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  1. Article: International Conventions & One Health.

    Basu, Atanu / Sandhu, Harpreet

    The Indian journal of medical research

    2021  Volume 153, Issue 3, Page(s) 253–255

    MeSH term(s) Global Health ; Humans ; International Cooperation ; One Health
    Language English
    Publishing date 2021-05-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_644_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Transmission electron microscopy imaging of SARS-CoV-2.

    Prasad, Sharda / Potdar, Varsha / Cherian, Sarah / Abraham, Priya / Basu, Atanu

    The Indian journal of medical research

    2020  Volume 151, Issue 2 & 3, Page(s) 241–243

    MeSH term(s) Betacoronavirus/ultrastructure ; COVID-19 ; Coronavirus Infections ; Humans ; Microscopy, Electron, Transmission ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country India
    Document type Letter
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_577_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human herpesvirus 6

    Basu Atanu

    Indian Journal of Human Genetics, Vol 9, Iss 1, Pp 29-

    Catalyst of genomic lesion in dysfunctional hematopoiesis ?

    2003  Volume 30

    Keywords Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Genetics ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2003-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Perspectives for repurposing drugs for the coronavirus disease 2019.

    Cherian, Sarah S / Agrawal, Megha / Basu, Atanu / Abraham, Priya / Gangakhedkar, Raman R / Bhargava, Balram

    The Indian journal of medical research

    2020  Volume 151, Issue 2 & 3, Page(s) 160–171

    Abstract: The newly emerged 2019 novel coronavirus (CoV), named as severe acute respiratory syndrome CoV-2 (SARS-CoV-2), like SARS-CoV (now, SARS-CoV-1) and Middle East respiratory syndrome CoV (MERS-CoV), has been associated with high infection rates with over 36, ...

    Abstract The newly emerged 2019 novel coronavirus (CoV), named as severe acute respiratory syndrome CoV-2 (SARS-CoV-2), like SARS-CoV (now, SARS-CoV-1) and Middle East respiratory syndrome CoV (MERS-CoV), has been associated with high infection rates with over 36,405 deaths. In the absence of approved marketed drugs against coronaviruses, the treatment and management of this novel CoV disease (COVID-19) worldwide is a challenge. Drug repurposing that has emerged as an effective drug discovery approach from earlier approved drugs could reduce the time and cost compared to de novo drug discovery. Direct virus-targeted antiviral agents target specific nucleic acid or proteins of the virus while host-based antivirals target either the host innate immune responses or the cellular machineries that are crucial for viral infection. Both the approaches necessarily interfere with viral pathogenesis. Here we summarize the present status of both virus-based and host-based drug repurposing perspectives for coronaviruses in general and the SARS-CoV-2 in particular.
    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Drug Discovery ; Drug Repositioning ; Humans ; Molecular Docking Simulation ; Pandemics ; Pneumonia, Viral/drug therapy ; Protease Inhibitors/therapeutic use ; Viral Proteins/antagonists & inhibitors
    Chemical Substances Antiviral Agents ; Protease Inhibitors ; Viral Proteins
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_585_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Dengue Virus NS1 Exposure Affects von Willebrand Factor Profile and Platelet Adhesion Properties of Cultured Vascular Endothelial Cells.

    Tadkalkar, Nitali / Prasad, Sharda / Gangodkar, Shobha / Ghosh, Kanjaksha / Basu, Atanu

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2018  Volume 35, Issue 3, Page(s) 502–506

    Abstract: Hematological abnormalities and altered vascular permeability are frequently encountered in Dengue virus infected patients, but the mechanisms that alter platelet-endothelium interactions remain incompletely understood. The DENV NS1 protein has been ... ...

