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  1. AU="Batina, Nikola"
  2. AU="Busche, Jacob A"
  3. AU="Quaresima, Luigi"
  4. AU="Arnaud Gautier"
  5. AU="Leary Peter"
  6. AU="Currò, Mariaconcetta"
  7. AU=Schulte Ryan T
  8. AU=Wichmann D
  9. AU="Arora, Prateek"
  10. AU="Junqueira, Helena Couto"
  11. AU="Kataria, Saurabh"
  12. AU=Wang Xia AU=Wang Xia
  13. AU="Tonnesen, Morten"
  14. AU="Ebrahimi-Fakhari, Darius"
  15. AU="Kalinich, Chaney C"
  16. AU="O'Neal, David N"
  17. AU="Bennett, Matthew R"
  18. AU="Chagas, Mariana W"

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  1. Artikel: Non-Genomic Actions of Estrogens on the DNA Repair Pathways Are Associated With Chemotherapy Resistance in Breast Cancer.

    Jiménez-Salazar, Javier E / Damian-Ferrara, Rebeca / Arteaga, Marcela / Batina, Nikola / Damián-Matsumura, Pablo

    Frontiers in oncology

    2021  Band 11, Seite(n) 631007

    Abstract: Estrogens have been implicated in the etiology of breast cancer for a long time. It has been stated that long-term exposure to estrogens is associated with a higher incidence of breast cancer, since estradiol ( ... ...

    Abstract Estrogens have been implicated in the etiology of breast cancer for a long time. It has been stated that long-term exposure to estrogens is associated with a higher incidence of breast cancer, since estradiol (E
    Sprache Englisch
    Erscheinungsdatum 2021-03-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.631007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Enzymatically assisted isolation of high-quality cellulose nanoparticles from water hyacinth stems

    Juárez-Luna, Gregorio N / Batina, Nikola / Favela-Torres, Ernesto / Quevedo, Iván R

    Carbohydrate polymers. 2019 Sept. 15, v. 220

    2019  

    Abstract: High quality cellulose nanoparticles (CNP) were isolated from water hyacinth stem cellulose (Cel-WH) extracted via successive thermochemical and alkaline-peroxide treatments, and further enzymatically hydrolysed using the commercial cellulase complex, ... ...

    Abstract High quality cellulose nanoparticles (CNP) were isolated from water hyacinth stem cellulose (Cel-WH) extracted via successive thermochemical and alkaline-peroxide treatments, and further enzymatically hydrolysed using the commercial cellulase complex, NS22086, at 50oC. The maximum CNP concentration was reached after 120 min of enzymatic hydrolysis, with a hydrodynamic diameter in the order of 200−250 nm and an increase of 5% in crystallinity as compared with Cel-WH. The obtained rod-shaped cellulose nanocrystals, as revealed by atomic force microscopy (AFM), exhibited a nominal diameter of 15.6−29.4 nm, a length of 56−184.8 nm, and a height of 2.85−6.43 nm, indicating a low tendency to form aggregates. In the present study, it was found that water hyacinth stems are a valuable source for the isolation of high-quality CNP using an environmentally friendly procedure, with potential applications in nanomedicine and nanopharmacology.
    Schlagwörter atomic force microscopy ; cellulose ; crystal structure ; Eichhornia crassipes ; endo-1,4-beta-glucanase ; enzymatic hydrolysis ; hydrodynamics ; nanocrystals ; nanomedicine ; nanoparticles ; stems
    Sprache Englisch
    Erscheinungsverlauf 2019-0915
    Umfang p. 110-117.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2019.05.058
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  3. Artikel ; Online: Enzymatically assisted isolation of high-quality cellulose nanoparticles from water hyacinth stems.

    Juárez-Luna, Gregorio N / Favela-Torres, Ernesto / Quevedo, Iván R / Batina, Nikola

    Carbohydrate polymers

    2019  Band 220, Seite(n) 110–117

    Abstract: High quality cellulose nanoparticles (CNP) were isolated from water hyacinth stem cellulose (Cel-WH) extracted via successive thermochemical and alkaline-peroxide treatments, and further enzymatically hydrolysed using the commercial cellulase complex, ... ...

