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  1. Article ; Online: Early versus late caffeine and/or non-steroidal anti-inflammatory drugs (NSAIDS) for prevention of intermittent hypoxia-induced neuroinflammation in the neonatal rat.

    Batool, Myra / Cai, Charles L / Aranda, Jacob V / Hand, Ivan / Beharry, Kay D

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

    2024  Volume 84, Issue 3, Page(s) 227–250

    Abstract: Preterm infants often experience frequent intermittent hypoxia (IH) episodes which are associated with neuroinflammation. We tested the hypotheses that early caffeine and/or non-steroidal inflammatory drugs (NSAIDs) confer superior therapeutic benefits ... ...

    Abstract Preterm infants often experience frequent intermittent hypoxia (IH) episodes which are associated with neuroinflammation. We tested the hypotheses that early caffeine and/or non-steroidal inflammatory drugs (NSAIDs) confer superior therapeutic benefits for protection against IH-induced neuroinflammation than late treatment. Newborn rats were exposed to IH or hyperoxia (50% O
    MeSH term(s) Animals ; Animals, Newborn ; Rats ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Caffeine/pharmacology ; Caffeine/therapeutic use ; Rats, Sprague-Dawley ; Neuroinflammatory Diseases/prevention & control ; Neuroinflammatory Diseases/drug therapy ; Hypoxia/complications ; Female ; Male ; Disease Models, Animal ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Ibuprofen/pharmacology ; Ibuprofen/therapeutic use ; Ketorolac/pharmacology ; Ketorolac/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Caffeine (3G6A5W338E) ; Ibuprofen (WK2XYI10QM) ; Ketorolac (YZI5105V0L)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605533-3
    ISSN 1873-474X ; 0736-5748
    ISSN (online) 1873-474X
    ISSN 0736-5748
    DOI 10.1002/jdn.10321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Impact of Donor Human Milk in an Urban NICU Population.

    Allana, Ahreen / Lo, Kahmun / Batool, Myra / Hand, Ivan

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 11

    Abstract: The American Academy of Pediatrics recommends the use of donor human milk in infants when mother’s own milk is not available. Our objective was to analyze whether the use of donor human milk in preterm, very-low-birth-weight (VLBW, <1500 g) infants ... ...

    Abstract The American Academy of Pediatrics recommends the use of donor human milk in infants when mother’s own milk is not available. Our objective was to analyze whether the use of donor human milk in preterm, very-low-birth-weight (VLBW, <1500 g) infants affected the rates of necrotizing enterocolitis, duration of parenteral nutrition (PN), growth, culture-positive sepsis, length of hospital stay, and mortality in an urban NICU population with low exclusive breast-feeding rates. A retrospective cohort study was conducted comparing two 2-year epochs of VLBW neonates before and after the introduction of donor breast milk in our neonatal intensive care unit (NICU). With the introduction of donor human milk, there was a significant reduction in the rate of necrotizing enterocolitis (NEC) (5% vs. 13%; p = 0.04) and less severe NEC as defined by Stage III based on the Modified Bell Staging Criteria (10% to 3%; p = 0.04). In the donor milk era, there was earlier initiation of enteral feeding (2.69 days vs. 3.84; p = 0.006) and a more rapid return to birthweight (9.5 days. 10.9 days; p = 0.006). In this study, a change in practice to the use of donor breast milk in a population with low rates of human milk provision was associated with earlier initiation of enteral feeding, faster return to birth weight, and a reduced incidence of NEC.
    Language English
    Publishing date 2022-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9111639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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