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Article ; Online: Arc discharge rapid synthesis of engineered copper oxides nano shapes with potent antibacterial activity against multi-drug resistant bacteria

Bassma H. Elwakil / M. Toderas / Mostafa El-Khatib

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 10

Abstract: Abstract Nowadays Nano metals have received an eminent compromise of attention. Even though different nanostructure of same metal maybe gives different results in wide range applications. Copper oxide (CuO-NPs) and Copper Nano wires (CuO-NWs) were ... ...

Abstract	Abstract Nowadays Nano metals have received an eminent compromise of attention. Even though different nanostructure of same metal maybe gives different results in wide range applications. Copper oxide (CuO-NPs) and Copper Nano wires (CuO-NWs) were prepared in controlled size via the alternating current Arc discharge process. Deionized water and argon gas were the chosen dielectric medium during the process to obtain 2 different forms of copper oxides. By changing the dielectric material from deionized water to argon gas the shape of CuO nanoparticles changed from spherical (CuO-NPs) to wires (CuO-NWS). The yield prepared depicted the purity of the prepared CuO, and their diameters were about 10 ± 5 nm and 30 ± 3 nm for CuO-NWs and CuO-NPs respectively. In vitro cytotoxic effect of the prepared CuO-NWs & CuO-NPs using human normal lung fibroblast cell line (WI-38 cells) revealed that CuO-NWs & CuO-NPs CC50 values were 458.8 and 155.6 µg/mL respectively. Both yields showed potent antibacterial activity against different multi-drug resistant Acinetobacter baumannii strains. A complete eradication of the bacterial growth was noticed after 4 Hrs incubation with CuO-NWs. Moreover, CuO-NWs showed superior antibacterial activity (with minimum inhibitory concentration reached 1.8 µg/mL) over CuO-NPs. The detailed antibacterial activity mechanism of CuO-NWs was further investigated; data proved the precipitation and adsorption of the nanoparticles on the bacterial cell surface leading to cell deformation with reactive oxygen species increment. The results explicated that the nanoparticles shape plays an essential role in the antibacterial activity. Rotational Arc discharge machine might be a promising tool to obtain various metal nanostructures with low cost and environmentally friendly with potent activity.
Keywords	Medicine ; R ; Science ; Q
Subject code	540 ; 500
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fungal Secondary Metabolites/Dicationic Pyridinium Iodide Combinations in Combat against Multi-Drug Resistant Microorganisms

Ayoub M. Abdelalatif / Bassma H. Elwakil / Mohamed Zakaria Mohamed / Mohamed Hagar / Zakia A. Olama

Molecules, Vol 28, Iss 2434, p

2023 Volume 2434

Abstract: The spread of antibiotic-resistant opportunistic microbes is a huge socioeconomic burden and a growing concern for global public health. In the current study, two endophytic fungal strains were isolated from Mangifera Indica roots and identified as ... ...

Abstract	The spread of antibiotic-resistant opportunistic microbes is a huge socioeconomic burden and a growing concern for global public health. In the current study, two endophytic fungal strains were isolated from Mangifera Indica roots and identified as Aspergillus niger MT597434.1 and Trichoderma lixii KU324798.1. Secondary metabolites produced by A. niger and T. lixii were extracted and tested for their antimicrobial activity. The highest activity was noticed against Staphylococcus aureus and E. coli treated with A. niger and T. lixii secondary metabolites, respectively. A. niger crude extract was mainly composed of Pentadecanoic acid, 14-methyl-, methyl ester and 9-Octadecenoic acid ( Z )-, methyl ester (26.66 and 18.01%, respectively), while T. lixii crude extract’s major components were 2,4-Decadienal, ( E , E ) and 9-Octadecenoic acid ( Z )-, and methyl ester (10.69 and 10.32%, respectively). Moreover, a comparative study between the fungal extracts and dicationic pyridinium iodide showed that the combination of A. niger and T. lixii secondary metabolites with dicationic pyridinium iodide compound showed a synergistic effect against Klebsiella pneumoniae . The combined formulae inhibited the bacterial growth after 4 to 6 h through cell wall breakage and cells deformation, with intracellular components leakage and increased ROS production.
Keywords	endophytic fungi ; Trichoderma lixii ; Aspergillus niger ; dicationic pyridinium iodide ; multi-drug resistant ; Organic chemistry ; QD241-441
Subject code	500
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mechanistic action of lead removal by the native isolate Bacillus amyloliquefaciens ON261680.1

