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Article ; Online: Evaluation of the effect of sodium-glucose cotransporter-2 inhibitor treatment on choroidal vascular parameters in patients with type 2 diabetes mellitus.

Bolac, Ruveyde / Bas, Suleyman / Ozkan, Esma Merve Arda / Balci, Sevcan / Alpogan, Oksan

2023 Volume 44, Page(s) 103804

Abstract: Background: To evaluate the effect of sodium-glucose cotransporter-2 inhibitor treatment on choroidal vascular parameters in patients with type 2 diabetes mellitus (T2DM).: Methods: Twenty eyes of 20 patients with T2DM without diabetic retinopathy ... ...

Abstract	Background: To evaluate the effect of sodium-glucose cotransporter-2 inhibitor treatment on choroidal vascular parameters in patients with type 2 diabetes mellitus (T2DM). Methods: Twenty eyes of 20 patients with T2DM without diabetic retinopathy and 20 eyes of 20 age- and sex-matched patients as the control group were included in the study. The patients were evaluated using enhanced depth imaging optic coherence tomography before treatment and at the third month of treatment. The choroidal images were binarized into luminal areas (LAs) and stromal areas (SAs). The choroidal vascularity index (CVI) was defined as the ratio of the LA to the total circumscribed choroid area (TCA). Results: The mean age of the patients was 56.65±8.41 years. The patients' mean disease duration was 6.65±5.72 years, the mean HbA1c level was 8.89±1.62%, and the mean body mass index was 33.13±4.84 kg/m Conclusions: Empagliflozin provides an improvement in diabetic choroidal changes through its effect on choroidal vascularity parameters.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Diabetes Mellitus, Type 2/drug therapy ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Tomography, Optical Coherence/methods ; Photochemotherapy/methods ; Photosensitizing Agents ; Choroid/blood supply ; Glucose ; Sodium ; Retrospective Studies
Chemical Substances	empagliflozin (HDC1R2M35U) ; Sodium-Glucose Transporter 2 Inhibitors ; Photosensitizing Agents ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-09-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2023.103804
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Article ; Online: Comparison of muscle and fat parameters measured by ultrasonography and dual-energy x-ray absorptiometry between older palliative care patients with and without type 2 diabetes mellitus.

Catikkas, Nezahat Muge / Safer, Vildan Binay / Bas, Suleyman / Gunay, Deniz Sevindik / Durak, Ayfer / Utku, Irem Kirac / Safer, Umut

Journal of clinical ultrasound : JCU

2024

Abstract: Background and aims: There are limited data on the comparison of body compositions between diabetic and non-diabetic patients. We aimed to compare the muscle mass and fat parameters measured by ultrasonography (USG) and dual-energy x-ray absorptiometry ( ...

Abstract	Background and aims: There are limited data on the comparison of body compositions between diabetic and non-diabetic patients. We aimed to compare the muscle mass and fat parameters measured by ultrasonography (USG) and dual-energy x-ray absorptiometry (DXA) between older palliative care patients with and without type 2 diabetes mellitus (DM). Methods: We conducted a prospective, cross-sectional study. We recorded the demographics, comorbidities, blood pressures, microvascular complications, pressure injuries, ambulation and nutritional status, and laboratory parameters. We measured the handgrip strength with a hand dynamometer and anthropometric parameters. We analyzed the subcutaneous fat thickness, muscle thickness (MT), and cross-sectional area (CSA) of the rectus femoris (RF) and biceps brachii muscles by USG and the total and regional muscle mass and fat parameters by DXA. We performed a regression analysis to examine the independently associated factors of DM. Results: We included 55 patients (mean age: 79.0 ± 8.0 years, 56.4%: female). 43.6% had type 2 DM. The patients with DM had significantly higher glucose and HbA1c levels and lower RFMT and RFCSA values than the patients without DM (p < 0.01, for all). The RFMT was independently associated with DM after adjusting age, sex, and body mass index (Odds ratio = 0.735, 95% confidence interval = 0.565-0.956, p = 0.022). Conclusion: Our study demonstrated that the RFMT might be associated with type 2 DM. This was the first study comparing the body compositions measured by USG and DXA between older diabetic and non-diabetic palliative patients with a wide range of laboratory evaluations. Longitudinal, multi-center studies are warranted to understand the underlying mechanisms.
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23688
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Article ; Online: Efficacy of Agmatine Treatment in Experimental Acute Pancreatitis Rat Model.

Yeniçeri, Murat / Tanoğlu, Alpaslan / Salmanoğlu, Musa / Çırak, Zafer / Can Şenoymak, Mustafa / Baş, Süleyman / Sade Gökçen, Ayşe

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2024 Volume 35, Issue 1, Page(s) 27–31

Abstract: Background/aims: Acute pancreatitis which is characterized by pancreatic inflammation can sometimes be difficult to treat because of limited therapeutic options. The purpose of the study was to assess the effects of agmatine in the acute pancreatitis ... ...

