Article ; Online: C3:CH50 ratio as a proposed composite marker for eculizumab monitoring in atypical hemolytic uremic syndrome: Preliminary results.
Journal of immunoassay & immunochemistry
2017 Volume 38, Issue 2, Page(s) 178–189
Abstract: Treatment of atypical hemolytic uremic syndrome (aHUS) by the complement C5 inhibitor eculizumab (Soliris®) is highly effective but unfortunately, associated with an economic pressure on the health care systems even in high incomes countries. Despite ... ...
| Abstract | Treatment of atypical hemolytic uremic syndrome (aHUS) by the complement C5 inhibitor eculizumab (Soliris®) is highly effective but unfortunately, associated with an economic pressure on the health care systems even in high incomes countries. Despite spacing infusions having been proposed as the unique solution to minimize this economic impact, no reliable laboratory assays are available to tailor such therapy optimization. We aimed to propose and evaluate a complement composite marker for eculizumab efficacy monitoring in aHUS. We have retrospectively analyzed complement profiles data of eight aHUS patients under eculizumab from the International Registry of HUS/Thrombotic Thrombocytopenia Purpura, and calculated a novel marker "C3:CH |
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| MeSH term(s) | Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Atypical Hemolytic Uremic Syndrome/blood ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Biomarkers/blood ; Child ; Complement C3/analysis ; Complement Hemolytic Activity Assay ; Female ; Humans ; Male ; Retrospective Studies |
| Chemical Substances | Antibodies, Monoclonal, Humanized ; Biomarkers ; Complement C3 ; eculizumab (A3ULP0F556) |
| Language | English |
| Publishing date | 2017 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2050610-7 |
| ISSN | 1532-4230 ; 1532-1819 |
| ISSN (online) | 1532-4230 |
| ISSN | 1532-1819 |
| DOI | 10.1080/15321819.2016.1234485 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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