Nada Shaaban Emara / Bassma H. Elwakil / Mohamed Zakaria / Zakia A. Olama

Arabian Journal of Chemistry, Vol 16, Iss 8, Pp 104962- (2023)

2023

Abstract: Lead (Pb) is one of the substantial hazard pollutants that cause soil pollution. Bioremediation is an eco-friendly and cost-effective technique that provides a convenient solution for lead removal. In the present study, lead resistant bacterial strains ... ...

Abstract	Lead (Pb) is one of the substantial hazard pollutants that cause soil pollution. Bioremediation is an eco-friendly and cost-effective technique that provides a convenient solution for lead removal. In the present study, lead resistant bacterial strains were isolated from industrial effluents contaminated soil with lead minimum inhibitory concentrations reached 15000 ppm. The most resistant isolate was identified by 16S rRNA sequencing as Bacillus amyloliquefaciens ON261680.1. Taguchi statistical design was applied to optimize the environmental and nutritional factors that lead to maximum lead removal. The optimized conditions for the highest lead removal of lead concentration, incubation temperature, incubation time, peptone, yeast, beef extract, NaCl concentrations, pH, inoculum size and inoculum age were 10000 ppm, 30 °C, 96 hrs incubation, 0.5 g, 0.5 g, 1.5 g, 6 g, 9, 15 mL and 48 hrs old culture, respectively. The most significant factors (p < 0.05) were incubation time, pH, lead concentration, and incubation temperature. Mechanistic action was investigated through employing Fourier transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDX) and transmission electron microscopy (TEM). It was revealed that Bacillus amyloliquefaciens ON261680.1 removed the lead pollutant through bio-adsorption, deposition and complexation on the cell surface. The present study may pave the way to use Bacillus amyloliquefaciens ON261680.1 as an efficient bioremediation tool.
Keywords	Lead bioremediation ; Taguchi statistical design ; Lead resistant bacteria ; Mechanistic action ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Cinnamon Oil-Loaded Nanoliposomes with Potent Antibacterial and Antibiofilm Activities

Neveen M. Ellboudy / Bassma H. Elwakil / Marwa M. Shaaban / Zakia A. Olama

Molecules, Vol 28, Iss 4492, p

2023 Volume 4492

Abstract: Despite recent scientific advances, the global load of bacterial disease remains high and has been established against a backdrop of increasing antimicrobial resistance. Therefore, there is a pressing need for highly effective and natural antibacterial ... ...

Abstract	Despite recent scientific advances, the global load of bacterial disease remains high and has been established against a backdrop of increasing antimicrobial resistance. Therefore, there is a pressing need for highly effective and natural antibacterial agents. In the present work, the antibiofilm effect provided by essential oils was evaluated. Of these, cinnamon oil extract showed potent antibacterial and antibiofilm activities against Staphylococcus aureus at an MBEC of 75.0 µg/mL. It was revealed that benzyl alcohol, 2-propenal-3-phenyl, hexadecenoic acid, and oleic acid were the major components of the tested cinnamon oil extract. In addition, the interaction between the cinnamon oil and colistin showed a synergistic effect against S. aureus . Cinnamon oil that had been combined with colistin was encapsulated by liposomes to enhance the essential oil’s chemical stability, demonstrating a particle size of 91.67 nm, a PDI of 0.143, a zeta potential of −0.129 mV, and an MBEC of 50.0 µg/mL against Staphylococcus aureus . Scanning electron microscopy was employed to observe the morphological changes in the Staphylococcus aureus biofilm that was treated with the encapsulated cinnamon oil extract/colistin. As a natural and safe option, cinnamon oil exhibited satisfactory antibacterial and antibiofilm performance. The application of liposomes further improved the stability of the antibacterial agents and extended the essential oil release profile.
Keywords	cinnamon oil ; antibacterial ; antibiofilm ; nanoliposome ; colistin ; combination study ; Organic chemistry ; QD241-441
Subject code	660
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Novel Clotrimazole and Vitis vinifera loaded chitosan nanoparticles

Esraa E. Elshaer / Bassma H. Elwakil / Areej Eskandrani / Salma S. Elshewemi / Zakia A. Olama

Saudi Journal of Biological Sciences, Vol 29, Iss 3, Pp 1832-

Antifungal and wound healing efficiencies

2022 Volume 1841

Abstract: Chitosan integrated nanoparticles of clotrimazole and Egyptian Vitis vinifera juice extract was evaluated in order to maximize the antifungal activity and reduce the gross side effects. In the present study Egyptian Thompson Seedless Vitis vinifera and ... ...

