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Article: A Case of Hypopharyngeal Cancer Associated With Fanconi Anemia: A Helical Tomotherapy Experience.

Kavak, Gizem / Basci, Semih / Türker Kekilli, Esra / Dal, Mehmet S / Karakaya, Ebru

2021 Volume 13, Issue 11, Page(s) e19386

Abstract: Fanconi anemia (FA) is a disease that could be accompanied by multiple abnormalities, such as growth retardation, bone marrow abnormalities, and cancer susceptibility. Among the FA patients, head and neck squamous cell cancer (HNSCC) is the most observed ...

Abstract	Fanconi anemia (FA) is a disease that could be accompanied by multiple abnormalities, such as growth retardation, bone marrow abnormalities, and cancer susceptibility. Among the FA patients, head and neck squamous cell cancer (HNSCC) is the most observed solid cancer. The life expectancy of patients with FA has increased with recent medical advances. Furthermore, HNSCC is diagnosed in 3% of FA patients, and half of these patients die because of their HNSCC. The median age of HNSCC patients with FA is 31, and according to the literature HNSCC incidence of FA, patients is more than 700-fold of the normal population. Here, we reported the treatment details and challenges we faced during hypopharyngeal cancer treatment in a FA patient.
Language	English
Publishing date	2021-11-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.19386
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Article ; Online: The effect of pre-conditioning immunoglobulin and absolute lymphocyte count on the outcomes of allogeneic hematopoietic cell transplantation.

Kaçmaz, Murat / Başci, Semih / Ilhan, Gül / Yiğenoğlu, Tuğçe Nur / Çakar, Merih Kızıl / Dal, Mehmet Sinan / Altuntaş, Fevzi

Transplant immunology

2022 Volume 76, Page(s) 101776

Abstract: Introduction: The prevention of mortality and morbidity related to the increasingly used allogeneic hematopoietic cell transplantation (allo-HCT), along with the effects of pre- and post-transplant immune status on transplant outcomes, have become the ... ...

Abstract	Introduction: The prevention of mortality and morbidity related to the increasingly used allogeneic hematopoietic cell transplantation (allo-HCT), along with the effects of pre- and post-transplant immune status on transplant outcomes, have become the focus of the studies conducted on this subject in recent years. In parallel, this study was designed to investigate the effects of pre-conditioning immunoglobulin (pre-conditioning-Ig) and pre-conditioning absolute lymphocyte count (pre-conditioning-ALC) levels on transplant outcomes. Methods: This study was designed as a retrospective, observational and cross-sectional study. The objective of the study is to investigate the effects of pre-conditioning-Ig and ALC levels primarily on the rate of patients with febrile neutropenia (FEN) and the duration of FEN and length of hospital stay (LoS), and secondarily on acute graft-versus-host disease (aGVHD), cytomegalovirus (CMV) viremia, and mortality in the acute leukemia patients who underwent allo-HCT. Results: A total of 104 acute leukemia patients, of whom 55 had acute lymphoblastic leukemia (ALL) and 49 had acute myeloid leukemia (AML), were included in the study. Compared to the AML group, the median pre-conditioning-IgG, IgA, and IgM levels were found to be significantly lower in the ALL group (11.3 vs. 6.6, p < 0.001; 1.8 vs. 0.9, p < 0.001; and 0.7 vs. 0.4, p < 0.001; respectively). But, there was no significant difference between the groups in pre-conditioning-Ig and ALC levels and transplant outcomes. However, subgroup analysis revealed that high pre-conditioning-ALC levels were significantly correlated with aGVHD levels (Odds Ratio: 1.02; p = 0.034) and low pre-conditioning-IgM levels were significantly correlated with increased mortality rate (Hazard Ratio: 0.08; p = 0.042) in AML patients. Conclusion: The significant difference determined between the ALL and AML groups in pre-conditioning-Ig levels was not reflected on the effects of pre-conditioning-Ig and ALC levels on transplant outcomes. However, we observed that pre-conditioning-IgM and ALC levels have an impact on transplant outcomes in AML patients.
MeSH term(s)	Humans ; Retrospective Studies ; Cross-Sectional Studies ; Treatment Outcome ; Hematopoietic Stem Cell Transplantation/adverse effects ; Leukemia, Myeloid, Acute/etiology ; Lymphocyte Count ; Graft vs Host Disease ; Acute Disease ; Cytomegalovirus Infections/etiology ; Transplantation Conditioning ; Immunoglobulin M
Chemical Substances	Immunoglobulin M
Language	English
Publishing date	2022-12-23
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2022.101776
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Zs.A 3784: Show issues

