LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Optimization of Antimicrobial Stewardship Programs Using Therapeutic Drug Monitoring and Pharmacokinetics-Pharmacodynamics Protocols: A Cost-Benefit Review.

    Telles, João Paulo / Morales, Ronaldo / Yamada, Carolina Hikari / Marins, Tatiana A / D'Amaro Juodinis, Vanessa / Sztajnbok, Jaques / Silva, Moacyr / Bassetti, Bil Randerson / Albiero, James / Tuon, Felipe Francisco

    Therapeutic drug monitoring

    2023  Volume 45, Issue 2, Page(s) 200–208

    Abstract: Purpose: Antimicrobial stewardship programs are important for reducing antimicrobial resistance because they can readjust antibiotic prescriptions to local guidelines, switch intravenous to oral administration, and reduce hospitalization times. ... ...

    Abstract Purpose: Antimicrobial stewardship programs are important for reducing antimicrobial resistance because they can readjust antibiotic prescriptions to local guidelines, switch intravenous to oral administration, and reduce hospitalization times. Pharmacokinetics-pharmacodynamics (PK-PD) empirically based prescriptions and therapeutic drug monitoring (TDM) programs are essential for antimicrobial stewardship, but there is a need to fit protocols according to cost benefits. The cost benefits can be demonstrated by reducing toxicity and hospital stay, decreasing the amount of drug used per day, and preventing relapses in infection. Our aim was to review the data available on whether PK-PD empirically based prescriptions and TDM could improve the cost benefits of an antimicrobial stewardship program to decrease global hospital expenditures.
    Methods: A narrative review based on PubMed search with the relevant studies of vancomycin, aminoglycosides, beta-lactams, and voriconazole.
    Results: TDM protocols demonstrated important cost benefit for patients treated with vancomycin, aminoglycosides, and voriconazole mainly due to reduce toxicities and decreasing the hospital length of stay. In addition, PK-PD strategies that used infusion modifications to meropenem, piperacillin-tazobactam, ceftazidime, and cefepime, such as extended or continuous infusion, demonstrated important cost benefits, mainly due to reducing daily drug needs and lengths of hospital stays.
    Conclusions: TDM protocols and PK-PD empirically based prescriptions improve the cost-benefits and decrease the global hospital expenditures.
    MeSH term(s) Humans ; Aminoglycosides ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Ceftazidime ; Cost-Benefit Analysis ; Drug Monitoring ; Vancomycin/therapeutic use ; Voriconazole
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; Ceftazidime (9M416Z9QNR) ; Vancomycin (6Q205EH1VU) ; Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 424443-6
    ISSN 1536-3694 ; 0163-4356
    ISSN (online) 1536-3694
    ISSN 0163-4356
    DOI 10.1097/FTD.0000000000001067
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1503: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Factors associated with acquisition of carbapenem-resistant Enterobacteriaceae.

    Lavagnoli, Lilian Silva / Bassetti, Bil Randerson / Kaiser, Thais Dias Lemos / Kutz, Kátia Maria / Cerutti, Crispim

    Revista latino-americana de enfermagem

    2017  Volume 25, Page(s) e2935

    Abstract: Objective: to identify possible risk factors for acquisition of Enterobacterial strains with a marker for resistance to carbapenems.: Methods: exploratory case-control study performed in hospital settings. The study sample consisted of patients with ... ...

    Abstract Objective: to identify possible risk factors for acquisition of Enterobacterial strains with a marker for resistance to carbapenems.
    Methods: exploratory case-control study performed in hospital settings. The study sample consisted of patients with biological specimens that tested positive for carbapenem-resistant Enterobacteriaceae (cases), with the disk diffusion test and Etest, and controls with biological samples testing negative for carbapenem-resistant Enterobacteriaceae. In all, 65 patients were included: 13 (20%) cases and 52 (80%) controls.
    Results: the microorganisms isolated were Serratia marcescens (6), Klebsiella pneumoniae (4), and Enterobacter cloacae (3). Univariate analysis revealed that length of hospitalization prior to sample collection (p=0.002) and having a surgical procedure (p=0.006) were statistically significant. In the multivariable logistic regression model, both were still significant, with odds ratios of 0.93 (p = 0.009; 95% CI: 0.89 to 0.98) for length of hospitalization prior to sample collection, and 9.28 (p = 0.05; 95% CI: 1.01 to 85.14) for having a surgical procedure.
    Conclusion: shorter hospitalization times and increased surveillance of patients undergoing surgery could play a decisive role in reducing the spread of carbapenem-resistant microorganisms in hospital settings.
    MeSH term(s) Aged ; Carbapenem-Resistant Enterobacteriaceae ; Case-Control Studies ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors
    Language Spanish
    Publishing date 2017-10-05
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105698-5
    ISSN 1518-8345 ; 0104-1169
    ISSN (online) 1518-8345
    ISSN 0104-1169
    DOI 10.1590/1518-8345.1751.2935
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Nephrotoxicity during tenofovir treatment: a three-year follow-up study in a Brazilian reference clinic.