Abstract	Chitosan integrated nanoparticles of clotrimazole and Egyptian Vitis vinifera juice extract was evaluated in order to maximize the antifungal activity and reduce the gross side effects. In the present study Egyptian Thompson Seedless Vitis vinifera and Clotrimazole (Cz) loaded chitosan nanoparticles (NCs/VJ/Cz) showed a promising antifungal effect with average inhibition zone diameters of 74 and 72 mm against Candida albicans and Aspergillus niger respectively. NCs/VJ /Cz was stable with significant drug entrapment efficiency reached 94.7%; PDI 0.24; zeta potential value + 31 and average size 35.4 nm diameter. Ex vivo and in vivo evaluation of skin retention, permeation and wound repair potentialities of NCs/VJ /Cz ointment was examined by experimental rats with wounded skin fungal infection. Data proved the ability of NCs/VJ /Cz to gradually release the drugs in a sustained manner with complete wound healing effect and tissue repair after 7 days administration. As a conclusion NCs/VJ /Cz ointment can be used as a novel anti-dermatophytic agent with high wound healing capacity.
Keywords	Clotrimazole ; Egyptian Vitis vinifera ; Chitosan Nanoparticles ; Wound Healing ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Selenium nanoparticles coated bacterial polysaccharide with potent antimicrobial and anti-lung cancer activities

Nourhan S. Shehata / Bassma H. Elwakil / Salma S. Elshewemi / Doaa A. Ghareeb / Zakia A. Olama

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 23

Abstract: Abstract Bacterial exopolysaccharides are homopolymeric or heteropolymeric polysaccharides with large molecular weights (10–1000 kDa). Exopolysaccharides' functional uses and potential have revolutionized the industrial and medicinal industries. Hence, ... ...

Abstract	Abstract Bacterial exopolysaccharides are homopolymeric or heteropolymeric polysaccharides with large molecular weights (10–1000 kDa). Exopolysaccharides' functional uses and potential have revolutionized the industrial and medicinal industries. Hence, the aim of the present study was to optimize the production of bacterial exopolysaccharide and apply it as a capping agent for selenium nanoparticles synthesis. Exopolysaccharide (EPS) producing Lactic acid bacteria (LAB) were isolated from dairy products then biochemically characterized and assessed for their potential antimicrobial effect. The most potent EPS producer was identified as Lactiplantibacillus plantarum strain A2 with accession number OP218384 using 16S rRNA sequencing. Overall, FTIR data of the extracted EPS revealed similarity with amylopectin spectrum. 1H NMR spectrum revealed an α-anomeric configuration of the glycosidic linkage pattern in the polysaccharides while the 13C NMR spectrum can also be separated into two main portions, the anomeric carbons region (δ 98–102 ppm) and the non-anomeric carbons region (δ 60–81 ppm). Antimicrobial activity of the produced EPS showed maximum activity against Staphylococcus aureus, MRSA, Enterobacter aerogenes, Klebsiella pneumoniae and Candida albicans respectively. The EPS capsule layer surrounding the bacterial cells was detected by TEM study. Optimization of EPS production was evaluated using Taguchi design, trial 23 reported the highest biomass yield and EPS output (6.5 and 27.12 g/L respectively) with 2.4 and 3.3 folds increase (from the basal media) respectively. The optimized exopolysaccharide was used as a capping and stabilizing agent for selenium nanoparticles (EPS-SeNPs) synthesis. Zeta potential, size and PDI of the synthesized nanoparticles were − 19.7 mV, 45–65 nm and 0.446 respectively with strong bactericidal and fungicidal effect against the tested pathogens. Complete microbial growth eradication was recorded after 6, 8 and 10 h against Staphylococcus aureus, Candida albicans and Klebsiella ...
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design and synthesis of novel bis-pyridinium based-ionic liquids as potent antiparasitic agents

