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  1. Article ; Online: Lipid clinical trials with special reference to Indian population.

    Basha, Aseem / Ramakrishnan, Sivasubramanian

    Indian heart journal

    2024  Volume 76 Suppl 1, Page(s) S130–S137

    Abstract: Indians have a pattern of atherogenic dyslipidaemia characterised by not so high LDL-C but elevated small, dense LDL-C, elevated triglyceride levels and low HDL-C levels. In addition, different lipid-lowering drugs exhibit pharmacokinetic variability in ... ...

    Abstract Indians have a pattern of atherogenic dyslipidaemia characterised by not so high LDL-C but elevated small, dense LDL-C, elevated triglyceride levels and low HDL-C levels. In addition, different lipid-lowering drugs exhibit pharmacokinetic variability in Indians, which may have implications on the optimum doses required to achieve the desired LDL-C levels. Currently the management of dyslipidaemia in Indians are based on the landmark trials, which largely included western population. This review focusses on major clinical trials of lipid lowering drugs with special reference to the Indian population.
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Cholesterol, LDL ; Hypolipidemic Agents/therapeutic use ; Atherosclerosis/drug therapy ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol, LDL ; Hypolipidemic Agents
    Language English
    Publishing date 2024-02-20
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2024.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 616: Show issues Location:
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  2. Article: Atypical Electrocardiogram in Acute Pericarditis: A Case Report.

    Basha, Aymen / Raikhel, Marina / Hussaini, Syed / Afrashteh, Parinaz

    Cureus

    2023  Volume 15, Issue 8, Page(s) e42888

    Abstract: Pericarditis is a disorder defined by inflammation of the pericardium, commonly presenting with chest pain, fever, and pericardial friction. Electrocardiography (EKG) is frequently utilized to diagnose pericarditis, as it frequently reveals particular ... ...

    Abstract Pericarditis is a disorder defined by inflammation of the pericardium, commonly presenting with chest pain, fever, and pericardial friction. Electrocardiography (EKG) is frequently utilized to diagnose pericarditis, as it frequently reveals particular changes like ST-segment elevations and PR-segment depressions. Nevertheless, there are cases where individuals show all symptoms of pericarditis yet present an atypical or irregular EKG. This case report intends to highlight the case of a patient who came to an outpatient medical facility with all the common symptoms of pericarditis yet presented an atypical electrocardiogram. Moreover, this report intends to look into the hypothesis that in patients showing symptoms of pericarditis but with an atypical EKG, we might be looking at an irregular or even non-specific variant of pericarditis. This highlights the value of an extensive diagnostic approach consisting of high-quality imaging studies, such as transthoracic echocardiography, as well as medical assessments if an EKG does not give definite proof of pericarditis.
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.42888
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  3. Article: Double Aortic Valve Sign in Aortic Dissection.

    Kapil, Anish / Basha, Aseem / Yadav, Satyavir

    The Journal of emergency medicine

    2022  Volume 62, Issue 3, Page(s) 397–398

    MeSH term(s) Aneurysm, Dissecting/diagnosis ; Aneurysm, Dissecting/diagnostic imaging ; Aortic Aneurysm/complications ; Aortic Aneurysm/diagnostic imaging ; Aortic Valve/diagnostic imaging ; Aortic Valve Insufficiency/diagnostic imaging ; Humans
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2021.10.035
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  4. Article ; Online: Fatty acid metabolism changes in association with neurobehavioral deficits in animal models of fetal alcohol spectrum disorders.

    Hwang, Hye Mee / Kawasawa, Yuka Imamura / Basha, Aiesha / Mohammad, Shahid / Ito, Mariko / Hashimoto-Torii, Kazue

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 736

    Abstract: Fetal alcohol spectrum disorders (FASD) show behavioral problems due to prenatal alcohol exposure (PAE). A previous study reports changes in gene expressions linked to fatty acid (FA) metabolism in the cerebral cortex of the PAE mouse model. We find an ... ...

    Abstract Fetal alcohol spectrum disorders (FASD) show behavioral problems due to prenatal alcohol exposure (PAE). A previous study reports changes in gene expressions linked to fatty acid (FA) metabolism in the cerebral cortex of the PAE mouse model. We find an increase of palmitic acid and arachidonic acid in phospholipid in the cerebral cortex of PAE at postnatal day 30. The increase of palmitic acid is consistent with increase of the producing enzyme, Fasn (fatty acid synthase). Decrease of 26:6 FA is also consistent with the increase of the enzyme which uses 26:6 as a substrate for making very long chain FAs, Elovl4 (elongation of very long chain fatty acids protein 4). However, there is no increase in the elongated products. Rather, lipid droplets (LDs) accumulated in the brain. Although FA-associated metabolic measurements are not affected by PAE, the abundance of FA-related gut microbiota is altered. This suggests that the gut microbiome could serve as a tool to facilitate uncovering the brain pathophysiology of FASD and a potential target to mitigate neurobehavioral problems.
    MeSH term(s) Humans ; Mice ; Animals ; Female ; Pregnancy ; Fetal Alcohol Spectrum Disorders/metabolism ; Prenatal Exposure Delayed Effects/metabolism ; Disease Models, Animal ; Palmitic Acids ; Fatty Acids
    Chemical Substances Palmitic Acids ; Fatty Acids
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05127-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ternary Mixture of Pentanamide in Solvent Analogy with Halogenated Phenol: Experimental, Theoretical, and

