LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 73

Search options

  1. Article ; Online: Identifying discontinuities of flood frequency curves

    Miniussi, Arianna / Merz, Ralf / Kaule, Lisa / Basso, Stefano

    Journal of Hydrology. 2023 Feb., v. 617 p.128989-

    2023  

    Abstract: Discontinuities in flood frequency curves, here referred to as flood divides, hinder the estimation of rare floods. In this paper we develop an automated methodology for the detection of flood divides from observations and models, and apply it to a large ...

    Abstract Discontinuities in flood frequency curves, here referred to as flood divides, hinder the estimation of rare floods. In this paper we develop an automated methodology for the detection of flood divides from observations and models, and apply it to a large set of case studies in the USA and Germany. We then assess the reliability of the PHysically-based Extreme Value (PHEV) distribution of river flows to identify catchments that might experience a flood divide, validating its results against observations. This tool is suitable for the identification of flood divides, with a high correct detection rate especially in the autumn and summer seasons. It instead tends to indicate the emergence of flood divides not visible in the observations in spring and winter. We examine possible reasons of this behavior, finding them in the typical streamflow dynamics of the concerned case studies. By means of a controlled experiment we also re-evaluate detection capabilities of observations and PHEV after discarding the highest maxima for all cases where both empirical and theoretical estimates display flood divides. PHEV mostly confirms its capability to detect a flood divide as observed in the original flood frequency curve, even if the shortened one does not show it. These findings prove its reliability for the identification of flood divides and set the premises for a deeper investigation of physiographic and hydroclimatic attributes controlling the emergence of discontinuities in flood frequency curves.
    Keywords automation ; autumn ; rivers ; spring ; stream flow ; summer ; winter ; Germany ; Extreme floods ; Flood hazard ; Flood divide ; Flood frequency curves ; Physically-based framework ; Detection method
    Language English
    Dates of publication 2023-02
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1473173-3
    ISSN 1879-2707 ; 0022-1694
    ISSN (online) 1879-2707
    ISSN 0022-1694
    DOI 10.1016/j.jhydrol.2022.128989
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  2. Article: Reliable estimation of high floods: A method to select the most suitable ordinary distribution in the Metastatistical extreme value framework

    Mushtaq, Sumra / Miniussi, Arianna / Merz, Ralf / Basso, Stefano

    Advances in water resources. 2022 Mar., v. 161

    2022  

    Abstract: Recent advances in the study of extreme values, namely the Metastatistical extreme value (MEV) framework, showed good performances for the estimation of extremes in several fields. Here we adopt MEV for flood frequency analysis and leverage its intrinsic ...

    Abstract Recent advances in the study of extreme values, namely the Metastatistical extreme value (MEV) framework, showed good performances for the estimation of extremes in several fields. Here we adopt MEV for flood frequency analysis and leverage its intrinsic property of allowing for the choice of the distribution which best describes ordinary peaks to improve flood estimation. To this end, we develop a non-parametric approach to select ex ante the most suitable distribution of ordinary peaks between Gamma and Log-Normal. The method relies on the tail ratio, which we define as the ratio between the empirical 99th and 95th percentile of the ordinary peaks, and is tested by using daily streamflow time series from 182 gauges in Germany. Based on the value of the tail ratio index, we choose either the Gamma or the Log-Normal distributions to represent the ordinary peaks in each gauge. The approach correctly identifies the most suitable distribution of ordinary peaks in a large majority of the analyzed basins, and is robust to changes of the considered dataset. The preliminary selection of the ordinary distribution based on the tail ratio index improves the estimation of frequent and rare floods with respect to MEV applied with a single distribution not tailored on the specific statistical properties of the ordinary peaks. Finally, by comparing the developed methodology with the standard Generalized Extreme Value (GEV) distribution, we show that we are able to reduce the estimation uncertainty of high flood quantiles.
    Keywords data collection ; stream flow ; time series analysis ; uncertainty ; water ; Germany
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2023320-6
    ISSN 1872-9657 ; 0309-1708
    ISSN (online) 1872-9657
    ISSN 0309-1708
    DOI 10.1016/j.advwatres.2022.104127
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  3. Article: Parameter's Controls of Distributed Catchment Models—How Much Information is in Conventional Catchment Descriptors?

