LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 261

Search options

  1. Book ; Online ; E-Book: Holland-Frei cancer medicine

    Bast, Robert C.

    2023  

    Title variant Cancer medicine
    Author's details editors Robert C. Bast Jr [und 8 weitere]
    Keywords Neoplasms ; Medical Oncology / methods
    Language English
    Size 1 Online-Ressource (xxix, 1939 Seiten), Illustrationen, Diagramme
    Edition Tenth edition
    Publisher Wiley-Blackwell
    Publishing place Hoboken, New Jersey
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021723979
    ISBN 978-1-119-75069-7 ; 9781119750680 ; 1-119-75069-5 ; 1119750687
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book: Holland-Frei cancer medicine

    Holland, James F. / Bast, Robert C.

    2017  

    Title variant Cancer medicine
    Institution American Association for Cancer Research
    Author's details editors Robert C. Bast, James F. Holland [und 9 weitere] ; published in collaboration with AACR, American Association for Cancer Research
    Keywords Neoplasms
    Language English
    Size xxix, 1971 Seiten
    Edition Ninth edition
    Publisher John Wiley & Sons, Inc
    Publishing place Hoboken, New Jersey
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    Accompanying material Zugang zu Online-Ausgabe über Code
    HBZ-ID HT019265713
    ISBN 978-1-118-93469-2 ; 9781119000846 ; 9781119000839 ; 1-118-93469-5 ; 111900084X ; 1119000831
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 764 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Conference proceedings: Proceedings of the Eighth Biennial International Forum on Ovarian Cancer

    Bast, Robert C.

    [2001]

    (Gynecologic oncology ; 88,1, Pt.2)

    2003  

    Institution International Forum on Ovarian Cancer
    Author's details Robert C. Bast
    Series title Gynecologic oncology ; 88,1, Pt.2
    Collection
    Language English
    Size S157 S.
    Publisher Acad. Press
    Publishing place San Diego, CA
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013602487
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 885 -88,1,Pt.2- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The National Cancer Institute Early Detection Research Network: Two Decades of Progress.

    Bast, Robert C / Srivastava, Sudhir

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2020  Volume 29, Issue 12, Page(s) 2396–2400

    MeSH term(s) Disease Progression ; Early Detection of Cancer/methods ; Humans ; National Cancer Institute (U.S.) ; Neoplasms/prevention & control ; Research Design ; Time Factors ; United States
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-20-1158
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3693: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Circulating Cancer Biomarkers.

    Lokshin, Anna / Bast, Robert C / Rodland, Karin

    Cancers

    2021  Volume 13, Issue 4

    Abstract: Cancer is among the major public health problems worldwide, representing the leading cause of morbidity and mortality in industrialized countries [ ... ]. ...

    Abstract Cancer is among the major public health problems worldwide, representing the leading cause of morbidity and mortality in industrialized countries [...].
    Language English
    Publishing date 2021-02-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13040802
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: Holland-Frei cancer medicine

    Bast, Robert C

    2016  

    Abstract: The original reference resource for medical oncologists, radiation oncologists, internists, and allied specialties involved in the treatment of cancer patients, Holland-Frei Cancer Medicine covers the ever-expanding field of current cancer science and ... ...

    Title variant Cancer medicine
    Author's details editors, Robert C. Bast, Jr, Carlo M. Croce, William Hait, Waun Ki Hong, Donald W. Kufe, Martine Piccart-Gebhart, Raphael E. Pollock, Ralph R. Weichselbaum, Hongyang Wang, James F. Holland
    Abstract "The original reference resource for medical oncologists, radiation oncologists, internists, and allied specialties involved in the treatment of cancer patients, Holland-Frei Cancer Medicine covers the ever-expanding field of current cancer science and clinical oncology practice. In this new ninth edition an outstanding editorial team from world-renowned medical centers continue to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging, and therapy. Holland-Frei Cancer Medicine, Ninth Edition, brings scientific principles to clinical practice and is a testament to the ethos that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. This ninth edition features hundreds of full color illustrations, photographs, tables, graphs and algorithms that enhance understanding of complex topics and make this text an invaluable clinical tool. Over 15 brand new chapters covering the latest advances, including chapters on Cancer Metabolism, Bioinformatics, Biomarker Based Clinical Trial Design, Health Services Research and Survivorship bring this comprehensive resource up-to-date. Each chapter contains overview boxes, select references and other pedagogic features, designed to make the content easy to access and absorb"--Provided by publisher.
    MeSH term(s) Neoplasms
    Language English
    Size p. ;, cm.
    Edition 9th edition.
    Document type Book
    Note Preceded by Holland-Frei cancer medicine 8, 2010.
    ISBN 9781118934692 ; 1118934695
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Next steps in the early detection of ovarian cancer.