    Pinto Neto, Lauro Ferreira da Silva / Bassetti, Bil Randerson / Fraga, Igor Hernandes Valvassoura / Oliveira Santos, Carolina Rocio / Ximenes, Paula Daher / Miranda, Angélica Espinosa

    The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

    2015  Volume 20, Issue 1, Page(s) 14–18

    Abstract: In this study, 275 patients in use of tenofovir were retrospectively followed-up for three years to evaluate risk factors involved in impaired renal function. Analysis of variance (ANOVA) and Tukey's test were used to verify any differences in creatinine ...

    Abstract In this study, 275 patients in use of tenofovir were retrospectively followed-up for three years to evaluate risk factors involved in impaired renal function. Analysis of variance (ANOVA) and Tukey's test were used to verify any differences in creatinine levels and estimated clearance at 0, 6, 12, 24 and 36 months, adjusting for the co-variables sex, skin color, age >50 years, arterial hypertension, diabetes and the use of the ritonavir-boosted protease inhibitors (PI/r) lopinavir/r or atazanavir/r. The software package STATISTICA 10(®) was used for statistical analysis. The patients' mean age was 43.2±10.7 years. Systemic arterial hypertension (SAH) and diabetes were found in 20.4% and 8.7% of the patients, respectively. Overall, 96.7% were on tenofovir associated with lamivudine (TDF+3TC), 39.3% on lopinavir/r, 29.8% on efavirenz, and 17.6% on atazanavir/r. There was a statistically significant difference in estimated creatinine clearance at 24 months, when the co-variables male (F=3.95; p=0.048), SAH (F=6.964; p=0.009), and age over 50 years (F=45.81; p<0.001) were taken into consideration. Analysis of the co-variable use of atazanavir/r showed a tendency toward an increased risk over time (F=2.437; p=0.063); however, no significant time interaction was seen. At 36-month, a statistically significant difference was found for age over 50 years, (F=32.02; p<0.05) and there was a significant time-by-sex interaction (F=3.117; p=0.0149). TDF was discontinued in 12 patients, one because of a femoral neck fracture (0.7%) and 11 due to nephrotoxicity (4%). Of these latter cases, 9/11 patients were also using protease inhibitors. These data strongly alert that tenofovir use should be individualized with careful attention to renal function especially in male patients, over 50 years, with SAH, and probably those on ATV/r.
    MeSH term(s) Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Drug Therapy, Combination/adverse effects ; Female ; Follow-Up Studies ; Glomerular Filtration Rate/drug effects ; HIV Infections/drug therapy ; HIV Protease Inhibitors/administration & dosage ; HIV Protease Inhibitors/adverse effects ; Humans ; Kidney/drug effects ; Kidney/physiopathology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tenofovir/administration & dosage ; Tenofovir/adverse effects ; Time Factors ; Young Adult
    Chemical Substances Anti-HIV Agents ; HIV Protease Inhibitors ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2015-11-21
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2041400-6
    ISSN 1678-4391 ; 1413-8670
    ISSN (online) 1678-4391
    ISSN 1413-8670
    DOI 10.1016/j.bjid.2015.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5633: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study.

    Arns, Beatriz / Agani, Crepin Aziz Jose Oluwafoumi / Sesin, Guilhermo Prates / Horvath, Jaqueline Driemeyer C / Fogazzi, Débora Vacaro / Romeiro Silva, Fernanda Kelly / Costa, Lauren Sezera / Pereira, Adriano Jose / Nassar Junior, Antônio Paulo / Cavalcanti, Bruno Tomazini / Dietrich, Camila / Veiga, Viviane Cordeiro / Catarino, Daniela G M / Cheno, Maysa Yukari / Biasi, Alexandre / Ferronatto, Bianca Ramos / Bassetti, Bil Randerson / Fernandes, Caio Cesar Ferreira / Deutschendorf, Caroline /
    Grion, Cintia Magalhães Carvalho / Vidal, Claudia Fernanda de Lacerda / de Oliveira, Cláudio Dornas / Caser, Eliana Bernadete / Boschi, Emerson / Silva, Everton Macêdo / Pizzol, Felipe Dal / Urbano, Hugo Correa de Andrade / Silva, Iany / Maia, Israel Silva / Rego, Leila Rezegue de Moraes / Oliveira, Luana Pontes / Tavares, Maria Brandão / Dracoulakis, Marianna Deway Andrade / Bainy, Marina Peres / Golin, Nicole Alberti / Tomba, Pablo Oscar / Kurtz, Pedro Martins Pereira / Foernges, Rafael Botelho / Prestes, Rejane Martins / de Melo, Rodrigo Morel Vieira / Da Silva, Rodrigo Reghini / Toledo, Tatiana Gozzi Pancev / Lima, Valéria Paes / Fernandes, Vanildes de Fátima / Lovato, Wilson José / Zavascki, Alexandre Prehn

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e79

    Abstract: Objective: Data are scarce regarding hospital infection control committees and compliance with infection prevention and control (IPC) recommendations in Brazil, a country of continental dimensions. We assessed the main characteristics of infection ... ...

