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  1. Article: Exploring health and toxicity in food choices: 10 examples navigating the gray area.

    Bast, Aalt / Semen, Khrystyna O

    Frontiers in nutrition

    2024  Volume 10, Page(s) 1301757

    Abstract: People's perception on what is healthy and what is toxic food, determines food preferences and eating behavior. The difference between heathy and toxic food and food ingredients is however not always clear. This is illustrated with 10 examples. Unjustly, ...

    Abstract People's perception on what is healthy and what is toxic food, determines food preferences and eating behavior. The difference between heathy and toxic food and food ingredients is however not always clear. This is illustrated with 10 examples. Unjustly, all-natural food is regarded as safe. Regulation on health claims on food and food risks is not balanced. Biphasic responses of the physiological effect of food ingredients show that mild toxicity of these substances results in health promotion. Nutritional substances with drugs may have either a negative or a positive effect on health. New toxicological methodologies can be brought into play, to better understand the dynamics of health and disease. Unfortunately, we still cannot taste toxicity.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1301757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Pesticides and lung function.

    Bast, Aalt

    Current opinion in pulmonary medicine

    2021  Volume 27, Issue 4, Page(s) 262

    MeSH term(s) Humans ; Lung ; Occupational Exposure ; Pesticides/toxicity ; Respiratory Physiological Phenomena
    Chemical Substances Pesticides
    Language English
    Publishing date 2021-09-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Is a Vitamin K Epoxide Reductase Complex Subunit 1 (

    Drent, Marjolein / Wijnen, Petal / Bekers, Otto / Bast, Aalt

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Sarcoidosis is a systemic inflammatory disorder characterized by granuloma formation in various organs. It has been associated with nephrolithiasis. The vitamin K epoxide reductase complex subunit 1 ( ...

    Abstract Sarcoidosis is a systemic inflammatory disorder characterized by granuloma formation in various organs. It has been associated with nephrolithiasis. The vitamin K epoxide reductase complex subunit 1 (
    MeSH term(s) Humans ; Female ; Vitamin K Epoxide Reductases/genetics ; Male ; Sarcoidosis/genetics ; Sarcoidosis/complications ; Middle Aged ; Nephrolithiasis/genetics ; Risk Factors ; Adult ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Retrospective Studies ; Aged ; Alleles
    Chemical Substances Vitamin K Epoxide Reductases (EC 1.17.4.4) ; VKORC1 protein, human (EC 1.17.4.4)
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: The role of ageing in pulmonary disease.

    Bast, Aalt / Drent, Marjolein

    Current opinion in pulmonary medicine

    2022  Volume 28, Issue 4, Page(s) 294–295

    MeSH term(s) Aging ; Humans ; Lung Diseases
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Senescence in pulmonary arterial hypertension: is there a link?

    Semen, Khrystyna O / Bast, Aalt

    Current opinion in pulmonary medicine

    2022  Volume 28, Issue 4, Page(s) 303–306

    Abstract: Purpose of review: Cellular senescence has been recognized as a promising target in the treatment of many cardiovascular diseases. The pathways involved in the development of senescence share many similarities with pathobiological mechanisms of ... ...

    Abstract Purpose of review: Cellular senescence has been recognized as a promising target in the treatment of many cardiovascular diseases. The pathways involved in the development of senescence share many similarities with pathobiological mechanisms of pulmonary arterial hypertension (PAH). But the potential of senolytics to improve pulmonary hemodynamics and to reduce vascular remodelling in PAH has thus far not been investigated in depth.
    Recent findings: PAH does not seem to be a disease of only young people since the mean age of PAH patients is constantly increasing. Changes in expression of senescence biomarkers related to cell cycle arrest, namely upregulation of the tumour suppressor protein p53 and the cell cycle inhibitors p16ink4A an p21cip1 as well as an increase in apoptosis resistance biomarker Bcl2 (B-cell lymphoma 2) and development of senescence-associated phenotype characterized by excessive production of matrix metalloproteinase 2 and interleukin 6 were demonstrated in PAH patients. Initiatives to link the senescence-modulating effect of certain compounds to clinically relevant outcomes in PAH are still limited.
    Summary: Further exploration of the role of senescence in the pathobiology of PAH may point to new relevant treatment strategies. Identification of the cell-specific senescence biomarkers which can be used in vivo, could further promote identification of clinically relevant pathways and design of clinical studies which will help to establish effective therapeutic use of senolytic compounds.
    MeSH term(s) Adolescent ; Biomarkers/metabolism ; Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/metabolism ; Matrix Metalloproteinase 2/metabolism ; Pulmonary Arterial Hypertension ; Pulmonary Artery
    Chemical Substances Biomarkers ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Altered pharmacology and toxicology during ageing: implications for lung disease.