Esraa Abdelhamid Moneer / Basant A. Bakr / Sara H. Akl / Yahya H. Shahin / Bassma H. Elwakil / Mohamed Hagar / Keshav Raj Paudel / Ateyatallah Aljuhani / Mohamed Reda Aouad / Nadjet Rezki

Heliyon, Vol 9, Iss 4, Pp e15431- (2023)

2023

Abstract: Focused bis-pyridinium based-ionic liquids were successfully synthesized through the quaternization of the selected 1,2-di(pyridin-4-yl)ethane followed by metathetical anion exchange. The synthesized pyridinium derivatives were fully characterized using ... ...

Abstract	Focused bis-pyridinium based-ionic liquids were successfully synthesized through the quaternization of the selected 1,2-di(pyridin-4-yl)ethane followed by metathetical anion exchange. The synthesized pyridinium derivatives were fully characterized using various NMR-spectroscopic techniques including 1H, 13C, 11B, 31P and 19F NMR. The synthesized compounds were tested for their potential effect against Toxoplasma gondii. It was revealed that compound 5 had higher antiparasitic activity compared to other compounds. Parasitic reduction percentage reached 38, 50, 77 and 79 for groups III, IV, V and VI respectively in the liver with noticed distortion and deformation in tachyzoites’ shape. Surprisingly there was no statistically significant difference between the synthesized compound 5 and the known anti-toxoplasmosis drug pyrimethamine. Histopathological study proved the effectiveness of the synthesized compound 5 on liver, spleen and brain tissues with observed better histological features compared to pyrimethamine treated group. The present investigation may pave the way to the possible use of compound 5 to replace the known drug pyrimethamine with better antiparasitic profile and fewer side effects.
Keywords	Ionic liquids ; Dicationic ionic liquids ; Toxoplasmosis infections ; Antiparasitic agents ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	540
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In vivo bio-distribution and acute toxicity evaluation of greenly synthesized ultra-small gold nanoparticles with different biological activities

Faizah S. Aljohani / Moaaz T. Hamed / Basant A. Bakr / Yahya H. Shahin / Marwa M. Abu-Serie / Ashraf K. Awaad / Hadir El-Kady / Bassma H. Elwakil

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 20

Abstract: Abstract Ultra-small gold nanoparticles (Au-NPs) “≤ 10 nm diameters” have potent biomedical applications. Hence, the present study aimed to greenly synthesize ultra-small gold nanoparticles using Egyptian propolis extract. Different biological activities, ...

Abstract	Abstract Ultra-small gold nanoparticles (Au-NPs) “≤ 10 nm diameters” have potent biomedical applications. Hence, the present study aimed to greenly synthesize ultra-small gold nanoparticles using Egyptian propolis extract. Different biological activities, in vivo bio-distribution and acute toxicity study were assessed. Results revealed that, Egyptian propolis extract can successfully synthesize the highly pure and stable ultra-small Au-NPs with average diameter 7.8 nm. In vitro antimicrobial and antimycobacterial activities revealed the powerful effect of the prepared Au-NPs. Moreover, the cytotoxic effect on human cancer cell lines revealed the potent inhibition of the cancer cells’ proliferation with high reactive oxygen species-mediated apoptosis induction. In vivo bio-distribution and acute toxicity studies were performed (10 and 100 mg/kg doses) in male albino rats. The ultra-small Au-NPs showed low or no toxicity upon using the Au-NPs low dose. The mean area accumulation (%) of the Au-NPs was higher in the liver, kidney, and brain tissues (4.41, 2.96, and 0.3 times, respectively) treated with high Au-NPs dosage compared to those treated with the low dose. Surprisingly, Au-NP accumulation in brain tissue was observed in the glial cells only. Accordingly, the low dose (10 mg/kg) of Au-NPs can be used safely in a variety of biomedical applications.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Novel Hybrid 1,2,4- and 1,2,3-Triazoles Targeting Mycobacterium Tuberculosis Enoyl Acyl Carrier Protein Reductase (InhA)

Maged A. El Sawy / Maram M. Elshatanofy / Yeldez El Kilany / Kamal Kandeel / Bassma H. Elwakil / Mohamed Hagar / Mohamed Reda Aouad / Fawzia Faleh Albelwi / Nadjet Rezki / Mariusz Jaremko / El Sayed H. El Ashry

International Journal of Molecular Sciences, Vol 23, Iss 4706, p

Design, Synthesis, and Molecular Docking

2022 Volume 4706

Abstract: Tuberculosis (TB) caused by Mycobacterium tuberculosis is still a serious public health concern around the world. More treatment strategies or more specific molecular targets have been sought by researchers. One of the most important targets is M. ... ...

