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Article ; Online: What is the right pharmacotherapy for alcohol use disorder in patients with schizophrenia?

Batki, Steven L

2015 Volume 76, Issue 10, Page(s) e1336–7

MeSH term(s)	Alcoholism/drug therapy ; Antipsychotic Agents/therapeutic use ; Female ; Humans ; Male ; Risperidone/therapeutic use ; Schizophrenia/drug therapy
Chemical Substances	Antipsychotic Agents ; Risperidone (L6UH7ZF8HC)
Language	English
Publishing date	2015-10
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/JCP.14com09611
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Article ; Online: Working memory and alcohol demand relationships differ according to PTSD symptom severity among veterans with AUD.

Abram, Samantha V / Batki, Steven L / Pennington, David L

Experimental and clinical psychopharmacology

2021 Volume 29, Issue 2, Page(s) 166–177

Abstract: Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid with complex and often unclear associations. Working memory deficits may represent a shared mechanism implicated in emotion regulation and control over impulsive ... ...

Abstract	Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid with complex and often unclear associations. Working memory deficits may represent a shared mechanism implicated in emotion regulation and control over impulsive alcohol use. Here we test whether PTSD symptoms and working memory correlated with performance on a behavioral economic assessment of alcohol demand. 113 veterans (mean age 51 years; 89% male) completed an Alcohol Purchase Task (APT) and were assessed for PTSD, alcohol use, and working memory. We examined the interaction of PTSD symptoms and working memory on four indices of alcohol demand measured from the APT; specifically, we used separate models to test whether associations between working memory and intensity (consumption at $0), Omax (maximum expenditure), Pmax (price at maximum expenditure), and elasticity (price sensitivity), differed as a function of PTSD symptoms. In a model controlling for hazardous drinking, average drinking levels, age, sex, marital status, occupation, and education, we observed a significant interaction between PTSD symptoms and working memory on elasticity, whereby greater working memory capacity was associated with greater elasticity for veterans with lower PTSD symptoms. Follow-up analyses regarding specific PTSD symptom domains indicated that this effect was strongest for avoidance symptoms. Taken together, working memory abilities correlated with subjective valuations of alcohol in a laboratory setting for veterans with less severe PTSD symptoms. This work highlights the conditions under which working memory may be a potential target for interventions geared toward reducing alcohol use in veterans with co-occurring PTSD and AUD. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
MeSH term(s)	Adult ; Alcohol Drinking/psychology ; Alcoholism/psychology ; Female ; Humans ; Male ; Memory, Short-Term ; Middle Aged ; Stress Disorders, Post-Traumatic/psychology ; Veterans/psychology
Language	English
Publishing date	2021-05-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1209960-0
ISSN	1936-2293 ; 1064-1297
ISSN (online)	1936-2293
ISSN	1064-1297
DOI	10.1037/pha0000463
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Article ; Online: Impact of Alcohol Use, Traumatic Stress, and Cigarette Smoking on Cognitive Functioning in Veterans With Co-occurring Alcohol Use Disorder and Posttraumatic Stress Disorder.

Hua, Jessica P Y / Cano, Monique / Batki, Steven L / Pennington, David L

Military medicine

2022

Abstract: Introduction: Alcohol use disorder (AUD) and PTSD have high rates of co-occurrence in U.S. Military Veterans resulting in incrementally worse functional outcomes relative to having either one of these disorders alone. Cognitive dysfunction can impede ... ...