    Merz, Ralf / Tarasova, Larisa / Basso, Stefano

    Water resources research. 2020 Feb., v. 56, no. 2

    2020  

    Abstract: One major challenge in large scale modeling is the estimation of spatially consistent distributed parameters, that are parameters with a clear functional relationship to climate and landscape characteristics. We present a newly developed PArameter Set ... ...

    Abstract One major challenge in large scale modeling is the estimation of spatially consistent distributed parameters, that are parameters with a clear functional relationship to climate and landscape characteristics. We present a newly developed PArameter Set Shuffling (PASS) approach, which is able to provide such regionally consistent parameter sets. The PASS method does not require any a priori assumption on the relationship between model parameters and catchment descriptors. It instead derives these relationships from observed patterns of calibrated parameters and available catchment descriptors. We tested the PASS approach to derive parameters of a conceptual hydrological model applied to 263 German catchments. The resulting median model efficiencies for training and test catchments are, respectively, 0.74 and 0.72, similar to those obtained by other modeling approaches, which use regional calibration. In this study, a combination of catchment descriptors that clearly controls model parameters is not found. In fact, we show that various regional functional relationships between catchment descriptors and model parameters result in similarly good model performances. Moreover, catchment descriptors used for parameter prediction can be replaced in the parameter prediction, without any decrease in model performance. Our results suggest that by using conventional catchment descriptors based on averages, only the amount of information that is also retained in the existing correlations among climatic and catchment indicators is exploited. Development of a new generation of hydrologically meaningful catchment and climate descriptors is required to further improve our capability of forecasting hydrological dynamics of interest by means of large scale models and regionalization approaches.
    Keywords climate ; hydrologic models ; landscapes ; model validation ; prediction ; research ; water ; watersheds
    Language English
    Dates of publication 2020-02
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 5564-5
    ISSN 1944-7973 ; 0043-1397
    ISSN (online) 1944-7973
    ISSN 0043-1397
    DOI 10.1029/2019WR026008
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  4. Article ; Online: Characterizing hydrograph recessions from satellite-derived soil moisture.

    Basso, Stefano / Ghazanchaei, Zohreh / Tarasova, Larisa

    The Science of the total environment

    2020  Volume 756, Page(s) 143469

    Abstract: Hydrograph recessions, usually described through a power-law function of river flows, are among the most widely utilized hydrological signatures. Whereas theories explaining the genesis of recession exponents have been recently developed, ongoing ... ...

    Abstract Hydrograph recessions, usually described through a power-law function of river flows, are among the most widely utilized hydrological signatures. Whereas theories explaining the genesis of recession exponents have been recently developed, ongoing discussions on the physical meaning and suitable proxies of recession coefficients suggest their linkage to soil moisture states of whole river basins. This work investigates the possibility to explain hydrograph recession coefficients by means of satellite-derived soil moisture products such as the Soil Water Index of Copernicus Global Land Service. Analyses of basin-averaged Soil Water Index, computed for eleven river basins from the Central and Eastern United States with varied climates and landscapes, reveal the existence of an inverse relation between mean soil moisture and its variability in time, and provide a glance into the variability of river flows. A visible signature of satellite-derived soil moisture conditions on the values of the recession coefficient as well emerges when statistics of the Soil Water Index are paired with recession properties obtained by means of hydrograph recession analysis. In particular, drier river basins characterized by larger soil moisture variability tend to exhibit larger and more variable recession coefficients. These results suggest reliability of existing conjectures about the role of soil moisture for determining recession properties, and indicate that satellite-derived products can inform understanding of the intrinsic variability of the hydrologic response in river basins.
    Language English
    Publishing date 2020-11-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.143469
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Editorial on "Growth patterns of pulmonary metastases: should we adjust resection techniques to primary histology and size?"

    Basso, Stefano M M / Sulfaro, Sandro C / Ubiali, Paolo

    Journal of thoracic disease

    2018  Volume 10, Issue 1, Page(s) 121–125

    Language English
    Publishing date 2018-03-28
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2017.12.98
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Understanding Heavy Tails of Flood Peak Distributions

    Merz, Bruno / Basso, Stefano / Fischer, Svenja / Lun, David / Blöschl, Günter / Merz, Ralf / Guse, Björn / Viglione, Alberto / Vorogushyn, Sergiy / Macdonald, Elena / Wietzke, Luzie / Schumann, Andreas

    Water resources research. 2022 June, v. 58, no. 6

    2022  

    Abstract: Statistical distributions of flood peak discharge often show heavy tail behavior, that is, extreme floods are more likely to occur than would be predicted by commonly used distributions that have exponential asymptotic behavior. This heavy tail behavior ... ...