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Article ; Online: The outcome ofancy. COVID-19 in patients with hematological malign

Yigenoglu, Tugce N / Bascı, Semih / Dal, Mehmet S / Korkmaz, Serdal / Turgut, Burhan / Altuntas, Fevzi

Journal of medical virology

2020 Volume 93, Issue 3, Page(s) 1255

MeSH term(s)	COVID-19 ; Hematologic Neoplasms/complications ; Humans ; Retrospective Studies ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26607
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Zs.A 1320: Show issues

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Article ; Online: The effect of bulky mass on prognosis in diffuse large-B-cell lymphoma: still poor?

Başcı, Semih / Yiğenoğlu, Tuğçe Nur / Bakırtaş, Mehmet / Uncu Ulu, Bahar / Yaman, Samet / Dal, Mehmet Sinan / Kızıl Çakar, Merih / Altuntaş, Fevzi

Leukemia research

2021 Volume 102, Page(s) 106521

Abstract: The introduction of rituximab to the CHOP protocol has demonstrated an improvement in PFS and OS in DLBCL patients with both early and advanced stages. Most studies in the pre-rituximab period indicated that bulky disease has an unfavorable impact on ... ...

Abstract	The introduction of rituximab to the CHOP protocol has demonstrated an improvement in PFS and OS in DLBCL patients with both early and advanced stages. Most studies in the pre-rituximab period indicated that bulky disease has an unfavorable impact on clinical outcomes of DLBCL. The effect of bulky mass on the outcome of DLBCL patients undergoing R-CHOP therapy remained uncertain. One-hundred-twelve newly diagnosed DLBCL patients aged 18 and older were enrolled in the study. Patients were divided into groups-based presence of bulky disease. 56 patients with bulky disease and their age, gender, ECOG score, Ann Arbor stage, immunohistochemical origin, treatment, radiotherapy and comorbidity 1:1 matched 56 control patients with non-bulky disease included. Overall response rate at end of treatment was similar among groups (p = 0.1). Patients with bulky disease and non-bulky disease were comparable regarding overall survival (p = 0,9). All cohort investigated for predictors for survival, after multivariate analysis, ECOG score, Ann arbor stage, IPI score and LDH level were found significant. Here, we found no impact of bulky disease on remission and survival. We believe, with increasing available data, poor prognostic value of bulky disease will be weakening in the rituximab era.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; Cyclophosphamide ; Disease-Free Survival ; Doxorubicin ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Middle Aged ; Prednisone ; Prognosis ; Rituximab ; Treatment Outcome ; Vincristine
Chemical Substances	R-CHOP protocol ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2021.106521
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Zs.A 1321: Show issues

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Article ; Online: Single-Dose Rasburicase Might Be Adequate To Overcome Tumor Lysis Syndrome In Hematological Malignancies.

Yaman, Samet / Başcı, Semih / Turan, Gökhan / Ulu, Bahar Uncu / Yiğenoğlu, Tuğçe Nur / Dal, Mehmet Sinan / Kızıl Çakar, Merih / Altuntaş, Fevzi

Clinical lymphoma, myeloma & leukemia

2021 Volume 22, Issue 2, Page(s) e71–e76

Abstract: Introduction: Tumor lysis syndrome (TLS) is a commonly observed oncological emergency that requires prompt diagnosis and treatment. Rasburicase is a recombinant urate oxidase endorsed in TLS for the treatment of hyperuricemia. The effect of single-dose ... ...