Abstract	Background/aims: Acute pancreatitis which is characterized by pancreatic inflammation can sometimes be difficult to treat because of limited therapeutic options. The purpose of the study was to assess the effects of agmatine in the acute pancreatitis experimental rat model. Materials and methods: An acute pancreatitis model was created with the administration of cerulein in 40 female Sprague-Dawley rats. Agmatine was administered as a protective agent at 5 mg/kg (low dose) and 10 mg/kg (high dose). The rats were divided into 5 groups, each with 8 rats: group 1 (acute pancreatitis); group 2 (acute pancreatitis+low-dose agmatine 5 mg/kg); group 3 (acute pancreatitis+high-dose agmatine 10 mg/kg); group 4 (placebo, acute pancreatitis+saline); and group 5 (sham and saline infusion). All rats were sacrificed 24 hours after the last injection, and the levels of superoxide dismutase, interleukin-1 beta, and tumor necrosis factor-alpha were assessed in blood samples collected via cardiac puncture. Histopathological examination was performed by a pathologist, who was blind to the groups, according to the Schoenberg's pancreatitis scoring index. Results: The amylase (16.67 and 37.89 U/L), glutathione peroxidase (13.62 and 18.44 ng/mL), tumor necrosis factor-α (39.68 and 64 ng/mL), interleukin-1 (484.73 and 561.83 pg/mL), and transforming growth factor-β (110.52 and 126.34 ng/L) levels were significantly lower and superoxide dismutase (1.29 and 0.98 ng/L) and malondialdehyde (0.99 and 0.96 nmol/mL) levels were significantly higher in group 3 compared to group 1 (P < .05). Moreover glutathione peroxidase, tumor necrosis factor-α, and transforming growth factor-β levels were lower, and malondialdehyde levels were higher in the group 3 compared to group 2 (P < .05). Although the Schoenberg's pancreatitis scoring index was not significantly different between the high- and low-dose treatment groups, rats who received high-dose treatment had significantly lower scores compared to those with acute pancreatitis group. Conclusion: This is the first study that evaluated the efficacy of agmatine in an experimental model of acute pancreatitis. Agmatine, an anti-inflammatory and antioxidant agent, had a protective effect in an experimental rat model of acute pancreatitis.
MeSH term(s)	Rats ; Female ; Animals ; Pancreatitis/chemically induced ; Pancreatitis/drug therapy ; Rats, Sprague-Dawley ; Agmatine/pharmacology ; Agmatine/therapeutic use ; Tumor Necrosis Factor-alpha ; Acute Disease ; Glutathione Peroxidase/therapeutic use ; Superoxide Dismutase ; Malondialdehyde ; Transforming Growth Factors/therapeutic use ; Pancreas/pathology ; Ceruletide/therapeutic use
Chemical Substances	Agmatine (70J407ZL5Q) ; Tumor Necrosis Factor-alpha ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1) ; Malondialdehyde (4Y8F71G49Q) ; Transforming Growth Factors (76057-06-2) ; Ceruletide (888Y08971B)
Language	English
Publishing date	2024-03-07
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2024.23017
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Article ; Online: Ultrasonographically Measured Rectus Femoris Cross-sectional Area might Predict Osteosarcopenia.

Binay Safer, Vildan / Catikkas, Nezahat Muge / Bas, Suleyman / Sevindik Gunay, Deniz / Durak, Ayfer / Utku, Irem Kirac / Safer, Umut

Current medical imaging

2024

Abstract: Aim: We have aimed to investigate the role of ultrasonographic muscle parameters (UMP) in predicting osteosarcopenia in bedridden patients in a palliative care center.: Background: The role of ultrasound has not been evaluated in predicting ... ...

