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  1. Article ; Online: Associations between cohort derived dementia and COVID-19 serological diagnosis among older Black adults in rural South Africa.

    Harriman, Nigel Walsh / Bassil, Darina T / Farrell, Meagan T / Du Toit, Jacques / Gómez-Olivé Casas, F Xavier / Tollman, Stephen M / Berkman, Lisa F

    Frontiers in public health

    2024  Volume 11, Page(s) 1304572

    Abstract: Objectives: This study investigates the association between cohort derived dementia and serologically confirmed SARS-CoV-2 infection, an underexplored phenomena in low-and middle-income countries. Examining this relationship in a rural South African ... ...

    Abstract Objectives: This study investigates the association between cohort derived dementia and serologically confirmed SARS-CoV-2 infection, an underexplored phenomena in low-and middle-income countries. Examining this relationship in a rural South African community setting offers insights applicable to broader healthcare contexts.
    Methods: Data were collected from Black South Africans in the Mpumalanga province who participated in the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa. Cohort derived dementia was developed using a predictive model for consensus-based dementia diagnosis. Multinomial logistic regression models estimated the association between predicted dementia probability in 2018 and SARS-CoV-2 infection risk in 2021, controlling for demographics, socioeconomic status, and comorbidities.
    Results: Fifty-two percent of the tested participants had serologically confirmed SARS-CoV-2 infections. In the fully adjusted model, cohort derived dementia was significantly associated with over twice the risk of serological diagnosis of COVID-19 (RRR = 2.12,
    Conclusion: Complying with COVID-19 prevention recommendations may be difficult for individuals with impaired cognitive functioning due to their symptoms. Results can inform community-based public health initiatives to reduce COVID-19 transmission among South Africa's rapidly aging population.
    MeSH term(s) Adult ; Humans ; Aged ; South Africa/epidemiology ; Longitudinal Studies ; COVID-19/diagnosis ; COVID-19/epidemiology ; SARS-CoV-2 ; Dementia/diagnosis ; Dementia/epidemiology ; COVID-19 Testing
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1304572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mid-life employment trajectories and subsequent memory function and rate of decline in rural South Africa, 2000-22.

    Yu, Xuexin / Kabudula, Chodziwadziwa W / Wagner, Ryan G / Bassil, Darina T / Farrell, Meagan T / Tollman, Stephen M / Kahn, Kathleen / Berkman, Lisa F / Rosenberg, Molly S / Kobayashi, Lindsay C

    International journal of epidemiology

    2024  Volume 53, Issue 2

    Abstract: Aim: To investigate mid-life employment trajectories in relation to later-life memory function and rate of decline in rural South Africa.: Methods: Data from the Agincourt Health and Socio-Demographic Surveillance System were linked to the 'Health ... ...

    Abstract Aim: To investigate mid-life employment trajectories in relation to later-life memory function and rate of decline in rural South Africa.
    Methods: Data from the Agincourt Health and Socio-Demographic Surveillance System were linked to the 'Health and Ageing in Africa: A Longitudinal Study of an INDEPTH Community in South Africa' (HAALSI) in rural Agincourt, South Africa (N = 3133). Employment was assessed every 4 years over 2000-12 as being employed (0, 1, 2 and ≥3 time points), being employed in a higher-skill occupation (0, 1, 2 and ≥3 time points) and dynamic employment trajectories identified using sequence analysis. Latent memory z-scores were assessed over 2014-22. Mixed-effects linear regression models were fitted to examine the associations of interest.
    Results: Sustained mid-life employment from 2000-12 (β = 0.052, 95% CI: -0.028 to 0.132, 1 vs 0 time points; β = 0.163, 95% CI: 0.077 to 0.250, 2 vs 0 time points; β = 0.212, 95% CI: 0.128 to 0.296, ≥3 vs 0 time points) and greater time spent in a higher-skill occupation (β = 0.077, 95% CI: -0.020 to 0.175, 1 vs 0 time points; β = 0.241, 95% CI: 0.070 to 0.412, 2 vs 0 time points; β = 0.361, 95% CI: 0.201 to 0.520, ≥3 vs 0 time points) were associated with higher memory scores in 2014/15, but not subsequent rate of memory decline. Moving from a lower-skill to higher-skill occupation was associated with higher memory function, but a faster rate of decline over 2014-22.
    Conclusions: Sustained mid-life employment, particularly in higher-skill occupations, may contribute to later-life memory function in this post-Apartheid South African setting.
    MeSH term(s) Humans ; South Africa/epidemiology ; Longitudinal Studies ; Cognition ; Aging ; Employment ; Rural Population
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyae022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 893: Show issues Location:
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  3. Article ; Online: Telomere Length, Health, and Mortality in a Cohort of Older Black South African Adults.