Abstract	Tuberculosis (TB) caused by Mycobacterium tuberculosis is still a serious public health concern around the world. More treatment strategies or more specific molecular targets have been sought by researchers. One of the most important targets is M. tuberculosis’ enoyl-acyl carrier protein reductase InhA which is considered a promising, well-studied target for anti-tuberculosis medication development. Our team has made it a goal to find new lead structures that could be useful in the creation of new antitubercular drugs. In this study, a new class of 1,2,3- and 1,2,4-triazole hybrid compounds was prepared. Click synthesis was used to afford 1,2,3-triazoles scaffold linked to 1,2,4-triazole by fixable mercaptomethylene linker. The new prepared compounds have been characterized by different spectroscopic tools. The designed compounds were tested in vitro against the InhA enzyme. At 10 nM, the inhibitors 5b, 5c, 7c, 7d, 7e, and 7f successfully and totally (100%) inhibited the InhA enzyme. The IC 50 values were calculated using different concentrations. With IC 50 values of 0.074 and 0.13 nM, 7c and 7e were the most promising InhA inhibitors. Furthermore, a molecular docking investigation was carried out to support antitubercular activity as well as to analyze the binding manner of the screened compounds with the target InhA enzyme’s binding site.
Keywords	tuberculosis ; InhA enzyme ; 1,2,3- and 1,2,4-Triazoles ; in vitro ; molecular docking ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring the Antiparasitic Activity of Tris -1,3,4-Thiadiazoles against Toxoplasma gondii -Infected Mice

Tahani M. Almutairi / Nadjet Rezki / Mohamed Reda Aouad / Mohamed Hagar / Basant A. Bakr / Moaaz T. Hamed / Maha Khairy Hassen / Bassma H. Elwakil / Esraa Abdelhamid Moneer

Molecules, Vol 27, Iss 2246, p

2022 Volume 2246

Abstract: Nitrogen-containing atoms in their core structures have been exclusive building blocks in drug discovery and development. One of the most significant and well-known heterocycles is the 1,3,4-thidiazole nucleus, which is found in a wide range of natural ... ...

Abstract	Nitrogen-containing atoms in their core structures have been exclusive building blocks in drug discovery and development. One of the most significant and well-known heterocycles is the 1,3,4-thidiazole nucleus, which is found in a wide range of natural products and therapeutic agents. In the present work, certain tris -1,3,4-thiadiazole derivatives ( 6 , 7 ) were synthesized through a multi-step synthesis approach. All synthesized compounds were characterized using different spectroscopic tools. Previously, thiadiazole compounds as anti- Toxoplasma gondii agents have been conducted and reported in vitro. However, this is the first study to test the anti- Toxoplasma gondii activity of manufactured molecular hybrids thiadiazole in an infected mouse model with the acute RH strain of T. gondii . All the observed results demonstrated compound ( 7 )’s powerful activity, with a considerable reduction in the parasite count reaching 82.6% in brain tissues, followed by liver and spleen tissues (65.35 and 64.81%, respectively). Inflammatory and anti-inflammatory cytokines assessments proved that Compound 7 possesses potent antiparasitic effect. Furthermore, docking tests against Tg CDPK1 and ROP18 kinase (two major enzymes involved in parasite invasion and egression) demonstrated compound 7 ’s higher potency compared to compound 6 and megazol. According to the mentioned results, tris -1,3,4-thiadiazole derivatives under test can be employed as potent antiparasitic agents against the acute RH strain of T. gondii .
Keywords	tris- 1,3,4-thiadiazoles ; antiparasite ; Toxoplasma gondii ; in vivo study ; immunological studies ; docking studies ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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