Abstract	Aim: We have aimed to investigate the role of ultrasonographic muscle parameters (UMP) in predicting osteosarcopenia in bedridden patients in a palliative care center. Background: The role of ultrasound has not been evaluated in predicting osteosarcopenia. Objective: Reduced muscle thickness (MT) and cross-sectional area (CSA) have often been observed in individuals with sarcopenia, reflecting muscle loss and atrophy. Meanwhile, the potential role of muscle ultrasound has not been evaluated in predicting osteosarcopenia. Methods: We have conducted a prospective, observational study between January 2021 and 2022. We have recorded the demographics, comorbidities, and nutritional status by using the mini nutritional assessment-short form. We measured handgrip strength with a hand dynamometer and the muscle mass with dual X-ray absorptiometry. Sarcopenia was defined by the European Working Group on Sarcopenia in Older People 2 criteria. Osteoporosis was diagnosed according to the World Health Organization criteria. We have categorized the body phenotypes into four groups: "non-sarcopenic non-osteoporotic," "sarcopenic alone," "osteoporotic alone," and "sarcopenic osteoporotic." We have measured the subcutaneous fat thickness (SFT), MT, and CSA of the rectus femoris (RF) and biceps brachii (BB) via ultrasonography. A multivariate regression analysis was performed and area under curve (AUC) values were used to evaluate the accuracy of UMPs. Results: We included 31 patients (mean age: 74.6±12.1 years, 54.8%: male). The prevalences of sarcopenia, osteoporosis, and sarcopenic osteoporosis were 71%, 48.4%, and 41.9%, respectively. Only the "sarcopenic osteoporotic" phenotype was negatively correlated with all UMPs. In the regression analysis, only the "sarcopenic osteoporotic" phenotype was independently associated with RFCSA (ß=-0.456, p= 0.024). The AUC for all patients was >0.700. Conclusion: RFCSA measurement might be useful in the screening for osteosarcopenia. This has been the first study investigating the relationship between UMPs and body phenotypes. Multi-center and large-scale studies are, however, needed.
Language	English
Publishing date	2024-03-19
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1573-4056
ISSN (online)	1573-4056
DOI	10.2174/0115734056275133231211115630
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Article ; Online: Role of testosterone to estradiol ratio in predicting the efficacy of recombinant human chorionic gonadotropin and testosterone treatment in male hypogonadism.

Çelik, Mehmet / Özçelik, Serhat / Baş, Süleyman / Sariaydin, Mehmet / Özçelik, Melike / Gozu, Hulya

Archives of endocrinology and metabolism

2021 Volume 65, Issue 5, Page(s) 617–624

Abstract: Objective: We aimed to investigate the role of testosterone to estradiol ratio in predicting the effectiveness of human chorionic gonadotropin and testosterone treatments in male hypogonadism.: Methods: Thirty-six male patients with hypogonadotropic ... ...

Abstract	Objective: We aimed to investigate the role of testosterone to estradiol ratio in predicting the effectiveness of human chorionic gonadotropin and testosterone treatments in male hypogonadism. Methods: Thirty-six male patients with hypogonadotropic hypogonadism were included in the study. Seventeen (47.2%) patients received weekly recombinant human choriogonadotropin alpha (hCG) treatment (group-1) and 19 (52.8%) received testosterone replacement therapy (T treatment) every 21 days (group-2). Under these treatments, adequate frequency of morning erection (≥3/week), testosterone to estradiol ratio (T/E), and testicular volume changes were analyzed. Results: The mean age of the patients was 28.5 ± 8.7 years. When the frequency of morning erection (≥3/week) was specified as adequate, the cut-off value for effective T/E ratio was found to be 12.0 (sensitivity 93.8%, specificity 90.0%). There was no significant difference between the treatment groups in terms of total testosterone levels, T/E ratio, or frequency of morning erections (≥3/week) (p > 0.05). However, there was a statistically significant difference between the groups in terms of median left-right testicular volume in favor of group-1 (p < 0,05). Conclusion: In patients with hypogonadism who are under treatment, elevated estradiol-induced erectile dysfunction symptoms may persist even if serum testosterone levels are normal. Testosterone to estradiol ratio can be used as a predictive value in the effective treatment of hypogonadotropic hypogonadism with hCG and T.
MeSH term(s)	Adult ; Chorionic Gonadotropin ; Estradiol ; Humans ; Hypogonadism/drug therapy ; Male ; Spermatogenesis ; Testosterone ; Young Adult
Chemical Substances	Chorionic Gonadotropin ; Testosterone (3XMK78S47O) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2021-09-29
Publishing country	Brazil
Document type	Journal Article
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-3997000000399
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Article: Evaluation of inflammatory parameters in patients who attempted suicide by taking drugs.

Akkus, Mustafa / Davarci, Pinar Zehra / Bas, Süleyman / Odluyurt, Hulya / Aydogan, Miray

Bratislavske lekarske listy

2021 Volume 123, Issue 6, Page(s) 435–439

Abstract: Objectives: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are markers reflecting the inflammation process that can be easily calculated in the hemogram examination. In this study, we aimed to ... ...