    Gao, Sarah / Rohr, Julia K / de Vivo, Immaculata / Ramsay, Michele / Krieger, Nancy / Kabudula, Chodziwadziwa W / Farrell, Meagan T / Bassil, Darina T / Harriman, Nigel W / Corona-Perez, Diana / Pesic, Katarina / Berkman, Lisa F

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2023  Volume 78, Issue 11, Page(s) 1983–1990

    Abstract: Telomere length (TL) may be a biomarker of aging processes as well as age-related diseases. However, most studies of TL and aging are conducted in high-income countries. Less is known in low- and middle-income countries (LMICs) such as South Africa, ... ...

    Abstract Telomere length (TL) may be a biomarker of aging processes as well as age-related diseases. However, most studies of TL and aging are conducted in high-income countries. Less is known in low- and middle-income countries (LMICs) such as South Africa, where life expectancy remains lower despite population aging. We conducted a descriptive analysis of TL in a cohort of older adults in rural South Africa. TL was assayed from venous blood draws using quantitative polymerase chain reaction (T/S ratio). We examined the correlation between TL and biomarkers, demographic characteristics, mental/cognitive health measures, and physical performance measures in a subsample of the Wave 1 2014-2015 "Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa" (HAALSI) cohort (n = 510). We used logistic regression to measure the association between TL and mortality through Wave 3 (2021-2022). In bivariate analyses, TL was significantly correlated with age (r = -0.29, p < .0001), self-reported female sex (r = 0.13, p = .002), mortality (r = -0.1297, p = .003), diastolic blood pressure (r = 0.09, p = .037), pulse pressure (r = -0.09, p = .045), and being a grandparent (r = -0.17, p = .0001). TL was significantly associated with age (β = -0.003; 95% confidence interval [CI] = -0.005, -0.003). TL was significantly associated in unadjusted multivariate analyses with mortality, but the relationship between TL and mortality was attenuated after adjusting for age (odds ratio [OR] = 0.19; 95% CI = 0.03, 1.27) and other covariates (OR = 0.17; 95% CI = 0.02, 1.19). Our study is the first analysis of TL in an older adult South African population. Our results corroborate existing relationships between TL and age, sex, cardiometabolic disease, and mortality found in higher-income countries.
    MeSH term(s) Humans ; Female ; Aged ; Longitudinal Studies ; South Africa/epidemiology ; Aging/genetics ; Life Expectancy ; Biomarkers ; Telomere
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glad153
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  4. Article: Feasibility of an online consensus approach for the diagnosis of cognitive impairment and dementia in rural South Africa.

    Bassil, Darina T / Farrell, Meagan T / Weerman, Albert / Guo, Muqi / Wagner, Ryan G / Brickman, Adam M / Glymour, M Maria / Langa, Kenneth M / Manly, Jennifer J / Tipping, Brent / Butler, India / Tollman, Stephen / Berkman, Lisa F

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2023  Volume 15, Issue 2, Page(s) e12420

    Abstract: Introduction: We describe the development and feasibility of using an online consensus approach for diagnosing cognitive impairment and dementia in rural South Africa.: Methods: Cognitive assessments, clinical evaluations, and informant interviews ... ...