    Abstract Statistical distributions of flood peak discharge often show heavy tail behavior, that is, extreme floods are more likely to occur than would be predicted by commonly used distributions that have exponential asymptotic behavior. This heavy tail behavior may surprise flood managers and citizens, as human intuition tends to expect light tail behavior, and the heaviness of the tails is very difficult to predict, which may lead to unnecessarily high flood damage. Despite its high importance, the literature on the heavy tail behavior of flood distributions is rather fragmented. In this review, we provide a coherent overview of the processes causing heavy flood tails and the implications for science and practice. Specifically, we propose nine hypotheses on the mechanisms causing heavy tails in flood peak distributions related to processes in the atmosphere, the catchment, and the river system. We then discuss to which extent the current knowledge supports or contradicts these hypotheses. We also discuss the statistical conditions for the emergence of heavy tail behavior based on derived distribution theory and relate them to the hypotheses and flood generation mechanisms. We review the degree to which the heaviness of the tails can be predicted from process knowledge and data. Finally, we recommend further research toward testing the hypotheses and improving the prediction of heavy tails.
    Keywords flood damage ; humans ; mathematical theory ; prediction ; research ; rivers ; tail ; water ; watersheds
    Language English
    Dates of publication 2022-06
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note REVIEW
    ZDB-ID 5564-5
    ISSN 1944-7973 ; 0043-1397
    ISSN (online) 1944-7973
    ISSN 0043-1397
    DOI 10.1029/2021WR030506
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  7. Article ; Online: Diagnosis of Malignant Pleural Effusion Using CT Scan and Pleural-Fluid Cytology Together. A Preliminary Case-Control Study.

    Basso, Stefano M M / Lumachi, Franco / Del Conte, Alessandro / Sulfaro, Sandro / Maffeis, Federica / Ubiali, Paolo

    Anticancer research

    2020  Volume 40, Issue 2, Page(s) 1135–1139

    Abstract: Background/aim: The purposes of this study were to evaluate the usefulness of chest computed tomographic (CT) scan plus pleural fluid cytology (PFC) together in patients with malignant pleural effusion (PE), and to compare the results of these ... ...

    Abstract Background/aim: The purposes of this study were to evaluate the usefulness of chest computed tomographic (CT) scan plus pleural fluid cytology (PFC) together in patients with malignant pleural effusion (PE), and to compare the results of these diagnostic tools in patients with malignant PE due to non-small-cell lung cancer and pulmonary metastases from other malignancies.
    Patients and methods: The medical records of 185 patients with PE, who underwent chest CT, PFC and video-assisted thoracoscopy (VATS) thoracentesis followed by VATS-guided biopsy for diagnostic purpose, were reviewed. At the final diagnosis, 123 (66.5%) patients had malignant PE (cases), and 62 (33.5%) had benign PE (controls).
    Results: Overall, the sensitivity, specificity, and accuracy of CT and PFC were 65.0% vs. 67.5% 98.4% vs. 98.4%, and 76.2% vs. 77.8%, respectively. The combination of CT plus PFC significantly improved sensitivity (86.2%, p=0.003) and accuracy (90.8%, p=0.02).
    Conclusion: CT and PFC used together may lead to approximately 100% specificity and >90% sensitivity in distinguishing between benign and malignant PE.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biopsy ; Case-Control Studies ; Cytodiagnosis ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Pleural Effusion, Malignant/diagnosis ; Sensitivity and Specificity ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-01-17
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.14054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Pathophysiology and treatment of nonfamilial hyperparathyroidism.

    Lumachi, Franco / Basso, Stefano M M

    Recent patents on CNS drug discovery

    2014  Volume 9, Issue 3, Page(s) 164–172

    Abstract: Primary hyperparathyroidism (HPT) is the main cause of hypercalcemia and the most common parathyroid glands disease. The diagnosis is easy in patients with hypercalcemia and elevated PTH serum level. Minimally invasive parathyroidectomy (PTx) represents ... ...