Abstract	Objectives: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are markers reflecting the inflammation process that can be easily calculated in the hemogram examination. In this study, we aimed to investigate the changes in NLR, PLR and MPV values in patients who attempted suicide by taking drugs. Methods: In total, 124 patients who were admitted to the emergency department after attempting suicide by taking drugs and who were followed up in the internal medicine department for observation purposes for 24-72 hours were included in the study. The study was retrospective and the data of the patients were recorded by scanning the hospital automation system. The NLR, PLR and MPV of the patients at the time of admission to the emergency department and at the time of discharge were evaluated and compared with each other. Results: The NLR and PLR values of the patients at admission were found to be significantly higher than those values at discharge. In our study, NLR and PLR values were found to be high during the period when patients attempted suicide. Conclusion: The high detection of these markers of inflammation suggests that it may be a marker predictive of suicide attempt by taking medication (Tab. 4, Ref. 28).
MeSH term(s)	Biomarkers ; Humans ; Inflammation ; Lymphocytes ; Mean Platelet Volume ; Neutrophils ; Platelet Count ; Retrospective Studies ; Suicide, Attempted
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-09-29
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	127421-1
ISSN	0006-9248
ISSN	0006-9248
DOI	10.4149/BLL_2022_067
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Zs.B 355: Show issues

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Article ; Online: Effects of tissue cytomegalovirus quantitative polymerase chain reaction in the management of ulcerative colitis flare-ups: Should we wave aside?

Kochan, Koray / Keskin, Elmas Biberci / Seven, Gulseren / Bas, Suleyman / Kiremitci, Sercan / Gecer, Melin / Senturk, Hakan

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

2021 Volume 22, Issue 4, Page(s) 297–304

Abstract: Background and study aims: The role of cytomegalovirus (CMV) infection for disease reactivation in ulcerative colitis (UC) patients remains controversial and diagnostic tests are yet to be standardized. We aimed to define the clinical relevance of CMV ... ...

Abstract	Background and study aims: The role of cytomegalovirus (CMV) infection for disease reactivation in ulcerative colitis (UC) patients remains controversial and diagnostic tests are yet to be standardized. We aimed to define the clinical relevance of CMV detection by mucosal polymerase chain reaction (PCR) in UC patients by comparing the clinical course of UC in CMV-treated and CMV-untreated groups in tissue CMV-PCR positive cases. Patients and methods: In this retrospective study, 141 patients diagnosed with moderate-to-severe UC admitted to our clinic with disease flare, colonic tissue CMV PCR was assessed. Results: The median age of the study population was 39 years, and 99 (70.2%) patients were male. Eighty-eight (62.4%) patients were CMV-PCR (+) and 53 (37.6%) were CMV PCR (-). The CMV-PCR (+) and CMV PCR (-) groups showed no significant difference concerning age, sex, disease duration, site of involvement and disease activity and administered treatments. The median tissue CMV-PCR was 41,098 IU/mL (IQR:2,344.25-136,192). Thirty-four of 88 CMV-PCR (+) patients received antiviral therapy. The tissue CMV-PCR level of patients who received antiviral therapy was 124,381 IU/mL (IQR: 19,309-412,335), and it was 6,292 IU/mL (IQR: 997-71,154) in patients who did not receive antiviral therapy; (p < 0.001). Sixteen (47.1%) of 34 patients who received antiviral therapy achieved remission. Two of the non-responders underwent colectomy (one because of dysplasia and one who did not respond subsequent biologic agent either). Remaing 16 achieved remission by escalating the immunsuppresive/biologic agent therapy. Conclusion: CMV infection is responsible for only a minority of cases of UC flares and all are steroid-resistant cases. Most of the patients non-responsive to antiviral treatment respond to increased anti-inflammatory treatment. Hesitancy in the decision of escalating immunsuppresive treatment rather than CMV disease may be responsible for worsening disease course and increased colectomy rate in a significant number of the patients who are tissue CMV-PCR (+).
MeSH term(s)	Adult ; Colitis, Ulcerative/drug therapy ; Cytomegalovirus/genetics ; Diagnostic Tests, Routine ; Humans ; Male ; Polymerase Chain Reaction ; Retrospective Studies
Language	English
Publishing date	2021-12-03
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2502114-X
ISSN	2090-2387 ; 1687-1979
ISSN (online)	2090-2387
ISSN	1687-1979
DOI	10.1016/j.ajg.2021.11.005
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Article ; Online: Evaluation of the effect of sodium-glucose cotransporter-2 inhibitor treatment on choroidal vascular parameters in patients with type 2 diabetes mellitus.

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Article ; Online: Comparison of muscle and fat parameters measured by ultrasonography and dual-energy x-ray absorptiometry between older palliative care patients with and without type 2 diabetes mellitus.

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Article ; Online: Efficacy of Agmatine Treatment in Experimental Acute Pancreatitis Rat Model.

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Article ; Online: Ultrasonographically Measured Rectus Femoris Cross-sectional Area might Predict Osteosarcopenia.

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Article ; Online: Role of testosterone to estradiol ratio in predicting the efficacy of recombinant human chorionic gonadotropin and testosterone treatment in male hypogonadism.

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Article: Evaluation of inflammatory parameters in patients who attempted suicide by taking drugs.

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Article ; Online: Effects of tissue cytomegalovirus quantitative polymerase chain reaction in the management of ulcerative colitis flare-ups: Should we wave aside?

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