Article ; Online: Garcinolic Acid Distinguishes Between GACKIX Domains and Modulates Interaction Networks.
Chembiochem : a European journal of chemical biology
2023 Volume 24, Issue 21, Page(s) e202300439
Abstract: Natural products are often uniquely suited to modulate protein-protein interactions (PPIs) due to their architectural and functional group complexity relative to synthetic molecules. Here we demonstrate that the natural product garcinolic acid ... ...
| Abstract | Natural products are often uniquely suited to modulate protein-protein interactions (PPIs) due to their architectural and functional group complexity relative to synthetic molecules. Here we demonstrate that the natural product garcinolic acid allosterically blocks the CBP/p300 KIX PPI network and displays excellent selectivity over related GACKIX motifs. It does so via a strong interaction (K |
|---|---|
| MeSH term(s) | Protein Structure, Tertiary ; Protein Domains ; Binding Sites ; Protein Binding ; CREB-Binding Protein/chemistry |
| Chemical Substances | CREB-Binding Protein (EC 2.3.1.48) |
| Language | English |
| Publishing date | 2023-09-07 |
| Publishing country | Germany |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2020469-3 |
| ISSN | 1439-7633 ; 1439-4227 |
| ISSN (online) | 1439-7633 |
| ISSN | 1439-4227 |
| DOI | 10.1002/cbic.202300439 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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