    Abstract Introduction: We describe the development and feasibility of using an online consensus approach for diagnosing cognitive impairment and dementia in rural South Africa.
    Methods: Cognitive assessments, clinical evaluations, and informant interviews from Cognition and Dementia in the Health and Aging in Africa Longitudinal Study (HAALSI Dementia) were reviewed by an expert panel using a web-based platform to assign a diagnosis of cognitively normal, mild cognitive impairment (MCI), or dementia.
    Results: Six hundred thirty-five participants were assigned a final diagnostic category, with 298 requiring adjudication conference calls. Overall agreement between each rater's independent diagnosis and final diagnosis (via the portal or consensus conference) was 78.3%. A moderate level of agreement between raters' individual ratings and the final diagnostic outcomes was observed (average κ coefficient = 0.50).
    Discussion: Findings show initial feasibility in using an online consensus approach for the diagnosis of cognitive impairment and dementia in remote, rural, and low-resource settings.
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1002/dad2.12420
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  5. Article ; Online: Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.

    Del Brutto, Victor J / Khasiyev, Farid / Liu, Minghua / Spagnolo-Allende, Antonio / Qiao, Ye / Melgarejo Arias, Jesus D / Guzman, Vanessa A / Igwe, Kay C / Sanchez, Danurys L / Andrews, Howard / Morales, Clarissa D / Farrell, Meagan T / Bassil, Darina T / Seshadri, Sudha / Wagner, Ryan G / Mngomezulu, Victor / Manly, Jennifer / Elkind, Mitchell Sv / Berkman, Lisa /
    Romero, Jose R / Maestre, Gladys E / Del Brutto, Oscar H / Brickman, Adam M / Venketasubramanian, Narayanaswamy / Chen, Christopher / Robert, Caroline / Hilal, Saima / Rundek, Tatjana / Wasserman, Bruce A / Gutierrez, Jose

    The neuroradiology journal

    2023  , Page(s) 19714009231224429

    Abstract: Background and purpose: Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent fetal ... ...

    Abstract Background and purpose: Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent fetal posterior cerebral artery (fPCA) correlate with brain arterial diameters across populations.
    Methods: Participants had a time-of-flight MRA from nine international cohorts. Arterial diameters of the cavernous internal carotid arteries (ICA), middle cerebral arteries (MCA), and basilar artery (BA) were measured using LAVA software. Regression models assessed the association between exposures and brain arterial diameters.
    Results: We included 6,518 participants (mean age: 70 ± 9 years; 41% men). Unilateral fPCA was present in 13.2% and bilateral in 3.2%. Larger ICA, MCA, and BA diameters correlated with older age (Weighted average [WA] per 10 years: 0.18 mm, 0.11 mm, and 0.12 mm), male sex (WA: 0.24 mm, 0.13 mm, and 0.21 mm), and TCV (WA: for one TCV standard deviation: 0.24 mm, 0.29 mm, and 0.18 mm). Unilateral and bilateral fPCAs showed a positive correlation with ICA diameters (WA: 0.39 mm and 0.73 mm) and negative correlation with BA diameters (WA: -0.88 mm and -1.73 mm). Regression models including age, sex, TCV, and fPCA explained on average 15%, 13%, and 25% of the ICA, MCA, and BA diameter interindividual variation, respectively. Using height instead of TCV as a surrogate of head size decreased the R-squared by 3% on average.
    Conclusion: Brain arterial diameters correlated with age, sex, TCV, and fPCA. These factors should be considered when defining abnormal diameter cutoffs across populations.
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/19714009231224429
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2823: Show issues Location:
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  6. Article ; Online: Cohort Profile Update: Cognition and dementia in the Health and Aging in Africa Longitudinal Study of an INDEPTH community in South Africa (HAALSI dementia).

    Bassil, Darina T / Farrell, Meagan T / Wagner, Ryan G / Brickman, Adam M / Glymour, M Maria / Langa, Kenneth M / Manly, Jennifer J / Salinas, Joel / Tipping, Brent / Tollman, Stephen / Berkman, Lisa F

    International journal of epidemiology

    2017  Volume 51, Issue 4, Page(s) e217–e226

    MeSH term(s) Aging ; Cognition ; Dementia/epidemiology ; Humans ; Longitudinal Studies ; Rural Population ; South Africa/epidemiology
    Language English
    Publishing date 2017-12-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyab250
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    In stock of ZB MED Cologne/Königswinter

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