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  1. Article: Neonatal polycythaemia.

    Bashir, Bashir Abdrhman / Othman, Suhair Abdrahim

    Sudanese journal of paediatrics

    2020  Volume 19, Issue 2, Page(s) 81–83

    Abstract: Neonatal polycythaemia has multifactorial causes, and can be designated as active (increased foetal erythropoiesis) or passive (red blood cell transfusion) polycythaemia. Hematocrit estimated from capillary blood (regularly obtained through "heel sticks" ...

    Abstract Neonatal polycythaemia has multifactorial causes, and can be designated as active (increased foetal erythropoiesis) or passive (red blood cell transfusion) polycythaemia. Hematocrit estimated from capillary blood (regularly obtained through "heel sticks" in newborns) is normally the principal laboratory feature facility by which polycythaemia is recognszed. An unusually high proportion of haematocrit builds the risk of hyperviscosity, microcirculatory hypoperfusion, and in the long run multisystem organ dysfunction. A report enclosed in this short communication gives a brief review of neonatal polycythaemia, its causes, management and complications.
    Language English
    Publishing date 2020-01-22
    Publishing country Sudan
    Document type Journal Article ; Review
    ZDB-ID 3035197-2
    ISSN 1858-8360 ; 0256-4408
    ISSN (online) 1858-8360
    ISSN 0256-4408
    DOI 10.24911/SJP.106-1566075225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A rare haematological disorder in a Sudanese child: Evans syndrome, case report and literature review.

    Bashir, Bashir Abdrhman / Othman, Suhair A / Malik, Amel Aziz

    Sudanese journal of paediatrics

    2021  Volume 21, Issue 1, Page(s) 89–94

    Abstract: Evans syndrome is a condition in which autoimmune-mediated red blood cells and platelet destruction happens consecutively. It may be associated with a reduction in neutrophil count as a result of immune neutropenia. No sex preference is known and it ... ...

    Abstract Evans syndrome is a condition in which autoimmune-mediated red blood cells and platelet destruction happens consecutively. It may be associated with a reduction in neutrophil count as a result of immune neutropenia. No sex preference is known and it presents in all ages and any ethnic cohort. Generally, this syndrome tends to be chronic and is characterised by remission and exacerbation. We document a case of the immune-mediated disease associated with Epstein-Barr virus infection in an 8-year-old boy from eastern Sudan who presented with both immune thrombocytopenia purpura and autoimmune haemolytic anaemia. Complete blood count and peripheral blood picture revealed features consistent with immune haemolytic anaemia (rouleaux formation and spherocytes) and thrombocytopenia. Direct anti-human globulin test and indirect anti-human globulin test were positive. Evans syndrome is a potentially life-threatening condition due to the concomitant existence with antiplatelet and anti-erythrocyte antibodies distinguished by a positive antiglobulin test and possibly linked to other autoimmune or lymphoproliferative diseases.
    Language English
    Publishing date 2021-04-15
    Publishing country Sudan
    Document type Case Reports
    ZDB-ID 3035197-2
    ISSN 1858-8360 ; 0256-4408
    ISSN (online) 1858-8360
    ISSN 0256-4408
    DOI 10.24911/SJP.106-1583095341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients.

    Bashir, Bashir Abdrhman / Mohamed, Mohamed Hassan / Hussain, Mohamed A / Osman, Wadah / Mothana, Ramzi A / Hasson, Sidgi

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 10

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/etiology ; HIV ; HIV Infections/complications ; HIV Infections/epidemiology ; Cross-Sectional Studies ; ADAM Proteins ; Antibodies, Antiphospholipid
    Chemical Substances ADAM Proteins (EC 3.4.24.-) ; Antibodies, Antiphospholipid
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59101826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot.

    Bashir, Bashir Abdrhman / Ali, Mohamed Salih

    BMC hematology

    2018  Volume 18, Page(s) 11

    Abstract: Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. ... ...

    Abstract Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot.
    Methods: A case-control study was conducted during the period from July to September 2017 at Dr. Awaad medical center, Red Sea State, Sudan. 57 diabetic patients with septic foot, aged between 17 and 78 years along with 57 non-diabetic subjects as control were enrolled. Sociodemographic data were collected using a structured questionnaire. Venipuncture blood was taken with necessary safety measures. Diabetes profile, coagulation studies as well as platelet indices were estimated. Data was analyzed using SPSS version 24.0 for windows. Ethical approval was considered and written consent from each participant was obtained.
    Results: The mean age of diabetic patients with septic foot and healthy controls were 48.49 ± 15.8 and 32.77 ± 14.0, respectively. The duration of the diabetes onset was 10.43 ± 9.5 years. Plasma prothrombin time (PT) value (12.61 ± 2.6 vs 13.67 ± 1.5,
    Conclusion: Diabetes mellitus is associated with prothrombotic tendency. Hypercoagulable state in DSF is indicated by shortened PT finding. PDW is a manifesting evidence that proves the presence of more reactive and aggregable platelets in DSF patients.
    Language English
    Publishing date 2018-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2744433-8
    ISSN 2052-1839
    ISSN 2052-1839
    DOI 10.1186/s12878-018-0104-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Natural regulatory anticoagulants proteins among Sudanese patients with dengue virus infection.

