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  1. Book ; Online: «Con assoluta sincerità»

    Bassi, Giulia

    Il lavoro editoriale di Natalia Ginzburg (1943-1952)

    (Studi di letterature moderne e comparate)

    2023  

    Series title Studi di letterature moderne e comparate
    Keywords Literature & literary studies ; Natalia Ginzburg ; Einaudi ; 20th century literature ; publishing ; translation
    Language Italian
    Size 1 electronic resource (198 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note Italian
    HBZ-ID HT030375831
    ISBN 9791221500660
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis.

    Bassi, Geetika / Mishra, Suresh

    iScience

    2022  Volume 25, Issue 4, Page(s) 104165

    Abstract: Mitochondria are essential for steroidogenesis. In steroidogenic cells, the initiation of steroidogenesis from cholesterol occurs on the matrix side of the inner mitochondrial membrane by the enzyme P450scc. This requires cholesterol import from the ... ...

    Abstract Mitochondria are essential for steroidogenesis. In steroidogenic cells, the initiation of steroidogenesis from cholesterol occurs on the matrix side of the inner mitochondrial membrane by the enzyme P450scc. This requires cholesterol import from the cytoplasm through the outer mitochondrial membrane, facilitated by the StAR protein. The subsequent steps leading to P450scc remain elusive. Here we report that the male transgenic mice that expressed a mutant form of a mitochondrial protein prohibitin-1 (PHB1
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Thesis ; Online: Ligand Discovery and Affinity Maturation with Single Stranded DNA Encoded Chemical Libraries

    Bassi, Gabriele

    2020  

    Abstract: Drugs are chemical or biological compounds, able to specific interact with one or more target proteins, hence driving a pharmacological benefit for the prevention, diagnosis or treatment of a pathology. In the past, the isolation of novel drugs has often ...

    Abstract Drugs are chemical or biological compounds, able to specific interact with one or more target proteins, hence driving a pharmacological benefit for the prevention, diagnosis or treatment of a pathology. In the past, the isolation of novel drugs has often started from the screening of bioactive compounds from nature, on the basis of trial and error approaches. More recently, however, also thanks to advances in molecular biology and in the production of recombinant proteins, it has become important to discover protein ligands by screening organic molecules in large compound collections, called “chemical libraries”. At present, it is customary for large pharmaceutical companies to try and identify specific protein ligands (called “hits”) starting from chemical libraries that may contain up to one million compounds. Similar activities are prohibitively expensive for academic groups. In many cases, high-throughput screening assays are used. Once a hit compound is identified, suitable modifications using medicinal chemistry are performed in order to generate improved molecules, which may deserve to be tested both in vitro and in vivo. If the so-called “lead compounds” exhibit the required specificity and potency, alongside other parameters which are important for clinical development, the product candidates may progress towards late-stage industrial activities. In many cases, however, screening campaigns based on high-throughput screening fail to delivery hits. For this reason, there is a considerable interest in the development of novel methodologies for the construction and screening of large chemical libraries. DNA-Encoded chemical libraries (DELs) are collections of small organic molecules, individually coupled to DNA fragments which act as amplifiable identification barcodes. DELs can be very large (i.e., containing millions to billions of compounds), as they can be synthesized using split&pool procedures, starting from a moderate number of starting building blocks. In this thesis, I describe the synthesis ...
    Keywords Drug discovery and development ; medicinal chemistry ; info:eu-repo/classification/ddc/500 ; Natural sciences
    Subject code 500
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Failure in reflective functioning as a key factor in the association between problematic social networking sites use, attachment and childhood maltreatment: A network analysis approach on gender differences.

    Bassi, Giulia / Mancinelli, Elisa / Salcuni, Silvia / Gori, Alessio / Musetti, Alessandro

    Development and psychopathology

    2023  , Page(s) 1–9

    Abstract: Following a network analysis approach, the present study aims to explore the pattern of mutual relationships between failure in reflective functioning (RF) - defined as hypomentalization - problematic social networking sites use (PSNSU), attachment ... ...