    Abstract High quality cellulose nanoparticles (CNP) were isolated from water hyacinth stem cellulose (Cel-WH) extracted via successive thermochemical and alkaline-peroxide treatments, and further enzymatically hydrolysed using the commercial cellulase complex, NS22086, at 50ºC. The maximum CNP concentration was reached after 120 min of enzymatic hydrolysis, with a hydrodynamic diameter in the order of 200-250 nm and an increase of 5% in crystallinity as compared with Cel-WH. The obtained rod-shaped cellulose nanocrystals, as revealed by atomic force microscopy (AFM), exhibited a nominal diameter of 15.6-29.4 nm, a length of 56-184.8 nm, and a height of 2.85-6.43 nm, indicating a low tendency to form aggregates. In the present study, it was found that water hyacinth stems are a valuable source for the isolation of high-quality CNP using an environmentally friendly procedure, with potential applications in nanomedicine and nanopharmacology.
    Mesh-Begriff(e) Cellulase/chemistry ; Cellulose/chemistry ; Eichhornia/chemistry ; Hydrolysis ; Microscopy, Atomic Force/methods ; Nanomedicine/instrumentation ; Nanoparticles/chemistry ; Plant Stems/chemistry ; X-Ray Diffraction/methods
    Chemische Substanzen Cellulose (9004-34-6) ; Cellulase (EC 3.2.1.4)
    Sprache Englisch
    Erscheinungsdatum 2019-05-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2019.05.058
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: AFM and MFM techniques for enzyme activity imaging and quantification

    Arredondo, Michelle / Stoytcheva, Margarita / Morales-Reyes, Israel / Batina, Nikola

    Biotechnology, biotechnological equipment. 2018 July 4, v. 32, no. 4

    2018  

    Abstract: In this work, a new approach for enzyme activity monitoring is suggested. It is based on the real-time imaging, by atomic force microscopy (AFM) and magnetic force microscopy (MFM), of the degradation of a nanoparticles-loaded enzyme responsive layer, ... ...

    Abstract In this work, a new approach for enzyme activity monitoring is suggested. It is based on the real-time imaging, by atomic force microscopy (AFM) and magnetic force microscopy (MFM), of the degradation of a nanoparticles-loaded enzyme responsive layer, namely Fe₃O₄-nanoparticles-loaded gelatin. The roughness analysis allowed the quantification of the trypsin-induced ferrogel degradation and the correlation of the AFM and MFM data obtained.
    Schlagwörter atomic force microscopy ; biotechnology ; enzyme activity ; enzymes ; equipment ; gelatin ; roughness
    Sprache Englisch
    Erscheinungsverlauf 2018-0704
    Umfang p. 1065-1074.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 1214963-9
    ISSN 1314-3530 ; 0205-2067 ; 1310-2818
    ISSN (online) 1314-3530
    ISSN 0205-2067 ; 1310-2818
    DOI 10.1080/13102818.2018.1470904
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    Z 6265: Hefte anzeigen

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  5. Artikel: Development of a Nanostructured Electrochemical Genosensor for the Detection of the K-ras Gene.

    Garcia-Melo, Luis Fernando / Morales-Rodríguez, Miguel / Madrigal-Bujaidar, Eduardo / Madrigal-Santillán, Eduardo O / Morales-González, José Antonio / Pineda Cruces, Rosa Natali / Campoy Ramírez, Jorge Alfredo / Damian-Matsumura, Pablo / Tellez-Plancarte, Alexandro / Batina, Nikola / Álvarez-González, Isela

    Journal of analytical methods in chemistry

    2022  Band 2022, Seite(n) 6575140

    Abstract: In the scientific literature, it has been documented that electrochemical genosensors are novel analytical tools with proven clinical diagnostic potential for the identification of carcinogenic processes due to genetic and epigenetic alterations, as well ...

    Abstract In the scientific literature, it has been documented that electrochemical genosensors are novel analytical tools with proven clinical diagnostic potential for the identification of carcinogenic processes due to genetic and epigenetic alterations, as well as infectious diseases due to viruses or bacteria. In the present work, we describe the construction of an electrochemical genosensor for the identification of the k12p.1 mutation; it was based on use of Screen-Printed Gold Electrode (SPGE), Cyclic Voltammetry (CV), and Atomic Force Microscopy (AFM), for the monitoring the electron transfer trough the functionalized nanostructured surface and corresponding morphological changes. The sensitivity of the genosensor showed a linear response for the identification of the k12p.1 mutation of the
    Sprache Englisch
    Erscheinungsdatum 2022-10-17
    Erscheinungsland Egypt
    Dokumenttyp Journal Article
    ZDB-ID 2654178-6
    ISSN 2090-8873 ; 2090-8865
    ISSN (online) 2090-8873
    ISSN 2090-8865
    DOI 10.1155/2022/6575140
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  6. Artikel ; Online: Gold nanoparticle uptake is enhanced by estradiol in MCF-7 breast cancer cells.