Abstract	Introduction: Tumor lysis syndrome (TLS) is a commonly observed oncological emergency that requires prompt diagnosis and treatment. Rasburicase is a recombinant urate oxidase endorsed in TLS for the treatment of hyperuricemia. The effect of single-dose 7.5 mg rasburicase at longer follow-ups was not widely investigated. Patients and methods: Eighty-two patients included in the study with clinical TLS and laboratory TLS. The primary endpoint was the normalization of uric acid (<6mg/dL) within 24 hours of rasburicase administration, which was described as treatment success. The secondary endpoint was defined as having sustained response at the first week. The third endpoint was defined as the reaching the baseline renal function before TLS. Results: We found that the use of a 7.5 mg dose of rasburicase controlled uric acid in 74 of 82 (90,2%) patients at the 24th hour. In the first week, uric acid remained at normal levels in 69 of 82 (84,1%) patients. At 24 hours, the TLS risk group was the only predictor for failing uric acid normalization; at the end of the first week, no predictive factor was identified for failing uric acid normalization. Conclusion: Rasburicase at 7.5 mg dose is an important agent for controlling laboratory and clinical TLS at 24 hours and extending its effect to the first week.
MeSH term(s)	Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Humans ; Hyperuricemia/drug therapy ; Hyperuricemia/etiology ; Tumor Lysis Syndrome/diagnosis ; Tumor Lysis Syndrome/drug therapy ; Tumor Lysis Syndrome/etiology ; Urate Oxidase/therapeutic use
Chemical Substances	rasburicase (08GY9K1EUO) ; Urate Oxidase (EC 1.7.3.3)
Language	English
Publishing date	2021-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540992-X
ISSN	2152-2669 ; 2152-2650
ISSN (online)	2152-2669
ISSN	2152-2650
DOI	10.1016/j.clml.2021.08.009
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Zs.A 5903: Show issues

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Article ; Online: Could blood groups have prognostic significance on survival in patients with diffuse large B cell lymphoma?

Ulu, Bahar Uncu / Başcı, Semih / Bakırtaş, Mehmet / Yiğenoğlu, Tuğçe Nur / Batgi, Hikmetullah / Yıldız, Jale / Darçın, Tahir / Şahin, Derya / Baysal, Nuran Ahu / İskender, Dicle / Çakar, Merih Kızıl / Dal, Mehmet Sinan / Altuntaş, Fevzi

Leukemia research

2022 Volume 115, Page(s) 106810

Abstract: The prognostic importance of the ABO blood group in non-Hodgkin lymphoma is largely unknown. We aim to investigate the prognostic significance of blood groups on the survival in diffuse large B-cell lymphoma (DLBCL) patients. 412 people (206 DLBCL ... ...

Abstract	The prognostic importance of the ABO blood group in non-Hodgkin lymphoma is largely unknown. We aim to investigate the prognostic significance of blood groups on the survival in diffuse large B-cell lymphoma (DLBCL) patients. 412 people (206 DLBCL patients and 206 healthy donors) were included. The blood group types of patients treated at our center from 2009 to 2019 were analyzed retrospectively and compared to the results from healthy thrombocyte donors. The distribution of the ABO blood groups was as follows: blood type A (45.2%), B (9.7%), O (38.8%), and AB (6.3%). We found no statistically significant difference between patients and the control group in terms of ABO and Rhesus blood group distribution (p = 0.27 and p = 0.45, respectively). The median follow-up time was 18 months (0-116). In the Cox regression analysis ABO blood groups, and Rh group were not significant predictors of survival in patients with DLBCL, whereas ECOG score, IPI score, Ann-Arbor stage, and LDH level were found significant. Receiving R-CHOP as the first-line treatment was associated with better survival in the multivariate analysis. No statistically significant difference was found between the control and DLBCL patient groups regarding the distribution of ABO and Rh blood groups.
MeSH term(s)	ABO Blood-Group System/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse ; Multivariate Analysis ; Prognosis ; Retrospective Studies ; Rituximab/therapeutic use
Chemical Substances	ABO Blood-Group System ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2022.106810
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Article: Convalescent plasma therapy in patients with COVID-19.

Altuntas, Fevzi / Yigenoglu, Tugce Nur / Bascı, Semih / Dal, Mehmet Sinan / Korkmaz, Serdal / Turgut, Burhan / Erkurt, Mehmet Ali

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2020 Volume 60, Issue 1, Page(s) 103017

MeSH term(s)	COVID-19/therapy ; Coronavirus Infections ; Humans ; Immunization, Passive ; Plasma ; SARS-CoV-2
Language	English
Publishing date	2020-11-19
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2020.103017
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Article: The outcome of COVID-19 in patients with hematological malignancy

Yigenoglu, Tugce N / Basci, Semih / Dal, Mehmet S / Korkmaz, Serdal / Turgut, Burhan / Altuntas, Fevzi

J. med. virol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #871394
Database	COVID19

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Article: Does Total Body Irradiation Have a Favorable Impact on Thrombocyte Engraftment as per Neutrophil Engraftment in Allogeneic Stem Cell Transplantation?