    Bast, Aalt / Drent, Marjolein

    Current opinion in pulmonary medicine

    2022  Volume 28, Issue 4, Page(s) 314–320

    Abstract: Purpose of review: Drug use in elderly people is high compared to younger people. Simultaneously, elderly are at greater risk when exposed to environmental substances. It is puzzling therefore, that ageing, as a variable in pharmacological and ... ...

    Abstract Purpose of review: Drug use in elderly people is high compared to younger people. Simultaneously, elderly are at greater risk when exposed to environmental substances. It is puzzling therefore, that ageing, as a variable in pharmacological and toxicological processes is not investigated in more depth. Moreover, recent data suggest that molecular manifestations of the ageing process also hallmark the pathogenesis of chronic lung diseases, which may impact pharmacology and toxicology.
    Recent findings: In particular, absorption, distribution, metabolism and excretion (ADME) processes of drugs and toxins alter because of ageing. Polypharmacy, which is quite usual with increasing age, increases the risk of drug-drug interactions. Individual differences in combination of drugs use in conjunction with individual variations in drug metabolizing enzymes can influence lung function.
    Summary: Exploring exposure throughout life (i.e. during ageing) to potential triggers, including polypharmacy, may avoid lung disease or unexplained cases of lung damage. Understanding of the ageing process further unravels critical features of chronic lung disease and helps to define new protective targets and therapies. Optimizing resilience can be key in pharmacology and toxicology and helps in maintaining healthy lungs for a longer period.
    MeSH term(s) Aged ; Aging/metabolism ; Drug Interactions ; Humans ; Lung Diseases ; Polypharmacy ; Respiratory Physiological Phenomena
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Drug-Gene Risk Stratification in Patients with Suspected Drug-Induced Interstitial Lung Disease.

    Drent, Marjolein / Wijnen, Petal A / Jessurun, Naomi T / Harmsze, Ankie M / Bekers, Otto / Bast, Aalt

    Drug safety

    2024  Volume 47, Issue 4, Page(s) 355–363

    Abstract: Background: Pulmonary toxicity has been associated with drug use. This is often not recognized in clinical practice, and underestimated.: Objective: We aimed to establish whether polymorphisms in certain genes corresponding with a metabolic pathway ... ...

    Abstract Background: Pulmonary toxicity has been associated with drug use. This is often not recognized in clinical practice, and underestimated.
    Objective: We aimed to establish whether polymorphisms in certain genes corresponding with a metabolic pathway of drug(s) used are associated with pulmonary toxicity in patients with suspected drug-induced interstitial lung disease (DI-ILD).
    Methods: This retrospective observational study explored genetic variations in three clinically relevant cytochrome P450 (CYP) iso-enzymes (i.e., CYP2D6, CYP2C9, and CYP2C19) in a group of patients with a fibroticinterstitial lung disease, either non-specific interstitial pneumonia (n = 211) or idiopathic pulmonary fibrosis (n = 256), with a suspected drug-induced origin.
    Results: Of the 467 patients, 79.0% showed one or more polymorphisms in the tested genes accompanied by the use of drug(s) metabolized by a corresponding affected metabolic pathway (60.0% poor metabolizers and/or using two or more drugs [likely DI-ILD], 37.5% using three or more [highly likely DI-ILD]). Most commonly used drugs were statins (63.1%) with a predominance among men (69.4 vs 47.1%, p < 0.0001). Nitrofurantoin, not metabolized by the tested pathways, was prescribed more frequently among women (51.9 vs 4.5%, p < 0.00001).
    Conclusions: In our cohort with suspected DI-ILD, 79% carried one or more genetic variants accompanied by the use of drugs metabolized by a corresponding affected pathway. In 60%, the diagnosis of DI-ILD was likely, whereas in 37.5%, it was highly likely, based on CYP analyses. This study underlines the importance of considering both drug use and genetic make-up as a possible cause, or at least a contributing factor, in the development and/or progression of fibrotic lung diseases.
    Clinical trial registration: ClinicalTrials.gov identifier NCT00267800, registered in 2005.
    MeSH term(s) Male ; Humans ; Female ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/genetics ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/genetics ; Cytochrome P-450 Enzyme System/genetics ; Drug-Related Side Effects and Adverse Reactions/complications ; Risk Assessment
    Chemical Substances Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2024-03-09
    Publishing country New Zealand
    Document type Observational Study ; Journal Article
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-024-01400-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Editorial: Personalized nutrition with polyphenols-which, for whom, when and how?