    Lara-Cruz, Carlos / Jiménez-Salazar, Javier E / Arteaga, Marcela / Arredondo, Michelle / Ramón-Gallegos, Eva / Batina, Nikola / Damián-Matsumura, Pablo

    International journal of nanomedicine

    2019  Band 14, Seite(n) 2705–2718

    Abstract: Purpose: ...

    Abstract Purpose:
    Mesh-Begriff(e) Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Estradiol/pharmacology ; Female ; Gold/metabolism ; Humans ; MCF-7 Cells ; Metal Nanoparticles/chemistry ; Microscopy, Atomic Force ; Models, Biological ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, Estrogen/metabolism
    Chemische Substanzen Receptors, Estrogen ; Estradiol (4TI98Z838E) ; Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2019-05-01
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S196683
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6606: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel: Simultaneous recording of electrical activity and the underlying ionic currents in NG108-15 cells cultured on gold substrate.

    Acosta-García, Ma Cristina / Morales-Reyes, Israel / Jiménez-Anguiano, Anabel / Batina, Nikola / Castellanos, N P / Godínez-Fernández, R

    Heliyon

    2018  Band 4, Heft 2, Seite(n) e00550

    Abstract: This paper shows the simultaneous recording of electrical activity and the underlying ionic currents by using a gold substrate to culture NG108-15 cells. Cells grown on two different substrates (plastic Petri dishes and gold substrates) were ... ...

    Abstract This paper shows the simultaneous recording of electrical activity and the underlying ionic currents by using a gold substrate to culture NG108-15 cells. Cells grown on two different substrates (plastic Petri dishes and gold substrates) were characterized quantitatively through scanning electron microscopy (SEM) as well as qualitatively by optical and atomic force microscopy (AFM). No significant differences were observed between the surface area of cells cultured on gold substrates and Petri dishes, as indicated by measurements performed on SEM images. We also evaluated the electrophysiological compatibility of the cells through standard patch-clamp experiments by analyzing features such as the resting potential, membrane resistance, ionic currents, etc. Cells grown on both substrates showed no significant differences in their dependency on voltage, as well as in the magnitude of the Na+ and K+ current density; however, cells cultured on the gold substrate showed a lower membrane capacitance when compared to those grown on Petri dishes. By using two separate patch-clamp amplifiers, we were able to record the membrane current with the conventional patch-clamp technique and through the gold substrate simultaneously. Furthermore, the proposed technique allowed us to obtain simultaneous recordings of the electrical activity (such as action potentials firing) and the underlying membrane ionic currents. The excellent conductivity of gold makes it possible to overcome important difficulties found in conventional electrophysiological experiments such as those presented by the resistance of the electrolytic bath solution. We conclude that the technique here presented constitutes a solution to the problem of the simultaneous recording of electrical activity and the underlying ionic currents, which for decades, had been solved only partially.
    Sprache Englisch
    Erscheinungsdatum 2018-03-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2018.e00550
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  8. Artikel: Simultaneous recording of electrical activity and the underlying ionic currents in NG108-15 cells cultured on gold substrate

    Acosta-García, Ma. Cristina / Morales-Reyes, Israel / Jiménez-Anguiano, Anabel / Batina, Nikola / Castellanos, N.P / Godínez-Fernández, R

    Heliyon. 2018 Feb., v. 4, no. 2

    2018  

    Abstract: This paper shows the simultaneous recording of electrical activity and the underlying ionic currents by using a gold substrate to culture NG108-15 cells. Cells grown on two different substrates (plastic Petri dishes and gold substrates) were ... ...

