is a neurodevelopmental disorder associated with intellectual disability, sleep disturbances, early onset obesity and vast behavioral deficits. We used the Behavior Problems Inventory-01 to categorize the frequency and ... ...

    Abstract Smith-Magenis syndrome (SMS) is a neurodevelopmental disorder associated with intellectual disability, sleep disturbances, early onset obesity and vast behavioral deficits. We used the Behavior Problems Inventory-01 to categorize the frequency and severity of behavioral abnormalities in a SMS cohort relative to individuals with intellectual disability of heterogeneous etiology. Self-injurious, stereotyped, and aggressive/destructive behavioral scores indicated that both frequency and severity were significantly higher among individuals with SMS relative to those with intellectual disability. Next, we categorized food behaviors in our SMS cohort across age using the Food Related Problems Questionnaire (FRPQ) and found that problems began to occur in SMS children as early as 5-11 years old, but children 12-18 years old and adults manifested the most severe problems. Furthermore, we evaluated the similarities of SMS adult food-related behaviors to those with intellectual disability and found that SMS adults had more severe behavioral problems. Many neurodevelopmental disorders exhibit syndromic obesity including SMS. Prader-Willi syndrome (PWS) is the most frequent neurodevelopmental disorder with syndromic obesity and has a well-established management and treatment plan. Using the FRPQ we found that SMS adults had similar scores relative to PWS adults. Both syndromes manifest weight gain early in development, and the FRPQ scores highlight specific areas in which behavioral similarities exist, including preoccupation with food, impaired satiety, and negative behavioral responses. SMS food-related behavior treatment paradigms are not as refined as PWS, suggesting that current PWS treatments for prevention of obesity may be beneficial for individuals with SMS.
    MeSH term(s) Adolescent ; Adult ; Aggression/psychology ; Case-Control Studies ; Child ; Child, Preschool ; Cohort Studies ; Feeding Behavior/psychology ; Female ; Humans ; Hyperphagia/etiology ; Hyperphagia/physiopathology ; Hyperphagia/psychology ; Intellectual Disability/etiology ; Intellectual Disability/physiopathology ; Intellectual Disability/psychology ; Male ; Middle Aged ; Obesity/etiology ; Overweight/etiology ; Prader-Willi Syndrome/psychology ; Problem Behavior/psychology ; Self-Injurious Behavior/etiology ; Self-Injurious Behavior/physiopathology ; Self-Injurious Behavior/psychology ; Severity of Illness Index ; Smith-Magenis Syndrome/complications ; Smith-Magenis Syndrome/physiopathology ; Smith-Magenis Syndrome/psychology ; Stereotyped Behavior ; Young Adult
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639175-8
    ISSN 1873-3379 ; 0891-4222
    ISSN (online) 1873-3379
    ISSN 0891-4222
    DOI 10.1016/j.ridd.2015.08.011
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    Zs.B 2592: Show issues Location:
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