    Abstract Following a network analysis approach, the present study aims to explore the pattern of mutual relationships between failure in reflective functioning (RF) - defined as hypomentalization - problematic social networking sites use (PSNSU), attachment anxiety and avoidance, and childhood maltreatment among emerging adults, with a focus on gender differences. The study sample comprises
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1036173-x
    ISSN 1469-2198 ; 0954-5794
    ISSN (online) 1469-2198
    ISSN 0954-5794
    DOI 10.1017/S0954579423001268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Efficacy of Digital Cognitive-Behavioral Interventions in Supporting the Psychological Adjustment and Sleep Quality of Pregnant Women with Sub-Clinical Symptoms: A Systematic Review and Meta-Analysis.

    Mancinelli, Elisa / Bassi, Giulia / Gabrielli, Silvia / Salcuni, Silvia

    International journal of environmental research and public health

    2022  Volume 19, Issue 15

    Abstract: The present meta-analysis investigated the overall and differential efficacy of digital cognitive-behavioral therapies (CBTs) vs. third-generation CBTs deployed to pregnant women in reducing sub-clinical depression, anxiety, and stress symptoms while ... ...

    Abstract The present meta-analysis investigated the overall and differential efficacy of digital cognitive-behavioral therapies (CBTs) vs. third-generation CBTs deployed to pregnant women in reducing sub-clinical depression, anxiety, and stress symptoms while fostering sleep quality and quality of life. A PRISMA-guided systematic search was used, including randomized controlled trials (RCTs) evaluating the above-mentioned interventions. Data were pooled using either the mean difference (MD) or standardized MD (SMD). Sub-group analyses were carried out when appropriate. The primary outcomes were depression, anxiety, and stress symptoms, as well as sleep quality and quality of life. The interventions' acceptability was evaluated through the odds ratio (OR) of drop-out rates. Seven RCTs were included, comprising 1873 pregnant women. The results showed the interventions' efficacy in terms of reducing depression symptoms (SMD = -0.36, CI = 0.61, -0.11, k = 9) at the endpoint, although it was not maintained at follow-up during the postpartum period. The interventions' efficacy in terms of reducing anxiety symptoms (SMD = 1.96, CI = -2.72, -1.21, k = 3) at the endpoint was also significant, while having no effect on sleep quality. The interventions were well accepted (OR = 1.68; 95% CI = 0.84, 3.35; k = 7). Although no sound conclusions can be drawn concerning the joint or differential efficacy of the considered interventions, this study was useful in highlighting the need to develop evidence-based digital prevention programs for pregnant women with sub-clinical symptoms.
    MeSH term(s) Cognition ; Cognitive Behavioral Therapy/methods ; Depression/diagnosis ; Depression/therapy ; Emotional Adjustment ; Female ; Humans ; Pregnancy ; Pregnant Women ; Sleep Quality
    Language English
    Publishing date 2022-08-03
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19159549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nosocomial Pneumonia in the Mechanically Ventilated Patient.

    Fanning, Jonathon / Panigada, Mauro / Li Bassi, Gianluigi

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 3, Page(s) 426–439

    Abstract: Ventilator-associated pneumonia (VAP) is a common complication occurring in critically ill patients who are mechanically ventilated and is the leading cause of nosocomial infection-related death. Etiologic agents for VAP widely differ based on the ... ...

    Abstract Ventilator-associated pneumonia (VAP) is a common complication occurring in critically ill patients who are mechanically ventilated and is the leading cause of nosocomial infection-related death. Etiologic agents for VAP widely differ based on the population of intensive care unit patients, duration of hospital stay, and prior antimicrobial therapy. VAP due to multidrug-resistant pathogens is associated with the highest morbidity and mortality, likely due to delays in appropriate antimicrobial treatment. International guidelines are currently available to guide diagnostic and therapeutic strategies. VAP can be prevented through various pharmacological and non-pharmacological interventions, which are more effective when grouped as bundles. When VAP is clinically suspected, diagnostic strategies should include early collection of respiratory samples to guide antimicrobial therapy. Empirical treatment should be based on the most likely etiologic microorganisms and antibiotics likely to be active against these microorganisms. Response to therapy should be reassessed after 3 to 5 days and antimicrobials adjusted or de-escalated to reduce the burden of the disease. Finally, considering that drug resistance is increasing worldwide, several novel antibiotics are being tested to efficiently treat VAP in the coming decades.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Critical Illness ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/etiology ; Humans ; Intensive Care Units ; Pneumonia, Ventilator-Associated/diagnosis ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/epidemiology ; Respiration, Artificial/adverse effects
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1749448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1555: Show issues Location:
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  7. Article ; Online: Mechanical Ventilation in the Critically Ill Patient.