    Abstract This paper shows the simultaneous recording of electrical activity and the underlying ionic currents by using a gold substrate to culture NG108-15 cells. Cells grown on two different substrates (plastic Petri dishes and gold substrates) were characterized quantitatively through scanning electron microscopy (SEM) as well as qualitatively by optical and atomic force microscopy (AFM). No significant differences were observed between the surface area of cells cultured on gold substrates and Petri dishes, as indicated by measurements performed on SEM images. We also evaluated the electrophysiological compatibility of the cells through standard patch-clamp experiments by analyzing features such as the resting potential, membrane resistance, ionic currents, etc. Cells grown on both substrates showed no significant differences in their dependency on voltage, as well as in the magnitude of the Na+ and K+ current density; however, cells cultured on the gold substrate showed a lower membrane capacitance when compared to those grown on Petri dishes. By using two separate patch-clamp amplifiers, we were able to record the membrane current with the conventional patch-clamp technique and through the gold substrate simultaneously. Furthermore, the proposed technique allowed us to obtain simultaneous recordings of the electrical activity (such as action potentials firing) and the underlying membrane ionic currents. The excellent conductivity of gold makes it possible to overcome important difficulties found in conventional electrophysiological experiments such as those presented by the resistance of the electrolytic bath solution. We conclude that the technique here presented constitutes a solution to the problem of the simultaneous recording of electrical activity and the underlying ionic currents, which for decades, had been solved only partially.
    Schlagwörter atomic force microscopy ; capacitance ; electric potential difference ; gold ; patch-clamp technique ; surface area
    Sprache Englisch
    Erscheinungsverlauf 2018-02
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2018.e00550
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  9. Artikel: Classification of hexagonal adlayer arrangements by means of collective geometrical properties.

    Tkatchenko, Alexandre / Batina, Nikola

    The Journal of chemical physics

    2006  Band 125, Heft 16, Seite(n) 164702

    Abstract: Unequal-sphere packing model is applied for the simulation of large number of hexagonal adlayer structures with surface coverage between theta=13 and theta=1 on the hexagonal substrate, with atomic radius of the adsorbate and substrate atoms as the only ... ...

    Abstract Unequal-sphere packing model is applied for the simulation of large number of hexagonal adlayer structures with surface coverage between theta=13 and theta=1 on the hexagonal substrate, with atomic radius of the adsorbate and substrate atoms as the only input. Each structure is characterized with respect to collective adlayer properties: the average adlayer height and the adlayer roughness. The distribution of hexagonal arrangements is presented in a special plot, which can be used for identification and characterization of hexagonal adlayers of different surface coverages and atomic registries. The most likely structures are related to the extreme values of our model parameters. The usefulness of this methodology is successfully demonstrated by comparison with some real adsorbate-substrate systems, i.e., halogens and rare gases adsorbed on (111) surface. Besides the agreement with experimental results, our model offers new insight into the formation of atomic adlayers and detailed analysis of the atomic registry. We believe that our approach will be of use for identification of probable structures among the large number of combinatorial possibilities in theoretical studies and for better interpretation of experimental results (i.e., scanning-tunneling microscopy images of atomic adlayers).
    Sprache Englisch
    Erscheinungsdatum 2006-10-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.2360530
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  10. Artikel: Detailed characterization of (3 x 3) iodine adlayer on Pt(111) by unequal-sphere packing model.

    Tkatchenko, Alexandre / Batina, Nikola

    The Journal of chemical physics

    2005  Band 122, Heft 9, Seite(n) 94705

    Abstract: A simple unequal-sphere packing model is applied to study the iodine (3x3) adlayer on the Pt(111) surface. By using a newly introduced parameter, defined as the average adsorbate height, three characteristic adlattices, (3x3)-sym, (3x3)-asym, and (3x3)- ... ...

    Abstract A simple unequal-sphere packing model is applied to study the iodine (3x3) adlayer on the Pt(111) surface. By using a newly introduced parameter, defined as the average adsorbate height, three characteristic adlattices, (3x3)-sym, (3x3)-asym, and (3x3)-lin, have been selected and characterized in great detail, including the exact adatom registry. The (3x3)-sym iodine adlattice, observed in many experimental studies, appears to be, on average, the closest one to the substrate surface. A special contour plot of average adsorbate height vs X and Y positions of the (3x3) iodine unit cell indicates the existence of two local minima, which are related to preferential formation of (3x3)-sym and (3x3)-asym iodine adlattices. Our model gives good agreement with experimental findings, and explains the mechanism of preferential appearance of (3x3)-sym and (3x3)-asym structures.
    Sprache Englisch
    Erscheinungsdatum 2005-03-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.1856458
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