    Abstract Primary hyperparathyroidism (HPT) is the main cause of hypercalcemia and the most common parathyroid glands disease. The diagnosis is easy in patients with hypercalcemia and elevated PTH serum level. Minimally invasive parathyroidectomy (PTx) represents the treatment of choice for symptomatic patients, leading to several advantages, including immediate normalization of hypercalcemia and significant improvement of bone mineral density, cardiovascular dysfunctions, neuropsychological symptoms and quality of life. Secondary and tertiary HPT are relatively common complications in patients with chronic kidney disease (CKD) or advanced kidney failure, and in kidney transplant recipients who did not achieve complete calcium/phosphate metabolism normalization, respectively. The drugs available for patients with secondary HPT, and to treat hyperphosphatemia include non-calcium-containing phosphate binder, calcitriol analogues, calcimimetic agents, or a combination of two or more drugs. Although recent studies report that PTx significantly improves survival also in patients with CKD and severe secondary HPT, the indications for surgery are not yet well established. Subtotal or total PTx with or without autotransplantation are the surgical options for treating all patients with secondary HPT. Total PTx leads to a faster reduction in serum calcium level and normalization of PTH, but the risk of hypoparathyroidism is higher than after subtotal PTx. Further studies are needed to confirm the usefulness of the drugs currently recommended, and others will have to be tested in the near future.
    MeSH term(s) Humans ; Hyperparathyroidism/diagnosis ; Hyperparathyroidism/etiology ; Hyperparathyroidism/therapy ; Parathyroidectomy ; Quality of Life
    Language English
    Publishing date 2014-12-30
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2253602-4
    ISSN 2212-3954 ; 1574-8898
    ISSN (online) 2212-3954
    ISSN 1574-8898
    DOI 10.2174/1574889810666150131141054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Shifts in flood generation processes exacerbate regional flood anomalies in Europe.

    Tarasova, Larisa / Lun, David / Merz, Ralf / Blöschl, Günter / Basso, Stefano / Bertola, Miriam / Miniussi, Arianna / Rakovec, Oldrich / Samaniego, Luis / Thober, Stephan / Kumar, Rohini

    Communications earth & environment

    2023  Volume 4, Issue 1, Page(s) 49

    Abstract: Anomalies in the frequency of river floods, i.e., flood-rich or -poor periods, cause biases in flood risk estimates and thus make climate adaptation measures less efficient. While observations have recently confirmed the presence of flood anomalies in ... ...

    Abstract Anomalies in the frequency of river floods, i.e., flood-rich or -poor periods, cause biases in flood risk estimates and thus make climate adaptation measures less efficient. While observations have recently confirmed the presence of flood anomalies in Europe, their exact causes are not clear. Here we analyse streamflow and climate observations during 1960-2010 to show that shifts in flood generation processes contribute more to the occurrence of regional flood anomalies than changes in extreme rainfall. A shift from rain on dry soil to rain on wet soil events by 5% increased the frequency of flood-rich periods in the Atlantic region, and an opposite shift in the Mediterranean region increased the frequency of flood-poor periods, but will likely make singular extreme floods occur more often. Flood anomalies driven by changing flood generation processes in Europe may further intensify in a warming climate and should be considered in flood estimation and management.
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ISSN 2662-4435
    ISSN (online) 2662-4435
    DOI 10.1038/s43247-023-00714-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Current medical treatment of estrogen receptor-positive breast cancer.

    Lumachi, Franco / Santeufemia, Davide A / Basso, Stefano Mm

    World journal of biological chemistry

    2015  Volume 6, Issue 3, Page(s) 231–239

    Abstract: Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in ... ...

    Abstract Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of (1) ovarian function suppression (OFS), usually obtained using gonadotropin-releasing hormone agonists (GnRHa); (2) selective estrogen receptor modulators or down-regulators (SERMs or SERDs); and (3) aromatase inhibitors (AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs (i.e., tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs (i.e., fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type I are permanent steroidal inhibitors of aromatase, while type II are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs (i.e., anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors (palbociclib) and mammalian target of rapamycin (mTOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness.
    Language English
    Publishing date 2015-08-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2564793-3
    ISSN 1949-8454
    ISSN 1949-8454
    DOI 10.4331/wjbc.v6.i3.231
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top