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  1. Article: Effect of air filtration on house dust mite, cat and dog allergens and particulate matter in homes.

    Maya-Manzano, José María / Pusch, Gudrun / Ebner von Eschenbach, Cordula / Bartusel, Elke / Belzner, Thomas / Karg, Erwin / Bardolatzy, Ulrich / Scheja, Michael / Schmidt-Weber, Carsten / Buters, Jeroen

    Clinical and translational allergy

    2022  Volume 12, Issue 4, Page(s) e12137

    Abstract: Background: Indoor allergens (i.e. from mite, cat and dog) are carried by airborne particulate matter. Thus, removal of particles would reduce allergen exposure. This work aims to assess the performance of air filtration on particulate matter and thus ... ...

    Abstract Background: Indoor allergens (i.e. from mite, cat and dog) are carried by airborne particulate matter. Thus, removal of particles would reduce allergen exposure. This work aims to assess the performance of air filtration on particulate matter and thus allergen removal in 22 bedrooms.
    Methods: Indoor air was sampled (with and without air filtration) with a cascade impactor and allergens were measured using enzyme-linked immunosorbent assay (ELISA). Particulate matter (including ultrafine particles) was also monitored.
    Results: The median of allergen reduction was 75.2% for Der f 1 (
    Conclusions: Air filtration was effective in removing mites, cat and dog allergens and also particulate matter from ambient indoor air, offering a fast and simple solution to mitigate allergen exposome.
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Artemisia pollen is the main vector for airborne endotoxin.

    Oteros, Jose / Bartusel, Elke / Alessandrini, Francesca / Núñez, Andrés / Moreno, Diego A / Behrendt, Heidrun / Schmidt-Weber, Carsten / Traidl-Hoffmann, Claudia / Buters, Jeroen

    The Journal of allergy and clinical immunology

    2018  Volume 143, Issue 1, Page(s) 369–377.e5

    Abstract: Background: Endotoxin (LPS) released from gram-negative bacteria causes strong immunologic and inflammatory effects and, when airborne, can contribute to respiratory conditions, such as allergic asthma.: Objectives: We sought to identify the source ... ...

    Abstract Background: Endotoxin (LPS) released from gram-negative bacteria causes strong immunologic and inflammatory effects and, when airborne, can contribute to respiratory conditions, such as allergic asthma.
    Objectives: We sought to identify the source of airborne endotoxin and the effect of this endotoxin on allergic sensitization.
    Methods: We determined LPS levels in outdoor air on a daily basis for 4 consecutive years in Munich (Germany) and Davos (Switzerland). Air was sampled as particulate matter (PM) greater than 10 μm (PM > 10) and PM between 2.5 and 10 μm. LPS levels were determined by using the recombinant Factor C assay.
    Results: More than 60% of the annual endotoxin exposure was detected in the PM > 10 fraction, showing that bacteria do not aerosolize as independent units or aggregates but adhered to large particles. In Munich 70% of annual exposure was detected between June 12th and August 28th. Multivariate modeling showed that endotoxin levels could be explained by phenological parameters (ie, plant growth). Indeed, days with high airborne endotoxin levels correlated well with the amount of Artemisia pollen in the air. Pollen collected from plants across Europe (100 locations) showed that the highest levels of endotoxin were detected on Artemisia vulgaris (mugwort) pollen, with little on other pollen. Microbiome analysis showed that LPS concentrations on mugwort pollen were related to the presence of Pseudomonas species and Pantoea species communities. In a mouse model of allergic disease, the presence of LPS on mugwort pollen was needed for allergic sensitization.
    Conclusions: The majority of airborne endotoxin stems from bacteria dispersed with pollen of only one plant: mugwort. This LPS was essential for inducing inflammation of the lung and allergic sensitization.
    MeSH term(s) Air Pollution, Indoor/analysis ; Animals ; Artemisia/chemistry ; Artemisia/immunology ; Artemisia/microbiology ; Asthma/immunology ; Asthma/microbiology ; Germany ; Humans ; Lipopolysaccharides/chemistry ; Lipopolysaccharides/immunology ; Mice, Inbred BALB C ; Pantoea/immunology ; Particulate Matter/chemistry ; Particulate Matter/immunology ; Pollen/chemistry ; Pollen/immunology ; Pollen/microbiology ; Pseudomonas/immunology
    Chemical Substances Lipopolysaccharides ; Particulate Matter
    Language English
    Publishing date 2018-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.05.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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