    Weseler, Antje R / Bast, Aalt / Sthijns, Mireille M J P E

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1193339

    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1193339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: How COVID-19 impacted surplus food redistribution in the Netherlands: An explorative study.

    Rao, Madhura / Bast, Aalt / de Boer, Alie

    Food security

    2022  Volume 14, Issue 6, Page(s) 1377–1385

    Abstract: The COVID-19 pandemic has been detrimental to food security globally. The Netherlands, despite its advanced stage of development, saw a surge in food insecurity among its most vulnerable citizens. Dutch food aid is managed by private charities and social ...

    Abstract The COVID-19 pandemic has been detrimental to food security globally. The Netherlands, despite its advanced stage of development, saw a surge in food insecurity among its most vulnerable citizens. Dutch food aid is managed by private charities and social organisations that often aim to address the problems of food insecurity and food waste by redistributing surplus food that is safe to consume. This paper investigates how the pandemic impacted surplus food redistribution in the country by employing an Exploratory-Descriptive-Qualitative approach. This is done by analysing data from interviews with relevant stakeholders involved in redistributing surplus food in the Netherlands as well as media reports on the topic. Our findings indicate that the interviewed organisations experienced drastic fluctuations in supply and demand. To cope with these changes, rapid organisational and supply chain innovation was observed. Next to this, there seems to have been disproportionate negative impact on smaller charities in comparison to bigger, better established organisations. Based on our findings, we discuss what the future of surplus food distribution in the Netherlands might look like and why changes made during the pandemic must be well documented and carefully analysed.
    Language English
    Publishing date 2022-05-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2486755-X
    ISSN 1876-4525 ; 1876-4517
    ISSN (online) 1876-4525
    ISSN 1876-4517
    DOI 10.1007/s12571-022-01291-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: How COVID-19 impacted surplus food redistribution in the Netherlands: An explorative study

    Rao, Madhura / Bast, Aalt / de Boer, Alie

    Food Sec.. 2022 Dec., v. 14, no. 6 p.1377-1385

    2022  

    Abstract: The COVID-19 pandemic has been detrimental to food security globally. The Netherlands, despite its advanced stage of development, saw a surge in food insecurity among its most vulnerable citizens. Dutch food aid is managed by private charities and social ...

    Abstract The COVID-19 pandemic has been detrimental to food security globally. The Netherlands, despite its advanced stage of development, saw a surge in food insecurity among its most vulnerable citizens. Dutch food aid is managed by private charities and social organisations that often aim to address the problems of food insecurity and food waste by redistributing surplus food that is safe to consume. This paper investigates how the pandemic impacted surplus food redistribution in the country by employing an Exploratory-Descriptive-Qualitative approach. This is done by analysing data from interviews with relevant stakeholders involved in redistributing surplus food in the Netherlands as well as media reports on the topic. Our findings indicate that the interviewed organisations experienced drastic fluctuations in supply and demand. To cope with these changes, rapid organisational and supply chain innovation was observed. Next to this, there seems to have been disproportionate negative impact on smaller charities in comparison to bigger, better established organisations. Based on our findings, we discuss what the future of surplus food distribution in the Netherlands might look like and why changes made during the pandemic must be well documented and carefully analysed.
    Keywords COVID-19 infection ; developmental stages ; food aid ; food security ; food waste ; interviews ; pandemic ; stakeholders ; supply balance ; supply chain ; Netherlands
    Language English
    Dates of publication 2022-12
    Size p. 1377-1385.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 2486755-X
    ISSN 1876-4525 ; 1876-4517
    ISSN (online) 1876-4525
    ISSN 1876-4517
    DOI 10.1007/s12571-022-01291-y
    Database NAL-Catalogue (AGRICOLA)

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