Abstract	Introduction: Alcohol use disorder (AUD) and PTSD have high rates of co-occurrence in U.S. Military Veterans resulting in incrementally worse functional outcomes relative to having either one of these disorders alone. Cognitive dysfunction can impede one's ability to benefit from standard behavioral AUD and PTSD treatments. Cigarette smoking is also highly prevalent among U.S. Military Veterans, and cognitive dysfunction is associated with chronic cigarette use among individuals with AUD and PTSD independently. However, much less is known about to what extent cigarette smoking further impairs cognitive functioning in individuals with both co-occurring AUD and PTSD. Materials and methods: U.S. Veterans with co-occurring AUD and PTSD (n = 162) completed a comprehensive cognitive assessment covering various domains: working memory, processing speed, mental switching, cognitive inhibition, auditory-verbal learning, auditory-verbal memory, and verbal fluency. To examine the impact of alcohol use, traumatic stress, and cigarette smoking on cognitive function, we conducted a three-way interaction examining the moderated effects of smoking status on the association between alcohol use and PTSD symptoms on a composite domain of global cognition. Results: Smoking status in Veterans with co-occurring AUD and PTSD moderated the relationship between alcohol use and global cognition (P = .042), such that higher levels of alcohol use in the past week were related to worse global cognitive function among Veterans cigarette smokers (P = .015) but not among nonsmokers (P = .833). On follow-up analyses of individual cognitive domains, greater alcohol use in the past week was associated with lower cognitive inhibition in smokers but not nonsmokers, with traumatic stress symptoms moderating this effect (P = .039). Additionally, smoking status moderated the relationship between alcohol use and auditory-verbal learning, such that there was a differential relationship between alcohol use and auditory-verbal learning between smokers and nonsmokers. Conclusions: Overall, results provide evidence for the compounding impact of alcohol use, traumatic stress, and cigarette smoking on cognitive functioning. Impaired cognitive performance on a global level as well as on individual domains of cognitive inhibition and auditory-verbal learning were evident. Cognitive dysfunction may impede a Veteran's ability to benefit from therapeutic treatment, and these cognitive domains may represent potential targets for cognitive training efforts. Further, study results support smoking cessation initiatives and smoke-free policies enacted at Veterans Affairs healthcare facilities and medical centers.
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usac282
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Book: Substance abuse treatment for persons with HIV, AIDS

Batki, Steven L. / Selwyn, Peter A.

(Treatment improvement protocol (TIP) series ; 37 ; DHHS publication (SMA) ; 00-3410)

2000

Author's details	Steven L. Batki ; Peter A. Selwyn
Series title	Treatment improvement protocol (TIP) series ; 37 DHHS publication (SMA) ; 00-3410 DHHS publication Treatment improvement protocol TIP series
Collection	DHHS publication Treatment improvement protocol TIP series
Language	English
Size	XXVI, 316 S.
Publisher	U. S. Dept. of Health and Human Services
Publishing place	Rockville, Md
Publishing country	United States
Document type	Book
HBZ-ID	HT012827946
Database	Catalogue ZB MED Medicine, Health

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Article: Intranasal Oxytocin for Stimulant Use Disorder Among Male Veterans Enrolled in an Opioid Treatment Program: A Randomized Controlled Trial.

Stauffer, Christopher S / Samson, Salem / Hickok, Alex / Hoffman, William F / Batki, Steven L

Frontiers in psychiatry

2022 Volume 12, Page(s) 804997

Abstract: The increasing prevalence of illicit stimulant use among those in opioid treatment programs poses a significant risk to public health, stimulant users have the lowest rate of retention and poorest outcomes among those in addiction treatment, and current ... ...

Abstract	The increasing prevalence of illicit stimulant use among those in opioid treatment programs poses a significant risk to public health, stimulant users have the lowest rate of retention and poorest outcomes among those in addiction treatment, and current treatment options are limited. Oxytocin administration has shown promise in reducing addiction-related behavior and enhancing salience to social cues. We conducted a randomized, double-blind, placebo-controlled clinical trial of intranasal oxytocin administered twice daily for 6 weeks to male Veterans with stimulant use disorder who were also receiving opioid agonist therapy and counseling (
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.804997
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Article: The Impact of Exercise and Virtual Reality Executive Function Training on Cognition Among Heavy Drinking Veterans With Traumatic Brain Injury: A Pilot Feasibility Study.