    Bashir, Bashir Abdrhman / Saeed, Osman Khalaf Allah

    International journal of health sciences

    2017  Volume 11, Issue 2, Page(s) 3–8

    Abstract: The coagulation system: Abnormalities in natural physiologic anticoagulants are observed in dengue infection. Laboratory values such as protein C (PC), protein S (PS), and antithrombin (AT) indicate this problem on the coagulation system in dengue. ... ...

    Abstract The coagulation system: Abnormalities in natural physiologic anticoagulants are observed in dengue infection. Laboratory values such as protein C (PC), protein S (PS), and antithrombin (AT) indicate this problem on the coagulation system in dengue. Recently, an interrelationship between dengue and the levels of natural anticoagulants has been observed.
    Objective: The study conducted to find out the effect of dengue on the natural anticoagulant proteins.
    Methods: A case-control study was conducted in Port Sudan Teaching Hospital from February 2013 to June 2014 for 334 cases of dengue caused by dengue virus, 217 (65%) males and 117 (35%) were females along with 101 cases of control 64 (63.4%) males and 37 (36.6%) were females. Laboratory-positive dengue cases were confirmed by immunoglobulin (Ig) M and IgG immune chromatography rapid test and the WHO criteria were used for classifying the dengue severity. Platelet count (PLT), plasma prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, D-dimer (DD), aspartate transaminase, alanine transaminase, PC, PS, and AT were performed.
    Results: Of 334, 289 patients had dengue fever (DF) and 45 patients had dengue hemorrhagic fever (DHF). Thrombocytopenia was present in 279 (83.5%). PLT was found to be significantly low in the case of dengue (
    Conclusion: The findings of this study suggest that lower levels of these proteins in patients with dengue are attributed to disseminated intravascular coagulation.
    Language English
    Publishing date 2017-03-23
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2603595-9
    ISSN 1658-3639
    ISSN 1658-3639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Potential Therapeutic Target and Vaccines for SARS-CoV-2.

    Hussain, Mohamed A / Hassan, Mohamed M / Bashir, Bashir Abdrhman / Gamar, Tarig A / Gasmalbari, Elmuaiz / Mohamed, Ahmed Osman / Osman, Wadah / Sherif, Asmaa E / Elgaml, Abdelaziz / Alhaddad, Aisha A / Ghazawi, Kholoud F / Miski, Samar F / Ainousah, Bayan E / Andijani, Yusra Saleh / Ibrahim, Sabrin R M / Mohamed, Gamal A / Ashour, Ahmed

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: The coronavirus has become the most interesting virus for scientists because of the recently emerging deadly SARS-CoV-2. This study aimed to understand the behavior of SARS-CoV-2 through the comparative genomic analysis with the closest one among the ... ...

    Abstract The coronavirus has become the most interesting virus for scientists because of the recently emerging deadly SARS-CoV-2. This study aimed to understand the behavior of SARS-CoV-2 through the comparative genomic analysis with the closest one among the seven species of coronavirus that infect humans. The genomes of coronavirus species that infect humans were retrieved from NCBI, and then subjected to comparative genomic analysis using different bioinformatics tools. The study revealed that SARS-CoV-2 is the most similar to SARS-CoV among the coronavirus species. The core genes were shared by the two genomes, but there were some genes, found in one of them but not in both, such as ORF8, which is found in SARS-CoV-2. The ORF8 protein of SARS-CoV-2 could be considered as a good therapeutic target for stopping viral transmission, as it was predicted to be a transmembrane protein, which is responsible for interspecies transmission. This is supported by the molecular interaction of ORF8 with both the ORF7 protein, which contains a transmembrane domain that is essential to retaining the protein in the Golgi compartment, and the S protein, which facilitates the entry of the coronavirus into host cells. ORF1ab, ORF1a, ORF8, and S proteins of SARS-CoV-2 could be immunogenic and capable of evoking an immune response, which means that these four proteins could be considered a potential vaccine source. Overall, SARS-CoV-2 is most related to SARS-CoV. ORF8 could be considered a potential therapeutic target for stopping viral transmission, and ORF1ab, ORF1a, ORF8, and the S proteins of SARS-CoV-2 could be utilized as a potential vaccine source.
    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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