    Basha, A Aathif / Ali Khan, F Liakath / Kubaib, Attar / Imran, Predhanekar Mohamed / Nebbache, Nadia

    ACS omega

    2023  Volume 8, Issue 37, Page(s) 33928–33942

    Abstract: This research describes the preparation of mixtures of new halogen-substituted phenol derivatives and their effects due to linkages with a fatty amide (pentanamide). The molecules were optimized using DFT, and the vibrational and electronic analysis was ... ...

    Abstract This research describes the preparation of mixtures of new halogen-substituted phenol derivatives and their effects due to linkages with a fatty amide (pentanamide). The molecules were optimized using DFT, and the vibrational and electronic analysis was done subsequently. The energies of frontier molecular orbitals (FMOs) were used to estimate the global chemical reactivity parameters as we suggest that hydrogen-bonded networks may have contributed to the stability and reactivity of the compound. In addition to the experimental investigation, dielectric parameters were calculated. Fukui functions were analyzed to study the chemical reactivity. To get insight into interactions of σ → π* orbitals, natural bond orbital calculations were done. Additionally, surface analysis of the MEP and Hirshfeld charges were performed at the equivalent DFT levels. The research also indicated that both (interaction region indicator) IRI and (electron delocalize range) EDR would proficiently identify chemical-bonding and weak interaction regions, providing a significant advantage in exploring diverse chemical systems and reactions. This indicated that compounds could diffuse through noncovalent interactions, including intramolecular hydrogen bonding. Dielectric relaxation studies taken at five distinct molar ratios identified significant dielectric properties such as ε', ε″, ε
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c04710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Mean Inner Potential of Hematite α-Fe2O3 Across the Morin Transition.

    Auslender, Avi / Basha, Adham / Grave, Daniel A / Rothschild, Avner / Diéguez, Oswaldo / Kohn, Amit

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 3, Page(s) 919–930

    Abstract: We measure the mean inner potential (MIP) of hematite, α-Fe2O3, using electron holography and transmission electron microscopy. Since the MIP is sensitive to valence electrons, we propose its use as a chemical bonding parameter for solids. Hematite can ... ...

    Abstract We measure the mean inner potential (MIP) of hematite, α-Fe2O3, using electron holography and transmission electron microscopy. Since the MIP is sensitive to valence electrons, we propose its use as a chemical bonding parameter for solids. Hematite can test the sensitivity of the MIP as a bonding parameter because of the Morin magnetic phase transition. Across this transition temperature, no change in the corundum crystal structure can be distinguished, while a change in hybridized Fe-3d and O-2p states was reported, affecting ionic bonding. For a given crystallographic phase, the change in the MIP with temperature is expected to be minor due to thermal expansion. Indeed, we measure the temperature dependence in corundum α-Al2O3(112¯0) between 95 and 295 K showing a constant MIP value of ∼16.8 V within the measurement accuracy of 0.45 V. Thus, our objectives are as follows: measure the MIP of hematite as a function of temperature and examine the sensitivity of the MIP as a bonding parameter for crystals. Measured MIPs of α-Fe2O3(112¯0) above the Morin transition are equal, 17.85 ± 0.50 V, 17.93 ± 0.50 V, at 295 K, 230 K, respectively. Below the Morin transition, at 95 K, a significant reduction of ∼1.3 V is measured to 16.56 ± 0.46 V. We show that this reduction follows charge redistribution resulting in increased ionic bonding.
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad047
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  7. Article ; Online: Evaluating direct detection detectors for short-range order characterization of amorphous materials by electron scattering.

    Basha, Adham / Levi, George / Houben, Lothar / Amrani, Tamir / Goldfarb, Ilan / Kohn, Amit

    Ultramicroscopy

    2023  Volume 249, Page(s) 113737

    Abstract: The introduction of direct electron detectors (DEDs) to transmission electron microscopy has set off the 'resolution revolution', especially for cryoTEM low-dose imaging of soft matter. In comparison to traditional indirect electron detectors such as ... ...