    Abstract Hematological abnormalities and altered vascular permeability are frequently encountered in Dengue virus infected patients, but the mechanisms that alter platelet-endothelium interactions remain incompletely understood. The DENV NS1 protein has been implicated in adverse disease outcomes. In the present study the role of NS1 protein in affecting the expression of vWF and platelet adhesion properties of endothelial cells was studied in vitro. The results suggest that vWF is down regulated in cultured endothelial cells 6 and 24 h after exposure with increase in vWF levels in culture supernatants at corresponding time points. Ultrastructural studies showed distinct evidence of endothelial cell activation morphology and degranulation of Weibel-Palade bodies in NS1 exposed cells that also showed increased platelet activation physiology. The findings suggest that changes in vWF production and secretion may be induced in endothelial cells exposed to DENV NS1 protein; and play a role in bleeding complications of severe DENV disease.
    Language English
    Publishing date 2018-12-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-018-1058-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Electron microscopy imaging of SARS-CoV-2 at different temperatures.

    Prasad, Sharda / Meena, Virendra Kumar / Yadav, Pragya D / Sarkale, Prasad / Baradkar, Shreekant / Cherian, Sarah / Abraham, Priya / Basu, Atanu

    The Indian journal of medical research

    2021  Volume 153, Issue 5&6, Page(s) 692–695

    MeSH term(s) COVID-19 ; Humans ; Microscopy, Electron ; Microscopy, Electron, Transmission ; SARS-CoV-2 ; Temperature
    Language English
    Publishing date 2021-06-18
    Publishing country India
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_4264_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Transmission electron microscopy imaging of SARS-CoV-2

    Basu, Atanu / Prasad, Sharda / Potdar, Varsha / Cherian, Sarah / Abraham, Priya

    Indian Journal of Medical Research

    2020  

    Keywords General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ZDB-ID 390883-5
    ISSN 0019-5340 ; 0971-5916
    ISSN 0019-5340 ; 0971-5916
    DOI 10.4103/ijmr.ijmr_577_20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Development of

    Choudhary, Manohar Lal / Vipat, Veena / Jadhav, Sheetal / Basu, Atanu / Cherian, Sarah / Abraham, Priya / Potdar, Varsha A

    The Indian journal of medical research

    2020  Volume 151, Issue 2 & 3, Page(s) 251–254

    MeSH term(s) Betacoronavirus ; COVID-19 ; Clinical Laboratory Techniques ; Coronavirus ; Coronavirus Infections ; India ; Pandemics ; Pneumonia, Viral ; RNA ; Reverse Transcriptase Polymerase Chain Reaction ; SARS Virus/genetics ; SARS-CoV-2
    Chemical Substances RNA (63231-63-0)
    Keywords covid19
    Language English
    Publishing date 2020-04-03
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_671_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Perspectives for repurposing drugs for the coronavirus disease 2019

    Cherian, Sarah S / Agrawal, Megha / Basu, Atanu / Abraham, Priya / Gangakhedkar, Raman R / Bhargava, Balram

    Indian J Med Res

    Abstract: The newly emerged 2019 novel coronavirus (CoV), named as severe acute respiratory syndrome CoV-2 (SARS-CoV-2), like SARS-CoV (now, SARS-CoV-1) and Middle East respiratory syndrome CoV (MERS-CoV), has been associated with high infection rates with over 36, ...

    Abstract The newly emerged 2019 novel coronavirus (CoV), named as severe acute respiratory syndrome CoV-2 (SARS-CoV-2), like SARS-CoV (now, SARS-CoV-1) and Middle East respiratory syndrome CoV (MERS-CoV), has been associated with high infection rates with over 36,405 deaths. In the absence of approved marketed drugs against coronaviruses, the treatment and management of this novel CoV disease (COVID-19) worldwide is a challenge. Drug repurposing that has emerged as an effective drug discovery approach from earlier approved drugs could reduce the time and cost compared to de novo drug discovery. Direct virus-targeted antiviral agents target specific nucleic acid or proteins of the virus while host-based antivirals target either the host innate immune responses or the cellular machineries that are crucial for viral infection. Both the approaches necessarily interfere with viral pathogenesis. Here we summarize the present status of both virus-based and host-based drug repurposing perspectives for coronaviruses in general and the SARS-CoV-2 in particular.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32317408
    Database COVID19

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