    Abstract Objective: Data are scarce regarding hospital infection control committees and compliance with infection prevention and control (IPC) recommendations in Brazil, a country of continental dimensions. We assessed the main characteristics of infection control committees (ICCs) on healthcare-associated infections (HAIs) in Brazilian hospitals.
    Methods: This cross-sectional study was conducted in ICCs of public and private hospitals distributed across all Brazilian regions. Data were collected directly from the ICC staff by completing an online questionnaire and during on-site visits through face-to-face interviews.
    Results: In total, 53 Brazilian hospitals were evaluated from October 2019 to December 2020. All hospitals had implemented the IPC core components in their programs. All centers had protocols for the prevention and control of ventilator-associated pneumonia as well as bloodstream, surgical site, and catheter-associated urinary tract infections. Most hospitals (80%) had no budget specifically allocated to the IPC program; 34% of the laundry staff had received specific IPC training; and only 7.5% of hospitals reported occupational infections in healthcare workers.
    Conclusions: In this sample, most ICCs complied with the minimum requirements for IPC programs. The main limitation regarding ICCs was the lack of financial support. The findings of this survey support the development of strategic plans to improve IPCs in Brazilian hospitals.
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.136
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Erratum: Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study - CORRIGENDUM.

    Arns, Beatriz / Agani, Crepin Aziz Jose Oluwafoumi / Sesin, Guilhermo Prates / Horvath, Jaqueline Driemeyer C / Fogazzi, Débora Vacaro / Romeiro Silva, Fernanda Kelly / Costa, Lauren Sezera / Pereira, Adriano Jose / Nassar Junior, Antônio Paulo / Cavalcanti, Bruno Tomazini / Dietrich, Camila / Veiga, Viviane Cordeiro / Catarino, Daniela G M / Cheno, Maysa Yukari / Biasi, Alexandre / Ferronatto, Bianca Ramos / Bassetti, Bil Randerson / Fernandes, Caio Cesar Ferreira / Deutschendorf, Caroline /
    Grion, Cintia Magalhães Carvalho / Vidal, Claudia Fernanda de Lacerda / de Oliveira, Cláudio Dornas / Caser, Eliana Bernadete / Boschi, Emerson / Silva, Everton Macêdo / Pizzol, Felipe Dal / Urbano, Hugo Correa de Andrade / Silva, Iany / Maia, Israel Silva / Rego, Leila Rezegue de Moraes / Oliveira, Luana Pontes / Tavares, Maria Brandão / Dracoulakis, Marianna Deway Andrade / Bainy, Marina Peres / Golin, Nicole Alberti / Tomba, Pablo Oscar / Kurtz, Pedro Martins Pereira / Foernges, Rafael Botelho / Prestes, Rejane Martins / de Melo, Rodrigo Morel Vieira / Da Silva, Rodrigo Reghini / Toledo, Tatiana Gozzi Pancev / Lima, Valéria Paes / Fernandes, Vanildes de Fátima / Lovato, Wilson José / Zavascki, Alexandre Prehn

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e102

    Abstract: This corrects the article DOI: 10.1017/ash.2023.136.]. ...

    Abstract [This corrects the article DOI: 10.1017/ash.2023.136.].
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Published Erratum
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.189
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Polineuropatia desmielinizante inflamatória crônica pós-tratamento com interferon peguilado alfa 2b em um paciente co-infectado HIV/HCV: relato de caso.

    Bassetti, Bil Randerson / Trés, Eduardo Sturzeneker / Ciríaco, Jovana Gobbi Marchesi / Pinto Neto, Lauro Ferreira Silva

    Revista da Sociedade Brasileira de Medicina Tropical

    2010  Volume 43, Issue 1, Page(s) 89–91

    Abstract: Chronic inflammatory demyelinating polyneuropathy has a strong association with HIV and HCV infection. A rare association between chronic inflammatory demyelinating polyneuropathy and hepatitis C treatment with pegylated interferon alpha was described ... ...

    Title translation Chronic inflammatory demyelinating polyneuropathy after treatment with pegylated interferon alpha 2b in a patient with HIV/HCV coinfection: case report.
    Abstract Chronic inflammatory demyelinating polyneuropathy has a strong association with HIV and HCV infection. A rare association between chronic inflammatory demyelinating polyneuropathy and hepatitis C treatment with pegylated interferon alpha was described recently. We described the first case of chronic inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2b in a white man infected with HIV and HCV. The patient recovered completely with the use of intravenous hyperimmune immunoglobulin. Infectologists and hepatologists should be alert regarding this rare and serious association, which requires immediately drug discontinuation and early treatment.
    MeSH term(s) Antiviral Agents/adverse effects ; HIV Infections/complications ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Interferon alpha-2 ; Interferon-alpha/adverse effects ; Male ; Middle Aged ; Polyethylene Glycols/adverse effects ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/chemically induced ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/drug therapy ; Recombinant Proteins
    Chemical Substances Antiviral Agents ; Immunoglobulins, Intravenous ; Interferon alpha-2 ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (3WJQ0SDW1A) ; peginterferon alfa-2b (G8RGG88B68)
    Language Portuguese
    Publishing date 2010-03-06
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/s0037-86822010000100019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top