    Abstract The introduction of direct electron detectors (DEDs) to transmission electron microscopy has set off the 'resolution revolution', especially for cryoTEM low-dose imaging of soft matter. In comparison to traditional indirect electron detectors such as Charged-Coupled Devices (CCD), DEDs show an improved modulation transfer function (MTF) and detective quantum efficiency (DQE) across all spatial frequencies, as well as faster frame rates which enable single electron counting. The benefits of such characteristics for imaging, spectroscopy and electron holography have been demonstrated previously. However, studies are lacking on the application of DEDs for localized characterization of short- to medium- range-order (SRO, MRO) in amorphous materials using electron scattering. Therefore, we evaluate the performance of a Monolithic Active Pixel Sensor DED for the characterization of SRO and MRO in nanoscale volumes of amorphous materials, using SiO
    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1479043-9
    ISSN 1879-2723 ; 0304-3991
    ISSN (online) 1879-2723
    ISSN 0304-3991
    DOI 10.1016/j.ultramic.2023.113737
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  8. Article ; Online: Non-Alcoholic Fatty Liver Disease: Translating Disease Mechanisms into Therapeutics Using Animal Models.

    Basha, Amina / May, Sarah C / Anderson, Ryan M / Samala, Niharika / Mirmira, Raghavendra G

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a range of pathologies arising from fat accumulation in the liver in the absence of excess alcohol use or other causes of liver disease. Its complications include cirrhosis and liver failure, hepatocellular ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is a range of pathologies arising from fat accumulation in the liver in the absence of excess alcohol use or other causes of liver disease. Its complications include cirrhosis and liver failure, hepatocellular carcinoma, and eventual death. NAFLD is the most common cause of liver disease globally and is estimated to affect nearly one-third of individuals in the United States. Despite knowledge that the incidence and prevalence of NAFLD are increasing, the pathophysiology of the disease and its progression to cirrhosis remain insufficiently understood. The molecular pathogenesis of NAFLD involves insulin resistance, inflammation, oxidative stress, and endoplasmic reticulum stress. Better insight into these molecular pathways would allow for therapies that target specific stages of NAFLD. Preclinical animal models have aided in defining these mechanisms and have served as platforms for screening and testing of potential therapeutic approaches. In this review, we will discuss the cellular and molecular mechanisms thought to contribute to NAFLD, with a focus on the role of animal models in elucidating these mechanisms and in developing therapies.
    MeSH term(s) Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Carcinoma, Hepatocellular/metabolism ; Liver Cirrhosis/metabolism ; Liver Neoplasms/metabolism ; Disease Models, Animal
    Language English
    Publishing date 2023-06-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129996
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  9. Article ; Online: Conundrum of aortic stenosis in a case of multivalvular rheumatic heart disease: perspicuity is in the details.

    Ahmed, Ahamed Shaheer / Kumar, Rahul / Basha, Aseem

    BMJ case reports

    2020  Volume 13, Issue 8

    Abstract: A 36-year-old woman presented with dyspnoea on exertion for 5 years. She was evaluated elsewhere and diagnosed to have severe mitral stenosis. She was referred for mitral valve replacement to our centre. Echocardiography revealed a thickened aortic valve ...

    Abstract A 36-year-old woman presented with dyspnoea on exertion for 5 years. She was evaluated elsewhere and diagnosed to have severe mitral stenosis. She was referred for mitral valve replacement to our centre. Echocardiography revealed a thickened aortic valve with mild aortic regurgitation, with transaortic gradient suggestive of mild aortic stenosis, in addition to severe rheumatic mitral stenosis. Detailed echocardiographic analysis and cardiac catheterisation revealed features suggestive of moderate to severe aortic stenosis. Detailed assessment of aortic valve needs to be done in patients with coexistent mitral stenosis. Each modality for assessment of aortic stenosis has its own limitations and a decision regarding treatment needs to be taken based on combined analysis of all the parameters. Dimensionless velocity index is a relatively less time-consuming, flow independent measure of aortic stenosis. Prompt recognition of this concealed aortic stenosis helps to avoid repeat valve surgery. Subsequently, patient was sent for dual valve replacement.
    MeSH term(s) Adult ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/drug therapy ; Aortic Valve Stenosis/etiology ; Aortic Valve Stenosis/surgery ; Echocardiography ; Female ; Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/drug therapy ; Mitral Valve Insufficiency/physiopathology ; Rheumatic Heart Disease/complications ; Treatment Outcome
    Language English
    Publishing date 2020-08-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236141
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  10. Article ; Online: Cornual pregnancy treated with methotrexate.

    Basha, A / Amarin, Z

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

    2013  Volume 33, Issue 5, Page(s) 531–532

    MeSH term(s) Abortifacient Agents, Nonsteroidal/therapeutic use ; Adult ; Female ; Humans ; Methotrexate/therapeutic use ; Pregnancy ; Pregnancy, Ectopic/drug therapy
    Chemical Substances Abortifacient Agents, Nonsteroidal ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2013-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 604639-3
    ISSN 1364-6893 ; 0144-3615
    ISSN (online) 1364-6893
    ISSN 0144-3615
    DOI 10.3109/01443615.2013.777697
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