LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Solubility Enhancement of Antidiabetic Drugs Using a Co-Crystallization Approach.

    Batisai, Eustina

    ChemistryOpen

    2021  Volume 10, Issue 12, Page(s) 1260–1268

    Abstract: The co-crystallization approach has been used to enhance specific desirable properties of active pharmaceutical ingredients (APIs) such as solubility, dissolution rate, and stability. Solubility is a fundamental property that affects the bioavailability ... ...

    Abstract The co-crystallization approach has been used to enhance specific desirable properties of active pharmaceutical ingredients (APIs) such as solubility, dissolution rate, and stability. Solubility is a fundamental property that affects the bioavailability and dosage of the API. The co-crystal approach is one of the emerging methods with the potential for improving the solubility of these drugs. This paper reviews the latest progress on improving the solubility of some antidiabetic drug molecules using the co-crystal approach.
    MeSH term(s) Biological Availability ; Crystallization ; Hypoglycemic Agents ; Solubility
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2021-12-18
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2655605-4
    ISSN 2191-1363 ; 2191-1363
    ISSN (online) 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.202100246
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Multicomponent crystals of anti-tuberculosis drugs: a mini-review.

    Batisai, Eustina

    RSC advances

    2020  Volume 10, Issue 61, Page(s) 37134–37141

    Abstract: Tuberculosis (TB) is the leading cause of death from a single infectious agent globally. Some of the early research on TB treatment indicated drug resistance as one of the key challenges in fighting this disease. The discovery that administering two or ... ...

    Abstract Tuberculosis (TB) is the leading cause of death from a single infectious agent globally. Some of the early research on TB treatment indicated drug resistance as one of the key challenges in fighting this disease. The discovery that administering two or more drugs simultaneously could lead to much more effective treatment, with reduced drug resistance and shorter periods of chemotherapy, was, therefore, a very significant breakthrough in TB drug research. Pursuant to this discovery, the World Health Organisation (WHO) recommended TB treatment employing fixed-dose combinations (FDCs) containing first line anti-TB drugs; rifampicin, isoniazid, pyrazinamide, streptomycin and ethambutol. Regardless, certain challenges associated with FDCs remain and these include chemical instability and reduced bioavailability of rifampicin. Therefore, some research effort has been directed towards finding ways to deal with these challenges. One such effort involves the use of pharmaceutical co-crystals of the active pharmaceutical ingredients. Consequently, several pharmaceutical co-crystals of isoniazid and pyrazinamide have been reported. This paper aims at reviewing the multicomponent crystal structures of two first-line anti-TB drugs; isoniazid and pyrazinamide. The review will first set out a brief history of the disease, milestones in TB chemotherapy and the challenges associated with current treatment regimens. This will then be followed by a brief introduction to pharmaceutical co-crystals and how they can improve the physical and chemical properties of the active pharmaceutical ingredients. Secondly, multicomponent crystals of the two active pharmaceutical ingredients will be analysed by manual inspection for common supramolecular synthons between the drug molecules as well as between drug molecules and co-formers. Lastly; stability, solubility and dissolution experiments carried out on the pharmaceutical co-crystals of pyrazinamide and isoniazid will be analysed to gain insights into progress made with regards to improving stability and solubility of the active pharmaceutical ingredients.
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d0ra06478e
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Multicomponent crystals of anti-tuberculosis drugs: a mini-review

    Batisai, Eustina

    RSC advances. 2020 Oct. 07, v. 10, no. 61

    2020  

    Abstract: Tuberculosis (TB) is the leading cause of death from a single infectious agent globally. Some of the early research on TB treatment indicated drug resistance as one of the key challenges in fighting this disease. The discovery that administering two or ... ...

    Abstract Tuberculosis (TB) is the leading cause of death from a single infectious agent globally. Some of the early research on TB treatment indicated drug resistance as one of the key challenges in fighting this disease. The discovery that administering two or more drugs simultaneously could lead to much more effective treatment, with reduced drug resistance and shorter periods of chemotherapy, was, therefore, a very significant breakthrough in TB drug research. Pursuant to this discovery, the World Health Organisation (WHO) recommended TB treatment employing fixed-dose combinations (FDCs) containing first line anti-TB drugs; rifampicin, isoniazid, pyrazinamide, streptomycin and ethambutol. Regardless, certain challenges associated with FDCs remain and these include chemical instability and reduced bioavailability of rifampicin. Therefore, some research effort has been directed towards finding ways to deal with these challenges. One such effort involves the use of pharmaceutical co-crystals of the active pharmaceutical ingredients. Consequently, several pharmaceutical co-crystals of isoniazid and pyrazinamide have been reported. This paper aims at reviewing the multicomponent crystal structures of two first-line anti-TB drugs; isoniazid and pyrazinamide. The review will first set out a brief history of the disease, milestones in TB chemotherapy and the challenges associated with current treatment regimens. This will then be followed by a brief introduction to pharmaceutical co-crystals and how they can improve the physical and chemical properties of the active pharmaceutical ingredients. Secondly, multicomponent crystals of the two active pharmaceutical ingredients will be analysed by manual inspection for common supramolecular synthons between the drug molecules as well as between drug molecules and co-formers. Lastly; stability, solubility and dissolution experiments carried out on the pharmaceutical co-crystals of pyrazinamide and isoniazid will be analysed to gain insights into progress made with regards to improving stability and solubility of the active pharmaceutical ingredients.
    Keywords World Health Organization ; active pharmaceutical ingredients ; bioavailability ; crystal structure ; crystals ; death ; drug resistance ; drug therapy ; history ; isoniazid ; lead ; paper ; pathogens ; research ; rifampicin ; solubility ; streptomycin ; tuberculosis
    Language English
    Dates of publication 2020-1007
    Size p. 37134-37141.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-light
    ISSN 2046-2069
    DOI 10.1039/d0ra06478e
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Creation of new guest accessible space under gas pressure in a flexible MOF: multidimensional insight through combination of in situ techniques.

