Article ; Online: Coinfection of fungi with SARS-CoV-2 is a detrimental health risk for COVID-19 patients.
Beni-Suef University journal of basic and applied sciences
2022 Volume 11, Issue 1, Page(s) 64
Abstract: Background: Notable fungal coinfections with SARS-CoV-2 in COVID-19 patients have been reported worldwide in an alarming way. : Main body: Impaired CD4 + T cell response due to SARS-CoV-2 infection creates an opportunity for fungi to take over the ... ...
| Abstract | Background: Notable fungal coinfections with SARS-CoV-2 in COVID-19 patients have been reported worldwide in an alarming way. Main body: Impaired CD4 + T cell response due to SARS-CoV-2 infection creates an opportunity for fungi to take over the host cells and, consequently, cause severe fungal coinfections, including candidiasis and candidemia, mucormycosis, invasive pulmonary aspergillosis (IPA), and COVID-19-associated pulmonary aspergillosis (CAPA). Among them, mucormycosis and CAPA have been reported with a mortality rate of 66% in India and 60% in Colombia. Moreover, IPA has been reported in Belgium, Netherlands, France, and Germany with a morbidity rate of 20.6%, 19.6%, 33.3%, and 26%, respectively. Several antifungal drugs have been applied to combat fungal coinfection in COVID-19 patients, including Voriconazole, Isavuconazole, and Echinocandins. Conclusion: SARS-CoV-2 deteriorates the immune system so that several fungi could take that opportunity and cause life-threatening health situations. To reduce the mortality and morbidity of fungal coinfections, it needs immunity boosting, proper hygiene and sanitation, and appropriate medication based on the diagnosis. |
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| Language | English |
| Publishing date | 2022-05-04 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 2768279-1 |
| ISSN | 2314-8543 ; 2314-8535 ; 2314-8543 |
| ISSN (online) | 2314-8543 |
| ISSN | 2314-8535 ; 2314-8543 |
| DOI | 10.1186/s43088-022-00245-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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