Pennington, David L / Reavis, Jill V / Cano, Monique T / Walker, Erica / Batki, Steven L

Frontiers in behavioral neuroscience

2022 Volume 16, Page(s) 802711

Abstract: Executive function (EF) underlies self-control deficits in alcohol use disorder (AUD) and traumatic brain injury (TBI). Cognitive training is a promising adjunctive treatment targeting TBI- and AUD- related cognitive dysfunction. However, major ... ...

Abstract	Executive function (EF) underlies self-control deficits in alcohol use disorder (AUD) and traumatic brain injury (TBI). Cognitive training is a promising adjunctive treatment targeting TBI- and AUD- related cognitive dysfunction. However, major limitations related to compliance and generalizability in the field of cognitive training exist. Physical activity is associated with enhanced cognitive performance across several executive functions and may enhance the benefits of cognitive training. Virtual reality provides multisensory embodied experiences which are likely to engage brain networks more efficiently than standard cognitive training systems, ultimately resulting in greater near- and far-transfer effects. This pilot study aimed to obtain feasibility data and a preliminary assessment of an enriched virtual reality (VR) EF training (EFT) intervention combined with exercise (NCT03786276). Using an 8-week randomized adaptive design study, 30 AUD treatment seeking U.S. Veterans completed nine sessions of exercise-only ( Clinical trial registration: www.ClinicalTrials.gov, Identifier: NCT03786276.
Language	English
Publishing date	2022-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2022.802711
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Article ; Online: Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis.

Luk, Jeremy W / Satre, Derek D / Cheung, Ramsey / Wong, Robert J / Monto, Alexander / Chen, Jennifer Y / Batki, Steven L / Ostacher, Michael J / Snyder, Hannah R / Shui, Amy M / Liao, Meimei / Haight, Christina G / Khalili, Mandana

Hepatology communications

2024 Volume 8, Issue 2

Abstract: Background: Management of cirrhosis is challenging and has been complicated by the COVID-19 pandemic due to decreased access to care, increased psychological distress, and alcohol misuse. Recently, The National Institute on Alcohol Abuse and Alcoholism ... ...

Abstract	Background: Management of cirrhosis is challenging and has been complicated by the COVID-19 pandemic due to decreased access to care, increased psychological distress, and alcohol misuse. Recently, The National Institute on Alcohol Abuse and Alcoholism has broadened the definition of recovery from alcohol use disorder to include quality of life (QoL) as an indicator of recovery. This study examined the associations of alcohol-associated cirrhosis etiology and problematic drinking with liver disease QoL (LDQoL). Methods: Patients with cirrhosis (N=329) were recruited from 3 sites (63% from 2 Veterans Affairs Health Care Systems and 37% from 1 safety net hospital) serving populations that are economically or socially marginalized. Cirrhosis etiology was ascertained by chart review of medical records. Problematic drinking was defined by ≥8 on the Alcohol Use Disorders Identification Test. Multivariable general linear modeling adjusting for age, sex, race/ethnicity, site, pandemic-related stress, and history of anxiety/depressive disorder were conducted. Sensitivity analyses further adjusted for indicators of liver disease severity. Results: Participants were on average 64.6 years old, 17% female, 58% non-White, 44% with alcohol-associated cirrhosis, and 17% with problematic drinking. Problematic drinking was significantly associated with worse LDQoL scores in the overall scale and in the memory/concentration and health distress subscales. These associations remained significant after adjusting for indicators of liver disease severity, including Model for End-Stage Liver Disease-Sodium score and decompensated cirrhosis status. Conclusions: Among patients with cirrhosis, problematic drinking was associated with worse LDQoL, especially in the domains of memory/concentration and health distress. Assessment and awareness of cognitive deficits and negative emotionality within the context of cirrhosis and problematic drinking may help clinicians provide better integrated care for this population.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Quality of Life/psychology ; Alcoholism/complications ; Alcoholism/epidemiology ; Pandemics ; End Stage Liver Disease ; Severity of Illness Index ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/complications ; Ethanol
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000379
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Article ; Online: Effects of buprenorphine on opioid craving in comparison to other medications for opioid use disorder: A systematic review of randomized controlled trials.