Uncu Ulu, Bahar / Yiğenoğlu, Tuğçe Nur / Şahin, Derya / Başcı, Semih / İskender, Dicle / Adaş, Yasemin / Atasever Akkaş, Ebru / Hacıbekiroğlu, Tuba / Kızıl Çakar, Merih / Dal, Mehmet Sinan / Altuntaş, Fevzi

Cureus

2021 Volume 13, Issue 11, Page(s) e19462

Abstract: Introduction: In this study, we aim to analyze the effect of total body irradiation (TBI) on neutrophil and thrombocyte engraftment durations in acute leukemia (AL) patients who achieved allogeneic hematopoietic stem cell transplantation (Allo-SCT) at ... ...

Abstract	Introduction: In this study, we aim to analyze the effect of total body irradiation (TBI) on neutrophil and thrombocyte engraftment durations in acute leukemia (AL) patients who achieved allogeneic hematopoietic stem cell transplantation (Allo-SCT) at our center. Methods: The data of 193 acute leukemia patients who were performed Allo-SCT from matched-related donors were analyzed retrospectively. Results: Thrombocyte engraftment duration was statistically shorter (12 days) in acute lymphoblastic leukemia (ALL) patients who received TBI-based conditioning when compared to ALL patients who received non-TBI-based conditioning (14 days; p=0.037). On the other hand, no statistically significant difference was observed between acute leukemia patients who received TBI or non-TBI-based conditioning regarding neutrophil engraftment duration. Conclusion: We found that TBI had a favorable impact on thrombocyte engraftment (TE) rather than neutrophil engraftment (NE) in Allo-SCT in patients with acute leukemia. TBI might have an impact on the engraftment of thrombocytes as per than neutrophils may be attributed to immune mechanisms and microenvironment in the patient's bone marrow (BM).
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.19462
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Article: Does myeloma genetic have an effect on stem cell mobilization?

Başcı, Semih / Yiğenoğlu, Tuğçe Nur / Yaman, Samet / Bozan, Ersin / Ulu, Bahar Uncu / Bakırtaş, Mehmet / Kılınç, Ali / Özcan, Nurgül / Bahsi, Taha / Dal, Mehmet Sinan / Çakar, Merih Kızıl / Altuntaş, Fevzi

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2021 Volume 60, Issue 6, Page(s) 103249

Abstract: Background: Autologous stem cell transplantation (ASCT) after induction treatment is the standard of care. Our understanding of myeloma genetics has been very limited and its effect to stem cell mobilization is not widely investigated. We aimed to ... ...

Abstract	Background: Autologous stem cell transplantation (ASCT) after induction treatment is the standard of care. Our understanding of myeloma genetics has been very limited and its effect to stem cell mobilization is not widely investigated. We aimed to investigate the effect of genetic abnormalities on stem cell mobilization in myeloma. Methods: The data of 150 MM patients who underwent stem cell mobilization at our center between 2009-2020 were included and analyzed retrospectively. Pre-treatment bone marrow cytogenetics and fluorescence in situ hybridization tests were performed for each patient. Results: Groups were divided into two as patients with normal cytogenetic and abnormal cytogenetic. No difference observed between groups regarding age, gender and ECOG (p = 0.4; p = 0.2; p = 0.3). Groups were similar concerning myeloma characteristics, received treatment and treatment response. Median CD34+ cells/kg harvested was 444(2-11.29) in normal cytogenetic group whereas it was 4,8(2.4-8.6) in abnormal cytogenetic group(p = 0.2). Optimal CD34+ cells level achievement was 73 (67 %) in normal cytogenetic group while it was 25(71.4 %) in abnormal cytogenetic group(p = 0.6). Neutrophil and platelet engraftment durations were similar among cytogenetic groups (p = 0.7; p = 0.9). R-ISS based groups were also did not differ regarding harvested CD34+ cells and achievement optimal CD34 level (p = 0.79, p = 0.74). Engraftment durations for neutrophil and platelet were comparable between R-ISS based groups (p = 0.59, p = 0.65) CONCLUSIONS: Here we were not able to find any impact of genetic abnormalities on stem cell mobilization in myeloma patients. Expanded studies can aid to identify the effect of particular genetic anomalies on the stem cell mobilization.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Hematopoietic Stem Cell Mobilization/methods ; Humans ; Male ; Middle Aged ; Multiple Myeloma/mortality ; Multiple Myeloma/therapy ; Survival Analysis
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2021.103249
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