    Bhatt, Prashant M / Batisai, Eustina / Smith, Vincent J / Barbour, Leonard J

    Chemical communications (Cambridge, England)

    2016  Volume 52, Issue 76, Page(s) 11374–11377

    Abstract: Metal-organic frameworks (MOFs) are an important class of porous materials with numerous potential applications. Molecular level understanding of various processes involving MOFs is very important in order to design porous materials with improved ... ...

    Abstract Metal-organic frameworks (MOFs) are an important class of porous materials with numerous potential applications. Molecular level understanding of various processes involving MOFs is very important in order to design porous materials with improved properties. Here we describe the elucidation by means of single-crystal X-ray diffraction (SCD) of three different phases of Zn
    Language English
    Publishing date 2016-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c6cc06709c
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Creation of new guest accessible space under gas pressure in a flexible MOF: multidimensional insight through combination of in situ techniques

    Bhatt, Prashant M / Batisai, Eustina / Smith, Vincent J / Barbour, Leonard J

    Chemical communications. 2016 Sept. 15, v. 52, no. 76

    2016  

    Abstract: Metal–organic frameworks (MOFs) are an important class of porous materials with numerous potential applications. Molecular level understanding of various processes involving MOFs is very important in order to design porous materials with improved ... ...

    Abstract Metal–organic frameworks (MOFs) are an important class of porous materials with numerous potential applications. Molecular level understanding of various processes involving MOFs is very important in order to design porous materials with improved properties. Here we describe the elucidation by means of single-crystal X-ray diffraction (SCD) of three different phases of Zn2(bdc)2(bpy) at different pressures of CO2. Moreover, this is a rare example where new space is created in the structure under gas pressure – space that was not previously occupied by guest molecules in any of the related structures. In addition to in situ SCD and sorption analysis, pressure-gradient differential scanning calorimetry (PG-DSC) provides very useful information about the system. This study represents the first instance where PG-DSC has been used to study the sorption behavior of a flexible porous framework.
    Keywords X-ray diffraction ; carbon dioxide ; chemical reactions ; coordination compounds ; differential scanning calorimetry ; porous media ; sorption
    Language English
    Dates of publication 2016-0915
    Size p. 11374-11377.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c6cc06709c
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A mechanochemically synthesised solid solution enables engineering of the sorption properties of a Werner clathrate.

    Batisai, Eustina / Lusi, Matteo / Jacobs, Tia / Barbour, Leonard J

    Chemical communications (Cambridge, England)

    2012  Volume 48, Issue 100, Page(s) 12171–12173

    Abstract: Mechanochemical synthesis has been used to obtain two Werner complexes and their solid solution that could not be obtained by conventional "wet" chemistry; remarkably, despite the structural and chemical similarity, the solid solution exhibits sorption ... ...

    Abstract Mechanochemical synthesis has been used to obtain two Werner complexes and their solid solution that could not be obtained by conventional "wet" chemistry; remarkably, despite the structural and chemical similarity, the solid solution exhibits sorption properties that differ from those of the pure compounds.
    Language English
    Publishing date 2012-12-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c2cc37261d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: A mechanochemically synthesised solid solution enables engineering of the sorption properties of a Werner clathrate

    Batisai, Eustina / Barbour, Leonard J / Jacobs, Tia / Lusi, Matteo

    Chemical communications. 2012 Nov. 21, v. 48, no. 100

    2012  

    Abstract: Mechanochemical synthesis has been used to obtain two Werner complexes and their solid solution that could not be obtained by conventional “wet” chemistry; remarkably, despite the structural and chemical similarity, the solid solution exhibits sorption ... ...

    Abstract Mechanochemical synthesis has been used to obtain two Werner complexes and their solid solution that could not be obtained by conventional “wet” chemistry; remarkably, despite the structural and chemical similarity, the solid solution exhibits sorption properties that differ from those of the pure compounds.
    Keywords chemical communication ; chemical compounds ; chemical reactions ; engineering ; mechanochemistry ; sorption
    Language English
    Dates of publication 2012-1121
    Size p. 12171-12173.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c2cc37261d
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top