    Bast, Robert C / Han, Chae Young / Lu, Zhen / Lu, Karen H

    Communications medicine

    2021  Volume 1

    Abstract: A recent ovarian cancer screening trial found no reduction in mortality, despite increased detection of early stage disease. Here, we discuss these findings and examine next steps to develop more effective approaches for the early detection of ovarian ... ...

    Abstract A recent ovarian cancer screening trial found no reduction in mortality, despite increased detection of early stage disease. Here, we discuss these findings and examine next steps to develop more effective approaches for the early detection of ovarian cancer.
    Language English
    Publishing date 2021-10-05
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-021-00037-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Reply to Comment on "Osteopontin, Macrophage Migration Inhibitory Factor and Anti-Interleukin-8 Autoantibodies Complement CA125 for Detection of Early Stage Ovarian Cancer"

    Guo, Jing / Lu, Zhen / Bast, Robert C

    Cancers

    2019  Volume 11, Issue 9

    Abstract: We appreciate Mor et al [ ... ]. ...

    Abstract We appreciate Mor et al [...].
    Language English
    Publishing date 2019-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11091386
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Novel Approaches to Ovarian Cancer Screening.

    Nebgen, Denise R / Lu, Karen H / Bast, Robert C

    Current oncology reports

    2019  Volume 21, Issue 8, Page(s) 75

    Abstract: Purpose of review: Both conventional and novel approaches to early detection of ovarian cancer are reviewed in the context of new developments in our understanding of ovarian cancer biology.: Recent findings: While CA125 as a single value lacks ... ...

    Abstract Purpose of review: Both conventional and novel approaches to early detection of ovarian cancer are reviewed in the context of new developments in our understanding of ovarian cancer biology.
    Recent findings: While CA125 as a single value lacks adequate specificity or sensitivity for screening, large studies have shown that a 2-stage strategy which tracks CA125 change over time and prompts transvaginal ultrasound (TVS) for a small subset of women with abnormally rising biomarker values achieves adequate specificity and detects a higher fraction of early-stage disease. Sensitivity could clearly be improved in both blood tests and in imaging. Metastasis can occur from ovarian cancers too small to increase blood levels of protein antigens and a significant fraction of ovarian cancers arise from the fimbriae of fallopian tubes that cannot be imaged with TVS. Autoantibodies, miRNA, ctDNA, DNA methylation in blood, and cervical mucus might improve sensitivity of the initial phase and magnetic relaxometry and autofluorescence could improve imaging in the second phase. Enhancing the sensitivity of two-stage strategies for early detection could reduce mortality from ovarian cancer.
    MeSH term(s) Biomarkers, Tumor/blood ; Early Detection of Cancer ; Fallopian Tubes/pathology ; Female ; Humans ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/pathology ; Papanicolaou Test ; Sensitivity and Specificity ; Ultrasonography ; Vaginal Smears
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2019-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-019-0816-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5521: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas.

    Bildik, Gamze / Gray, Joshua P / Mao, Weiqun / Yang, Hailing / Ozyurt, Rumeysa / Orellana, Vivian R / De Wever, Olivier / Carey, Mark S / Bast, Robert C / Lu, Zhen

    Autophagy

    2024  Volume 20, Issue 3, Page(s) 675–691

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) and low-grade ovarian cancer (LGSOC) are characterized by the prevalence of KRAS oncogene mutations. DIRAS3 is the first endogenous non-RAS protein that heterodimerizes with RAS, disrupts RAS clustering, blocks RAS ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) and low-grade ovarian cancer (LGSOC) are characterized by the prevalence of KRAS oncogene mutations. DIRAS3 is the first endogenous non-RAS protein that heterodimerizes with RAS, disrupts RAS clustering, blocks RAS signaling, and inhibits cancer cell growth. Here, we found that DIRAS3-mediated KRAS inhibition induces ROS-mediated apoptosis in PDAC and LGSOC cells with KRAS mutations, but not in cells with wild-type KRAS, by downregulating NFE2L2/Nrf2 transcription, reducing antioxidants, and inducing oxidative stress. DIRAS3 also induces cytoprotective macroautophagy/autophagy that may protect mutant KRAS cancer cells from oxidative stress, by inhibiting mutant KRAS, activating the STK11/LKB1-PRKAA/AMPK pathway, increasing lysosomal CDKN1B/p27 localization, and inducing autophagic gene expression. Treatment with chloroquine or the novel dimeric chloroquine analog DC661 significantly enhances DIRAS3-mediated inhibition of mutant KRAS tumor cell growth in vitro and in vivo. Taken together, our study demonstrates that DIRAS3 plays a critical role in regulating mutant KRAS-driven oncogenesis in PDAC and LGSOC.
    MeSH term(s) Female ; Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; Autophagy/physiology ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/pathology ; Chloroquine/pharmacology
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Reactive Oxygen Species ; Chloroquine (886U3H6UFF) ; KRAS protein, human
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2299516
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6741: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top