Baxley, Catherine / Borsari, Brian / Reavis, Jill V / Manuel, Jennifer K / Herbst, Ellen / Becker, William / Pennington, David / Batki, Steven L / Seal, Karen

Addictive behaviors

2022 Volume 139, Page(s) 107589

Abstract: Background: Craving is a distressing symptom of opioid use disorder (OUD) that can be alleviated with medications for OUD (MOUD). Buprenorphine is an effective MOUD that may suppress craving; however, treatment discontinuation and resumed opioid use is ... ...

Abstract	Background: Craving is a distressing symptom of opioid use disorder (OUD) that can be alleviated with medications for OUD (MOUD). Buprenorphine is an effective MOUD that may suppress craving; however, treatment discontinuation and resumed opioid use is common during the early phases of treatment. More information on the craving response through the high-risk period of initiating buprenorphine may provide meaningful information on how to better target craving, which in turn may enhance outcomes. This systematic review investigated buprenorphine doses and formulations on craving during the induction and maintenance phases of treatment, and for context also compared the craving response to other MOUD (i.e., methadone, extended-release naltrexone [XR-NTX]). Methods: PubMed, PsycInfo, Embase, and Cochrane Central databases were searched for randomized trials of buprenorphine versus placebo, various buprenorphine formulations/doses, or other MOUD that included a measure of opioid craving. Results: A total of 10 studies were selected for inclusion. Buprenorphine and buprenorphine/naloxone (BUP/NAL) were each associated with lower craving than placebo over time. Craving was greater among those prescribed lower versus higher buprenorphine doses. In comparison to other MOUD, buprenorphine or BUP/NAL was linked to greater craving than methadone in 3 of the 6 studies. BUP/NAL was associated with greater reported craving than XR-NTX. Discussion: Craving is reduced over time with buprenorphine and BUP/NAL, although other MOUD may provide greater reductions in craving. Although there is currently considerable variability in the measurement of craving, it may be a valuable concept to address with individuals receiving MOUD, especially early in treatment.
MeSH term(s)	Humans ; Buprenorphine/therapeutic use ; Analgesics, Opioid/therapeutic use ; Narcotic Antagonists/therapeutic use ; Craving ; Delayed-Action Preparations ; Randomized Controlled Trials as Topic ; Opioid-Related Disorders/drug therapy ; Naltrexone/therapeutic use ; Buprenorphine, Naloxone Drug Combination/therapeutic use ; Methadone/therapeutic use
Chemical Substances	Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid ; Narcotic Antagonists ; Delayed-Action Preparations ; Naltrexone (5S6W795CQM) ; Buprenorphine, Naloxone Drug Combination ; Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2022-12-17
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	197618-7
ISSN	1873-6327 ; 0306-4603
ISSN (online)	1873-6327
ISSN	0306-4603
DOI	10.1016/j.addbeh.2022.107589
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Article ; Online: Care of the Transgender Patient.

Herbst, Ellen D / Harris, Edith / Pennington, David L / Batki, Steven L

Annals of internal medicine

2019 Volume 171, Issue 10, Page(s) 775

MeSH term(s)	Attitude of Health Personnel ; Humans ; Transgender Persons ; Transsexualism
Language	English
Publishing date	2019-11-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/L19-0534
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Article ; Online: Toward personalized medicine in the pharmacotherapy of alcohol use disorder: targeting patient genes and patient goals.

Batki, Steven L / Pennington, David L

The American journal of psychiatry

2014 Volume 171, Issue 4, Page(s) 391–394

MeSH term(s)	Alcoholism/drug therapy ; Female ; Fructose/analogs & derivatives ; Fructose/therapeutic use ; Humans ; Male ; Polymorphism, Single Nucleotide ; Receptors, Kainic Acid/genetics
Chemical Substances	Gluk1 kainate receptor ; Receptors, Kainic Acid ; topiramate (0H73WJJ391) ; Fructose (30237-26-4)
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/appi.ajp.2014.14010061
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