    Li Bassi, Gianluigi / Laffey, John G

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 3, Page(s) 319–320

    MeSH term(s) Critical Illness/therapy ; Humans ; Intensive Care Units ; Prospective Studies ; Respiration, Artificial
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1749449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1555: Show issues Location:
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  8. Article ; Online: The intracellular cholesterol pool in steroidogenic cells plays a role in basal steroidogenesis.

    Bassi, Geetika / Sidhu, Simarjit Kaur / Mishra, Suresh

    The Journal of steroid biochemistry and molecular biology

    2022  Volume 220, Page(s) 106099

    Abstract: The framework of steroidogenesis across steroidogenic cells is constructed around cholesterol - the precursor substrate molecule for all steroid hormones - including its cellular uptake, storage in intracellular lipid droplets, mobilization upon ... ...

    Abstract The framework of steroidogenesis across steroidogenic cells is constructed around cholesterol - the precursor substrate molecule for all steroid hormones - including its cellular uptake, storage in intracellular lipid droplets, mobilization upon steroidogenic stimulation, and finally, its transport to the mitochondria, where steroidogenesis begins. Thus, cholesterol and the mitochondria are highly interconnected in steroidogenic cells. Moreover, accruing evidence suggests that autophagy and mitochondrial dynamics are important cellular events in the regulation of trophic hormone-induced cholesterol homeostasis and steroidogenesis. However, a potential role of cholesterol in itself in the regulation of steroidogenic factors and events remain largely unexplored. We tested the hypothesis that cholesterol plays a role in the regulation of cell-intrinsic factors and events involving steroidogenesis. Here, we show that depleting the intracellular cholesterol pool in steroidogenic cells induces autophagy, affects mitochondrial dynamics, and upregulates steroidogenic factors and basal steroidogenesis in three different steroidogenic cell types producing different steroid hormones. Notably, the cholesterol insufficiency-induced changes in different steroidogenic cell types occur independent of pertinent hormone stimulation and work in a dynamic and temporal manner with or without hormonal stimulation. Such effects of cholesterol deprivation on autophagy and mitochondrial dynamics were not observed in the non-steroidogenic cells, indicating that cholesterol insufficiency-induced changes in steroidogenic cells are specific to steroidogenesis. Thus, our data suggests a role of cholesterol in steroidogenesis beyond being a mere substrate for steroid hormones. The implications of our findings are broad and offer new insights into trophic hormone-dependent and hormone-independent steroidogenesis during development, as well as in health and disease.
    MeSH term(s) Biological Transport ; Cholesterol/metabolism ; Hormones/metabolism ; Mitochondria/metabolism ; Steroids/metabolism
    Chemical Substances Hormones ; Steroids ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2022.106099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: First attempt at etiological therapy of Addison's Disease; Pericapsular injections of streptomycin.

    BASSI, G

    Minerva medica

    2007  Volume 39, Issue 40 Pt 2, Page(s) 316

    Title translation Primo tentativo di terapia etiologica del morbo di Addison; iniezioni pericapsulari di streptomicina.
    MeSH term(s) Addison Disease/therapy ; Adrenal Insufficiency ; Humans ; Hypoadrenocorticism, Familial
    Language Italian
    Publishing date 2007-12-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Selective digestive decontamination: a pre-emptive treatment for a few European ecological niches or a worldwide implementation?

    Li Bassi, G / Aguilera, E

    Minerva anestesiologica

    2015  Volume 81, Issue 7, Page(s) 705–708

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Decontamination ; Digestive System ; Humans ; Oropharynx
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2015-07
    Publishing country Italy
    Document type Comment ; Editorial
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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